Protein Description

Gene Symbol NONO
Entrez ID 4841
Uniprot ID Q15233
Description non-POU domain containing, octamer-binding
Chromosomal Location chrX: 71,283,192-71,301,168
Ontology GO ID GO Term Definition Evidence

BP

GO:0000398

mRNA splicing, via spliceosome

The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.

IBA

BP

GO:0006281

DNA repair

The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.

IEA

BP

GO:0006310

DNA recombination

Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.

IEA

BP

GO:0006351

transcription, DNA-templated

The cellular synthesis of RNA on a template of DNA.

IEA

BP

GO:0006355

regulation of transcription, DNA-templated

Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

IBA

BP

GO:0006397

mRNA processing

Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.

TAS

BP

GO:0007623

circadian rhythm

Any biological process in an organism that recurs with a regularity of approximately 24 hours.

ISS

BP

GO:0008380

RNA splicing

The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.

TAS

BP

GO:0042752

regulation of circadian rhythm

Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.

ISS

BP

GO:0045892

negative regulation of transcription, DNA-templated

Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.

ISS

BP

GO:1903377

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

Any process that stops, prevents or reduces the frequency, rate or extent of oxidative stress-induced neuron intrinsic apoptotic signaling pathway.

IDA

CC

GO:0005634

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

IDA|ISS

CC

GO:0005654

nucleoplasm

That part of the nuclear content other than the chromosomes or the nucleolus.

IDA

CC

GO:0005730

nucleolus

A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.

IEA

CC

GO:0016020

membrane

A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

IDA

CC

GO:0016363

nuclear matrix

The dense fibrillar network lying on the inner side of the nuclear membrane.

IDA

CC

GO:0016607

nuclear speck

A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.

IEA

CC

GO:0042382

paraspeckles

Discrete subnuclear bodies in the interchromatin nucleoplasmic space, often located adjacent to nuclear specks. 10-20 paraspeckles are typically found in human cell nuclei.

IDA

CC

GO:0090575

RNA polymerase II transcription factor complex

A transcription factor complex that acts at promoters of genes transcribed by RNA polymerase II.

ISS

MF

GO:0000166

nucleotide binding

Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.

IEA

MF

GO:0000976

transcription regulatory region sequence-specific DNA binding

Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.

IBA

MF

GO:0000980

RNA polymerase II distal enhancer sequence-specific DNA binding

Interacting selectively and non-covalently with a RNA polymerase II (Pol II) distal enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of some promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter.

ISS

MF

GO:0001047

core promoter binding

Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for the basal transcription machinery. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.

ISS

MF

GO:0003682

chromatin binding

Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.

ISS

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0044822

poly(A) RNA binding

Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases.

IDA

Domain ID Description

IPR000504

RNA recognition motif domain

IPR012975

NOPS

IPR034552

p54nrb, RNA recognition motif 1

IPR034558

p54nrb, RNA recognition motif 2

Pathway ID Pathway Term Pathway Source

WP411

mRNA Processing

WikiPathways

WP3594

Circadian rythm related genes

WikiPathways

h_antisensePathway

RNA polymerase III transcription

BioCarta

No diseases found.

Tissue Cell Type

adrenal gland

glandular cells

appendix

glandular cells

bone marrow

hematopoietic cells

breast

adipocytes

breast

glandular cells

breast

myoepithelial cells

bronchus

respiratory epithelial cells

caudate

glial cells

caudate

neuronal cells

cerebellum

cells in molecular layer

cerebellum

Purkinje cells

cerebral cortex

endothelial cells

cerebral cortex

glial cells

cerebral cortex

neuronal cells

cervix, uterine

glandular cells

cervix, uterine

squamous epithelial cells

colon

endothelial cells

colon

glandular cells

duodenum

glandular cells

endometrium

glandular cells

epididymis

glandular cells

esophagus

squamous epithelial cells

fallopian tube

glandular cells

gallbladder

glandular cells

heart muscle

myocytes

hippocampus

neuronal cells

kidney

cells in glomeruli

kidney

cells in tubules

liver

hepatocytes

lung

pneumocytes

nasopharynx

respiratory epithelial cells

oral mucosa

squamous epithelial cells

pancreas

exocrine glandular cells

pancreas

islets of Langerhans

parathyroid gland

glandular cells

placenta

decidual cells

prostate

glandular cells

rectum

glandular cells

salivary gland

glandular cells

seminal vesicle

glandular cells

skeletal muscle

myocytes

skin

keratinocytes

skin

Langerhans

skin

melanocytes

skin

epidermal cells

small intestine

glandular cells

smooth muscle

smooth muscle cells

soft tissue

fibroblasts

soft tissue

peripheral nerve

stomach

glandular cells

testis

cells in seminiferous ducts

testis

Leydig cells

thyroid gland

glandular cells

urinary bladder

urothelial cells

vagina

squamous epithelial cells

No databases found.

