Protein Description

Gene Symbol NPM1
Entrez ID 4869
Uniprot ID P06748
Description nucleophosmin (nucleolar phosphoprotein B23, numatrin)
Chromosomal Location chr5: 171,387,116-171,411,137
Ontology GO ID GO Term Definition Evidence

BP

GO:0006281

DNA repair

The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.

IDA

BP

GO:0006334

nucleosome assembly

The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA.

IDA

BP

GO:0006886

intracellular protein transport

The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.

TAS

BP

GO:0006913

nucleocytoplasmic transport

The directed movement of molecules between the nucleus and the cytoplasm.

IDA|TAS

BP

GO:0006950

response to stress

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

IMP

BP

GO:0006977

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage and resulting in the stopping or reduction in rate of the cell cycle.

TAS

BP

GO:0007098

centrosome cycle

The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle.

IMP|ISS

BP

GO:0007165

signal transduction

The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

NAS

BP

GO:0007569

cell aging

An aging process that has as participant a cell after a cell has stopped dividing. Cell aging may occur when a cell has temporarily stopped dividing through cell cycle arrest (GO:0007050) or when a cell has permanently stopped dividing, in which case it is undergoing cellular senescence (GO:0090398). May precede cell death (GO:0008219) and succeed cell maturation (GO:0048469).

IMP|ISS

BP

GO:0008104

protein localization

Any process in which a protein is transported to, or maintained in, a specific location.

IDA

BP

GO:0008284

positive regulation of cell proliferation

Any process that activates or increases the rate or extent of cell proliferation.

IDA

BP

GO:0008285

negative regulation of cell proliferation

Any process that stops, prevents or reduces the rate or extent of cell proliferation.

IMP|ISS

BP

GO:0010826

negative regulation of centrosome duplication

Any process that decreases the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized.

IMP

BP

GO:0016032

viral process

A multi-organism process in which a virus is a participant. The other participant is the host. Includes infection of a host cell, replication of the viral genome, and assembly of progeny virus particles. In some cases the viral genetic material may integrate into the host genome and only subsequently, under particular circumstances, 'complete' its life cycle.

IEA

BP

GO:0032071

regulation of endodeoxyribonuclease activity

Any process that modulates the frequency, rate or extent of endodeoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks.

IDA

BP

GO:0034080

CENP-A containing nucleosome assembly

The formation of nucleosomes containing the histone H3 variant CENP-A to form centromeric chromatin. This specialised chromatin occurs at centromeric region in point centromeres, and the central core in modular centromeres.

TAS

BP

GO:0042255

ribosome assembly

The aggregation, arrangement and bonding together of the mature ribosome and of its subunits.

TAS

BP

GO:0043066

negative regulation of apoptotic process

Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.

IDA|NAS

BP

GO:0043085

positive regulation of catalytic activity

Any process that activates or increases the activity of an enzyme.

IEA

BP

GO:0043523

regulation of neuron apoptotic process

Any process that modulates the occurrence or rate of cell death by apoptotic process in neurons.

IEA

BP

GO:0044387

negative regulation of protein kinase activity by regulation of protein phosphorylation

The stopping, prevention, or reduction in frequency, rate or extent of protein kinase activity as a result of regulating the phosphorylation status of that protein kinase.

IDA

BP

GO:0045727

positive regulation of translation

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA.

IDA

BP

GO:0045740

positive regulation of DNA replication

Any process that activates or increases the frequency, rate or extent of DNA replication.

IEA

BP

GO:0045893

positive regulation of transcription, DNA-templated

Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.

IDA

BP

GO:0046599

regulation of centriole replication

Any process that modulates the frequency, rate or extent of the formation of a daughter centriole of an existing centriole.

IMP

BP

GO:0051092

positive regulation of NF-kappaB transcription factor activity

Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.

IMP

BP

GO:0051259

protein oligomerization

The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.

IDA

BP

GO:0051260

protein homooligomerization

The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.

IEA

BP

GO:0060699

regulation of endoribonuclease activity

Any process that modulates the rate, frequency or extent of the catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks.

IDA

BP

GO:0060735

regulation of eIF2 alpha phosphorylation by dsRNA

Any process that modulates the rate, frequency, or extent of eIF2 alpha phosphorylation as a cellular response to double-stranded RNA.

IDA

BP

GO:1902751

positive regulation of cell cycle G2/M phase transition

Any process that activates or increases the frequency, rate or extent of cell cycle G2/M phase transition.

IDA

CC

GO:0005634

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

IDA|ISS

CC

GO:0005654

nucleoplasm

That part of the nuclear content other than the chromosomes or the nucleolus.

IDA|TAS

CC

GO:0005730

nucleolus

A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.

IDA

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

IDA|ISS

CC

GO:0005813

centrosome

A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.

IDA|ISS

CC

GO:0005829

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

TAS

CC

GO:0005925

focal adhesion

Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.

