Gene Symbol | PCNA |
Entrez ID | 5111 |
Uniprot ID | P12004 |
Description | proliferating cell nuclear antigen |
Chromosomal Location | chr20: 5,114,953-5,126,626 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0000082 |
G1/S transition of mitotic cell cycle |
The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated. |
TAS |
BP |
GO:0000083 |
regulation of transcription involved in G1/S transition of mitotic cell cycle |
Any process that regulates transcription such that the target genes are involved in the transition between G1 and S phase of the mitotic cell cycle. |
TAS |
BP |
GO:0000722 |
telomere maintenance via recombination |
Any recombinational process that contributes to the maintenance of proper telomeric length. |
TAS |
BP |
GO:0000723 |
telomere maintenance |
Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences. |
TAS |
BP |
GO:0006271 |
DNA strand elongation involved in DNA replication |
The process in which a DNA strand is synthesized from template DNA during replication by the action of polymerases, which add nucleotides to the 3' end of the nascent DNA strand. |
TAS |
BP |
GO:0006272 |
leading strand elongation |
The synthesis of DNA from a template strand in the 5' to 3' direction; leading strand elongation is continuous as it proceeds in the same direction as the replication fork. |
IBA |
BP |
GO:0006283 |
transcription-coupled nucleotide-excision repair |
The nucleotide-excision repair process that carries out preferential repair of DNA lesions on the actively transcribed strand of the DNA duplex. In addition, the transcription-coupled nucleotide-excision repair pathway is required for the recognition and repair of a small subset of lesions that are not recognized by the global genome nucleotide excision repair pathway. |
TAS |
BP |
GO:0006296 |
nucleotide-excision repair, DNA incision, 5'-to lesion |
The endonucleolytic cleavage of the damaged strand of DNA 5' to the site of damage. The incision occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound. The incision follows the incision formed 3' to the site of damage. |
TAS |
BP |
GO:0006297 |
nucleotide-excision repair, DNA gap filling |
Repair of the gap in the DNA helix by DNA polymerase and DNA ligase after the portion of the strand containing the lesion has been removed by pyrimidine-dimer repair enzymes. |
TAS |
BP |
GO:0006298 |
mismatch repair |
A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. |
IDA|TAS |
BP |
GO:0006977 |
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest |
A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage and resulting in the stopping or reduction in rate of the cell cycle. |
TAS |
BP |
GO:0007507 |
heart development |
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. |
IEA |
BP |
GO:0008283 |
cell proliferation |
