Gene Symbol | PDE7A |
Entrez ID | 5150 |
Uniprot ID | Q13946 |
Description | phosphodiesterase 7A |
Chromosomal Location | chr8: 65,717,510-65,842,322 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0006198 |
cAMP catabolic process |
The chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). |
IEA |
BP |
GO:0007165 |
signal transduction |
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
IEA |
CC |
GO:0005829 |
cytosol |
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
TAS |
MF |
GO:0004115 |
3',5'-cyclic-AMP phosphodiesterase activity |
Catalysis of the reaction: adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate. |
IDA|TAS |
MF |
GO:0046872 |
metal ion binding |
Interacting selectively and non-covalently with any metal ion. |
IEA |
Domain ID | Description |
---|---|
IPR002073 |
3'5'-cyclic nucleotide phosphodiesterase, catalytic domain |
IPR003607 |
HD/PDEase domain |
IPR023088 |
3'5'-cyclic nucleotide phosphodiesterase |
IPR023174 |
3'5'-cyclic nucleotide phosphodiesterase, conserved site |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
hsa00230 |
Purine metabolism |
KEGG |
hsa05032 |
Morphine addiction |
KEGG |
WP35 |
G Protein Signaling Pathways |
WikiPathways |
WP2858 |
Ectoderm Differentiation |
WikiPathways |
Tissue | Cell Type |
---|---|
heart muscle |
myocytes |
placenta |
trophoblastic cells |
skeletal muscle |
myocytes |
Pubmed ID | Author | Year | Title |
---|---|---|---|
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
VPS13A |
23230 |
Q96RL7 |
0.63 |
THBS3 |
7059 |
P49746 |
0.63 |
UBXN11 |
91544 |
Q5T124 |
0.63 |