IDA

CC

GO:0016020

membrane

A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

IDA

CC

GO:0030529

intracellular ribonucleoprotein complex

An intracellular macromolecular complex containing both protein and RNA molecules.

IDA

CC

GO:0031616

spindle pole centrosome

A centrosome from which one pole of a mitotic or meiotic spindle is organized.

IDA

MF

GO:0003677

DNA binding

Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

IEA

MF

GO:0003713

transcription coactivator activity

Interacting selectively and non-covalently with a activating transcription factor and also with the basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery.

IDA

MF

GO:0003723

RNA binding

Interacting selectively and non-covalently with an RNA molecule or a portion thereof.

IDA

MF

GO:0004860

protein kinase inhibitor activity

Stops, prevents or reduces the activity of a protein kinase, an enzyme which phosphorylates a protein.

IDA

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0005547

phosphatidylinositol-3,4,5-trisphosphate binding

Interacting selectively and non-covalently with phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions.

IEA

MF

GO:0019901

protein kinase binding

Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.

IPI

MF

GO:0030957

Tat protein binding

Interacting selectively and non-covalently with Tat, a viral transactivating regulatory protein from the human immunodeficiency virus, or the equivalent protein from another virus.

IDA

MF

GO:0042393

histone binding

Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity.

IDA

MF

GO:0042803

protein homodimerization activity

Interacting selectively and non-covalently with an identical protein to form a homodimer.

IDA

MF

GO:0043023

ribosomal large subunit binding

Interacting selectively and non-covalently with any part of the larger ribosomal subunit.

IDA

MF

GO:0043024

ribosomal small subunit binding

Interacting selectively and non-covalently with any part of the small ribosomal subunit.

IDA

MF

GO:0044822

poly(A) RNA binding

Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases.

IDA

MF

GO:0046982

protein heterodimerization activity

Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.

IMP

MF

GO:0051059

NF-kappaB binding

Interacting selectively and non-covalently with NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters.

IDA|ISS

MF

GO:0051082

unfolded protein binding

Interacting selectively and non-covalently with an unfolded protein.

IDA|ISS

Domain ID Description

IPR004301

Nucleoplasmin family

IPR024057

Nucleoplasmin core domain

IPR032569

Nucleophosmin, C-terminal

No pathways found.

UMLS CUI UMLS Term

C0023467

Leukemia, Myelocytic, Acute

C0023487

Acute Promyelocytic Leukemia

C0038356

Stomach Neoplasms

C0206182

Lymphomatoid Papulosis

C1301362

Lymphoma, Primary Cutaneous Anaplastic Large Cell

Tissue Cell Type

adrenal gland

glandular cells

appendix

glandular cells

appendix

lymphoid tissue

bone marrow

hematopoietic cells

breast

adipocytes

breast

glandular cells

breast

myoepithelial cells

bronchus

respiratory epithelial cells

caudate

glial cells

caudate

neuronal cells

cerebellum

cells in granular layer

cerebellum

cells in molecular layer

cerebellum

Purkinje cells

cerebral cortex

endothelial cells

cerebral cortex

glial cells

cerebral cortex

neuronal cells

cervix, uterine

squamous epithelial cells

colon

endothelial cells

colon

glandular cells

duodenum

glandular cells

endometrium

cells in endometrial stroma

endometrium

glandular cells

epididymis

glandular cells

esophagus

squamous epithelial cells

fallopian tube

glandular cells

gallbladder

glandular cells

heart muscle

myocytes

hippocampus

glial cells

hippocampus

neuronal cells

kidney

cells in glomeruli

kidney

cells in tubules

liver

bile duct cells

liver

hepatocytes

lung

macrophages

lung

pneumocytes

lymph node

germinal center cells

lymph node

non-germinal center cells

nasopharynx

respiratory epithelial cells

oral mucosa

squamous epithelial cells

ovary

ovarian stroma cells

pancreas

exocrine glandular cells

pancreas

islets of Langerhans

parathyroid gland

glandular cells

placenta

decidual cells

placenta

trophoblastic cells

prostate

glandular cells

rectum

glandular cells

salivary gland

glandular cells

seminal vesicle

glandular cells

skeletal muscle

myocytes

skin

fibroblasts

skin

keratinocytes

skin

Langerhans

skin

melanocytes

skin

epidermal cells

small intestine

glandular cells

smooth muscle

smooth muscle cells

soft tissue

adipocytes

soft tissue

fibroblasts

soft tissue

peripheral nerve

spleen

cells in red pulp

spleen

cells in white pulp

stomach

glandular cells

testis

cells in seminiferous ducts

testis

Leydig cells

thyroid gland

glandular cells

tonsil

germinal center cells

tonsil

non-germinal center cells

tonsil

squamous epithelial cells

urinary bladder

urothelial cells

vagina

squamous epithelial cells

No databases found.