The multiplication or reproduction of cells, resulting in the expansion of a cell population. |
TAS |
BP |
GO:0016925 |
protein sumoylation |
The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxyl terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein. |
TAS |
BP |
GO:0019985 |
translesion synthesis |
The replication of damaged DNA by synthesis across a lesion in the template strand; a specialized DNA polymerase or replication complex inserts a defined nucleotide across from the lesion which allows DNA synthesis to continue beyond the lesion. This process can be mutagenic depending on the damaged nucleotide and the inserted nucleotide. |
IDA|TAS |
BP |
GO:0030855 |
epithelial cell differentiation |
The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium. |
IEP |
BP |
GO:0031297 |
replication fork processing |
The process in which a DNA replication fork that has stalled is to a functional state and replication is restarted. The stalling may be due to DNA damage, DNA secondary structure, bound proteins, dNTP shortage, or other causes. |
ISS |
BP |
GO:0032077 |
positive regulation of deoxyribonuclease activity |
Any process that activates or increases the frequency, rate or extent of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid. |
IDA |
BP |
GO:0032355 |
response to estradiol |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen. |
IEA |
BP |
GO:0033683 |
nucleotide-excision repair, DNA incision |
A process that results in the endonucleolytic cleavage of the damaged strand of DNA. The incision occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound. |
TAS |
BP |
GO:0034644 |
cellular response to UV |
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers. |
IDA |
BP |
GO:0042276 |
error-prone translesion synthesis |
The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions and causes an increase in the endogenous mutation level. For example, in E. coli, a low fidelity DNA polymerase, pol V, copies lesions that block replication fork progress. This produces mutations specifically targeted to DNA template damage sites, but it can also produce mutations at undamaged sites. |
TAS |
BP |
GO:0042769 |
DNA damage response, detection of DNA damage |
The series of events required to receive a stimulus indicating DNA damage has occurred and convert it to a molecular signal. |
TAS |
BP |
GO:0044849 |
estrous cycle |
A type of ovulation cycle, which occurs in most mammalian therian females, where the endometrium is resorbed if pregnancy does not occur. |
IEA |
BP |
GO:0045739 |
positive regulation of DNA repair |
Any process that activates or increases the frequency, rate or extent of DNA repair. |
IMP |
BP |
GO:0045740 |
positive regulation of DNA replication |
Any process that activates or increases the frequency, rate or extent of DNA replication. |
IMP |
BP |
GO:0046686 |
response to cadmium ion |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus. |
IEA |
BP |
GO:0070301 |
cellular response to hydrogen peroxide |
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus. |
IEA |
BP |
GO:0070987 |
error-free translesion synthesis |
The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions but does not causes an increase in the endogenous mutation level. For S. cerevisiae, RAD30 encodes DNA polymerase eta, which incorporates two adenines. When incorporated across a thymine-thymine dimer, it does not increase the endogenous mutation level. |
TAS |
BP |
GO:0071548 |
response to dexamethasone |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dexamethasone stimulus. |
IEA |
BP |
GO:0097421 |
liver regeneration |
The regrowth of lost or destroyed liver. |
IEA |
BP |
GO:1902065 |
response to L-glutamate |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an L-glutamate stimulus. |
IEA |
BP |
GO:1902990 |
mitotic telomere maintenance via semi-conservative replication |
Any telomere maintenance via semi-conservative replication that is involved in mitotic cell cycle. |
ISS |
CC |
GO:0000784 |
nuclear chromosome, telomeric region |
The terminal region of a linear nuclear chromosome that includes the telomeric DNA repeats and associated proteins. |
IDA |
CC |
GO:0005634 |
nucleus |
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
IDA |
CC |
GO:0005654 |
nucleoplasm |
That part of the nuclear content other than the chromosomes or the nucleolus. |
IDA|TAS |
CC |
GO:0005657 |
replication fork |
The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes. |
IDA |
CC |
GO:0005663 |
DNA replication factor C complex |
A complex that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase. In eukaryotes the complex consists of five polypeptides. |
TAS |
CC |
GO:0005737 |
cytoplasm |
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
IDA |
CC |
GO:0005813 |
centrosome |
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle. |
IDA |
CC |
GO:0030894 |
replisome |
A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins. |
TAS |
CC |
GO:0043596 |
nuclear replication fork |
The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes. |
IDA |
CC |
GO:0043626 |
PCNA complex |
A protein complex composed of three identical PCNA monomers, each comprising two similar domains, which are joined in a head-to-tail arrangement to form a homotrimer. Forms a ring-like structure in solution, with a central hole sufficiently large to accommodate the double helix of DNA. Originally characterized as a DNA sliding clamp for replicative DNA polymerases and as an essential component of the replisome, and has also been shown to be involved in other processes including Okazaki fragment processing, DNA repair, translesion DNA synthesis, DNA methylation, chromatin remodeling and cell cycle regulation. |
IDA |
CC |
GO:0070062 |
