Protein Description

Gene Symbol PCNA
Entrez ID 5111
Uniprot ID P12004
Description proliferating cell nuclear antigen
Chromosomal Location chr20: 5,114,953-5,126,626
Ontology GO ID GO Term Definition Evidence

BP

GO:0000082

G1/S transition of mitotic cell cycle

The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated.

TAS

BP

GO:0000083

regulation of transcription involved in G1/S transition of mitotic cell cycle

Any process that regulates transcription such that the target genes are involved in the transition between G1 and S phase of the mitotic cell cycle.

TAS

BP

GO:0000722

telomere maintenance via recombination

Any recombinational process that contributes to the maintenance of proper telomeric length.

TAS

BP

GO:0000723

telomere maintenance

Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences.

TAS

BP

GO:0006271

DNA strand elongation involved in DNA replication

The process in which a DNA strand is synthesized from template DNA during replication by the action of polymerases, which add nucleotides to the 3' end of the nascent DNA strand.

TAS

BP

GO:0006272

leading strand elongation

The synthesis of DNA from a template strand in the 5' to 3' direction; leading strand elongation is continuous as it proceeds in the same direction as the replication fork.

IBA

BP

GO:0006283

transcription-coupled nucleotide-excision repair

The nucleotide-excision repair process that carries out preferential repair of DNA lesions on the actively transcribed strand of the DNA duplex. In addition, the transcription-coupled nucleotide-excision repair pathway is required for the recognition and repair of a small subset of lesions that are not recognized by the global genome nucleotide excision repair pathway.

TAS

BP

GO:0006296

nucleotide-excision repair, DNA incision, 5'-to lesion

The endonucleolytic cleavage of the damaged strand of DNA 5' to the site of damage. The incision occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound. The incision follows the incision formed 3' to the site of damage.

TAS

BP

GO:0006297

nucleotide-excision repair, DNA gap filling

Repair of the gap in the DNA helix by DNA polymerase and DNA ligase after the portion of the strand containing the lesion has been removed by pyrimidine-dimer repair enzymes.

TAS

BP

GO:0006298

mismatch repair

A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination.

IDA|TAS

BP

GO:0006977

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage and resulting in the stopping or reduction in rate of the cell cycle.

TAS

BP

GO:0007507

heart development

The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.

IEA

BP

GO:0008283

cell proliferation

The multiplication or reproduction of cells, resulting in the expansion of a cell population.

TAS

BP

GO:0016925

protein sumoylation

The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxyl terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein.

TAS

BP

GO:0019985

translesion synthesis

The replication of damaged DNA by synthesis across a lesion in the template strand; a specialized DNA polymerase or replication complex inserts a defined nucleotide across from the lesion which allows DNA synthesis to continue beyond the lesion. This process can be mutagenic depending on the damaged nucleotide and the inserted nucleotide.

IDA|TAS

BP

GO:0030855

epithelial cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium.

IEP

BP

GO:0031297

replication fork processing

The process in which a DNA replication fork that has stalled is to a functional state and replication is restarted. The stalling may be due to DNA damage, DNA secondary structure, bound proteins, dNTP shortage, or other causes.

ISS

BP

GO:0032077

positive regulation of deoxyribonuclease activity

Any process that activates or increases the frequency, rate or extent of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid.

IDA

BP

GO:0032355

response to estradiol

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.

IEA

BP

GO:0033683

nucleotide-excision repair, DNA incision

A process that results in the endonucleolytic cleavage of the damaged strand of DNA. The incision occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound.

TAS

BP

GO:0034644

cellular response to UV

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.

IDA

BP

GO:0042276

error-prone translesion synthesis

The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions and causes an increase in the endogenous mutation level. For example, in E. coli, a low fidelity DNA polymerase, pol V, copies lesions that block replication fork progress. This produces mutations specifically targeted to DNA template damage sites, but it can also produce mutations at undamaged sites.

TAS

BP

GO:0042769

DNA damage response, detection of DNA damage

The series of events required to receive a stimulus indicating DNA damage has occurred and convert it to a molecular signal.

TAS

BP

GO:0044849

estrous cycle

A type of ovulation cycle, which occurs in most mammalian therian females, where the endometrium is resorbed if pregnancy does not occur.