Pubmed ID Author Year Title

22617121

Ouandaogo et al.

2012

Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

Gene Symbol Entrez ID Uniprot ID Score

SURF4

6836

O15260

0.49

ZYX

7791

Q15942

0.49

PRPF6

24148

O94906

0.49

RPL10L

140801

Q96L21

0.49

PLCG2

5336

P16885

0.52

HABP4

22927

Q5JVS0

0.52

ALK

238

Q9UM73

0.55

APP

351

P05067

0.56

PRMT2

3275

P55345

0.56

HIST2H2AC

8338

Q16777

0.56

XPO1

7514

O14980

0.62

ACACA

31

Q13085

0.63

ACY1

95

Q03154

0.63

SLC25A5

292

P05141

0.63

ANXA2

302

P07355

0.63

ARHGAP5

394

Q13017

0.63

ATP5A1

498

P25705

0.63

C1QBP

708

Q07021

0.63

MRPL49

740

Q13405

0.63

CALU

813

O43852

0.63

CENPC

1060

Q03188

0.63

CENPF

1063

P49454

0.63

CFL1

1072

P23528

0.63

CLTC

1213

Q00610

0.63

COPB1

1315

P53618

0.63

CSNK2B

1460

P67870

0.63

CSTF3

1479

Q12996

0.63

DHX15

1665

O43143

0.63

EEF1A1

1915

P68104

0.63

EEF1B2

1933

P24534

0.63

EEF1D

1936

P29692

0.63

EEF1G

1937

P26641

0.63

EEF2

1938

P13639

0.63

EIF2S1

1965

P05198

0.63

EIF4A1

1973

P60842

0.63

EIF5A

1984

P63241

0.63

CTTN

2017

Q14247

0.63

ENO1

2023

P06733

0.63

EPAS1

2034

Q99814

0.63

FANCA

2175

O15360

0.63

FANCC

2176

Q00597

0.63

FASN

2194

P49327

0.63

FLNA

2316

P21333

0.63

FLNB

2317

O75369

0.63

FLNC

2318

Q14315

0.63

GNAI2

2771

P04899

0.63

GOLGA2

2801

Q08379

0.63

GOLGA3

2802

Q08378

0.63

GRB7

2886

Q14451

0.63

GRN

2896

P28799

0.63

HIST1H1D

3007

P16402

0.63

HIST1H1E

3008

P10412

0.63

HIST1H1A

3024

Q02539

0.63

HIVEP2

3097

P31629

0.63

HNRNPH1

3187

P31943

0.63

DNAJA1

3301

P31689

0.63

HSPA4

3308

P34932

0.63

HSPA5

3309

P11021

0.63

HSPB1

3315

P04792

0.63

HSP90AA1

3320

P07900

0.63

HSP90AB1

3326

P08238

0.63

ICT1

3396

Q14197

0.63

IMPDH2

3615

P12268

0.63

IMPG1

3617

Q17R60

0.63

JAK1

3716

P23458

0.63

JUNB

3726

P17275

0.63

KDR

3791

P35968

0.63

KIF11

3832

P52732

0.63

KPNA1

3836

P52294

0.63

IPO5

3843

O00410

0.63

KTN1

3895

Q86UP2

0.63

LAMB2

3913

P55268

0.63

RPSA

3921

P08865

0.63

LGALS1

3956

P09382

0.63

LLGL1

3996

Q15334

0.63

MAP1B

4131

P46821

0.63

MC4R

4160

P32245

0.63

HNRNPM

4670

P52272

0.63

NUMA1

4926

Q14980

0.63

NUP98

4928

P52948

0.63

PC

5091

P11498

0.63

PCBP1

5093

Q15365

0.63

SLC25A3

5250

Q00325

0.63

PIK3R1

5295

P27986

0.63

PKM

5315

P14618

0.63

POLR2E

5434

P19388

0.63

PPA1

5464

Q15181

0.63

PPID

5481

Q08752

0.63

PPM1G

5496

O15355

0.63

PPP1CC

5501

P36873

0.63

PPP2CA

5515

P67775

0.63

PRKAR1A

5573

P10644

0.63

PRKCA

5578

P17252

0.63

PRKCI

5584

P41743

0.63

PROS1

5627

P07225

0.63

PSMC5

5705

P62195

0.63

PSMD1

5707

Q99460

0.63

PSMD4

5710

P55036

0.63

PSMD12

5718

O00232

0.63

PTPN14

5784

Q15678

0.63

PYGB

5834

P11216

0.63

RB1

5925

P06400

0.63

RBBP4

5928

Q09028

