| Gene Symbol | ODC1 |
| Entrez ID | 4953 |
| Uniprot ID | P11926 |
| Description | ornithine decarboxylase 1 |
| Chromosomal Location | chr2: 10,439,968-10,448,504 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0001822 |
kidney development |
The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine. |
IEA |
|
BP |
GO:0006521 |
regulation of cellular amino acid metabolic process |
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids. |
TAS |
|
BP |
GO:0006595 |
polyamine metabolic process |
The chemical reactions and pathways involving polyamines, any organic compound containing two or more amino groups. |
TAS |
|
BP |
GO:0008284 |
positive regulation of cell proliferation |
Any process that activates or increases the rate or extent of cell proliferation. |
IEA |
|
BP |
GO:0009615 |
response to virus |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus. |
IEP |
|
BP |
GO:0033387 |
putrescine biosynthetic process from ornithine |
The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane by decarboxylation of ornithine. |
IBA|IEA|ISS |
|
BP |
GO:0042176 |
regulation of protein catabolic process |
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. |
ISS |
|
CC |
GO:0005575 |
cellular_component |
The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together. |
ND |
|
CC |
GO:0005737 |
cytoplasm |
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
IBA|ISS |
|
CC |
GO:0005829 |
cytosol |
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
TAS |
|
CC |
GO:0048471 |
perinuclear region of cytoplasm |
Cytoplasm situated near, or occurring around, the nucleus. |
IEA |
|
MF |
GO:0004586 |
ornithine decarboxylase activity |
Catalysis of the reaction: L-ornithine + H(+) = CO(2) + putrescine. |
IDA|ISS|TAS |
|
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
|
MF |
GO:0042803 |
protein homodimerization activity |
Interacting selectively and non-covalently with an identical protein to form a homodimer. |
ISS |
| Domain ID | Description |
|---|---|
|
IPR000183 |
Ornithine/DAP/Arg decarboxylase |
|
IPR002433 |
Ornithine decarboxylase |
|
IPR009006 |
Alanine racemase/group IV decarboxylase, C-terminal |
|
IPR022643 |
Orn/DAP/Arg decarboxylase 2, C-terminal |
|
IPR022644 |
Orn/DAP/Arg decarboxylase 2, N-terminal |
|
IPR022653 |
Orn/DAP/Arg decarboxylase 2, pyridoxal-phosphate binding site |
|
IPR022657 |
Orn/DAP/Arg decarboxylase 2, conserved site |
|
IPR029066 |
PLP-binding barrel |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
|
hsa00330 |
Arginine and proline metabolism |
KEGG |
|
hsa00480 |
Glutathione metabolism |
KEGG |
|
hsa01100 |
Metabolic pathways |
KEGG |
|
WP1984 |
Integrated Breast Cancer Pathway |
WikiPathways |
|
WP497 |
Urea cycle and metabolism of amino groups |
WikiPathways |
|
WP3925 |
Amino Acid metabolism |
WikiPathways |
| UMLS CUI | UMLS Term |
|---|---|
|
C0009375 |
Colonic Neoplasms |
|
C0009404 |
Colorectal Neoplasms |
|
C0019693 |
HIV Infections |
|
C0030354 |
Papilloma |
|
C0037286 |
Skin Neoplasms |
| Tissue | Cell Type |
|---|---|
|
liver |
hepatocytes |
|
pancreas |
exocrine glandular cells |
|
placenta |
decidual cells |
|
salivary gland |
glandular cells |
|
small intestine |
glandular cells |
|
testis |
Leydig cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
MAP2K1 |
5604 |
Q02750 |
0.49 |
|
TMOD1 |
7111 |
P28289 |
0.49 |
|
ZNF510 |
22869 |
Q9Y2H8 |
0.49 |
|
STX17 |
55014 |
P56962 |
0.49 |
|
KAT5 |
10524 |
Q92993 |
0.63 |
|
GORASP2 |
26003 |
Q9H8Y8 |
0.63 |
|
AZI2 |
64343 |
Q9H6S1 |
0.75 |
|
ODC1 |
4953 |
P11926 |
0.85 |
|
CEP131 |
22994 |
Q9UPN4 |
0.87 |
|
BAAT |
570 |
Q14032 |
0.49 |
|
TDRD7 |
23424 |
Q8NHU6 |
0.49 |
|
NANS |
54187 |
Q9NR45 |
0.49 |
|
HEMGN |
55363 |
Q9BXL5 |
0.49 |
|
TSTD2 |
158427 |
Q5T7W7 |
0.49 |
|
SMAD3 |
4088 |
P84022 |
0.56 |
|
CSNK2B |
1460 |
P67870 |
0.63 |
|
SSR1 |
6745 |
P43307 |
0.63 |
|
TK1 |
7083 |
P04183 |
0.63 |
|
OAZ2 |
4947 |
O95190 |
0.80 |
|
OAZ3 |
51686 |
Q9UMX2 |
0.84 |
|
OAZ1 |
4946 |
P54368 |
0.86 |