BP

GO:0001300

chronological cell aging

The process associated with progression of the cell from its inception to the end of its lifespan that occurs when the cell is in a non-dividing, or quiescent, state.

IEP

BP

GO:0001525

angiogenesis

Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.

IEP

BP

GO:0002576

platelet degranulation

The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet.

TAS

BP

GO:0007623

circadian rhythm

Any biological process in an organism that recurs with a regularity of approximately 24 hours.

TAS

BP

GO:0010469

regulation of receptor activity

Any process that modulates the frequency, rate or extent of receptor activity. Receptor activity is when a molecule combines with an extracellular or intracellular messenger to initiate a change in cell activity.

IDA

BP

GO:0010757

negative regulation of plasminogen activation

Any process that decreases the rate, frequency or extent of plasminogen activation. Plasminogen activation is the process in which plasminogen is processed to plasmin.

IDA|IMP

BP

GO:0010951

negative regulation of endopeptidase activity

Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins.

IDA

BP

GO:0014912

negative regulation of smooth muscle cell migration

Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell migration.

IDA

BP

GO:0030194

positive regulation of blood coagulation

Any process that activates or increases the frequency, rate or extent of blood coagulation.

IMP

BP

GO:0030195

negative regulation of blood coagulation

Any process that stops, prevents, or reduces the frequency, rate or extent of blood coagulation.

IC

BP

GO:0030198

extracellular matrix organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix.

TAS

BP

GO:0030336

negative regulation of cell migration

Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.

IDA

BP

GO:0032757

positive regulation of interleukin-8 production

Any process that activates or increases the frequency, rate, or extent of interleukin-8 production.

IMP

BP

GO:0033629

negative regulation of cell adhesion mediated by integrin

Any process that stops, prevents, or reduces the frequency, rate, or extent of cell adhesion mediated by integrin.

IDA

BP

GO:0035491

positive regulation of leukotriene production involved in inflammatory response

Any process that increases the rate, frequency or extent of the synthesis or release of any leukotriene following a stimulus as part of an inflammatory response.

IMP

BP

GO:0042730

fibrinolysis

A process that solubilizes fibrin in the bloodstream of a multicellular organism, chiefly by the proteolytic action of plasmin.

TAS

BP

GO:0045766

positive regulation of angiogenesis

Any process that activates or increases angiogenesis.

IMP

BP

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.

TAS

BP

GO:0048260

positive regulation of receptor-mediated endocytosis

Any process that activates or increases the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport.

IDA

BP

GO:0050729

positive regulation of inflammatory response

Any process that activates or increases the frequency, rate or extent of the inflammatory response.

IGI

BP

GO:0050829

defense response to Gram-negative bacterium

Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.

IGI

BP

GO:0051918

negative regulation of fibrinolysis

Any process that stops, prevents, or reduces the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots.

IDA

BP

GO:0061044

negative regulation of vascular wound healing

Any process that decreases the rate, frequency, or extent of blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to damaged vasculature.

IGI

BP

GO:0061045

negative regulation of wound healing

Any process that decreases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury.

IC

BP

GO:0071222

cellular response to lipopolysaccharide

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.

IMP

BP

GO:0090026

positive regulation of monocyte chemotaxis

Any process that increases the frequency, rate, or extent of monocyte chemotaxis.

IMP

BP

GO:1902042

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors.

IMP

BP

GO:2000098

negative regulation of smooth muscle cell-matrix adhesion

Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell-matrix adhesion.

IDA

BP

GO:2000352

negative regulation of endothelial cell apoptotic process

Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell apoptotic process.

IMP

CC

GO:0005576

extracellular region

The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

IDA|TAS

CC

GO:0005615

extracellular space

That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

IDA

CC

GO:0005886

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

TAS

CC

GO:0031012

extracellular matrix

A structure lying external to one or more cells, which provides structural support for cells or tissues.

IDA

CC

GO:0031093

platelet alpha granule lumen

The volume enclosed by the membrane of the platelet alpha granule.

TAS

CC

GO:0070062

extracellular exosome

A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.

IDA

MF

GO:0002020

protease binding

Interacting selectively and non-covalently with any protease or peptidase.

IPI

MF

GO:0004867

serine-type endopeptidase inhibitor activity

Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme.

IDA|TAS

MF

GO:0005102

receptor binding

Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

IPI

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI