| Gene Symbol | NRAS |
| Entrez ID | 4893 |
| Uniprot ID | P01111 |
| Description | neuroblastoma RAS viral (v-ras) oncogene homolog |
| Chromosomal Location | chr1: 114,704,469-114,716,894 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0000165 |
MAPK cascade |
An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell. |
TAS |
|
BP |
GO:0002223 |
stimulatory C-type lectin receptor signaling pathway |
Any series of molecular signals generated as a consequence of binding to a C-type lectin receptor capable of cellular activation. |
TAS |
|
BP |
GO:0007173 |
epidermal growth factor receptor signaling pathway |
A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription. |
TAS |
|
BP |
GO:0007265 |
Ras protein signal transduction |
A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state. |
TAS |
|
BP |
GO:0007411 |
axon guidance |
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues. |
TAS |
|
BP |
GO:0038095 |
Fc-epsilon receptor signaling pathway |
A series of molecular signals initiated by the binding of the Fc portion of immunoglobulin E (IgE) to an Fc-epsilon receptor on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region. |
TAS |
|
BP |
GO:0038128 |
ERBB2 signaling pathway |
A series of molecular signals initiated by binding of a ligand to a member of the ERBB family of receptors on the surface of a cell, where the signal is transmitted by ERBB2. The pathway ends with regulation of a downstream cellular process, e.g. transcription. ERBB2 receptors are themselves unable to bind to ligands, but act as a signal-amplifying tyrosine kinase within a heterodimeric pair. |
TAS |
|
BP |
GO:0050900 |
leukocyte migration |
The movement of a leukocyte within or between different tissues and organs of the body. |
TAS |
|
BP |
GO:0072600 |
establishment of protein localization to Golgi |
The directed movement of a protein to a specific location in the Golgi apparatus. |
IMP |
|
CC |
GO:0000139 |
Golgi membrane |
The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
IEA |
|
CC |
GO:0005794 |
Golgi apparatus |
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. |
IDA |
|
CC |
GO:0005886 |
plasma membrane |
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
TAS |
|
CC |
GO:0016020 |
membrane |
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
IDA |
|
CC |
GO:0070062 |
extracellular exosome |
A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. |
IDA |
|
MF |
GO:0005525 |
GTP binding |
Interacting selectively and non-covalently with GTP, guanosine triphosphate. |
IEA |
|
MF |
GO:0032403 |
protein complex binding |
Interacting selectively and non-covalently with any protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IDA |
| Domain ID | Description |
|---|---|
|
IPR001806 |
Small GTPase superfamily |
|
IPR005225 |
Small GTP-binding protein domain |
|
IPR020849 |
Small GTPase superfamily, Ras type |
|
IPR027417 |
P-loop containing nucleoside triphosphate hydrolase |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
|
hsa01521 |
EGFR tyrosine kinase inhibitor resistance |
KEGG |
|
hsa01522 |
Endocrine resistance |
KEGG |
|
hsa04010 |
MAPK signaling pathway |
KEGG |
|