Pubmed ID Author Year Title

22617121

Ouandaogo et al.

2012

Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

22951915

Haozi et al.

2012

Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

Gene Symbol Entrez ID Uniprot ID Score

ATP6V0A1

535

Q93050

0.49

SCARB2

950

Q14108

0.49

CTTN

2017

Q14247

0.49

IL7R

3575

P16871

0.49

NDUFS3

4722

O75489

0.49

PCNA

5111

P12004

0.49

ALDH18A1

5832

P54886

0.49

RALA

5898

P11233

0.49

RALB

5899

P11234

0.49

RRM2

6241

P31350

0.49

SON

6651

P18583

0.49

TPM2

7169

P07951

0.49

VCL

7414

P18206

0.49

TRIM24

8805

O15164

0.49

COX5A

9377

P20674

0.49

SLK

9748

Q9H2G2

0.49

ZC3H11A

9877

O75152

0.49

SCO2

9997

O43819

0.49

SUGP2

10147

Q8IX01

0.49

POP1

10940

Q99575

0.49

HABP4

22927

Q5JVS0

0.49

NUP210

23225

Q8TEM1

0.49

RPL36

25873

Q9Y3U8

0.49

STRN4

29888

Q9NRL3

0.49

MRPL39

54148

Q9NYK5

0.49

TMED9

54732

Q9BVK6

0.49

NUP133

55746

Q8WUM0

0.49

SQRDL

58472

Q9Y6N5

0.49

MRPL41

64975

Q8IXM3

0.49

DYNC2H1

79659

Q8NCM8

0.49

AGMAT

79814

Q9BSE5

0.49

IBA57

200205

Q5T440

0.49

HNRNPA3

220988

P51991

0.49

UBAC2

337867

Q8NBM4

0.49

CSTF2

1478

P33240

0.56

PTBP1

5725

P26599

0.56

SMARCB1

6598

Q12824

0.56

SMARCC1

6599

Q92922

0.56

EEF1A1

1915

P68104

0.63

HDAC2

3066

Q92769

0.63

ORC5

5001

O43913

0.63

PRKAA2

5563

P54646

0.63

SNRPA

6626

P09012

0.63

LMO4

8543

P61968

0.63

HDAC3

8841

O15379

0.63

SYNPO

11346

Q8N3V7

0.63

SIN3A

25942

Q96ST3

0.63

PLEKHF2

79666

Q9H8W4

0.63

C11orf68

83638

Q9H3H3

0.63

PPP1CA

5499

P62136

0.70

MAD1L1

8379

Q9Y6D9

0.73

FXR2

9513

P51116

0.73

PARK7

11315

Q99497

0.73

U2AF2

11338

P26368

0.73

ZNRD1

30834

Q9P1U0

0.73

CRTC2

200186

Q53ET0

0.73

CA2

760

P00918

0.75

NONO

4841

Q15233

0.83

PIN1

5300

Q13526

0.85

SPI1

6688

P17947

0.85

PSPC1

55269

Q8WXF1

0.89

DLD

1738

P09622

0.49

HNRNPU

3192

Q00839

0.49

HSPA1A

3303

P0DMV8

0.49

HSPA1B

3304

P0DMV9

0.49

HNRNPM

4670

P52272

0.49

HIST3H3

8290

Q16695

0.49

CPSF6

11052

Q16630

0.49

GORASP2

26003

Q9H8Y8

0.49

ZFAND6

54469

Q6FIF0

0.49

UBE2I

7329

P63279

0.52

POLR2A

5430

P24928

0.55

GRB2

2885

P62993

0.56

PPP1CB

5500

P62140

0.56

PPP1CC

5501

P36873

0.56

LMNA

4000

P02545

0.59

ATP1A1

476

P05023

0.63

CD81

975

P60033

0.63

CDC5L

988

Q99459

0.63

CRY2

1408

Q49AN0

0.63

CTNNB1

1499

P35222

0.63

DDX6

1656

P26196

0.63

ELAVL1

1994

Q15717

0.63

EPS15

