Gene Symbol | NONO |
Entrez ID | 4841 |
Uniprot ID | Q15233 |
Description | non-POU domain containing, octamer-binding |
Chromosomal Location | chrX: 71,283,192-71,301,168 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0000398 |
mRNA splicing, via spliceosome |
The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. |
IBA |
BP |
GO:0006281 |
DNA repair |
The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. |
IEA |
BP |
GO:0006310 |
DNA recombination |
Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. |
IEA |
BP |
GO:0006351 |
transcription, DNA-templated |
The cellular synthesis of RNA on a template of DNA. |
IEA |
BP |
GO:0006355 |
regulation of transcription, DNA-templated |
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. |
IBA |
BP |
GO:0006397 |
mRNA processing |
Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. |
TAS |
BP |
GO:0007623 |
circadian rhythm |
Any biological process in an organism that recurs with a regularity of approximately 24 hours. |
ISS |
BP |
GO:0008380 |
RNA splicing |
The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA. |
TAS |
BP |
GO:0042752 |
regulation of circadian rhythm |
Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours. |
ISS |
BP |
GO:0045892 |
negative regulation of transcription, DNA-templated |
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. |
ISS |
BP |
GO:1903377 |
negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway |
Any process that stops, prevents or reduces the frequency, rate or extent of oxidative stress-induced neuron intrinsic apoptotic signaling pathway. |
IDA |
CC |
GO:0005634 |
nucleus |
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
IDA|ISS |
CC |
GO:0005654 |
nucleoplasm |
That part of the nuclear content other than the chromosomes or the nucleolus. |
IDA |
CC |
GO:0005730 |
nucleolus |
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
IEA |
CC |
GO:0016020 |
membrane |
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
IDA |
CC |
GO:0016363 |
nuclear matrix |
The dense fibrillar network lying on the inner side of the nuclear membrane. |
IDA |
CC |
GO:0016607 |
nuclear speck |
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. |
IEA |
CC |
GO:0042382 |
paraspeckles |
Discrete subnuclear bodies in the interchromatin nucleoplasmic space, often located adjacent to nuclear specks. 10-20 paraspeckles are typically found in human cell nuclei. |
IDA |
CC |
GO:0090575 |
RNA polymerase II transcription factor complex |
A transcription factor complex that acts at promoters of genes transcribed by RNA polymerase II. |
ISS |
MF |
GO:0000166 |
nucleotide binding |
Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. |
IEA |
MF |
GO:0000976 |
transcription regulatory region sequence-specific DNA binding |
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. |
IBA |
MF |
GO:0000980 |