hsa04012 |
ErbB signaling pathway |
KEGG |
|
hsa04014 |
Ras signaling pathway |
KEGG |
|
hsa04015 |
Rap1 signaling pathway |
KEGG |
|
hsa04062 |
Chemokine signaling pathway |
KEGG |
|
hsa04068 |
FoxO signaling pathway |
KEGG |
|
hsa04071 |
Sphingolipid signaling pathway |
KEGG |
|
hsa04072 |
Phospholipase D signaling pathway |
KEGG |
|
hsa04137 |
Mitophagy - animal |
KEGG |
|
hsa04140 |
Autophagy - animal |
KEGG |
|
hsa04150 |
mTOR signaling pathway |
KEGG |
|
hsa04151 |
PI3K-Akt signaling pathway |
KEGG |
|
hsa04210 |
Apoptosis |
KEGG |
|
hsa04211 |
Longevity regulating pathway |
KEGG |
|
hsa04213 |
Longevity regulating pathway - multiple species |
KEGG |
|
hsa04360 |
Axon guidance |
KEGG |
|
hsa04370 |
VEGF signaling pathway |
KEGG |
|
hsa04371 |
Apelin signaling pathway |
KEGG |
|
hsa04540 |
Gap junction |
KEGG |
|
hsa04550 |
Signaling pathways regulating pluripotency of stem cells |
KEGG |
|
hsa04650 |
Natural killer cell mediated cytotoxicity |
KEGG |
|
hsa04660 |
T cell receptor signaling pathway |
KEGG |
|
hsa04662 |
B cell receptor signaling pathway |
KEGG |
|
hsa04664 |
Fc epsilon RI signaling pathway |
KEGG |
|
hsa04720 |
Long-term potentiation |
KEGG |
|
hsa04722 |
Neurotrophin signaling pathway |
KEGG |
|
hsa04725 |
Cholinergic synapse |
KEGG |
|
hsa04726 |
Serotonergic synapse |
KEGG |
|
hsa04730 |
Long-term depression |
KEGG |
|
hsa04810 |
Regulation of actin cytoskeleton |
KEGG |
|
hsa04910 |
Insulin signaling pathway |
KEGG |
|
hsa04912 |
GnRH signaling pathway |
KEGG |
|
hsa04915 |
Estrogen signaling pathway |
KEGG |
|
hsa04916 |
Melanogenesis |
KEGG |
|
hsa04917 |
Prolactin signaling pathway |
KEGG |
|
hsa04919 |
Thyroid hormone signaling pathway |
KEGG |
|
hsa04921 |
Oxytocin signaling pathway |
KEGG |
|
hsa04933 |
AGE-RAGE signaling pathway in diabetic complications |
KEGG |
|
hsa05034 |
Alcoholism |
KEGG |
|
hsa05160 |
Hepatitis C |
KEGG |
|
hsa05161 |
Hepatitis B |
KEGG |
|
hsa05166 |
HTLV-I infection |
KEGG |
|
hsa05200 |
Pathways in cancer |
KEGG |
|
hsa05203 |
Viral carcinogenesis |
KEGG |
|
hsa05205 |
Proteoglycans in cancer |
KEGG |
|
hsa05206 |
MicroRNAs in cancer |
KEGG |
|
hsa05211 |
Renal cell carcinoma |
KEGG |
|
hsa05213 |
Endometrial cancer |
KEGG |
|
hsa05214 |
Glioma |
KEGG |
|
hsa05215 |
Prostate cancer |
KEGG |
|
hsa05216 |
Thyroid cancer |
KEGG |
|
hsa05218 |
Melanoma |
KEGG |
|
hsa05219 |
Bladder cancer |
KEGG |
|
hsa05220 |
Chronic myeloid leukemia |
KEGG |
|
hsa05221 |
Acute myeloid leukemia |
KEGG |
|
hsa05223 |
Non-small cell lung cancer |
KEGG |
|
hsa05224 |
Breast cancer |
KEGG |
|
hsa05230 |
Central carbon metabolism in cancer |
KEGG |
|
hsa05231 |
Choline metabolism in cancer |
KEGG |
|
WP3929 |
Chemokine signaling pathway |
WikiPathways |
|
WP2290 |
RalA downstream regulated genes |
WikiPathways |
|
WP35 |
G Protein Signaling Pathways |
WikiPathways |
|
WP3844 |
PI3K-AKT-mTOR signaling pathway and therapeutic opportunities |
WikiPathways |
|
WP3303 |
Rac1/Pak1/p38/MMP-2 pathway |
WikiPathways |
|
WP732 |
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling |
WikiPathways |
|
WP710 |
DNA Damage Response (only ATM dependent) |
WikiPathways |
|
