Gene Symbol | ODC1 |
Entrez ID | 4953 |
Uniprot ID | P11926 |
Description | ornithine decarboxylase 1 |
Chromosomal Location | chr2: 10,439,968-10,448,504 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0001822 |
kidney development |
The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine. |
IEA |
BP |
GO:0006521 |
regulation of cellular amino acid metabolic process |
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids. |
TAS |
BP |
GO:0006595 |
polyamine metabolic process |
The chemical reactions and pathways involving polyamines, any organic compound containing two or more amino groups. |
TAS |
BP |
GO:0008284 |
positive regulation of cell proliferation |
Any process that activates or increases the rate or extent of cell proliferation. |
IEA |
BP |
GO:0009615 |
response to virus |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus. |
IEP |
BP |
GO:0033387 |
putrescine biosynthetic process from ornithine |
The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane by decarboxylation of ornithine. |
IBA|IEA|ISS |
BP |
GO:0042176 |
regulation of protein catabolic process |
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. |
ISS |
CC |
GO:0005575 |
cellular_component |
The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together. |
ND |
CC |
GO:0005737 |
cytoplasm |
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
IBA|ISS |
CC |
GO:0005829 |
cytosol |
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
TAS |
CC |
GO:0048471 |
perinuclear region of cytoplasm |
Cytoplasm situated near, or occurring around, the nucleus. |
IEA |
MF |
GO:0004586 |
ornithine decarboxylase activity |
Catalysis of the reaction: L-ornithine + H(+) = CO(2) + putrescine. |
IDA|ISS|TAS |
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
MF |
GO:0042803 |
protein homodimerization activity |
Interacting selectively and non-covalently with an identical protein to form a homodimer. |
ISS |
Domain ID | Description |
---|---|
IPR000183 |
Ornithine/DAP/Arg decarboxylase |
IPR002433 |
Ornithine decarboxylase |
IPR009006 |
Alanine racemase/group IV decarboxylase, C-terminal |
IPR022643 |
Orn/DAP/Arg decarboxylase 2, C-terminal |
IPR022644 |
Orn/DAP/Arg decarboxylase 2, N-terminal |
IPR022653 |
Orn/DAP/Arg decarboxylase 2, pyridoxal-phosphate binding site |
IPR022657 |
Orn/DAP/Arg decarboxylase 2, conserved site |
IPR029066 |
PLP-binding barrel |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
hsa00330 |
Arginine and proline metabolism |
KEGG |
hsa00480 |
Glutathione metabolism |
KEGG |
hsa01100 |
Metabolic pathways |
KEGG |
WP1984 |
Integrated Breast Cancer Pathway |
WikiPathways |
WP497 |
Urea cycle and metabolism of amino groups |
WikiPathways |
WP3925 |
Amino Acid metabolism |
WikiPathways |
UMLS CUI | UMLS Term |
---|---|
C0009375 |
Colonic Neoplasms |
C0009404 |
Colorectal Neoplasms |
C0019693 |
HIV Infections |
C0030354 |
Papilloma |
C0037286 |
Skin Neoplasms |
Tissue | Cell Type |
---|---|
liver |
hepatocytes |
pancreas |
exocrine glandular cells |
placenta |
decidual cells |
salivary gland |
glandular cells |
small intestine |
glandular cells |
testis |
Leydig cells |
Pubmed ID | Author | Year | Title |
---|---|---|---|
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
MAP2K1 |
5604 |
Q02750 |
0.49 |
TMOD1 |
7111 |
P28289 |
0.49 |
ZNF510 |
22869 |
Q9Y2H8 |
0.49 |
STX17 |
55014 |
P56962 |
0.49 |
KAT5 |
10524 |
Q92993 |
0.63 |
GORASP2 |
26003 |
Q9H8Y8 |
0.63 |
AZI2 |
64343 |
Q9H6S1 |
0.75 |
ODC1 |
4953 |
P11926 |
0.85 |
CEP131 |
22994 |
Q9UPN4 |
0.87 |
BAAT |
570 |
Q14032 |
0.49 |
TDRD7 |
23424 |
Q8NHU6 |
0.49 |
NANS |
54187 |
Q9NR45 |
0.49 |
HEMGN |
55363 |
Q9BXL5 |
0.49 |
TSTD2 |
158427 |
Q5T7W7 |
0.49 |
SMAD3 |
4088 |
P84022 |
0.56 |
CSNK2B |
1460 |
P67870 |
0.63 |
SSR1 |
6745 |
P43307 |
0.63 |
TK1 |
7083 |
P04183 |
0.63 |
OAZ2 |
4947 |
O95190 |
0.80 |
OAZ3 |
51686 |
Q9UMX2 |
0.84 |
OAZ1 |
4946 |
P54368 |
0.86 |