PCOSBase

Protein Description

Gene Symbol	PCYT1A
Entrez ID	5130
Uniprot ID	P49585
Description	phosphate cytidylyltransferase 1, choline, alpha
Chromosomal Location	chr3: 196,214,222-196,287,957

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Ontology	GO ID	GO Term	Definition	Evidence
BP	GO:0006656	phosphatidylcholine biosynthetic process	The chemical reactions and pathways resulting in the formation of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline.	ISS\|TAS
BP	GO:0006657	CDP-choline pathway	The phosphatidylcholine biosynthetic process that begins with the phosphorylation of choline and ends with the combination of CDP-choline with diacylglycerol to form phosphatidylcholine.	ISS
BP	GO:0008654	phospholipid biosynthetic process	The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester.	IEA
CC	GO:0005635	nuclear envelope	The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).	IEA
CC	GO:0005789	endoplasmic reticulum membrane	The lipid bilayer surrounding the endoplasmic reticulum.	ISS\|TAS
CC	GO:0005829	cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.	IEA
CC	GO:0005886	plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.	IEA
CC	GO:0042587	glycogen granule	Cytoplasmic bead-like structures of animal cells, visible by electron microscope. Each granule is a functional unit with the biosynthesis and catabolism of glycogen being catalyzed by enzymes bound to the granule surface.	ISS
MF	GO:0004105	choline-phosphate cytidylyltransferase activity	Catalysis of the reaction: CTP + choline phosphate = diphosphate + CDP-choline.	ISS\|TAS
MF	GO:0005516	calmodulin binding	Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.	IEA
MF	GO:0008289	lipid binding	Interacting selectively and non-covalently with a lipid.	IEA
MF	GO:0031210	phosphatidylcholine binding	Interacting selectively and non-covalently with phosphatidylcholine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of choline.	IEA
MF	GO:0042803	protein homodimerization activity	Interacting selectively and non-covalently with an identical protein to form a homodimer.	IEA

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Domain ID	Description
IPR004821	Cytidyltransferase-like domain
IPR014729	Rossmann-like alpha/beta/alpha sandwich fold

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Pathway ID	Pathway Term	Pathway Source
hsa00440	Phosphonate and phosphinate metabolism	KEGG
hsa00564	Glycerophospholipid metabolism	KEGG
hsa01100	Metabolic pathways	KEGG
hsa05231	Choline metabolism in cancer	KEGG
WP3933	Kennedy pathway	WikiPathways
WP528	Acetylcholine Synthesis	WikiPathways
WP3940	One carbon metabolism and related pathways	WikiPathways

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UMLS CUI	UMLS Term
C0080178	Spina Bifida

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Tissue	Cell Type
cerebellum	Purkinje cells
cervix, uterine	squamous epithelial cells
colon	endothelial cells
colon	glandular cells
duodenum	glandular cells
epididymis	glandular cells
esophagus	squamous epithelial cells
gallbladder	glandular cells
kidney	cells in glomeruli
nasopharynx	respiratory epithelial cells
parathyroid gland	glandular cells
placenta	decidual cells
placenta	trophoblastic cells
rectum	glandular cells
salivary gland	glandular cells
skeletal muscle	myocytes
skin	fibroblasts
skin	keratinocytes
skin	Langerhans
skin	melanocytes
skin	epidermal cells
small intestine	glandular cells
soft tissue	chondrocytes
testis	Leydig cells
thyroid gland	glandular cells
vagina	squamous epithelial cells

No databases found.

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Pubmed ID	Author	Year	Title
22951915	Haozi et al.	2012	Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

Gene Symbol	Entrez ID	Uniprot ID	Score
ACTB	60	P60709	0.55
FMR1	2332	Q06787	0.63
PRKAR2A	5576	P13861	0.63
S100A13	6284	Q99584	0.63
PDIA6	10130	Q15084	0.63
ING4	51147	Q9UNL4	0.63
APPL2	55198	Q8NEU8	0.63
UPF3A	65110	Q9H1J1	0.63
SMC6	79677	Q96SB8	0.63
PPP1R9B	84687	Q96SB3	0.63
FMNL2	114793	Q96PY5	0.63
CASP6	839	P55212	0.55
CASP8	841	Q14790	0.55
ACO2	50	Q99798	0.63
ACTN4	81	O43707	0.63
ALAS1	211	P13196	0.63
ALDOB	229	P05062	0.63
RHOA	387	P61586	0.63
ATP2B2	491	Q01814	0.63
BARD1	580	Q99728	0.63
CALD1	800	Q05682	0.63
CTSC	1075	P53634	0.63
CREBBP	1387	Q92793	0.63
CTSD	1509	P07339	0.63
FTL	2512	P02792	0.63
IDH3A	3419	P50213	0.63
MSH3	4437	P20585	0.63
MT1JP	4498		0.63
MYO5A	4644	Q9Y4I1	0.63
NASP	4678	P49321	0.63
NFATC3	4775	Q12968	0.63
OSBP	5007	P22059	0.63
PEG3	5178	Q9GZU2	0.63
PRKAB1	5564	Q9Y478	0.63
MAPK6	5597	Q16659	0.63
PYGB	5834	P11216	0.63
RPL17	6139	P18621	0.63
SUMO2	6613	P61956	0.63
STAT6	6778	P42226	0.63
TERF1	7013	P54274	0.63
TOP2B	7155	Q02880	0.63
NR2C1	7181	P13056	0.63
UVRAG	7405	Q9P2Y5	0.63
OGT	8473	O15294	0.63
URI1	8725	O94763	0.63
HERC1	8925	Q15751	0.63
HMGN3	9324	Q15651	0.63
TRIP4	9325	Q15650	0.63
UTP14C	9724	Q5TAP6	0.63
CEP170	9859	Q5SW79	0.63
RCAN2	10231	Q14206	0.63
IPO7	10527	O95373	0.63
SLU7	10569	O95391	0.63
ANKRD26	22852	Q9UPS8	0.63
MYCBP2	23077	O75592	0.63
ZCCHC14	23174	Q8WYQ9	0.63
ZC3H7B	23264	Q9UGR2	0.63
BRI3	25798	O95415	0.63
REXO2	25996	Q9Y3B8	0.63
AUTS2	26053	Q8WXX7	0.63
MAT2B	27430	Q9NZL9	0.63
DNAJC15	29103	Q9Y5T4	0.63
POLR1D	51082	Q9Y2S0	0.63
TRMT112	51504	Q9UI30	0.63
GIPC2	54810	Q8TF65	0.63
FNBP1L	54874	Q5T0N5	0.63
TMEM260	54916	Q9NX78	0.63
ABHD10	55347	Q9NUJ1	0.63
LRRC59	55379	Q96AG4	0.63
ARHGAP23	57636	Q9P227	0.63
ANKRA2	57763	Q9H9E1	0.63
GPBP1L1	60313	Q9HC44	0.63
NMNAT1	64802	Q9HAN9	0.63
FAM161A	84140	Q3B820	0.63
SETD3	84193	Q86TU7	0.63
ATPIF1	93974	Q9UII2	0.63
MAL2	114569	Q969L2	0.63
TARSL2	123283	A2RTX5	0.63
LOC340017	340017		0.63
CEP170P1	645455	Q96L14	0.63