Protein Description

Gene Symbol PDE7A
Entrez ID 5150
Uniprot ID Q13946
Description phosphodiesterase 7A
Chromosomal Location chr8: 65,717,510-65,842,322
Ontology GO ID GO Term Definition Evidence

BP

GO:0006198

cAMP catabolic process

The chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate).

IEA

BP

GO:0007165

signal transduction

The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

IEA

CC

GO:0005829

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

TAS

MF

GO:0004115

3',5'-cyclic-AMP phosphodiesterase activity

Catalysis of the reaction: adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.

IDA|TAS

MF

GO:0046872

metal ion binding

Interacting selectively and non-covalently with any metal ion.

IEA

Domain ID Description

IPR002073

3'5'-cyclic nucleotide phosphodiesterase, catalytic domain

IPR003607

HD/PDEase domain

IPR023088

3'5'-cyclic nucleotide phosphodiesterase

IPR023174

3'5'-cyclic nucleotide phosphodiesterase, conserved site

Pathway ID Pathway Term Pathway Source

hsa00230

Purine metabolism

KEGG

hsa05032

Morphine addiction

KEGG

WP35

G Protein Signaling Pathways

WikiPathways

WP2858

Ectoderm Differentiation

WikiPathways

No diseases found.

Tissue Cell Type

heart muscle

myocytes

placenta

trophoblastic cells

skeletal muscle

myocytes

No databases found.

Pubmed ID Author Year Title

22951915

Haozi et al.

2012

Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

Gene Symbol Entrez ID Uniprot ID Score

VPS13A

23230

Q96RL7

0.63

THBS3

7059

P49746

0.63

UBXN11

91544

Q5T124

0.63