Gene Symbol | PC |
Entrez ID | 5091 |
Uniprot ID | P11498 |
Description | pyruvate carboxylase |
Chromosomal Location | chr11: 66,848,233-66,958,376 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0006090 |
pyruvate metabolic process |
The chemical reactions and pathways involving pyruvate, 2-oxopropanoate. |
IEA |
BP |
GO:0006094 |
gluconeogenesis |
The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. |
IEA|TAS |
BP |
GO:0006629 |
lipid metabolic process |
The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. |
IEA |
BP |
GO:0006768 |
biotin metabolic process |
The chemical reactions and pathways involving biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid; the (+) enantiomer is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions. |
TAS |
BP |
GO:0010629 |
negative regulation of gene expression |
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form. |
IMP |
BP |
GO:0019074 |
viral RNA genome packaging |
The packaging of viral RNA (single-stranded or double-stranded) into a nucleocapsid. |
IMP |
BP |
GO:0044791 |
positive regulation by host of viral release from host cell |
A process in which a host organism activates or increases the frequency, rate or extent of the release of a virus with which it is infected, from its cells. |
IMP |
BP |
GO:0044794 |
positive regulation by host of viral process |
A process in which a host organism activates or increases the frequency, rate or extent of the release of a process being mediated by a virus with which it is infected. |
IMP |
CC |
GO:0005737 |
cytoplasm |
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
IDA |
CC |
GO:0005739 |
mitochondrion |
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
IDA |
CC |
GO:0005759 |
mitochondrial matrix |
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. |
TAS |
CC |
GO:0005829 |
cytosol |
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
TAS |
MF |
GO:0003677 |
DNA binding |
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
IEA |
MF |
GO:0004075 |
biotin carboxylase activity |
Catalysis of the reaction: ATP + biotin-carboxyl-carrier protein + CO2 = ADP + phosphate + carboxybiotin-carboxyl-carrier protein. |
IEA |
MF |
GO:0004736 |
pyruvate carboxylase activity |
Catalysis of the reaction: ATP + bicarbonate + pyruvate = ADP + 2 H(+) + oxaloacetate + phosphate. |
TAS |
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
MF |
GO:0005524 |
ATP binding |
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
IEA |
MF |
GO:0009374 |
biotin binding |
Interacting selectively and non-covalently with biotin (cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid), the (+) enantiomer of which is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions. |
IEA |
MF |
GO:0046872 |
metal ion binding |
Interacting selectively and non-covalently with any metal ion. |
IEA |
Domain ID | Description |
---|---|
IPR000089 |
Biotin/lipoyl attachment |
IPR000891 |
Pyruvate carboxyltransferase |
IPR001882 |
Biotin-binding site |
IPR003379 |
Carboxylase, conserved domain |
IPR005479 |
Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain |
IPR005481 |
Biotin carboxylase-like, N-terminal domain |
IPR005482 |
Biotin carboxylase, C-terminal |
IPR005930 |
Pyruvate carboxylase |
IPR011053 |
Single hybrid motif |
IPR011054 |
Rudiment single hybrid motif |
IPR011761 |
ATP-grasp fold |
IPR011764 |
Biotin carboxylation domain |
IPR013785 |
Aldolase-type TIM barrel |
IPR013815 |
ATP-grasp fold, subdomain 1 |
IPR016185 |
Pre-ATP-grasp domain |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