0.63

RNH1

6050

P13489

0.63

RPL17

6139

P18621

0.63

RPL19

6143

P84098

0.63

RPL36AL

6166

Q969Q0

0.63

RPLP0

6175

P05388

0.63

RPLP1

6176

P05386

0.63

MRPL12

6182

P52815

0.63

RPS12

6206

P25398

0.63

S100A10

6281

P60903

0.63

S100A11

6282

P31949

0.63

SNRPD1

6632

P62314

0.63

SNRPD2

6633

P62316

0.63

SNRPF

6636

P62306

0.63

TRIM21

6737

P19474

0.63

SURF6

6838

O75683

0.63

TCP1

6950

P17987

0.63

TPR

7175

P12270

0.63

TUFM

7284

P49411

0.63

TXN

7295

P10599

0.63

UTRN

7402

P46939

0.63

VASP

7408

P50552

0.63

VCP

7415

P55072

0.63

PABPN1

8106

Q86U42

0.63

TRRAP

8295

Q9Y4A5

0.63

SDPR

8436

O95810

0.63

NIPSNAP1

8508

Q9BPW8

0.63

YBX3

8531

P16989

0.63

CDC14A

8556

Q9UNH5

0.63

UNC5C

8633

O95185

0.63

EIF3G

8666

O75821

0.63

EIF3H

8667

O15372

0.63

EIF3I

8668

Q13347

0.63

SQSTM1

8878

Q13501

0.63

BAG2

9532

O95816

0.63

PRDX6

9588

P30041

0.63

DOCK4

9732

Q8N1I0

0.63

MRPL19

9801

P49406

0.63

KEAP1

9817

Q14145

0.63

URB1

9875

O60287

0.63

USP15

9958

Q9Y4E8

0.63

CEBPZ

10153

Q03701

0.63

PSME3

10197

P61289

0.63

POP7

10248

O75817

0.63

DNAJA2

10294

O60884

0.63

NPM2

10361

Q86SE8

0.63

TUBB3

10381

Q13509

0.63

TAB1

10454

Q15750

0.63

EIF3M

10480

Q7L2H7

0.63

PRDX4

10549

Q13162

0.63

AGR2

10551

O95994

0.63

RPP38

10557

P78345

0.63

MRPL28

10573

Q13084

0.63

CCT2

10576

P78371

0.63

NUP50

10762

Q9UKX7

0.63

RPP40

10799

O75818

0.63

MRPS30

10884

Q9NP92

0.63

PAPOLA

10914

P51003

0.63

SPIN1

10927

Q9Y657

0.63

POP1

10940

Q99575

0.63

HNRNPA0

10949

Q13151

0.63

DSTN

11034

P60981

0.63

NUDT21

11051

O43809

0.63

CPSF6

11052

Q16630

0.63

PWP1

11137

Q13610

0.63

CDC37

11140

Q16543

0.63

AKAP11

11215

Q9UKA4

0.63

PARK7

11315

Q99497

0.63

COPE

11316

O14579

0.63

STK38

11329

Q15208

0.63

COPG1

22820

Q9Y678

0.63

DZIP1

22873

Q86YF9

0.63

CEP152

22995

O94986

0.63

RBM34

23029

P42696

0.63

NCOA6

23054

Q14686

0.63

TAB2

23118

Q9NYJ8

0.63

RCOR1

23186

Q9UKL0

0.63

RRS1

23212

Q15050

0.63

DNAJC13

23317

O75165

0.63

RRP8

23378

O43159

0.63

DICER1

23405

Q9UPY3

0.63

SIRT1

23411

Q96EB6

0.63

KCTD2

23510

Q14681

0.63

NUP62

23636

P37198

0.63

SAMM50

25813

Q9Y512

0.63

NEPRO

25871

Q6NW34

0.63

NOC2L

26155

Q9Y3T9

0.63

MYCBP

26292

Q99417

0.63

MRPL46

26589

Q9H2W6

0.63

RANBP6

26953

O60518

0.63

MRPL18

29074

Q9H0U6

0.63

GLTSCR2

29997

Q9NZM5

0.63

TXNDC12

51060

O95881

0.63

RPL26L1

51121

Q9UNX3

0.63

RSL24D1

51187

Q9UHA3

0.63

MRPL37

51253

Q9BZE1

0.63

NIP7

51388

Q9Y221

0.63

NOP16

51491

Q9Y3C1

0.63

SRRT

51593

Q9BXP5

0.63

RBMX2

51634

Q9Y388

0.63

CPSF2

53981

Q9P2I0

0.63

MRPL39

54148

Q9NYK5

0.63

KCTD5

54442

Q9NXV2

0.63

MRPL50

54534

Q8N5N7

0.63

DDX56

54606

Q9NY93

0.63

GPATCH4

54865

Q5T3I0

0.63

RPP25

54913

