Protein Description

Gene Symbol ODC1
Entrez ID 4953
Uniprot ID P11926
Description ornithine decarboxylase 1
Chromosomal Location chr2: 10,439,968-10,448,504
Ontology GO ID GO Term Definition Evidence

BP

GO:0001822

kidney development

The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine.

IEA

BP

GO:0006521

regulation of cellular amino acid metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids.

TAS

BP

GO:0006595

polyamine metabolic process

The chemical reactions and pathways involving polyamines, any organic compound containing two or more amino groups.

TAS

BP

GO:0008284

positive regulation of cell proliferation

Any process that activates or increases the rate or extent of cell proliferation.

IEA

BP

GO:0009615

response to virus

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.

IEP

BP

GO:0033387

putrescine biosynthetic process from ornithine

The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane by decarboxylation of ornithine.

IBA|IEA|ISS

BP

GO:0042176

regulation of protein catabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.

ISS

CC

GO:0005575

cellular_component

The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.

ND

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

IBA|ISS

CC

GO:0005829

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

TAS

CC

GO:0048471

perinuclear region of cytoplasm

Cytoplasm situated near, or occurring around, the nucleus.

IEA

MF

GO:0004586

ornithine decarboxylase activity

Catalysis of the reaction: L-ornithine + H(+) = CO(2) + putrescine.

IDA|ISS|TAS

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0042803

protein homodimerization activity

Interacting selectively and non-covalently with an identical protein to form a homodimer.

ISS

Domain ID Description

IPR000183

Ornithine/DAP/Arg decarboxylase

IPR002433

Ornithine decarboxylase

IPR009006

Alanine racemase/group IV decarboxylase, C-terminal

IPR022643

Orn/DAP/Arg decarboxylase 2, C-terminal

IPR022644

Orn/DAP/Arg decarboxylase 2, N-terminal

IPR022653

Orn/DAP/Arg decarboxylase 2, pyridoxal-phosphate binding site

IPR022657

Orn/DAP/Arg decarboxylase 2, conserved site

IPR029066

PLP-binding barrel

Pathway ID Pathway Term Pathway Source

hsa00330

Arginine and proline metabolism

KEGG

hsa00480

Glutathione metabolism

KEGG

hsa01100

Metabolic pathways

KEGG

WP1984

Integrated Breast Cancer Pathway

WikiPathways

WP497

Urea cycle and metabolism of amino groups

WikiPathways

WP3925

Amino Acid metabolism

WikiPathways

UMLS CUI UMLS Term

C0009375

Colonic Neoplasms

C0009404

Colorectal Neoplasms

C0019693

HIV Infections

C0030354

Papilloma

C0037286

Skin Neoplasms

Tissue Cell Type

liver

hepatocytes

pancreas

exocrine glandular cells

placenta

decidual cells

salivary gland

glandular cells

small intestine

glandular cells

testis

Leydig cells

No databases found.

Pubmed ID Author Year Title

22951915

Haozi et al.

2012

Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

Gene Symbol Entrez ID Uniprot ID Score

MAP2K1

5604

Q02750

0.49

TMOD1

7111

P28289

0.49

ZNF510

22869

Q9Y2H8

0.49

STX17

55014

P56962

0.49

KAT5

10524

Q92993

0.63

GORASP2

26003

Q9H8Y8

0.63

AZI2

64343

Q9H6S1

0.75

ODC1

4953

P11926

0.85

CEP131

22994

Q9UPN4

0.87

BAAT

570

Q14032

0.49

TDRD7

23424

Q8NHU6

0.49

NANS

54187

Q9NR45

0.49

HEMGN

55363

Q9BXL5

0.49

TSTD2

158427

Q5T7W7

0.49

SMAD3

4088

P84022

0.56

CSNK2B

1460

P67870

0.63

SSR1

6745

P43307

0.63

TK1

7083

P04183

0.63

OAZ2

4947

O95190

0.80

OAZ3

51686

Q9UMX2

0.84

OAZ1

4946

P54368

0.86