Gene Symbol | ASCL1 |
Entrez ID | 429 |
Uniprot ID | P50553 |
Description | achaete-scute family bHLH transcription factor 1 |
Chromosomal Location | chr12: 102,957,686-102,960,516 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
IDA |
BP |
GO:0001764 |
neuron migration |
The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature. |
IEA |
BP |
GO:0003358 |
noradrenergic neuron development |
The process whose specific outcome is the progression of a noradrenergic neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. |
ISS |
BP |
GO:0003359 |
noradrenergic neuron fate commitment |
The process in which the developmental fate of a cell becomes restricted such that it will develop into a noradrenergic neuron. |
IMP |
BP |
GO:0006351 |
transcription, DNA-templated |
The cellular synthesis of RNA on a template of DNA. |
IEA |
BP |
GO:0007219 |
Notch signaling pathway |
A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. |
IDA |
BP |
GO:0007346 |
regulation of mitotic cell cycle |
Any process that modulates the rate or extent of progress through the mitotic cell cycle. |
IEA |
BP |
GO:0007400 |
neuroblast fate determination |
The cell fate determination process in which a cell becomes capable of differentiating autonomously into a neuroblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this process is found in Mus musculus. |
IEA |
BP |
GO:0007405 |
neuroblast proliferation |
The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron. |
IEA |
BP |
GO:0010226 |
response to lithium ion |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lithium (Li+) ion stimulus. |
IEA |
BP |
GO:0010468 |
regulation of gene expression |
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form. |
ISS |
BP |
GO:0014003 |
oligodendrocyte development |
The process aimed at the progression of an oligodendrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An oligodendrocyte is a type of glial cell involved in myelinating the axons in the central nervous system. |
IEA |
BP |
GO:0021527 |
spinal cord association neuron differentiation |
The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of association neurons. Association neurons are cells located in the dorsal portion of the spinal cord that integrate sensory input. Differentiation includes the processes involved in commitment of a cell to a specific fate. |
IEA |
BP |
GO:0021530 |
spinal cord oligodendrocyte cell fate specification |
The process in which a cell becomes capable of differentiating autonomously into an oligodendrocyte in an environment that is neutral with respect to the developmental pathway. |
IEA |
BP |
GO:0021750 |
vestibular nucleus development |
The process whose specific outcome is the progression of the vestibular nucleus over time, from its formation to the mature structure. |
IEA |
BP |
GO:0021892 |
cerebral cortex GABAergic interneuron differentiation |
The process in which a relatively unspecialized cell acquires specialized features of a GABAergic interneuron residing in the cerebral cortex. |
IEP |
BP |
GO:0021902 |
commitment of neuronal cell to specific neuron type in forebrain |
The commitment of neuronal precursor cells to become specialized types of neurons in the forebrain. |
IEA |
BP |
GO:0021954 |
central nervous system neuron development |
The process whose specific outcome is the progression of a neuron whose cell body is located in the central nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron. |
IEA |
BP |
GO:0021987 |
cerebral cortex development |
The progression of the cerebral cortex over time from its initial formation until its mature state. The cerebral cortex is the outer layered region of the telencephalon. |
IEA |
BP |
GO:0022008 |
neurogenesis |
Generation of cells within the nervous system. |
IDA |
BP |
GO:0030856 |
regulation of epithelial cell differentiation |
Any process that modulates the frequency, rate or extent of epithelial cell differentiation. |
IEA |
BP |
GO:0032526 |
response to retinoic acid |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus. |
IEP |
BP |
GO:0043066 |
negative regulation of apoptotic process |
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. |
IMP |
BP |
GO:0043525 |
positive regulation of neuron apoptotic process |
Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process. |
IEA |
BP |
GO:0045665 |
negative regulation of neuron differentiation |
Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation. |
IDA |
BP |
GO:0045666 |
positive regulation of neuron differentiation |
Any process that activates or increases the frequency, rate or extent of neuron differentiation. |
ISS |
BP |
GO:0045747 |
positive regulation of Notch signaling pathway |
Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway. |
IEA |
BP |
GO:0045787 |
positive regulation of cell cycle |
Any process that activates or increases the rate or extent of progression through the cell cycle. |
IEA |
BP |
GO:0045892 |
negative regulation of transcription, DNA-templated |
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. |
IDA |
BP |
GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
IDA |
BP |
GO:0048469 |
cell maturation |
A developmental process, independent of morphogenetic (shape) change, that is required for a cell to attain its fully functional state. |
IEA |
BP |
GO:0048485 |
sympathetic nervous system development |
The process whose specific outcome is the progression of the sympathetic nervous system over time, from its formation to the mature structure. The sympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system (the other being the parasympathetic nervous system). The sympathetic preganglionic neurons have their cell bodies in the thoracic and lumbar regions of the spinal cord and connect to the paravertebral chain of sympathetic ganglia. Innervate heart and blood vessels, sweat glands, viscera and the adrenal medulla. Most sympathetic neurons, but not all, use noradrenaline as a post-ganglionic neurotransmitter. |
NAS |
BP |
GO:0048665 |
neuron fate specification |
The process in which a cell becomes capable of differentiating autonomously into a neuron in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. |
IEA |
BP |
GO:0050883 |
musculoskeletal movement, spinal reflex action |