extracellular exosome |
A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. |
IDA |
CC |
GO:0070557 |
PCNA-p21 complex |
A protein complex that contains the cyclin-dependent protein kinase inhibitor p21WAF1/CIP1 bound to PCNA; formation of the complex inhibits DNA replication. |
IDA |
MF |
GO:0000701 |
purine-specific mismatch base pair DNA N-glycosylase activity |
Catalysis of the removal of purines present in mismatches, especially opposite oxidized purines, by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site. |
IDA |
MF |
GO:0003682 |
chromatin binding |
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. |
IDA |
MF |
GO:0003684 |
damaged DNA binding |
Interacting selectively and non-covalently with damaged DNA. |
IDA |
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
MF |
GO:0019899 |
enzyme binding |
Interacting selectively and non-covalently with any enzyme. |
IPI |
MF |
GO:0030331 |
estrogen receptor binding |
Interacting selectively and non-covalently with an estrogen receptor. |
IEA |
MF |
GO:0030337 |
DNA polymerase processivity factor activity |
An enzyme regulator activity that increases the processivity of polymerization by DNA polymerase, by allowing the polymerase to move rapidly along DNA while remaining topologically bound to it. |
IBA |
MF |
GO:0030971 |
receptor tyrosine kinase binding |
Interacting selectively and non-covalently with a receptor that possesses protein tyrosine kinase activity. |
IPI |
MF |
GO:0032139 |
dinucleotide insertion or deletion binding |
Interacting selectively and non-covalently with double-stranded DNA containing a dinucleotide insertion or deletion. |
IDA |
MF |
GO:0032405 |
MutLalpha complex binding |
Interacting selectively and non-covalently with the mismatch repair complex MutLalpha. |
IDA |
MF |
GO:0035035 |
histone acetyltransferase binding |
Interacting selectively and non-covalently with the enzyme histone acetyltransferase. |
IPI |
MF |
GO:0042802 |
identical protein binding |
Interacting selectively and non-covalently with an identical protein or proteins. |
IPI |
MF |
GO:0070182 |
DNA polymerase binding |
Interacting selectively and non-covalently with a DNA polymerase. |
IPI |
Domain ID | Description |
---|---|
IPR000730 |
Proliferating cell nuclear antigen, PCNA |
IPR022648 |
Proliferating cell nuclear antigen, PCNA, N-terminal |
IPR022649 |
Proliferating cell nuclear antigen, PCNA, C-terminal |
IPR022659 |
Proliferating cell nuclear antigen, PCNA, conserved site |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
hsa03030 |
DNA replication |
KEGG |
hsa03410 |
Base excision repair |
KEGG |
hsa03420 |
Nucleotide excision repair |
KEGG |
hsa03430 |
Mismatch repair |
KEGG |
hsa04110 |
Cell cycle |
KEGG |
hsa04530 |
Tight junction |
KEGG |
hsa05161 |
Hepatitis B |
KEGG |
hsa05166 |
HTLV-I infection |
KEGG |
WP437 |