2060

P42566

0.63

EWSR1

2130

Q01844

0.63

FN1

2335

P02751

0.63

SFN

2810

P31947

0.63

ITGA4

3676

P13612

0.63

JUN

3725

P05412

0.63

KCND3

3752

Q9UK17

0.63

MDM2

4193

Q00987

0.63

MLH1

4292

P40692

0.63

YBX1

4904

P67809

0.63

NTRK1

4914

P04629

0.63

PITX3

5309

O75364

0.63

MAPK13

5603

O15264

0.63

PSMA3

5684

P25788

0.63

RPA1

6117

P27694

0.63

RPA2

6118

P15927

0.63

RPA3

6119

P35244

0.63

RPS6KB2

6199

Q9UBS0

0.63

SMARCA2

6595

P51531

0.63

SUMO3

6612

P55854

0.63

STAU1

6780

O95793

0.63

TADA2A

6871

O75478

0.63

NR2C1

7181

P13056

0.63

TSG101

7251

Q99816

0.63

WHSC1

7468

O96028

0.63

XPO1

7514

O14980

0.63

YWHAZ

7534

P63104

0.63

CUL3

8452

Q13618

0.63

CUL2

8453

Q13617

0.63

BHLHE40

8553

O14503

0.63

EED

8726

O75530

0.63

KIAA0101

9768

Q15004

0.63

CUL7

9820

Q14999

0.63

PAN2

9924

Q504Q3

0.63

HDAC5

10014

Q9UQL6

0.63

CHAF1A

10036

Q13111

0.63

HUWE1

10075

Q7Z6Z7

0.63

TOPORS

10210

Q9NS56

0.63

SRRM1

10250

Q8IYB3

0.63

UBD

10537

O15205

0.63

COPS5

10987

Q92905

0.63

IRAK3

11213

Q9Y616

0.63

SNW1

22938

Q13573

0.63

OBSL1

23363

O75147

0.63

SRRM2

23524

Q9UQ35

0.63

NUPR1

26471

O60356

0.63

DEC1

50514

Q9P2X7

0.63

ASB3

51130

Q9Y575

0.63

DDX41

51428

Q9UJV9

0.63

WWOX

51741

Q9NZC7

0.63

MED9

55090

Q9NWA0

0.63

MED29

55588

Q9NX70

0.63

CAND1

55832

Q86VP6

0.63

YLPM1

56252

P49750

0.63

SMARCAD1

56916

Q9H4L7

0.63

BHLHE41

79365

Q9C0J9

0.63

CCDC8

83987

Q9H0W5

0.63

MED10

84246

Q9BTT4

0.63

MAP1LC3A

84557

Q9H492

0.63

MED19

219541

A0JLT2

0.63

SUMO4

387082

Q6EEV6

0.63

ASB18

401036

Q6ZVZ8

0.63

SCARNA22

677770

N/A

0.63

APBB1

322

O00213

0.68

ERG

2078

P11308

0.68

SMARCD1

6602

Q96GM5

0.68

SUMO1

7341

P63165

0.68

TCERG1

10915

O14776

0.68

WBP4

11193

O75554

0.68

PRPF40A

55660

O75400

0.68

NFKB1

4790

P19838

0.70

ARRB2

409

P32121

0.72

H2AFX

3014

P16104

0.72

PMS1

5378

P54277

0.72

RELB

5971

Q01201

0.72

TRAF1

7185

Q13077

0.72

TP63

8626

Q9H3D4

0.72

SOCS3

9021

O14543

0.72

RIPK3

11035

Q9Y572

0.72

TBK1

29110

Q9UHD2

0.72

SMN1; SMN2

6606

Q16637

0.72

FUS

2521

P35637

0.74

SUMO2

6613

P61956

0.74

TOP1

7150

P11387

0.75

RNF43

54894

Q68DV7

0.75

HDAC1

3065

Q13547

0.76

ESR1

2099

P03372

0.78

HNRNPA1

3178

P09651

0.78

SMARCA4

6597

P51532

0.78

MYC

4609

P01106

0.82

VCAM1

7412

P19320

0.82

AR

367

P10275

0.90

SFPQ

6421

P23246

0.90