Q9BUL9

0.63

CHCHD3

54927

Q9NX63

0.63

BANP

54971

Q8N9N5

0.63

GID8

54994

Q9NWU2

0.63

PAK1IP1

55003

Q9NWT1

0.63

RBM28

55131

Q9NW13

0.63

SDAD1

55153

Q9NVU7

0.63

BRIX1

55299

Q8TDN6

0.63

TTC27

55622

Q6P3X3

0.63

DDX27

55661

Q96GQ7

0.63

IPO9

55705

Q96P70

0.63

FGD6

55785

Q6ZV73

0.63

TEX15

56154

Q9BXT5

0.63

PPAN

56342

Q9NQ55

0.63

MRPS22

56945

P82650

0.63

REXO4

57109

Q9GZR2

0.63

CASKIN1

57524

Q8WXD9

0.63

SLAIN2

57606

Q9P270

0.63

ELMO2

63916

Q96JJ3

0.63

NCAPG

64151

Q9BPX3

0.63

PAPD5

64282

Q8NDF8

0.63

NOC3L

64318

Q8WTT2

0.63

DDX31

64794

Q9H8H2

0.63

NMNAT1

64802

Q9HAN9

0.63

PAPOLG

64895

Q9BWT3

0.63

MRPS26

64949

Q9BYN8

0.63

MRPL38

64978

Q96DV4

0.63

MRPL11

65003

Q9Y3B7

0.63

MRPL44

65080

Q9H9J2

0.63

DDX54

79039

Q8TDD1

0.63

MRPL24

79590

Q96A35

0.63

KCTD17

79734

Q8N5Z5

0.63

RPF1

80135

Q9H9Y2

0.63

MUS81

80198

Q96NY9

0.63

WDR26

80232

Q9H7D7

0.63

GRWD1

83743

Q9BQ67

0.63

TAF3

83860

Q5VWG9

0.63

RPF2

84154

Q9H7B2

0.63

CHCHD6

84303

Q9BRQ6

0.63

ZNF512

84450

Q96ME7

0.63

MRPL43

84545

Q8N983

0.63

MAK16

84549

Q9BXY0

0.63

PARD6B

84612

Q9BYG5

0.63

GLYR1

84656

Q49A26

0.63

TUBA1C

84790

Q9BQE3

0.63

NUDCD1

84955

Q96RS6

0.63

PPIL4

85313

Q8WUA2

0.63

OSBPL1A

114876

Q9BXW6

0.63

TRMT61A

115708

Q96FX7

0.63

MRPL53

116540

Q96EL3

0.63

MRPL54

116541

Q6P161

0.63

FTSJ3

117246

Q8IY81

0.63

MRPL52

122704

Q86TS9

0.63

MRPL10

124995

Q7Z7H8

0.63

CHCHD4

131474

Q8N4Q1

0.63

RPP25L

138716

Q8N5L8

0.63

SPTY2D1

144108

Q68D10

0.63

ZNF800

168850

Q2TB10

0.63

CENPV

201161

Q7Z7K6

0.63

SENP5

205564

Q96HI0

0.63

PTRF

284119

Q6NZI2

0.63

RPL7L1

285855

Q6DKI1

0.63

CCDC137

339230

Q6PK04

0.63

KNOP1

400506

Q1ED39

0.63

BOLA2

552900

Q9H3K6

0.63

ZFP62

643836

Q8NB50

0.63

ARF1

375

P84077

0.65

CDK2

1017

P24941

0.68

ELF4

2000

Q99607

0.68

PLCG1

5335

P19174

0.68

PADI4

23569

Q9UM07

0.70

BYSL

705

Q13895

0.72

CHD1

1105

O14646

0.72

GADD45A

1647

P24522

0.72

DDX1

1653

Q92499

0.72

DECR1

1666

Q16698

0.72

EIF1AX

1964

P47813

0.72

EIF4G2

1982

P78344

0.72

FBL

2091

P22087

0.72

FAU

2197

P62861

0.72

HIST1H1B

3009

P16401

0.72

HDAC2

3066

Q92769

0.72

MKI67

4288

P46013

0.72

MPG

4350

P29372

0.72

EXOSC10

5394

Q01780

0.72

RPL7

6129

P18124

0.72

RPL8

6132

P62917

0.72

RPL11

6135

P62913

0.72

RPL13

6137

P26373

0.72

RPL15

6138

P61313

0.72

RPL18

6141

Q07020

0.72

RPL18A

6142

Q02543

0.72

RPL21

6144

P46778

0.72

RPL22

6146

P35268

0.72

RPL27

6155

P61353

0.72

RPL27A

6157

P46776

0.72

RPL29

6159

P47914

0.72

RPL32

6161

P62910

0.72

RPL37

6167

P61927

0.72

RPL38

6169

P63173

0.72

RPS2

6187

P15880

0.72

RPS3

6188

P23396

0.72

RPS3A

6189

P61247

0.72

RPS9

6203

P46781

0.72

RPS11

6205

P62280

0.72

RPS13

