Protein Description

Gene Symbol NTS
Entrez ID 4922
Uniprot ID P30990
Description neurotensin
Chromosomal Location chr12: 85,874,295-85,882,992
Ontology GO ID GO Term Definition Evidence

BP

GO:0007165

signal transduction

The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

NAS

BP

GO:0050880

regulation of blood vessel size

Any process that modulates the size of blood vessels.

IEA

CC

GO:0005576

extracellular region

The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

TAS

CC

GO:0030133

transport vesicle

Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell.

IEA

CC

GO:0043679

axon terminus

Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it.

IBA

MF

GO:0005184

neuropeptide hormone activity

The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones.

IBA

Domain ID Description

IPR008055

Neurotensin/neuromedin N

No pathways found.

UMLS CUI UMLS Term

C0007370

Catalepsy

C0026837

Muscle Rigidity

C0424295

Hyperactive Behavior

C0428977

Bradycardia

No tissues found.

No databases found.

Pubmed ID Author Year Title

22617121

Ouandaogo et al.

2012

Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

22951915

Haozi et al.

2012

Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

Gene Symbol Entrez ID Uniprot ID Score

CPE

1363

P16870

0.52

ARRB2

409

P32121

0.55

NTSR2

23620

O95665

0.65

MEP1A

4224

Q16819

0.67

SORT1

6272

Q99523

0.85

NTSR1

4923

P30989

0.89

PREP

5550

P48147

0.52

ACE2

59272

Q9BYF1

0.52

NLN

57486

Q9BYT8

0.63