Protein Description

Gene Symbol PC
Entrez ID 5091
Uniprot ID P11498
Description pyruvate carboxylase
Chromosomal Location chr11: 66,848,233-66,958,376
Ontology GO ID GO Term Definition Evidence

BP

GO:0006090

pyruvate metabolic process

The chemical reactions and pathways involving pyruvate, 2-oxopropanoate.

IEA

BP

GO:0006094

gluconeogenesis

The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.

IEA|TAS

BP

GO:0006629

lipid metabolic process

The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.

IEA

BP

GO:0006768

biotin metabolic process

The chemical reactions and pathways involving biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid; the (+) enantiomer is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions.

TAS

BP

GO:0010629

negative regulation of gene expression

Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.

IMP

BP

GO:0019074

viral RNA genome packaging

The packaging of viral RNA (single-stranded or double-stranded) into a nucleocapsid.

IMP

BP

GO:0044791

positive regulation by host of viral release from host cell

A process in which a host organism activates or increases the frequency, rate or extent of the release of a virus with which it is infected, from its cells.

IMP

BP

GO:0044794

positive regulation by host of viral process

A process in which a host organism activates or increases the frequency, rate or extent of the release of a process being mediated by a virus with which it is infected.

IMP

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

IDA

CC

GO:0005739

mitochondrion

A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

IDA

CC

GO:0005759

mitochondrial matrix

The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.

TAS

CC

GO:0005829

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

TAS

MF

GO:0003677

DNA binding

Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

IEA

MF

GO:0004075

biotin carboxylase activity

Catalysis of the reaction: ATP + biotin-carboxyl-carrier protein + CO2 = ADP + phosphate + carboxybiotin-carboxyl-carrier protein.

IEA

MF

GO:0004736

pyruvate carboxylase activity

Catalysis of the reaction: ATP + bicarbonate + pyruvate = ADP + 2 H(+) + oxaloacetate + phosphate.

TAS

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0005524

ATP binding

Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

IEA

MF

GO:0009374

biotin binding

Interacting selectively and non-covalently with biotin (cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid), the (+) enantiomer of which is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions.

IEA

MF

GO:0046872

metal ion binding

Interacting selectively and non-covalently with any metal ion.

IEA

Domain ID Description

IPR000089

Biotin/lipoyl attachment

IPR000891

Pyruvate carboxyltransferase

IPR001882

Biotin-binding site

IPR003379

Carboxylase, conserved domain

IPR005479

Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain

IPR005481

Biotin carboxylase-like, N-terminal domain

IPR005482

Biotin carboxylase, C-terminal

IPR005930

Pyruvate carboxylase

IPR011053

Single hybrid motif

IPR011054

Rudiment single hybrid motif

IPR011761

ATP-grasp fold

IPR011764

Biotin carboxylation domain

IPR013785

Aldolase-type TIM barrel

IPR013815

ATP-grasp fold, subdomain 1

IPR016185

Pre-ATP-grasp domain

Pathway ID Pathway Term Pathway Source

hsa00020

Citrate cycle (TCA cycle)

KEGG

hsa00620

Pyruvate metabolism

KEGG

hsa01100

Metabolic pathways

KEGG

hsa01200

Carbon metabolism

KEGG

hsa01230

Biosynthesis of amino acids

KEGG

WP106

Alanine and aspartate metabolism

WikiPathways

WP357

Fatty Acid Biosynthesis

WikiPathways

WP534

Glycolysis and Gluconeogenesis

WikiPathways

WP2453

TCA Cycle and Deficiency of Pyruvate Dehydrogenase complex (PDHc)

WikiPathways

WP3925

Amino Acid metabolism

WikiPathways

h_malatexPathway

Shuttle for transfer of acetyl groups from mitochondria to the cytosol

BioCarta

UMLS CUI UMLS Term

C0006413

Burkitt Lymphoma

C0023893

Liver Cirrhosis, Experimental

C0034341

Pyruvate Carboxylase Deficiency Disease

Tissue Cell Type

adrenal gland

glandular cells

appendix

glandular cells

cerebellum

cells in granular layer

cerebellum

cells in molecular layer

cervix, uterine

squamous epithelial cells

colon

glandular cells

gallbladder

glandular cells

kidney

cells in tubules

liver

hepatocytes

nasopharynx

respiratory epithelial cells

parathyroid gland

glandular cells

placenta

decidual cells

prostate

glandular cells

rectum

glandular cells

seminal vesicle

glandular cells

skin

melanocytes

skin

epidermal cells

small intestine

glandular cells

stomach

glandular cells

testis

cells in seminiferous ducts

testis

Leydig cells

urinary bladder

urothelial cells

No databases found.

Pubmed ID Author Year Title

22617121

Ouandaogo et al.

2012

Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

Gene Symbol Entrez ID Uniprot ID Score

CAD

790

P27708

0.49

CCT6A

908

P40227

0.49

COPB1

1315

P53618

0.49

CYP27A1

1593

Q02318

0.49

FASN

2194

P49327

0.49

KPNA3

3840

O00505

0.49

PFAS

5198

O15067

0.49

RPS3A

6189

P61247

0.49

UQCRC2

7385

P22695

0.49

GOT2

2806

P00505

0.52

GOT1

2805

P17174

0.75

MDH2

4191

P40926

0.82

PC

5091

P11498

0.85

ATP1A1

476

P05023

0.49

CANX

821

P27824

0.49

CDH2

1000

P19022

0.49

GNB2

2783

P62879

0.49

ILF2

3608

Q12905

0.49

ILF3

3609

Q12906

0.49

MTHFD1

4522

P11586

0.49

NACA

4666

Q13765

0.49

SLC25A3

5250

Q00325

0.49

RPN1

6184

P04843

0.49

RPN2

6185

P04844

0.49

CCT3

7203

P49368

0.49

TUFM

7284

P49411

0.49

PPT2

9374

Q9UMR5

0.49

PRKCDBP

112464

Q969G5

0.49

PPP2R1A

5518

P30153

0.56

ADRB2

154

P07550

0.63

CDK9

1025

P50750

0.63

CSNK1A1

1452

P48729

0.63

EGFR

1956

P00533

0.63

MDM2

4193

Q00987

0.63

NFKB1

4790

P19838

0.63

NPM1

4869

P06748

0.63

NTRK1

4914

P04629

0.63

PHKG2

5261

P15735

0.63

PRKAA1

5562

Q13131

0.63

PSG1

5669

P11464

0.63

PTEN

5728

P60484

0.63

SUMO2

6613

P61956

0.63

STK4

6789

Q13043

0.63

THBS3

7059

P49746

0.63

TSHR

7253

P16473

0.63

UBE2N

7334

P61088

0.63

SUMO1

7341

P63165

0.63

HUWE1

10075

Q7Z6Z7

0.63

SIRT4

23409

Q9Y6E7

0.63

KLK5

25818

Q9Y337

0.63

RIOK2

55781

Q9BVS4

0.63

CBWD1

55871

Q9BRT8

0.63

HECW2

57520

Q9P2P5

0.63

DNASE2B

58511

Q8WZ79

0.63

ANTXR1

84168

Q9H6X2

0.63

DTWD2

285605

Q8NBA8

0.63

PPP2R2B

5521

Q00005

0.68

ERBB2

2064

P04626

0.72

IFIT1

3434

P09914

0.72

XRCC3

7517

O43542

0.72

RAB7A

7879

P51149

0.72

DYNLL1

8655

P63167

0.72