IEA

BP

GO:0045739

positive regulation of DNA repair

Any process that activates or increases the frequency, rate or extent of DNA repair.

IMP

BP

GO:0045740

positive regulation of DNA replication

Any process that activates or increases the frequency, rate or extent of DNA replication.

IMP

BP

GO:0046686

response to cadmium ion

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.

IEA

BP

GO:0070301

cellular response to hydrogen peroxide

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.

IEA

BP

GO:0070987

error-free translesion synthesis

The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions but does not causes an increase in the endogenous mutation level. For S. cerevisiae, RAD30 encodes DNA polymerase eta, which incorporates two adenines. When incorporated across a thymine-thymine dimer, it does not increase the endogenous mutation level.

TAS

BP

GO:0071548

response to dexamethasone

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dexamethasone stimulus.

IEA

BP

GO:0097421

liver regeneration

The regrowth of lost or destroyed liver.

IEA

BP

GO:1902065

response to L-glutamate

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an L-glutamate stimulus.

IEA

BP

GO:1902990

mitotic telomere maintenance via semi-conservative replication

Any telomere maintenance via semi-conservative replication that is involved in mitotic cell cycle.

ISS

CC

GO:0000784

nuclear chromosome, telomeric region

The terminal region of a linear nuclear chromosome that includes the telomeric DNA repeats and associated proteins.

IDA

CC

GO:0005634

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

IDA

CC

GO:0005654

nucleoplasm

That part of the nuclear content other than the chromosomes or the nucleolus.

IDA|TAS

CC

GO:0005657

replication fork

The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes.

IDA

CC

GO:0005663

DNA replication factor C complex

A complex that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase. In eukaryotes the complex consists of five polypeptides.

TAS

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

IDA

CC

GO:0005813

centrosome

A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.

IDA

CC

GO:0030894

replisome

A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins.

TAS

CC

GO:0043596

nuclear replication fork

The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes.

IDA

CC

GO:0043626

PCNA complex

A protein complex composed of three identical PCNA monomers, each comprising two similar domains, which are joined in a head-to-tail arrangement to form a homotrimer. Forms a ring-like structure in solution, with a central hole sufficiently large to accommodate the double helix of DNA. Originally characterized as a DNA sliding clamp for replicative DNA polymerases and as an essential component of the replisome, and has also been shown to be involved in other processes including Okazaki fragment processing, DNA repair, translesion DNA synthesis, DNA methylation, chromatin remodeling and cell cycle regulation.

IDA

CC

GO:0070062

extracellular exosome

A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.

IDA

CC

GO:0070557

PCNA-p21 complex

A protein complex that contains the cyclin-dependent protein kinase inhibitor p21WAF1/CIP1 bound to PCNA; formation of the complex inhibits DNA replication.

IDA

MF

GO:0000701

purine-specific mismatch base pair DNA N-glycosylase activity

Catalysis of the removal of purines present in mismatches, especially opposite oxidized purines, by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site.

IDA

MF

GO:0003682

chromatin binding

Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.

IDA

MF

GO:0003684

damaged DNA binding

Interacting selectively and non-covalently with damaged DNA.

IDA

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0019899

enzyme binding

Interacting selectively and non-covalently with any enzyme.

IPI

MF

GO:0030331

estrogen receptor binding

Interacting selectively and non-covalently with an estrogen receptor.

IEA

MF

GO:0030337

DNA polymerase processivity factor activity

An enzyme regulator activity that increases the processivity of polymerization by DNA polymerase, by allowing the polymerase to move rapidly along DNA while remaining topologically bound to it.

IBA

MF

GO:0030971

receptor tyrosine kinase binding

Interacting selectively and non-covalently with a receptor that possesses protein tyrosine kinase activity.

IPI

MF

GO:0032139

dinucleotide insertion or deletion binding

Interacting selectively and non-covalently with double-stranded DNA containing a dinucleotide insertion or deletion.

IDA

MF

GO:0032405

MutLalpha complex binding

Interacting selectively and non-covalently with the mismatch repair complex MutLalpha.

IDA

MF

GO:0035035

histone acetyltransferase binding

Interacting selectively and non-covalently with the enzyme histone acetyltransferase.