WP2870 |
Extracellular vesicle-mediated signaling in recipient cells |
WikiPathways |
|
WP51 |
Regulation of Actin Cytoskeleton |
WikiPathways |
|
WP3676 |
BDNF-TrkB Signaling |
WikiPathways |
|
WP2643 |
Nanoparticle-mediated activation of receptor signaling |
WikiPathways |
|
WP422 |
MAPK Cascade |
WikiPathways |
|
WP382 |
MAPK Signaling Pathway |
WikiPathways |
|
WP2261 |
Signaling Pathways in Glioblastoma |
WikiPathways |
|
WP2586 |
Aryl Hydrocarbon Receptor |
WikiPathways |
|
WP231 |
TNF alpha Signaling Pathway |
WikiPathways |
|
WP3932 |
Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
WikiPathways |
| UMLS CUI | UMLS Term |
|---|---|
|
C0004352 |
Autistic Disorder |
|
C0007131 |
Non-Small Cell Lung Carcinoma |
|
C0009404 |
Colorectal Neoplasms |
|
C0017661 |
Iga Glomerulonephritis |
|
C0024299 |
Lymphoma |
|
C0025202 |
Melanoma |
|
C0027659 |
Neoplasms, Experimental |
|
C0027819 |
Neuroblastoma |
|
C0028326 |
Noonan Syndrome |
|
C0034885 |
Rectal Neoplasms |
|
C0079731 |
B-Cell Lymphomas |
|
C0206682 |
Follicular Thyroid Carcinoma |
|
C0206729 |
Neurofibrosarcoma |
|
C0349639 |
Juvenile Myelomonocytic Leukemia |
|
C1328840 |
Autoimmune Lymphoproliferative Syndrome |
| Tissue | Cell Type |
|---|---|
|
appendix |
glandular cells |
|
colon |
glandular cells |
|
duodenum |
glandular cells |
|
gallbladder |
glandular cells |
|
rectum |
glandular cells |
|
salivary gland |
glandular cells |
|
small intestine |
glandular cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
AKT1 |
207 |
P31749 |
0.49 |
|
SMAD1 |
4086 |
Q15797 |
0.49 |
|
RASA1 |
5921 |
P20936 |
0.49 |
|
FBP2 |
8789 |
O00757 |
0.49 |
|
VAT1 |
10493 |
Q99536 |
0.49 |
|
FRAT2 |
23401 |
O75474 |
0.49 |
|
TDRD7 |
23424 |
Q8NHU6 |
0.49 |
|
LEF1 |
51176 |
Q9UJU2 |
0.49 |
|
TRMO |
51531 |
Q9BU70 |
0.49 |
|
SPATS2 |
65244 |
Q86XZ4 |
0.49 |
|
RNASEH2B |
79621 |
Q5TBB1 |
0.49 |
|
BCL2 |
596 |
P10415 |
0.52 |
|
SMAD4 |
4089 |
Q13485 |
0.52 |
|
SMURF2 |
64750 |
Q9HAU4 |
0.52 |
|
EEF1A1 |
1915 |
P68104 |
0.63 |
|
DNAJB1 |
3337 |
P25685 |
0.63 |
|
PLCE1 |
51196 |
Q9P212 |
0.63 |
|
PIK3CG |
5294 |
P48736 |
0.75 |
|
RAF1 |
5894 |
P04049 |
0.96 |
|
ALDOB |
229 |
P05062 |
0.49 |
|
CYLC2 |
1539 |
Q14093 |
0.49 |
|
FANCC |
2176 |
Q00597 |
0.49 |
|
PPP2CB |
5516 |
P62714 |
0.49 |
|
SFRP4 |
6424 |
Q6FHJ7 |
0.49 |
|
CORO2A |
7464 |
Q92828 |
0.49 |
|
XPA |
7507 |
P23025 |
0.49 |
|
MAPKAPK3 |
7867 |
Q16644 |
0.49 |
|
CD2AP |
23607 |
Q9Y5K6 |
0.49 |
|
STX17 |
55014 |
P56962 |
0.49 |
|
HEMGN |
55363 |
Q9BXL5 |
0.49 |
|
AOPEP |
84909 |
Q8N6M6 |
0.49 |
|
CCDC180 |
100499483 |
Q9P1Z9 |
0.49 |
|
ACVR1 |
90 |
Q04771 |
0.52 |
|
ARHGAP4 |
393 |
P98171 |
0.52 |
|
RACGAP1 |
29127 |
Q9H0H5 |
0.52 |
|
RASGRP2 |
10235 |
Q7LDG7 |
0.55 |
|
ELAVL1 |
1994 |
Q15717 |
0.63 |
|
MDM2 |
4193 |
Q00987 |
0.63 |
|
RABGGTB |
5876 |
P53611 |
0.63 |
|
RPS20 |
6224 |
P60866 |
0.63 |
|
SRI |
6717 |
P30626 |
0.63 |
|
TMEM185A |
84548 |
Q8NFB2 |
0.63 |
|
RAP1GDS1 |
5910 |
P52306 |
0.65 |
|
PIK3CA |
5290 |
P42336 |
0.71 |
|
MLLT4 |
4301 |
P55196 |
0.72 |
|
RGL2 |
5863 |
O15211 |
0.72 |
|
RASSF5 |
83593 |
Q8WWW0 |
0.72 |
|
FOXP4 |
116113 |
Q8IVH2 |
0.72 |
|
SHOC2 |
8036 |
Q9UQ13 |
0.84 |