hsa00020 |
Citrate cycle (TCA cycle) |
KEGG |
hsa00620 |
Pyruvate metabolism |
KEGG |
hsa01100 |
Metabolic pathways |
KEGG |
hsa01200 |
Carbon metabolism |
KEGG |
hsa01230 |
Biosynthesis of amino acids |
KEGG |
WP106 |
Alanine and aspartate metabolism |
WikiPathways |
WP357 |
Fatty Acid Biosynthesis |
WikiPathways |
WP534 |
Glycolysis and Gluconeogenesis |
WikiPathways |
WP2453 |
TCA Cycle and Deficiency of Pyruvate Dehydrogenase complex (PDHc) |
WikiPathways |
WP3925 |
Amino Acid metabolism |
WikiPathways |
h_malatexPathway |
Shuttle for transfer of acetyl groups from mitochondria to the cytosol |
BioCarta |
UMLS CUI | UMLS Term |
---|---|
C0006413 |
Burkitt Lymphoma |
C0023893 |
Liver Cirrhosis, Experimental |
C0034341 |
Pyruvate Carboxylase Deficiency Disease |
Tissue | Cell Type |
---|---|
adrenal gland |
glandular cells |
appendix |
glandular cells |
cerebellum |
cells in granular layer |
cerebellum |
cells in molecular layer |
cervix, uterine |
squamous epithelial cells |
colon |
glandular cells |
gallbladder |
glandular cells |
kidney |
cells in tubules |
liver |
hepatocytes |
nasopharynx |
respiratory epithelial cells |
parathyroid gland |
glandular cells |
placenta |
decidual cells |
prostate |
glandular cells |
rectum |
glandular cells |
seminal vesicle |
glandular cells |
skin |
melanocytes |
skin |
epidermal cells |
small intestine |
glandular cells |
stomach |
glandular cells |
testis |
cells in seminiferous ducts |
testis |
Leydig cells |
urinary bladder |
urothelial cells |
Pubmed ID | Author | Year | Title |
---|---|---|---|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
CAD |
790 |
P27708 |
0.49 |
CCT6A |
908 |
P40227 |
0.49 |
COPB1 |
1315 |
P53618 |
0.49 |
CYP27A1 |
1593 |
Q02318 |
0.49 |
FASN |
2194 |
P49327 |
0.49 |
KPNA3 |
3840 |
O00505 |
0.49 |
PFAS |
5198 |
O15067 |
0.49 |
RPS3A |
6189 |
P61247 |
0.49 |
UQCRC2 |
7385 |
P22695 |
0.49 |
GOT2 |
2806 |
P00505 |
0.52 |
GOT1 |
2805 |
P17174 |
0.75 |
MDH2 |
4191 |
P40926 |
0.82 |
PC |
5091 |
P11498 |
0.85 |
ATP1A1 |
476 |
P05023 |
0.49 |
CANX |
821 |
P27824 |
0.49 |
CDH2 |
1000 |
P19022 |
0.49 |
GNB2 |
2783 |
P62879 |
0.49 |
ILF2 |
3608 |
Q12905 |
0.49 |
ILF3 |
3609 |
Q12906 |
0.49 |
MTHFD1 |
4522 |
P11586 |
0.49 |
NACA |
4666 |
Q13765 |
0.49 |
SLC25A3 |
5250 |
Q00325 |
0.49 |
RPN1 |
6184 |
P04843 |
0.49 |
RPN2 |
6185 |
P04844 |
0.49 |
CCT3 |
7203 |
P49368 |
0.49 |
TUFM |
7284 |
P49411 |
0.49 |
PPT2 |
9374 |
Q9UMR5 |
0.49 |
PRKCDBP |
112464 |
Q969G5 |
0.49 |
PPP2R1A |
5518 |
P30153 |
0.56 |
ADRB2 |
154 |
P07550 |
0.63 |
CDK9 |
1025 |
P50750 |
0.63 |
CSNK1A1 |
1452 |
P48729 |
0.63 |
EGFR |
1956 |
P00533 |
0.63 |
MDM2 |
4193 |
Q00987 |
0.63 |
NFKB1 |
4790 |
P19838 |
0.63 |
NPM1 |
4869 |
P06748 |
0.63 |
NTRK1 |
4914 |
P04629 |
0.63 |
PHKG2 |
5261 |
P15735 |
0.63 |
PRKAA1 |
5562 |
Q13131 |
0.63 |
PSG1 |
5669 |
P11464 |
0.63 |
PTEN |
5728 |
P60484 |
0.63 |
SUMO2 |
6613 |
P61956 |
0.63 |
STK4 |
6789 |
Q13043 |
0.63 |
THBS3 |
7059 |
P49746 |
0.63 |
TSHR |
7253 |
P16473 |
0.63 |
UBE2N |
7334 |
P61088 |
0.63 |
SUMO1 |
7341 |
P63165 |
0.63 |
HUWE1 |
10075 |
Q7Z6Z7 |
0.63 |
SIRT4 |
23409 |
Q9Y6E7 |
0.63 |
KLK5 |
25818 |
Q9Y337 |
0.63 |
RIOK2 |
55781 |
Q9BVS4 |
0.63 |
CBWD1 |
55871 |
Q9BRT8 |
0.63 |
HECW2 |
57520 |
Q9P2P5 |
0.63 |
DNASE2B |
58511 |
Q8WZ79 |
0.63 |
ANTXR1 |
84168 |
Q9H6X2 |
0.63 |
DTWD2 |
285605 |
Q8NBA8 |
0.63 |
PPP2R2B |
5521 |
Q00005 |
0.68 |
ERBB2 |
2064 |
P04626 |
0.72 |
IFIT1 |
3434 |
P09914 |
0.72 |
XRCC3 |
7517 |
O43542 |
0.72 |
RAB7A |
7879 |
P51149 |
0.72 |
DYNLL1 |
8655 |
P63167 |
0.72 |