| Gene Symbol | PCYT1A |
| Entrez ID | 5130 |
| Uniprot ID | P49585 |
| Description | phosphate cytidylyltransferase 1, choline, alpha |
| Chromosomal Location | chr3: 196,214,222-196,287,957 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0006656 |
phosphatidylcholine biosynthetic process |
The chemical reactions and pathways resulting in the formation of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. |
ISS|TAS |
|
BP |
GO:0006657 |
CDP-choline pathway |
The phosphatidylcholine biosynthetic process that begins with the phosphorylation of choline and ends with the combination of CDP-choline with diacylglycerol to form phosphatidylcholine. |
ISS |
|
BP |
GO:0008654 |
phospholipid biosynthetic process |
The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester. |
IEA |
|
CC |
GO:0005635 |
nuclear envelope |
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). |
IEA |
|
CC |
GO:0005789 |
endoplasmic reticulum membrane |
The lipid bilayer surrounding the endoplasmic reticulum. |
ISS|TAS |
|
CC |
GO:0005829 |
cytosol |
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
IEA |
|
CC |
GO:0005886 |
plasma membrane |
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
IEA |
|
CC |
GO:0042587 |
glycogen granule |
Cytoplasmic bead-like structures of animal cells, visible by electron microscope. Each granule is a functional unit with the biosynthesis and catabolism of glycogen being catalyzed by enzymes bound to the granule surface. |
ISS |
|
MF |
GO:0004105 |
choline-phosphate cytidylyltransferase activity |
Catalysis of the reaction: CTP + choline phosphate = diphosphate + CDP-choline. |
ISS|TAS |
|
MF |
GO:0005516 |
calmodulin binding |
Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. |
IEA |
|
MF |
GO:0008289 |
lipid binding |
Interacting selectively and non-covalently with a lipid. |
IEA |
|
MF |
GO:0031210 |
phosphatidylcholine binding |
Interacting selectively and non-covalently with phosphatidylcholine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of choline. |
IEA |
|
MF |
GO:0042803 |
protein homodimerization activity |
Interacting selectively and non-covalently with an identical protein to form a homodimer. |
IEA |
| Domain ID | Description |
|---|---|
|
IPR004821 |
Cytidyltransferase-like domain |
|
IPR014729 |
Rossmann-like alpha/beta/alpha sandwich fold |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
|
hsa00440 |
Phosphonate and phosphinate metabolism |
KEGG |
|
hsa00564 |
Glycerophospholipid metabolism |
KEGG |
|
hsa01100 |
Metabolic pathways |
KEGG |
|
hsa05231 |
Choline metabolism in cancer |
KEGG |
|
WP3933 |
Kennedy pathway |
WikiPathways |
|
WP528 |
Acetylcholine Synthesis |
WikiPathways |
|
WP3940 |
One carbon metabolism and related pathways |
WikiPathways |
| UMLS CUI | UMLS Term |
|---|---|
|
C0080178 |
Spina Bifida |
| Tissue | Cell Type |
|---|---|
|
cerebellum |
Purkinje cells |
|
cervix, uterine |
squamous epithelial cells |
|
colon |
endothelial cells |
|
colon |
glandular cells |
|
duodenum |
glandular cells |
|
epididymis |
glandular cells |
|
esophagus |
squamous epithelial cells |
|
gallbladder |
glandular cells |
|
kidney |
cells in glomeruli |
|
nasopharynx |
respiratory epithelial cells |
|