IPI

MF

GO:0042802

identical protein binding

Interacting selectively and non-covalently with an identical protein or proteins.

IPI

MF

GO:0070182

DNA polymerase binding

Interacting selectively and non-covalently with a DNA polymerase.

IPI

Domain ID Description

IPR000730

Proliferating cell nuclear antigen, PCNA

IPR022648

Proliferating cell nuclear antigen, PCNA, N-terminal

IPR022649

Proliferating cell nuclear antigen, PCNA, C-terminal

IPR022659

Proliferating cell nuclear antigen, PCNA, conserved site

Pathway ID Pathway Term Pathway Source

hsa03030

DNA replication

KEGG

hsa03410

Base excision repair

KEGG

hsa03420

Nucleotide excision repair

KEGG

hsa03430

Mismatch repair

KEGG

hsa04110

Cell cycle

KEGG

hsa04530

Tight junction

KEGG

hsa05161

Hepatitis B

KEGG

hsa05166

HTLV-I infection

KEGG

WP437

EGF/EGFR Signaling Pathway

WikiPathways

WP466

DNA Replication

WikiPathways

WP3941

Oxidative Damage

WikiPathways

WP2572

Primary Focal Segmental Glomerulosclerosis FSGS

WikiPathways

WP3959

DNA IR-Double Strand Breaks (DSBs) and cellular response via ATM

WikiPathways

WP615

Senescence and Autophagy in Cancer

WikiPathways

WP45

G1 to S cell cycle control

WikiPathways

WP179

Cell Cycle

WikiPathways

WP531

Mismatch repair

WikiPathways

WP2446

Retinoblastoma (RB) in Cancer

WikiPathways

h_p53Pathway

p53 Signaling Pathway

BioCarta

UMLS CUI UMLS Term

C0001418

Adenocarcinoma

C0006118

Brain Neoplasms

C0009375

Colonic Neoplasms

C0017661

Iga Glomerulonephritis

C0017668

Focal Glomerulosclerosis

C0022116

Ischemia

C0024121

Lung Neoplasms

C0027659

Neoplasms, Experimental

C0033860

Psoriasis

C0206624

Hepatoblastoma

Tissue Cell Type

appendix

glandular cells

appendix

lymphoid tissue

bone marrow

hematopoietic cells

colon

glandular cells

lymph node

germinal center cells

small intestine

glandular cells

tonsil

germinal center cells

Database Name

DisGeNET

Pubmed ID Author Year Title

15820804

Oksjoki et al.

2005

Molecular profiling of polycystic ovaries for markers of cell invasion and matrix turnover

19141577

Kim et al.

2009

Transcriptional Profiling with a Pathway-Oriented Analysis Identifies Dysregulated Molecular Phenotypes in the Endometrium of Patients with Polycystic Ovary Syndrome

22617121

Ouandaogo et al.

2012

Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

22951915

Haozi et al.