RNA polymerase II distal enhancer sequence-specific DNA binding |
Interacting selectively and non-covalently with a RNA polymerase II (Pol II) distal enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of some promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter. |
ISS |
MF |
GO:0001047 |
core promoter binding |
Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for the basal transcription machinery. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors. |
ISS |
MF |
GO:0003682 |
chromatin binding |
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. |
ISS |
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
MF |
GO:0044822 |
poly(A) RNA binding |
Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases. |
IDA |
Domain ID | Description |
---|---|
IPR000504 |
RNA recognition motif domain |
IPR012975 |
NOPS |
IPR034552 |
p54nrb, RNA recognition motif 1 |
IPR034558 |
p54nrb, RNA recognition motif 2 |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
WP411 |
mRNA Processing |
WikiPathways |
WP3594 |
Circadian rythm related genes |
WikiPathways |
h_antisensePathway |
RNA polymerase III transcription |
BioCarta |
Tissue | Cell Type |
---|---|
adrenal gland |
glandular cells |
appendix |
glandular cells |
bone marrow |
hematopoietic cells |
breast |
adipocytes |
breast |
glandular cells |
breast |
myoepithelial cells |
bronchus |
respiratory epithelial cells |
caudate |
glial cells |
caudate |
neuronal cells |
cerebellum |
cells in molecular layer |
cerebellum |
Purkinje cells |
cerebral cortex |
endothelial cells |
cerebral cortex |
glial cells |
cerebral cortex |
neuronal cells |
cervix, uterine |
glandular cells |
cervix, uterine |
squamous epithelial cells |
colon |
endothelial cells |
colon |
glandular cells |
duodenum |
glandular cells |
endometrium |
glandular cells |
epididymis |
glandular cells |
esophagus |
squamous epithelial cells |
fallopian tube |
glandular cells |
gallbladder |
glandular cells |
heart muscle |
myocytes |
hippocampus |
neuronal cells |
kidney |
cells in glomeruli |
kidney |
cells in tubules |
liver |
hepatocytes |
lung |
pneumocytes |
nasopharynx |
respiratory epithelial cells |
oral mucosa |
squamous epithelial cells |
pancreas |
exocrine glandular cells |
pancreas |
islets of Langerhans |
parathyroid gland |
glandular cells |
placenta |
decidual cells |
prostate |
glandular cells |
rectum |
glandular cells |
salivary gland |
glandular cells |
seminal vesicle |
glandular cells |
skeletal muscle |
myocytes |
skin |
keratinocytes |
skin |
Langerhans |
skin |
melanocytes |
skin |
epidermal cells |
small intestine |
glandular cells |
smooth muscle |
smooth muscle cells |
soft tissue |
fibroblasts |
soft tissue |
peripheral nerve |
stomach |
glandular cells |
testis |
cells in seminiferous ducts |
testis |
Leydig cells |
thyroid gland |
glandular cells |