EGF/EGFR Signaling Pathway |
WikiPathways |
WP466 |
DNA Replication |
WikiPathways |
WP3941 |
Oxidative Damage |
WikiPathways |
WP2572 |
Primary Focal Segmental Glomerulosclerosis FSGS |
WikiPathways |
WP3959 |
DNA IR-Double Strand Breaks (DSBs) and cellular response via ATM |
WikiPathways |
WP615 |
Senescence and Autophagy in Cancer |
WikiPathways |
WP45 |
G1 to S cell cycle control |
WikiPathways |
WP179 |
Cell Cycle |
WikiPathways |
WP531 |
Mismatch repair |
WikiPathways |
WP2446 |
Retinoblastoma (RB) in Cancer |
WikiPathways |
h_p53Pathway |
p53 Signaling Pathway |
BioCarta |
UMLS CUI | UMLS Term |
---|---|
C0001418 |
Adenocarcinoma |
C0006118 |
Brain Neoplasms |
C0009375 |
Colonic Neoplasms |
C0017661 |
Iga Glomerulonephritis |
C0017668 |
Focal Glomerulosclerosis |
C0022116 |
Ischemia |
C0024121 |
Lung Neoplasms |
C0027659 |
Neoplasms, Experimental |
C0033860 |
Psoriasis |
C0206624 |
Hepatoblastoma |
Tissue | Cell Type |
---|---|
appendix |
glandular cells |
appendix |
lymphoid tissue |
bone marrow |
hematopoietic cells |
colon |
glandular cells |
lymph node |
germinal center cells |
small intestine |
glandular cells |
tonsil |
germinal center cells |
Database Name |
---|
DisGeNET |
Pubmed ID | Author | Year | Title |
---|---|---|---|
15820804 |
Oksjoki et al. |
2005 |
Molecular profiling of polycystic ovaries for markers of cell invasion and matrix turnover |
19141577 |
Kim et al. |
2009 |
Transcriptional Profiling with a Pathway-Oriented Analysis Identifies Dysregulated Molecular Phenotypes in the Endometrium of Patients with Polycystic Ovary Syndrome |
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
ARHGDIA |
396 |
P52565 |
0.49 |
P4HB |
5034 |
P07237 |
0.49 |
PPIB |
5479 |
P23284 |
0.49 |
CDC45 |
8318 |
O75419 |
0.49 |
PACSIN3 |
29763 |
Q9UKS6 |
0.49 |
PUS1 |
80324 |
Q9Y606 |
0.49 |
NACA2 |
342538 |
Q9H009 |
0.49 |
RAD17 |
5884 |
O75943 |
0.52 |
XPC |
7508 |
Q01831 |
0.52 |
BARD1 |
580 |
Q99728 |
0.56 |
GCK |
2645 |
P35557 |
0.56 |
GPI |
2821 |
P06744 |
0.56 |
LDHA |
3939 |
P00338 |
0.56 |
PFKM |
5213 |
P08237 |
0.56 |
PKLR |
5313 |
P30613 |
0.56 |
CALU |
813 |
O43852 |
0.63 |
CCNE1 |
898 |
P24864 |
0.63 |
DDX11 |
1663 |
Q96FC9 |
0.63 |
DHX15 |
1665 |
O43143 |
0.63 |
FANCA |
2175 |
O15360 |
0.63 |
FANCE |
2178 |
Q9HB96 |
0.63 |
FOXO3 |
2309 |
O43524 |
0.63 |
MBD1 |
4152 |
Q9UIS9 |
0.63 |
MCM4 |
4173 |
P33991 |
0.63 |
MCM7 |
4176 |
P33993 |
0.63 |
RAD23A |
5886 |
P54725 |
0.63 |
RAD51 |
5888 |
Q06609 |
0.63 |
RBBP6 |
5930 |
Q7Z6E9 |
0.63 |
RPA2 |
6118 |
P15927 |
0.63 |
RPA3 |
6119 |
P35244 |
0.63 |
SPAG1 |
6674 |
Q07617 |
0.63 |
TOP1 |
7150 |
P11387 |
0.63 |
UTY |
7404 |
O14607 |
0.63 |
PABPN1 |
8106 |
Q86U42 |
0.63 |
USP10 |
9100 |
Q14694 |
0.63 |
CCNE2 |
9134 |
O96020 |
0.63 |
ISG15 |
9636 |
P05161 |
0.63 |
SETDB1 |
9869 |
Q15047 |
0.63 |
DCLRE1A |
9937 |
Q6PJP8 |
0.63 |
GNPDA1 |
10007 |
P46926 |