6207

P62277

0.72

RPS14

6208

P62263

0.72

RPS15

6209

P62841

0.72

RPS16

6217

P62249

0.72

RPS17

6218

P08708

0.72

RPS18

6222

P62269

0.72

RPS19

6223

P39019

0.72

RPS20

6224

P60866

0.72

RPS23

6228

P62266

0.72

RPS24

6229

P62847

0.72

RPS25

6230

P62851

0.72

RPS27

6232

P42677

0.72

RPS29

6235

P62273

0.72

SKIV2L

6499

Q15477

0.72

SRP72

6731

O76094

0.72

XPC

7508

Q01831

0.72

IFRD2

7866

Q12894

0.72

HIST1H2BC; HIST1H2BE; HIST1H2BF; HIST1H2BG; HIST1H2BI

8339

P62807

0.72

SMARCA5

8467

O60264

0.72

CGGBP1

8545

Q9UFW8

0.72

EIF3A

8661

Q14152

0.72

EIF3C

8663

Q99613

0.72

PABPC4

8761

Q13310

0.72

USP10

9100

Q14694

0.72

TTC37

9652

Q6PGP7

0.72

JADE3

9767

Q92613

0.72

ABCF2

10061

Q9UG63

0.72

G3BP1

10146

Q13283

0.72

RACK1

10399

P63244

0.72

EMG1

10436

Q92979

0.72

IGF2BP3

10643

O00425

0.72

CPSF4

10898

O95639

0.72

PSIP1

11168

O75475

0.72

SUPT16H

11198

Q9Y5B9

0.72

RPL35

11224

P42766

0.72

PDCD11

22984

Q14690

0.72

LARP4B

23185

Q92615

0.72

RRP12

23223

Q5JTH9

0.72

LARP1

23367

Q6PKG0

0.72

RPL13A

23521

P40429

0.72

RPL36

25873

Q9Y3U8

0.72

MTHFD1L

25902

Q6UB35

0.72

AHCTF1

25909

Q8WYP5

0.72

FAM98A

25940

Q8NCA5

0.72

SERBP1

26135

Q8NC51

0.72

GNL3

26354

Q9BVP2

0.72

SND1

27044

Q7KZF4

0.72

NOB1

28987

Q9ULX3

0.72

RPS27L

51065

Q71UM5

0.72

DDX47

51202

Q9H0S4

0.72

EIF3L

51386

Q9Y262

0.72

RTCB

51493

Q9Y3I0

0.72

TRMT112

51504

Q9UI30

0.72

CPSF3

51692

Q9UKF6

0.72

DHX29

54505

Q7Z478

0.72

MTPAP

55149

Q9NVV4

0.72

NAT10

55226

Q9H0A0

0.72

TSR1

55720

Q2NL82

0.72

NKRF

55922

O15226

0.72

MEPCE

56257

Q7L2J0

0.72

BCCIP

56647

Q9P287

0.72

PNO1

56902

Q9NRX1

0.72

WDR18

57418

Q9BV38

0.72

SCAF1

58506

Q9H7N4

0.72

NOL6

65083

Q9H6R4

0.72

DDX50

79009

Q9BQ39

0.72

CCDC86

79080

Q9H6F5

0.72

ZNF622

90441

Q969S3

0.72

DHX57

90957

Q6P158

0.72

H2AFV

94239

Q71UI9

0.72

LARP4

113251

Q71RC2

0.72

WBSCR22

114049

O43709

0.72

RPS21

100291837

P63220

0.72

RPL9; RPL9P7; RPL9P8; RPL9P9

6133

P32969

0.72

YBX1

4904

P67809

0.73

DDX24

57062

Q9GZR7

0.73

DDX21

9188

Q9NR30

0.74

NOP2

4839

P46087

0.75

SHC1

6464

P29353

0.75

TRIM28

10155

Q13263

0.75

HDAC1

3065

Q13547

0.76

AURKB

9212

Q96GD4

0.77

USP36

57602

Q9P275

0.78

RPS10

6204

P46783

0.79

TFAP2A

7020

P05549

0.79

HIST1H3A

8350

P68431

0.79

DDX3X

1654

O00571

0.82

HIST1H1C

3006

P16403

0.82

NVL

4931

O15381

0.82

RPL3

6122

P39023

0.82

RPL4

6124

P36578

0.82

RPL7A

6130

P62424

0.82

RPL10

6134

P27635

0.82

RPL23A

6147

P62750

0.82

RPL24

6152

P83731

0.82

RPL37A

6168

P61513

0.82

RPS4X

6191

P62701

0.82

RPS5

6193

P46782

0.82

RPS6

6194

P62753

0.82

RPS8

6202

P62241

0.82

RPS28

6234

P62857

0.82

H1FX

8971

Q92522

0.82

RPL14

9045

P50914

0.82

PUM3

9933

Q15397