urinary bladder |
urothelial cells |
vagina |
squamous epithelial cells |
Pubmed ID | Author | Year | Title |
---|---|---|---|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
ATP6V0A1 |
535 |
Q93050 |
0.49 |
SCARB2 |
950 |
Q14108 |
0.49 |
CTTN |
2017 |
Q14247 |
0.49 |
IL7R |
3575 |
P16871 |
0.49 |
NDUFS3 |
4722 |
O75489 |
0.49 |
PCNA |
5111 |
P12004 |
0.49 |
ALDH18A1 |
5832 |
P54886 |
0.49 |
RALA |
5898 |
P11233 |
0.49 |
RALB |
5899 |
P11234 |
0.49 |
RRM2 |
6241 |
P31350 |
0.49 |
SON |
6651 |
P18583 |
0.49 |
TPM2 |
7169 |
P07951 |
0.49 |
VCL |
7414 |
P18206 |
0.49 |
TRIM24 |
8805 |
O15164 |
0.49 |
COX5A |
9377 |
P20674 |
0.49 |
SLK |
9748 |
Q9H2G2 |
0.49 |
ZC3H11A |
9877 |
O75152 |
0.49 |
SCO2 |
9997 |
O43819 |
0.49 |
SUGP2 |
10147 |
Q8IX01 |
0.49 |
POP1 |
10940 |
Q99575 |
0.49 |
HABP4 |
22927 |
Q5JVS0 |
0.49 |
NUP210 |
23225 |
Q8TEM1 |
0.49 |
RPL36 |
25873 |
Q9Y3U8 |
0.49 |
STRN4 |
29888 |
Q9NRL3 |
0.49 |
MRPL39 |
54148 |
Q9NYK5 |
0.49 |
TMED9 |
54732 |
Q9BVK6 |
0.49 |
NUP133 |
55746 |
Q8WUM0 |
0.49 |
SQRDL |
58472 |
Q9Y6N5 |
0.49 |
MRPL41 |
64975 |
Q8IXM3 |
0.49 |
DYNC2H1 |
79659 |
Q8NCM8 |
0.49 |
AGMAT |
79814 |
Q9BSE5 |
0.49 |
IBA57 |
200205 |
Q5T440 |
0.49 |
HNRNPA3 |
220988 |
P51991 |
0.49 |
UBAC2 |
337867 |
Q8NBM4 |
0.49 |
CSTF2 |
1478 |
P33240 |
0.56 |
PTBP1 |
5725 |
P26599 |
0.56 |
SMARCB1 |
6598 |
Q12824 |
0.56 |
SMARCC1 |
6599 |
Q92922 |
0.56 |
EEF1A1 |
1915 |
P68104 |
0.63 |
HDAC2 |
3066 |
Q92769 |
0.63 |
ORC5 |
5001 |
O43913 |
0.63 |
PRKAA2 |
5563 |
P54646 |
0.63 |
SNRPA |
6626 |
P09012 |
0.63 |
LMO4 |
8543 |
P61968 |
0.63 |
HDAC3 |
8841 |
O15379 |
0.63 |
SYNPO |
11346 |
Q8N3V7 |
0.63 |
SIN3A |
25942 |
Q96ST3 |
0.63 |
PLEKHF2 |
79666 |
Q9H8W4 |
0.63 |
C11orf68 |
83638 |
Q9H3H3 |
0.63 |
PPP1CA |
5499 |
P62136 |
0.70 |
MAD1L1 |
8379 |
Q9Y6D9 |
0.73 |
FXR2 |
9513 |
P51116 |
0.73 |
PARK7 |
11315 |
Q99497 |
0.73 |
U2AF2 |
11338 |
P26368 |
0.73 |
ZNRD1 |
30834 |
Q9P1U0 |
0.73 |
CRTC2 |
200186 |
Q53ET0 |
0.73 |
CA2 |
760 |
P00918 |
0.75 |
NONO |
4841 |
Q15233 |
0.83 |
PIN1 |
5300 |
Q13526 |
0.85 |
SPI1 |
6688 |
P17947 |
0.85 |
PSPC1 |
55269 |
Q8WXF1 |
0.89 |
DLD |
1738 |
P09622 |
0.49 |
HNRNPU |
3192 |
Q00839 |
0.49 |
HSPA1A |
3303 |
P0DMV8 |
0.49 |
HSPA1B |
3304 |
P0DMV9 |
0.49 |
HNRNPM |
4670 |
P52272 |
0.49 |
HIST3H3 |
8290 |
Q16695 |
0.49 |
CPSF6 |
11052 |
Q16630 |
0.49 |
GORASP2 |
26003 |
Q9H8Y8 |
0.49 |
ZFAND6 |
54469 |
Q6FIF0 |
0.49 |
UBE2I |
7329 |
P63279 |
0.52 |
POLR2A |
5430 |
P24928 |
0.55 |
GRB2 |
2885 |
P62993 |
0.56 |
PPP1CB |
5500 |
P62140 |
0.56 |
PPP1CC |
5501 |
P36873 |
0.56 |
LMNA |
4000 |
P02545 |
0.59 |
ATP1A1 |
476 |
P05023 |
0.63 |
CD81 |
975 |
P60033 |
0.63 |
CDC5L |
988 |
Q99459 |
0.63 |
CRY2 |
1408 |
Q49AN0 |
0.63 |
CTNNB1 |
1499 |
P35222 |
0.63 |
DDX6 |
1656 |
P26196 |
0.63 |
ELAVL1 |
1994 |
Q15717 |
0.63 |
EPS15 |
2060 |
P42566 |
0.63 |
EWSR1 |
2130 |
Q01844 |
0.63 |