2012

Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

Gene Symbol Entrez ID Uniprot ID Score

ARHGDIA

396

P52565

0.49

P4HB

5034

P07237

0.49

PPIB

5479

P23284

0.49

CDC45

8318

O75419

0.49

PACSIN3

29763

Q9UKS6

0.49

PUS1

80324

Q9Y606

0.49

NACA2

342538

Q9H009

0.49

RAD17

5884

O75943

0.52

XPC

7508

Q01831

0.52

BARD1

580

Q99728

0.56

GCK

2645

P35557

0.56

GPI

2821

P06744

0.56

LDHA

3939

P00338

0.56

PFKM

5213

P08237

0.56

PKLR

5313

P30613

0.56

CALU

813

O43852

0.63

CCNE1

898

P24864

0.63

DDX11

1663

Q96FC9

0.63

DHX15

1665

O43143

0.63

FANCA

2175

O15360

0.63

FANCE

2178

Q9HB96

0.63

FOXO3

2309

O43524

0.63

MBD1

4152

Q9UIS9

0.63

MCM4

4173

P33991

0.63

MCM7

4176

P33993

0.63

RAD23A

5886

P54725

0.63

RAD51

5888

Q06609

0.63

RBBP6

5930

Q7Z6E9

0.63

RPA2

6118

P15927

0.63

RPA3

6119

P35244

0.63

SPAG1

6674

Q07617

0.63

TOP1

7150

P11387

0.63

UTY

7404

O14607

0.63

PABPN1

8106

Q86U42

0.63

USP10

9100

Q14694

0.63

CCNE2

9134

O96020

0.63

ISG15

9636

P05161

0.63

SETDB1

9869

Q15047

0.63

DCLRE1A

9937

Q6PJP8

0.63

GNPDA1

10007

P46926

0.63

RBM7

10179

Q9Y580

0.63

HERC4

26091

Q5GLZ8

0.63

SEC22A

26984

Q96IW7

0.63

MRPL4

51073

Q9BYD3

0.63

DCTPP1

79077

Q9H773

0.63

ZRANB3

84083

Q5FWF4

0.63

FBXO18

84893

Q8NFZ0

0.63

H2AFV

94239

Q71UI9

0.63

TMEM218

219854

A2RU14

0.63

EGFR

1956

P00533

0.65

TDG

6996

Q13569

0.68

WHSC1

7468

O96028

0.68

FANCL

55120

Q9NW38

0.68

CHEK1

1111

O14757

0.70

UNG

7374

P13051

0.70

ANK3

288

Q12955

0.72

GOLGA1

2800

Q92805

0.72

EEA1

8411

Q15075

0.72

AKR7A2

8574

O43488

0.72

FIBP

9158

O43427

0.72

NOS1AP

9722

O75052

0.72

FAM13A

10144

O94988

0.72

RUVBL2

10856

Q9Y230

0.72

PRDX3

10935

P30048

0.72

SLC27A4

10999

Q6P1M0

0.72

B4GALT7

11285

Q9UBV7

0.72

CYFIP1

23191

Q7L576

0.72

UHRF1

29128

Q96T88

0.72

UHRF1BP1

54887

Q6BDS2

0.72

RNF20

56254

Q5VTR2

0.72

KIAA1522

57648

Q9P206

0.72

MRPS25

64432

P82663

0.72

ELMO3

79767

Q96BJ8

0.72

OBSCN

84033

Q5VST9

0.72

ACOT1

641371

Q86TX2

0.72

POM121C

100101267

A8CG34

0.72

MDM2

4193

Q00987

0.74

POLK

51426

Q9UBT6

0.74

CCNB1

891

P14635

0.75

ING2

3622

Q9H160

0.75

PARP10

84875

Q53GL7

0.75

CDK5

1020

Q00535

0.76

EXO1

9156

Q9UQ84

0.76

DTL

51514

Q9NZJ0

0.76

TRAIP

10293

Q9BWF2

0.77

FANCD2

2177

Q9BXW9

0.78

YBX1

4904

P67809

0.79

PPP1CC

5501

P36873

0.79

REV1

51455

Q9UBZ9

0.79

XRCC6

2547

P12956

0.84

ATAD5

79915

Q96QE3

0.84

CCND3

896

P30281

0.85

PARP1

142

P09874

0.86

APEX1

328

P27695

0.86

CDAN1

146059

Q8IWY9

0.88

ANXA2

302

P07355

0.89

CCND1

595

P24385

0.89

DNMT1

1786

P26358

0.89

ERCC5

2073

P28715

0.89

KIAA0101

9768

Q15004

0.89

CDC25C

995

P30307

0.90

CDKN1A