parathyroid gland |
glandular cells |
|
placenta |
decidual cells |
|
placenta |
trophoblastic cells |
|
rectum |
glandular cells |
|
salivary gland |
glandular cells |
|
skeletal muscle |
myocytes |
|
skin |
fibroblasts |
|
skin |
keratinocytes |
|
skin |
Langerhans |
|
skin |
melanocytes |
|
skin |
epidermal cells |
|
small intestine |
glandular cells |
|
soft tissue |
chondrocytes |
|
testis |
Leydig cells |
|
thyroid gland |
glandular cells |
|
vagina |
squamous epithelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
ACTB |
60 |
P60709 |
0.55 |
|
FMR1 |
2332 |
Q06787 |
0.63 |
|
PRKAR2A |
5576 |
P13861 |
0.63 |
|
S100A13 |
6284 |
Q99584 |
0.63 |
|
PDIA6 |
10130 |
Q15084 |
0.63 |
|
ING4 |
51147 |
Q9UNL4 |
0.63 |
|
APPL2 |
55198 |
Q8NEU8 |
0.63 |
|
UPF3A |
65110 |
Q9H1J1 |
0.63 |
|
SMC6 |
79677 |
Q96SB8 |
0.63 |
|
PPP1R9B |
84687 |
Q96SB3 |
0.63 |
|
FMNL2 |
114793 |
Q96PY5 |
0.63 |
|
CASP6 |
839 |
P55212 |
0.55 |
|
CASP8 |
841 |
Q14790 |
0.55 |
|
ACO2 |
50 |
Q99798 |
0.63 |
|
ACTN4 |
81 |
O43707 |
0.63 |
|
ALAS1 |
211 |
P13196 |
0.63 |
|
ALDOB |
229 |
P05062 |
0.63 |
|
RHOA |
387 |
P61586 |
0.63 |
|
ATP2B2 |
491 |
Q01814 |
0.63 |
|
BARD1 |
580 |
Q99728 |
0.63 |
|
CALD1 |
800 |
Q05682 |
0.63 |
|
CTSC |
1075 |
P53634 |
0.63 |
|
CREBBP |
1387 |
Q92793 |
0.63 |
|
CTSD |
1509 |
P07339 |
0.63 |
|
FTL |
2512 |
P02792 |
0.63 |
|
IDH3A |
3419 |
P50213 |
0.63 |
|
MSH3 |
4437 |
P20585 |
0.63 |
|
MT1JP |
4498 |
N/A |
0.63 |
|
MYO5A |
4644 |
Q9Y4I1 |
0.63 |
|
NASP |
4678 |
P49321 |
0.63 |
|
NFATC3 |
4775 |
Q12968 |
0.63 |
|
OSBP |
5007 |
P22059 |
0.63 |
|
PEG3 |
5178 |
Q9GZU2 |
0.63 |
|
PRKAB1 |
5564 |
Q9Y478 |
0.63 |
|
MAPK6 |
5597 |
Q16659 |
0.63 |
|
PYGB |
5834 |
P11216 |
0.63 |
|
RPL17 |
6139 |
P18621 |
0.63 |
|
SUMO2 |
6613 |
P61956 |
0.63 |
|
STAT6 |
6778 |
P42226 |
0.63 |
|
TERF1 |
7013 |
P54274 |
0.63 |
|
TOP2B |
7155 |
Q02880 |
0.63 |
|
NR2C1 |
7181 |
P13056 |
0.63 |
|
UVRAG |
7405 |
Q9P2Y5 |
0.63 |
|
OGT |
8473 |
O15294 |
0.63 |
|
URI1 |
8725 |
O94763 |
0.63 |
|
HERC1 |
8925 |
Q15751 |
0.63 |
|
HMGN3 |
9324 |
Q15651 |
0.63 |
|
TRIP4 |
9325 |
Q15650 |
0.63 |
|
UTP14C |
9724 |
Q5TAP6 |
0.63 |
|
CEP170 |
9859 |
Q5SW79 |
0.63 |
|
RCAN2 |
10231 |
Q14206 |
0.63 |
|
IPO7 |
10527 |
O95373 |
0.63 |
|
SLU7 |
10569 |
O95391 |
0.63 |
|
ANKRD26 |
22852 |
Q9UPS8 |
0.63 |
|
MYCBP2 |
23077 |
O75592 |
0.63 |
|
ZCCHC14 |
23174 |
Q8WYQ9 |
0.63 |
|
ZC3H7B |
23264 |
Q9UGR2 |
0.63 |
|
BRI3 |
25798 |
O95415 |
0.63 |
|
REXO2 |
25996 |
Q9Y3B8 |
0.63 |
|
AUTS2 |
26053 |
Q8WXX7 |
0.63 |
|
MAT2B |
27430 |
Q9NZL9 |
0.63 |
|
DNAJC15 |
29103 |
Q9Y5T4 |
0.63 |
|
POLR1D |
51082 |
Q9Y2S0 |
0.63 |
|
TRMT112 |
51504 |
Q9UI30 |
0.63 |
|
GIPC2 |
54810 |
Q8TF65 |
0.63 |
|
FNBP1L |
54874 |
Q5T0N5 |
0.63 |
|
TMEM260 |
54916 |
Q9NX78 |
0.63 |
|
ABHD10 |
55347 |
Q9NUJ1 |
0.63 |
|
LRRC59 |
55379 |
Q96AG4 |
0.63 |
|
ARHGAP23 |
57636 |
Q9P227 |
0.63 |
|
ANKRA2 |
57763 |
Q9H9E1 |
0.63 |
|
GPBP1L1 |
60313 |
Q9HC44 |
0.63 |
|
NMNAT1 |
64802 |
Q9HAN9 |
0.63 |
|
FAM161A |
84140 |
Q3B820 |
0.63 |
|
SETD3 |
84193 |
Q86TU7 |
0.63 |
|
ATPIF1 |
93974 |
Q9UII2 |
0.63 |
|
MAL2 |
114569 |
Q969L2 |
0.63 |
|
TARSL2 |
123283 |
A2RTX5 |
0.63 |
|
LOC340017 |
340017 |
N/A |
0.63 |
|
CEP170P1 |
645455 |
Q96L14 |
0.63 |