FN1 |
2335 |
P02751 |
0.63 |
SFN |
2810 |
P31947 |
0.63 |
ITGA4 |
3676 |
P13612 |
0.63 |
JUN |
3725 |
P05412 |
0.63 |
KCND3 |
3752 |
Q9UK17 |
0.63 |
MDM2 |
4193 |
Q00987 |
0.63 |
MLH1 |
4292 |
P40692 |
0.63 |
YBX1 |
4904 |
P67809 |
0.63 |
NTRK1 |
4914 |
P04629 |
0.63 |
PITX3 |
5309 |
O75364 |
0.63 |
MAPK13 |
5603 |
O15264 |
0.63 |
PSMA3 |
5684 |
P25788 |
0.63 |
RPA1 |
6117 |
P27694 |
0.63 |
RPA2 |
6118 |
P15927 |
0.63 |
RPA3 |
6119 |
P35244 |
0.63 |
RPS6KB2 |
6199 |
Q9UBS0 |
0.63 |
SMARCA2 |
6595 |
P51531 |
0.63 |
SUMO3 |
6612 |
P55854 |
0.63 |
STAU1 |
6780 |
O95793 |
0.63 |
TADA2A |
6871 |
O75478 |
0.63 |
NR2C1 |
7181 |
P13056 |
0.63 |
TSG101 |
7251 |
Q99816 |
0.63 |
WHSC1 |
7468 |
O96028 |
0.63 |
XPO1 |
7514 |
O14980 |
0.63 |
YWHAZ |
7534 |
P63104 |
0.63 |
CUL3 |
8452 |
Q13618 |
0.63 |
CUL2 |
8453 |
Q13617 |
0.63 |
BHLHE40 |
8553 |
O14503 |
0.63 |
EED |
8726 |
O75530 |
0.63 |
KIAA0101 |
9768 |
Q15004 |
0.63 |
CUL7 |
9820 |
Q14999 |
0.63 |
PAN2 |
9924 |
Q504Q3 |
0.63 |
HDAC5 |
10014 |
Q9UQL6 |
0.63 |
CHAF1A |
10036 |
Q13111 |
0.63 |
HUWE1 |
10075 |
Q7Z6Z7 |
0.63 |
TOPORS |
10210 |
Q9NS56 |
0.63 |
SRRM1 |
10250 |
Q8IYB3 |
0.63 |
UBD |
10537 |
O15205 |
0.63 |
COPS5 |
10987 |
Q92905 |
0.63 |
IRAK3 |
11213 |
Q9Y616 |
0.63 |
SNW1 |
22938 |
Q13573 |
0.63 |
OBSL1 |
23363 |
O75147 |
0.63 |
SRRM2 |
23524 |
Q9UQ35 |
0.63 |
NUPR1 |
26471 |
O60356 |
0.63 |
DEC1 |
50514 |
Q9P2X7 |
0.63 |
ASB3 |
51130 |
Q9Y575 |
0.63 |
DDX41 |
51428 |
Q9UJV9 |
0.63 |
WWOX |
51741 |
Q9NZC7 |
0.63 |
MED9 |
55090 |
Q9NWA0 |
0.63 |
MED29 |
55588 |
Q9NX70 |
0.63 |
CAND1 |
55832 |
Q86VP6 |
0.63 |
YLPM1 |
56252 |
P49750 |
0.63 |
SMARCAD1 |
56916 |
Q9H4L7 |
0.63 |
BHLHE41 |
79365 |
Q9C0J9 |
0.63 |
CCDC8 |
83987 |
Q9H0W5 |
0.63 |
MED10 |
84246 |
Q9BTT4 |
0.63 |
MAP1LC3A |
84557 |
Q9H492 |
0.63 |
MED19 |
219541 |
A0JLT2 |
0.63 |
SUMO4 |
387082 |
Q6EEV6 |
0.63 |
ASB18 |
401036 |
Q6ZVZ8 |
0.63 |
SCARNA22 |
677770 |
N/A |
0.63 |
APBB1 |
322 |
O00213 |
0.68 |
ERG |
2078 |
P11308 |
0.68 |
SMARCD1 |
6602 |
Q96GM5 |
0.68 |
SUMO1 |
7341 |
P63165 |
0.68 |
TCERG1 |
10915 |
O14776 |
0.68 |
WBP4 |
11193 |
O75554 |
0.68 |
PRPF40A |
55660 |
O75400 |
0.68 |
NFKB1 |
4790 |
P19838 |
0.70 |
ARRB2 |
409 |
P32121 |
0.72 |
H2AFX |
3014 |
P16104 |
0.72 |
PMS1 |
5378 |
P54277 |
0.72 |
RELB |
5971 |
Q01201 |
0.72 |
TRAF1 |
7185 |
Q13077 |
0.72 |
TP63 |
8626 |
Q9H3D4 |
0.72 |
SOCS3 |
9021 |
O14543 |
0.72 |
RIPK3 |
11035 |
Q9Y572 |
0.72 |
TBK1 |
29110 |
Q9UHD2 |
0.72 |
SMN1; SMN2 |
6606 |
Q16637 |
0.72 |
FUS |
2521 |
P35637 |
0.74 |
SUMO2 |
6613 |
P61956 |
0.74 |
TOP1 |
7150 |
P11387 |
0.75 |
RNF43 |
54894 |
Q68DV7 |
0.75 |
HDAC1 |
3065 |
Q13547 |
0.76 |
ESR1 |
2099 |
P03372 |
0.78 |
HNRNPA1 |
3178 |
P09651 |
0.78 |
SMARCA4 |
6597 |
P51532 |
0.78 |
MYC |
4609 |
P01106 |
0.82 |
VCAM1 |
7412 |
P19320 |
0.82 |
AR |
367 |
P10275 |
0.90 |
SFPQ |
6421 |
P23246 |
0.90 |