0.63 |
RBM7 |
10179 |
Q9Y580 |
0.63 |
HERC4 |
26091 |
Q5GLZ8 |
0.63 |
SEC22A |
26984 |
Q96IW7 |
0.63 |
MRPL4 |
51073 |
Q9BYD3 |
0.63 |
DCTPP1 |
79077 |
Q9H773 |
0.63 |
ZRANB3 |
84083 |
Q5FWF4 |
0.63 |
FBXO18 |
84893 |
Q8NFZ0 |
0.63 |
H2AFV |
94239 |
Q71UI9 |
0.63 |
TMEM218 |
219854 |
A2RU14 |
0.63 |
EGFR |
1956 |
P00533 |
0.65 |
TDG |
6996 |
Q13569 |
0.68 |
WHSC1 |
7468 |
O96028 |
0.68 |
FANCL |
55120 |
Q9NW38 |
0.68 |
CHEK1 |
1111 |
O14757 |
0.70 |
UNG |
7374 |
P13051 |
0.70 |
ANK3 |
288 |
Q12955 |
0.72 |
GOLGA1 |
2800 |
Q92805 |
0.72 |
EEA1 |
8411 |
Q15075 |
0.72 |
AKR7A2 |
8574 |
O43488 |
0.72 |
FIBP |
9158 |
O43427 |
0.72 |
NOS1AP |
9722 |
O75052 |
0.72 |
FAM13A |
10144 |
O94988 |
0.72 |
RUVBL2 |
10856 |
Q9Y230 |
0.72 |
PRDX3 |
10935 |
P30048 |
0.72 |
SLC27A4 |
10999 |
Q6P1M0 |
0.72 |
B4GALT7 |
11285 |
Q9UBV7 |
0.72 |
CYFIP1 |
23191 |
Q7L576 |
0.72 |
UHRF1 |
29128 |
Q96T88 |
0.72 |
UHRF1BP1 |
54887 |
Q6BDS2 |
0.72 |
RNF20 |
56254 |
Q5VTR2 |
0.72 |
KIAA1522 |
57648 |
Q9P206 |
0.72 |
MRPS25 |
64432 |
P82663 |
0.72 |
ELMO3 |
79767 |
Q96BJ8 |
0.72 |
OBSCN |
84033 |
Q5VST9 |
0.72 |
ACOT1 |
641371 |
Q86TX2 |
0.72 |
POM121C |
100101267 |
A8CG34 |
0.72 |
MDM2 |
4193 |
Q00987 |
0.74 |
POLK |
51426 |
Q9UBT6 |
0.74 |
CCNB1 |
891 |
P14635 |
0.75 |
ING2 |
3622 |
Q9H160 |
0.75 |
PARP10 |
84875 |
Q53GL7 |
0.75 |
CDK5 |
1020 |
Q00535 |
0.76 |
EXO1 |
9156 |
Q9UQ84 |
0.76 |
DTL |
51514 |
Q9NZJ0 |
0.76 |
TRAIP |
10293 |
Q9BWF2 |
0.77 |
FANCD2 |
2177 |
Q9BXW9 |
0.78 |
YBX1 |
4904 |
P67809 |
0.79 |
PPP1CC |
5501 |
P36873 |
0.79 |
REV1 |
51455 |
Q9UBZ9 |
0.79 |
XRCC6 |
2547 |
P12956 |
0.84 |
ATAD5 |
79915 |
Q96QE3 |
0.84 |
CCND3 |
896 |
P30281 |
0.85 |
PARP1 |
142 |
P09874 |
0.86 |
APEX1 |
328 |
P27695 |
0.86 |
CDAN1 |
146059 |
Q8IWY9 |
0.88 |
ANXA2 |
302 |
P07355 |
0.89 |
CCND1 |
595 |
P24385 |
0.89 |
DNMT1 |
1786 |
P26358 |
0.89 |
ERCC5 |
2073 |
P28715 |
0.89 |
KIAA0101 |
9768 |
Q15004 |
0.89 |
CDC25C |
995 |
P30307 |
0.90 |
CDKN1A |
1026 |
P38936 |
0.90 |
LIG1 |
3978 |
P18858 |
0.93 |
SUMO1 |
7341 |
P63165 |
0.93 |
MSH2 |
4436 |
P43246 |
0.94 |
RFC3 |
5983 |
P40938 |
0.95 |
CDK2 |
1017 |
P24941 |
0.96 |
POLD1 |
5424 |
P28340 |
0.96 |
GADD45A |
1647 |
P24522 |
0.97 |
RFC1 |
5981 |
P35251 |
0.97 |
RFC4 |
5984 |
P35249 |
0.97 |
PCNA |
5111 |
P12004 |
1.00 |
CALR |
811 |
P27797 |
0.49 |
EWSR1 |
2130 |
Q01844 |
0.49 |
LAMP2 |
3920 |
P13473 |
0.49 |
SNU13 |
4809 |
P55769 |
0.49 |
NONO |
4841 |
Q15233 |
0.49 |
HSP90B1 |
7184 |
P14625 |
0.49 |
HIST1H3A |
8350 |
P68431 |
0.49 |
USP39 |
10713 |
Q53GS9 |
0.49 |
BABAM1 |
29086 |
Q9NWV8 |
0.49 |
CCAR1 |
55749 |
Q8IX12 |
0.49 |
ATRX |
546 |
P46100 |
0.52 |
SMARCA4 |
6597 |
P51532 |
0.52 |
UBE2A |
7319 |
P49459 |
0.52 |
UBE2D3 |
7323 |
P61077 |
0.52 |
USP4 |
7375 |
Q13107 |
0.52 |
USP2 |
9099 |
O75604 |
0.52 |
SEC23IP |
11196 |
Q9Y6Y8 |
0.52 |
ZBTB1 |
22890 |
Q9Y2K1 |
0.52 |