1026

P38936

0.90

LIG1

3978

P18858

0.93

SUMO1

7341

P63165

0.93

MSH2

4436

P43246

0.94

RFC3

5983

P40938

0.95

CDK2

1017

P24941

0.96

POLD1

5424

P28340

0.96

GADD45A

1647

P24522

0.97

RFC1

5981

P35251

0.97

RFC4

5984

P35249

0.97

PCNA

5111

P12004

1.00

CALR

811

P27797

0.49

EWSR1

2130

Q01844

0.49

LAMP2

3920

P13473

0.49

SNU13

4809

P55769

0.49

NONO

4841

Q15233

0.49

HSP90B1

7184

P14625

0.49

HIST1H3A

8350

P68431

0.49

USP39

10713

Q53GS9

0.49

BABAM1

29086

Q9NWV8

0.49

CCAR1

55749

Q8IX12

0.49

ATRX

546

P46100

0.52

SMARCA4

6597

P51532

0.52

UBE2A

7319

P49459

0.52

UBE2D3

7323

P61077

0.52

USP4

7375

Q13107

0.52

USP2

9099

O75604

0.52

SEC23IP

11196

Q9Y6Y8

0.52

ZBTB1

22890

Q9Y2K1

0.52

SIRT1

23411

Q96EB6

0.52

POLM

27434

Q9NP87

0.52

DNTTIP2

30836

Q5QJE6

0.52

CHTF8

54921

P0CG13

0.52

IL17RB

55540

Q9NRM6

0.52

PALB2

79728

Q86YC2

0.52

SHPRH

257218

Q149N8

0.52

CSTF1

1477

Q05048

0.56

FSCN1

6624

Q16658

0.56

WDR48

57599

Q8TAF3

0.56

POLA1

5422

P09884

0.59

BAZ1B

9031

Q9UIG0

0.59

PPP1CA

5499

P62136

0.62

TCOF1

6949

Q13428

0.62

UBE2B

7320

P63146

0.62

DSCC1

79075

Q9BVC3

0.62

ABL1

25

P00519

0.63

APC

324

P25054

0.63

AIRE

326

O43918

0.63

BRCA1

672

P38398

0.63

CDC6

990

Q99741

0.63

CDK6

1021

Q00534

0.63

ERCC8

1161

Q13216

0.63

E2F3

1871

O00716

0.63

EPB41

2035

P11171

0.63

ERCC6

2074

Q03468

0.63

FUS

2521

P35637

0.63

HEXA

3073

P06865

0.63

HK1

3098

P19367

0.63

HLA-B

3106

P30480

0.63

HLA-C

3107

P30504

0.63

JUN

3725

P05412

0.63

MCC

4163

P23508

0.63

MGMT

4255

P16455

0.63

NEDD8

4738

Q15843

0.63

NTRK1

4914

P04629

0.63

PARK2

5071

O60260

0.63

POLR2A

5430

P24928

0.63

PTMA

5757

P06454

0.63

RPS6KB2

6199

Q9UBS0

0.63

RYK

6259

P34925

0.63

CCL2

6347

P13500

0.63

SETMAR

6419

Q53H47

0.63

SGTA

6449

O43765

0.63

SKI

6497

P12755

0.63

SUMO3

6612

P55854

0.63

SUMO2

6613

P61956

0.63

TFAP4

7023

Q01664

0.63

TP53

7157

P04637

0.63

TRAF6

7189

Q9Y4K3

0.63

WARS

7453

P23381

0.63

XPNPEP1

7511

Q9NQW7

0.63

TRIM25

7706

Q14258

0.63

CUL5

8065

Q93034

0.63

USP5

8078

P45974

0.63

KDM5C

8242

P41229

0.63

CUL4B

8450

Q13620

0.63

CUL3

8452

Q13618

0.63

CUL1

8454

Q13616

0.63

TSC22D1

8848

Q15714

0.63

PLAA

9373

Q9Y263

0.63

RECQL5

9400

O94762

0.63

MAGED1

9500

Q9Y5V3

0.63

IKBKE

9641

Q14164

0.63

CUL7

9820

Q14999

0.63

HDAC6

10013

Q9UBN7

0.63

HDAC5

10014

Q9UQL6

0.63

EIF1B

10289

O60739

0.63

KAT5

10524

Q92993

0.63

CBX1

10951

P83916

0.63

PTP4A3

11156

O75365

0.63

PDCD10

11235

Q9BUL8

0.63

USP18

11274

Q9UMW8

0.63

FAN1

22909

Q9Y2M0

0.63

KIN

22944

O60870

0.63

OBSL1

23363

O75147

0.63

FTSJ1

24140

Q9UET6

0.63

L3MBTL1

26013

Q9Y468