Involuntary movement caused by the application of a stimulus to an organism and a subsequent movement. The signal processing of this movement takes place in the spinal cord. |
IEA |
BP |
GO:0051593 |
response to folic acid |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a folic acid stimulus. |
IEA |
BP |
GO:0060163 |
subpallium neuron fate commitment |
The process in which in the subpallium, the developmental fate of a cell becomes restricted such that it will develop into a neuron. The subpallium is the base region of the telencephalon. |
IEA |
BP |
GO:0060165 |
regulation of timing of subpallium neuron differentiation |
The process controlling the timing and/or rate at which a relatively unspecialized cell in the subpallium acquires features of a neuron. The subpallium is the base region of the telencephalon. |
IEA |
BP |
GO:0060166 |
olfactory pit development |
The biological process whose specific outcome is the progression of the olfactory pit from an initial condition to its mature state. This process begins with the formation of the olfactory pit, which is an indentation of the olfactory placode, and ends when the pits hollows out to form the nasopharynx. |
IEA |
BP |
GO:0060487 |
lung epithelial cell differentiation |
The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell that contributes to the epithelium of the lung. |
NAS |
BP |
GO:0060579 |
ventral spinal cord interneuron fate commitment |
The process in which the developmental fate of a cell becomes restricted such that it will develop into a ventral spinal cord interneuron. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses. |
ISS |
BP |
GO:0061100 |
lung neuroendocrine cell differentiation |
The process in which a relatively unspecialized cell acquires specialized features of a neuroendocrine cell of the lung epithelium. |
IEA |
BP |
GO:0061102 |
stomach neuroendocrine cell differentiation |
The process in which a relatively unspecialized cell acquires specialized features of a neuroendocrine cell of the stomach epithelium. |
IEA |
BP |
GO:0061103 |
carotid body glomus cell differentiation |
The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a glomus cell of the carotid body. The carotid body is a specialized chemosensory organ that helps respond to hypoxia. |
IEA |
BP |
GO:0061104 |
adrenal chromaffin cell differentiation |
The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of an adrenal chromaffin cell. An adrenal chromaffin cell is a neuroendocrine cell that stores epinephrine secretory vesicles. |
IEA |
BP |
GO:0061549 |
sympathetic ganglion development |
The process whose specific outcome is the progression of a sympathetic ganglion over time, from its formation to the mature structure. |
ISS |
BP |
GO:0070849 |
response to epidermal growth factor |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus. |
IEA |
BP |
GO:0071259 |
cellular response to magnetism |
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnetic stimulus. |
IEA |
BP |
GO:2000179 |
positive regulation of neural precursor cell proliferation |
Any process that activates or increases the frequency, rate or extent of neural precursor cell proliferation. |
IEA |
CC |
GO:0005634 |
nucleus |
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
IDA |
CC |
GO:0043025 |
neuronal cell body |
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. |
IEA |
CC |
GO:0090575 |
RNA polymerase II transcription factor complex |
A transcription factor complex that acts at promoters of genes transcribed by RNA polymerase II. |
IBA |
MF |
GO:0000978 |
RNA polymerase II core promoter proximal region sequence-specific DNA binding |
Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II. |
IDA |
MF |
GO:0000989 |
transcription factor activity, transcription factor binding |
Interacting selectively and non-covalently with a specific transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well. |
ISS |
MF |
GO:0001078 |
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding |
Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
IDA |
MF |
GO:0003677 |
DNA binding |
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
ISS |
MF |
GO:0003682 |
chromatin binding |
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. |
IEA |
MF |
GO:0003700 |
transcription factor activity, sequence-specific DNA binding |
Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. |
IDA |
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
MF |
GO:0042803 |
protein homodimerization activity |
Interacting selectively and non-covalently with an identical protein to form a homodimer. |
IEA |
MF |
GO:0043425 |
bHLH transcription factor binding |
Interacting selectively and non-covalently with any of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways. |
IPI |
MF |
GO:0070888 |
E-box binding |
Interacting selectively and non-covalently with an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues. |
IDA |
Domain ID | Description |
---|---|
IPR011598 |
Myc-type, basic helix-loop-helix (bHLH) domain |
IPR015660 |
Achaete-scute transcription factor-related |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
WP706 |
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways |
WikiPathways |
WP2064 |
Neural Crest Differentiation |
WikiPathways |
WP2855 |
Dopaminergic Neurogenesis |
WikiPathways |
UMLS CUI | UMLS Term |
---|---|
C0027765 |
Nervous System Disorder |
C0149925 |
Small Cell Carcinoma Of Lung |
C0242488 |
Acute Lung Injury |
C3714756 |
Intellectual Disability |
Tissue | Cell Type |
---|---|
cerebral cortex |
glial cells |
cerebral cortex |
neuropil |
hippocampus |
glial cells |
Pubmed ID | Author | Year | Title |
---|---|---|---|
19141577 |
Kim et al. |
2009 |
Transcriptional Profiling with a Pathway-Oriented Analysis Identifies Dysregulated Molecular Phenotypes in the Endometrium of Patients with Polycystic Ovary Syndrome |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
MEF2C |
4208 |
Q06413 |
0.63 |
MEF2D |
4209 |
Q14814 |
0.63 |
MTNR1A |
4543 |
P48039 |
0.63 |
TCF3 |
6929 |
P15923 |
0.68 |
EP300 |
2033 |
Q09472 |
0.73 |
ASCL1 |
429 |
P50553 |
0.75 |
BMP2 |
650 |
P12643 |
0.52 |
UBQLN1 |
29979 |
Q9UMX0 |
0.63 |
NEUROG2 |
63973 |
Q9H2A3 |
0.65 |
TCF4 |
6925 |
P15884 |
0.78 |
MEF2A |
4205 |
Q02078 |
0.89 |