SIRT1 |
23411 |
Q96EB6 |
0.52 |
POLM |
27434 |
Q9NP87 |
0.52 |
DNTTIP2 |
30836 |
Q5QJE6 |
0.52 |
CHTF8 |
54921 |
P0CG13 |
0.52 |
IL17RB |
55540 |
Q9NRM6 |
0.52 |
PALB2 |
79728 |
Q86YC2 |
0.52 |
SHPRH |
257218 |
Q149N8 |
0.52 |
CSTF1 |
1477 |
Q05048 |
0.56 |
FSCN1 |
6624 |
Q16658 |
0.56 |
WDR48 |
57599 |
Q8TAF3 |
0.56 |
POLA1 |
5422 |
P09884 |
0.59 |
BAZ1B |
9031 |
Q9UIG0 |
0.59 |
PPP1CA |
5499 |
P62136 |
0.62 |
TCOF1 |
6949 |
Q13428 |
0.62 |
UBE2B |
7320 |
P63146 |
0.62 |
DSCC1 |
79075 |
Q9BVC3 |
0.62 |
ABL1 |
25 |
P00519 |
0.63 |
APC |
324 |
P25054 |
0.63 |
AIRE |
326 |
O43918 |
0.63 |
BRCA1 |
672 |
P38398 |
0.63 |
CDC6 |
990 |
Q99741 |
0.63 |
CDK6 |
1021 |
Q00534 |
0.63 |
ERCC8 |
1161 |
Q13216 |
0.63 |
E2F3 |
1871 |
O00716 |
0.63 |
EPB41 |
2035 |
P11171 |
0.63 |
ERCC6 |
2074 |
Q03468 |
0.63 |
FUS |
2521 |
P35637 |
0.63 |
HEXA |
3073 |
P06865 |
0.63 |
HK1 |
3098 |
P19367 |
0.63 |
HLA-B |
3106 |
P30480 |
0.63 |
HLA-C |
3107 |
P30504 |
0.63 |
JUN |
3725 |
P05412 |
0.63 |
MCC |
4163 |
P23508 |
0.63 |
MGMT |
4255 |
P16455 |
0.63 |
NEDD8 |
4738 |
Q15843 |
0.63 |
NTRK1 |
4914 |
P04629 |
0.63 |
PARK2 |
5071 |
O60260 |
0.63 |
POLR2A |
5430 |
P24928 |
0.63 |
PTMA |
5757 |
P06454 |
0.63 |
RPS6KB2 |
6199 |
Q9UBS0 |
0.63 |
RYK |
6259 |
P34925 |
0.63 |
CCL2 |
6347 |
P13500 |
0.63 |
SETMAR |
6419 |
Q53H47 |
0.63 |
SGTA |
6449 |
O43765 |
0.63 |
SKI |
6497 |
P12755 |
0.63 |
SUMO3 |
6612 |
P55854 |
0.63 |
SUMO2 |
6613 |
P61956 |
0.63 |
TFAP4 |
7023 |
Q01664 |
0.63 |
TP53 |
7157 |
P04637 |
0.63 |
TRAF6 |
7189 |
Q9Y4K3 |
0.63 |
WARS |
7453 |
P23381 |
0.63 |
XPNPEP1 |
7511 |
Q9NQW7 |
0.63 |
TRIM25 |
7706 |
Q14258 |
0.63 |
CUL5 |
8065 |
Q93034 |
0.63 |
USP5 |
8078 |
P45974 |
0.63 |
KDM5C |
8242 |
P41229 |
0.63 |
CUL4B |
8450 |
Q13620 |
0.63 |
CUL3 |
8452 |
Q13618 |
0.63 |
CUL1 |
8454 |
Q13616 |
0.63 |
TSC22D1 |
8848 |
Q15714 |
0.63 |
PLAA |
9373 |
Q9Y263 |
0.63 |
RECQL5 |
9400 |
O94762 |
0.63 |
MAGED1 |
9500 |
Q9Y5V3 |
0.63 |
IKBKE |
9641 |
Q14164 |
0.63 |
CUL7 |
9820 |
Q14999 |
0.63 |
HDAC6 |
10013 |
Q9UBN7 |
0.63 |
HDAC5 |
10014 |
Q9UQL6 |
0.63 |
EIF1B |
10289 |
O60739 |
0.63 |
KAT5 |
10524 |
Q92993 |
0.63 |
CBX1 |
10951 |
P83916 |
0.63 |
PTP4A3 |
11156 |
O75365 |
0.63 |
PDCD10 |
11235 |
Q9BUL8 |
0.63 |
USP18 |
11274 |
Q9UMW8 |
0.63 |
FAN1 |
22909 |
Q9Y2M0 |
0.63 |
KIN |
22944 |
O60870 |
0.63 |
OBSL1 |
23363 |
O75147 |
0.63 |
FTSJ1 |
24140 |
Q9UET6 |
0.63 |
L3MBTL1 |
26013 |
Q9Y468 |
0.63 |
FBXO6 |
26270 |
Q9NRD1 |
0.63 |
STK39 |
27347 |
Q9UEW8 |
0.63 |
PPME1 |
51400 |
Q9Y570 |
0.63 |
ELP3 |
55140 |
Q9H9T3 |
0.63 |
PIDD1 |
55367 |
Q9HB75 |
0.63 |
CHFR |
55743 |
Q96EP1 |
0.63 |
DMAP1 |
55929 |
Q9NPF5 |
0.63 |
AICDA |
57379 |
Q9GZX7 |
0.63 |
MAP1LC3B |
81631 |
Q9GZQ8 |
0.63 |
KCTD10 |
83892 |
Q9H3F6 |
0.63 |
SLX4 |
84464 |
Q8IY92 |
0.63 |
MAP1LC3A |
84557 |
Q9H492 |
0.63 |
TIRAP |
114609 |
P58753 |
0.63 |
LRRK2 |
120892 |
Q5S007 |
0.63 |
ASB8 |
140461 |
Q9H765 |
0.63 |
MAPK15 |
225689 |
Q8TD08 |
0.63 |
DDB1 |
100290337 |
Q16531 |
0.63 |
TNFAIP1 |
7126 |
Q13829 |
0.65 |
CHAF1B |
8208 |
Q13112 |
0.65 |
HIST2H3A; HIST2H3C; HIST2H3D |
126961 |
Q71DI3 |
0.65 |
TPI1 |
7167 |
P60174 |
0.68 |
KCTD13 |
253980 |
Q8WZ19 |
0.68 |
CREBBP |
1387 |
Q92793 |
0.70 |
MLH1 |
4292 |
P40692 |
0.70 |
CUL2 |
8453 |
Q13617 |
0.70 |
SMARCAD1 |
56916 |
Q9H4L7 |
0.70 |
BRCA2 |
675 |
P51587 |
0.72 |
CA2 |
760 |
P00918 |
0.72 |
ATF2 |
1386 |
P15336 |
0.72 |
EEF1A1 |
1915 |
P68104 |
0.72 |
FN1 |
2335 |
P02751 |
0.72 |
KRT7 |
3855 |
P08729 |
0.72 |
RPSA |
3921 |
P08865 |
0.72 |
MDH2 |
4191 |
P40926 |
0.72 |
MME |
4311 |
P08473 |
0.72 |
PPIA |
5478 |
P62937 |
0.72 |
RELA |
5970 |
Q04206 |
0.72 |
TIMELESS |
8914 |
Q9UNS1 |
0.72 |
PRDX6 |
9588 |
P30041 |
0.72 |
PDS5B |
23047 |
Q9NTI5 |
0.72 |
CLSPN |
63967 |
Q9HAW4 |
0.72 |
DSN1 |
79980 |
Q9H410 |
0.72 |
UHRF2 |
115426 |
Q96PU4 |
0.72 |
PRKDC |
5591 |
P78527 |
0.73 |
MYBBP1A |
10514 |
Q9BQG0 |
0.73 |
UBD |
10537 |
O15205 |
0.73 |
SUB1 |
10923 |
P53999 |
0.73 |
GADD45B |
4616 |
O75293 |
0.74 |
XRCC5 |
7520 |
P13010 |
0.74 |
CUL4A |
8451 |
Q13619 |
0.74 |
ALDOA |
226 |
P04075 |
0.75 |
CDKN2A |
1029 |
P42771 |
0.75 |
DHX9 |
1660 |
Q08211 |
0.75 |
ENO1 |
2023 |
P06733 |
0.75 |
GAPDH |
2597 |
P04406 |
0.75 |
PGAM1 |
5223 |
P18669 |
0.75 |
PGK1 |
5230 |
P00558 |
0.75 |
RBBP8 |
5932 |
Q99708 |
0.75 |
RNF8 |
9025 |
O76064 |
0.75 |
HUWE1 |
10075 |
Q7Z6Z7 |
0.75 |
USP1 |
7398 |
O94782 |
0.76 |
POLN |
353497 |
Q7Z5Q5 |
0.76 |
DNTT |
1791 |
P04053 |
0.78 |
POLD4 |
57804 |
Q9HCU8 |
0.78 |
MCL1 |
4170 |
Q07820 |
0.79 |
RAD21 |
5885 |
O60216 |
0.80 |
SPRTN |
83932 |
Q9H040 |
0.81 |
POLB |
5423 |
P06746 |
0.83 |
POLE |
5426 |
Q07864 |
0.84 |
RAD9A |
5883 |
Q99638 |
0.84 |
RPA1 |
6117 |
P27694 |
0.84 |
SIVA1 |
10572 |
O15304 |
0.85 |
HUS1 |
3364 |
O60921 |
0.86 |
PMS2 |
5395 |
P54278 |
0.86 |
OTUB1 |
55611 |
Q96FW1 |
0.86 |
CCNA2 |
890 |
P20248 |
0.87 |
POLL |
27343 |
Q9UGP5 |
0.87 |
RAD18 |
56852 |
Q9NS91 |
0.87 |
ING1 |
3621 |
Q9UK53 |
0.88 |
MUTYH |
4595 |
Q9UIF7 |
0.88 |
CDK4 |
1019 |
P11802 |
0.89 |
CDKN1C |
1028 |
P49918 |
0.89 |
CCNO |
10309 |
P22674 |
0.89 |
POLDIP2 |
26073 |
Q9Y2S7 |
0.89 |
KMT5A |
387893 |
Q9NQR1 |
0.89 |
EP300 |
2033 |
Q09472 |
0.90 |
HDAC1 |
3065 |
Q13547 |
0.90 |
WRN |
7486 |
Q14191 |
0.90 |
XRCC1 |
7515 |
P18887 |
0.90 |
CHAF1A |
10036 |
Q13111 |
0.90 |
POLD3 |
10714 |
Q15054 |
0.90 |
POLI |
11201 |
Q9UNA4 |
0.90 |
CDT1 |
81620 |
Q9H211 |
0.90 |
HLTF |
6596 |
Q14527 |
0.95 |
APEX2 |
27301 |
Q9UBZ4 |
0.95 |
CHTF18 |
63922 |
Q8WVB6 |
0.95 |
RFC2 |
5982 |
P35250 |
0.96 |
RFC5 |
5985 |
P40937 |
0.96 |
FEN1 |
2237 |
P39748 |
0.97 |
MSH6 |
2956 |
P52701 |
0.97 |
MSH3 |
4437 |
P20585 |
0.97 |
POLD2 |
5425 |
P49005 |
0.97 |
POLH |
5429 |
Q9Y253 |
0.97 |
GADD45G |
10912 |
O95257 |
0.97 |