0.82

GTPBP4

23560

Q9BZE4

0.82

RSL1D1

26156

O76021

0.82

GNL2

29889

Q13823

0.82

HP1BP3

50809

Q5SSJ5

0.82

TEX10

54881

Q9NXF1

0.82

HNRNPU

3192

Q00839

0.83

RPL5

6125

P46777

0.83

HIST2H2BE

8349

Q16778

0.84

EIF3E

3646

P60228

0.87

PELP1

27043

Q8IZL8

0.87

SENP3

26168

Q9H4L4

0.88

NCL

4691

P19338

0.90

NPM1

4869

P06748

0.90

TP53

7157

P04637

0.90

NPM3

10360

O75607

0.92

FAM129A

116496

Q9BZQ8

0.19

LAMP2

3920

P13473

0.49

NAP1L1

4673

P55209

0.49

HNRNPR

10236

O43390

0.49

UTP15

84135

Q8TED0

0.49

CLK1

1195

P49759

0.52

EP300

2033

Q09472

0.52

GZMM

3004

P51124

0.52

IRS1

3667

P35568

0.52

UBTF

7343

P17480

0.52

ACTB

60

P60709

0.55

PLK1

5347

P53350

0.55

CHAF1A

10036

Q13111

0.55

BOP1

23246

Q14137

0.55

CD247

919

P20963

0.56

KPNA2

3838

P52292

0.56

UBC

7316

P0CG48

0.56

MEX3C

51320

Q5U5Q3

0.56

ADRBK1

156

P25098

0.63

APEX1

328

P27695

0.63

FMNL1

752

O95466

0.63

CD4

920

P01730

0.63

CD81

975

P60033

0.63

CDC5L

988

Q99459

0.63

COX8A

1351

P10176

0.63

CRY1

1407

Q16526

0.63

CSNK1A1

1452

P48729

0.63

CSNK1E

1454

P49674

0.63

EGFR

1956

P00533

0.63

EWSR1

2130

Q01844

0.63

FUS

2521

P35637

0.63

GALE

2582

Q14376

0.63

GH1

2688

P01241

0.63

HLA-B

3106

P30480

0.63

HOXA7

3204

P31268

0.63

ICAM1

3383

P05362

0.63

ILK

3611

Q13418

0.63

ITGA4

3676

P13612

0.63

JUN

3725

P05412

0.63

MCC

4163

P23508

0.63

MCM2

4171

P49736

0.63

MID1

4281

O15344

0.63

AFF1

4299

P51825

0.63

MOV10

4343

Q9HCE1

0.63

ABCC1

4363

P33527

0.63

NFKB1

4790

P19838

0.63

NOS2

4843

P35228

0.63

NTRK1

4914

P04629

0.63

OSBP

5007

P22059

0.63

PARK2

5071

O60260

0.63

PHB

5245

P35232

0.63

PHKG2

5261

P15735

0.63

PML

5371

P29590

0.63

PPP2R1A

5518

P30153

0.63

PRKAA1

5562

Q13131

0.63

PRKCZ

5590

Q05513

0.63

RARA

5914

P10276

0.63

RPA1

6117

P27694

0.63

RPA2

6118

P15927

0.63

RPA3

6119

P35244

0.63

RPS6KA1

6195

Q15418

0.63

RPS6KB2

6199

Q9UBS0

0.63

RYK

6259

P34925

0.63

SIAH1

6477

Q8IUQ4

0.63

SMARCA4

6597

P51532

0.63

STAU1

6780

O95793

0.63

TRAF6

7189

Q9Y4K3

0.63

CNBP

7555

P62633

0.63

ZNF22

7570

P17026

0.63

CUL5

8065

Q93034

0.63

GAN

8139

Q9H2C0

0.63

UBL4A

8266

P11441

0.63

DYRK2

8445

Q92630

0.63

CUL4A

8451

Q13619

0.63

CUL3

8452

Q13618

0.63

CUL2

8453

Q13617

0.63

CUL1

8454

Q13616

0.63

CBX4

8535

O00257

0.63

COPS2

9318

P61201

0.63

HAND2

9464

P61296

0.63

IKBKE

9641

Q14164

0.63

KIAA0101

9768

Q15004

0.63

CUL7

9820

Q14999

0.63

PAN2

9924

Q504Q3

0.63

HDAC5

10014

Q9UQL6

0.63

HUWE1

10075

Q7Z6Z7

0.63

NSA2

10412

O95478

0.63

NXF1

10482

Q9UBU9

0.63

POP4

10775

O95707

0.63

EBNA1BP2

10969

Q99848

0.63

COPS6

10980

Q7L5N1

0.63

COPS5

10987

Q92905

0.63

GABARAP

11337

O95166

0.63

GABARAPL2

11345

P60520