0.63

FBXO6

26270

Q9NRD1

0.63

STK39

27347

Q9UEW8

0.63

PPME1

51400

Q9Y570

0.63

ELP3

55140

Q9H9T3

0.63

PIDD1

55367

Q9HB75

0.63

CHFR

55743

Q96EP1

0.63

DMAP1

55929

Q9NPF5

0.63

AICDA

57379

Q9GZX7

0.63

MAP1LC3B

81631

Q9GZQ8

0.63

KCTD10

83892

Q9H3F6

0.63

SLX4

84464

Q8IY92

0.63

MAP1LC3A

84557

Q9H492

0.63

TIRAP

114609

P58753

0.63

LRRK2

120892

Q5S007

0.63

ASB8

140461

Q9H765

0.63

MAPK15

225689

Q8TD08

0.63

DDB1

100290337

Q16531

0.63

TNFAIP1

7126

Q13829

0.65

CHAF1B

8208

Q13112

0.65

HIST2H3A; HIST2H3C; HIST2H3D

126961

Q71DI3

0.65

TPI1

7167

P60174

0.68

KCTD13

253980

Q8WZ19

0.68

CREBBP

1387

Q92793

0.70

MLH1

4292

P40692

0.70

CUL2

8453

Q13617

0.70

SMARCAD1

56916

Q9H4L7

0.70

BRCA2

675

P51587

0.72

CA2

760

P00918

0.72

ATF2

1386

P15336

0.72

EEF1A1

1915

P68104

0.72

FN1

2335

P02751

0.72

KRT7

3855

P08729

0.72

RPSA

3921

P08865

0.72

MDH2

4191

P40926

0.72

MME

4311

P08473

0.72

PPIA

5478

P62937

0.72

RELA

5970

Q04206

0.72

TIMELESS

8914

Q9UNS1

0.72

PRDX6

9588

P30041

0.72

PDS5B

23047

Q9NTI5

0.72

CLSPN

63967

Q9HAW4

0.72

DSN1

79980

Q9H410

0.72

UHRF2

115426

Q96PU4

0.72

PRKDC

5591

P78527

0.73

MYBBP1A

10514

Q9BQG0

0.73

UBD

10537

O15205

0.73

SUB1

10923

P53999

0.73

GADD45B

4616

O75293

0.74

XRCC5

7520

P13010

0.74

CUL4A

8451

Q13619

0.74

ALDOA

226

P04075

0.75

CDKN2A

1029

P42771

0.75

DHX9

1660

Q08211

0.75

ENO1

2023

P06733

0.75

GAPDH

2597

P04406

0.75

PGAM1

5223

P18669

0.75

PGK1

5230

P00558

0.75

RBBP8

5932

Q99708

0.75

RNF8

9025

O76064

0.75

HUWE1

10075

Q7Z6Z7

0.75

USP1

7398

O94782

0.76

POLN

353497

Q7Z5Q5

0.76

DNTT

1791

P04053

0.78

POLD4

57804

Q9HCU8

0.78

MCL1

4170

Q07820

0.79

RAD21

5885

O60216

0.80

SPRTN

83932

Q9H040

0.81

POLB

5423

P06746

0.83

POLE

5426

Q07864

0.84

RAD9A

5883

Q99638

0.84

RPA1

6117

P27694

0.84

SIVA1

10572

O15304

0.85

HUS1

3364

O60921

0.86

PMS2

5395

P54278

0.86

OTUB1

55611

Q96FW1

0.86

CCNA2

890

P20248

0.87

POLL

27343

Q9UGP5

0.87

RAD18

56852

Q9NS91

0.87

ING1

3621

Q9UK53

0.88

MUTYH

4595

Q9UIF7

0.88

CDK4

1019

P11802

0.89

CDKN1C

1028

P49918

0.89

CCNO

10309

P22674

0.89

POLDIP2

26073

Q9Y2S7

0.89

KMT5A

387893

Q9NQR1

0.89

EP300

2033

Q09472

0.90

HDAC1

3065

Q13547

0.90

WRN

7486

Q14191

0.90

XRCC1

7515

P18887

0.90

CHAF1A

10036

Q13111

0.90

POLD3

10714

Q15054

0.90

POLI

11201

Q9UNA4

0.90

CDT1

81620

Q9H211

0.90

HLTF

6596

Q14527

0.95

APEX2

27301

Q9UBZ4

0.95

CHTF18

63922

Q8WVB6

0.95

RFC2

5982

P35250

0.96

RFC5

5985

P40937

0.96

FEN1

2237

P39748

0.97

MSH6

2956

P52701

0.97

MSH3

4437

P20585

0.97

POLD2

5425

P49005

0.97

POLH

5429

Q9Y253

0.97

GADD45G

10912

O95257

0.97