0.63

LIMCH1

22998

Q9UPQ0

0.63

OBSL1

23363

O75147

0.63

TARDBP

23435

Q13148

0.63

GABARAPL1

23710

Q9H0R8

0.63

FBXO25

26260

Q8TCJ0

0.63

FBXO6

26270

Q9NRD1

0.63

AGO1

26523

Q9UL18

0.63

AGO2

27161

Q9UKV8

0.63

EEF2K

29904

O00418

0.63

SIRT7

51547

Q9NRC8

0.63

SIRT6

51548

Q8N6T7

0.63

ARMCX3

51566

Q9UH62

0.63

DCUN1D1

54165

Q96GG9

0.63

PINX1

54984

Q96BK5

0.63

MED9

55090

Q9NWA0

0.63

LGR4

55366

Q9BXB1

0.63

MED29

55588

Q9NX70

0.63

RIOK2

55781

Q9BVS4

0.63

CAND1

55832

Q86VP6

0.63

CTNNBL1

56259

Q8WYA6

0.63

GZF1

64412

Q9H116

0.63

TAF1D

79101

Q9H5J8

0.63

NOL12

79159

Q9UGY1

0.63

CDK5RAP3

80279

Q96JB5

0.63

MAP1LC3B

81631

Q9GZQ8

0.63

TMUB1

83590

Q9BVT8

0.63

CCDC8

83987

Q9H0W5

0.63

MED10

84246

Q9BTT4

0.63

PHF6

84295

Q8IWS0

0.63

NIFK

84365

Q9BYG3

0.63

MAP1LC3A

84557

Q9H492

0.63

IGSF8

93185

Q969P0

0.63

LRRK2

120892

Q5S007

0.63

LIN54

132660

Q6MZP7

0.63

SREK1

140890

Q8WXA9

0.63

MED19

219541

A0JLT2

0.63

SMN1; SMN2

6606

Q16637

0.63

RPGR

6103

Q92834

0.65

HIST3H3

8290

Q16695

0.65

ERG

2078

P11308

0.68

IRF1

3659

P10914

0.68

YY1

7528

P25490

0.68

CDKN1A

1026

P38936

0.70

CSNK2A1

1457

P68400

0.70

SWAP70

23075

Q9UH65

0.71

ARRB1

408

P49407

0.72

ARRB2

409

P32121

0.72

FN1

2335

P02751

0.72

PTBP1

5725

P26599

0.72

SRSF1

6426

Q07955

0.72

MAP3K14

9020

Q99558

0.72

RRP1B

23076

Q14684

0.72

CPSF1

29894

Q10570

0.72

OTUB1

55611

Q96FW1

0.72

CBX8

57332

Q9HC52

0.72

CBX2

84733

Q14781

0.72

GAPDH

2597

P04406

0.73

H2AFX

3014

P16104

0.73

HMGA1

3159

P17096

0.73

YWHAE

7531

P62258

0.73

HMGA2

8091

P52926

0.73

CTCF

10664

P49711

0.73

TCERG1

10915

O14776

0.73

HJURP

55355

Q8NCD3

0.73

ZNF668

79759

Q96K58

0.73

SUMO3

6612

P55854

0.74

SUMO1

7341

P63165

0.74

PARP1

142

P09874

0.75

TOP1

7150

P11387

0.75

DNAJB4

11080

Q9UDY4

0.75

USF2

7392

Q15853

0.76

AKT1

207

P31749

0.78

YWHAQ

10971

P27348

0.78

CDT1

81620

Q9H211

0.78

BARD1

580

Q99728

0.79

BRCA1

672

P38398

0.79

CDKN2A

1029

P42771

0.79

SUMO2

6613

P61956

0.79

GRB2

2885

P62993

0.81

CDKN2A

1029

Q8N726

0.82

ESR1

2099

P03372

0.82

NAP1L4

4676

Q99733

0.82

RPL10A

4736

P62906

0.82

PSMC4

5704

P43686

0.82

UQCRH

7388

P07919

0.82

VCAM1

7412

P19320

0.82

NOP56

10528

O00567

0.82

NSUN2

54888

Q08J23

0.82

DOT1L

84444

Q8TEK3

0.82

MYBBP1A

10514

Q9BQG0

0.84

EIF2AK2

5610

P19525

0.85

AURKA

6790

O14965

0.85

HIST1H4A; HIST1H4B; HIST1H4C; HIST1H4D; HIST1H4E; HIST1H4F; HIST1H4H; HIST1H4I; HIST1H4J; HIST1H4K; HIST1H4L; HIST2H4A; HIST2H4B; HIST4H4

121504

P62805

0.85

PA2G4

5036

Q9UQ80

0.86

RELA

5970

Q04206

0.86

LYAR

55646

Q9NX58

0.86

MDM2

4193

Q00987

0.87

RPL6

6128

Q02878

0.87

CENPA

1058

P49450

0.88

YWHAZ

7534

P63104

0.88

HEMGN

55363

Q9BXL5

0.88