Protein Description

Gene Symbol NME4
Entrez ID 4833
Uniprot ID O00746
Description NME/NM23 nucleoside diphosphate kinase 4
Chromosomal Location chr16: 396,725-410,367
Ontology GO ID GO Term Definition Evidence

BP

GO:0006163

purine nucleotide metabolic process

The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.

IBA

BP

GO:0006165

nucleoside diphosphate phosphorylation

The process of introducing a phosphate group into a nucleoside diphosphate to produce a nucleoside triphosphate.

IEA

BP

GO:0006183

GTP biosynthetic process

The chemical reactions and pathways resulting in the formation of GTP, guanosine triphosphate.

IEA

BP

GO:0006220

pyrimidine nucleotide metabolic process

The chemical reactions and pathways involving a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.

IBA

BP

GO:0006228

UTP biosynthetic process

The chemical reactions and pathways resulting in the formation of UTP, uridine (5'-)triphosphate.

IEA

BP

GO:0006241

CTP biosynthetic process

The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate.

IEA

BP

GO:0006869

lipid transport

The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.

IEA

BP

GO:0009116

nucleoside metabolic process

The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine).

TAS

BP

GO:0009142

nucleoside triphosphate biosynthetic process

The chemical reactions and pathways resulting in the formation of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar.

IBA

BP

GO:0015949

nucleobase-containing small molecule interconversion

The chemical reactions and pathways by which a nucleobase, nucleoside or nucleotide small molecule is synthesized from another nucleobase, nucleoside or nucleotide small molecule.

TAS

BP

GO:0042981

regulation of apoptotic process

Any process that modulates the occurrence or rate of cell death by apoptotic process.

IBA

CC

GO:0005739

mitochondrion

A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

IDA

CC

GO:0005743

mitochondrial inner membrane

The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.

TAS

CC

GO:0005758

mitochondrial intermembrane space

The region between the inner and outer lipid bilayers of the mitochondrial envelope.

IEA

CC

GO:0005759

mitochondrial matrix

The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.

IEA

MF

GO:0004550

nucleoside diphosphate kinase activity

Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.

EXP

MF

GO:0005524

ATP binding

Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

IEA

MF

GO:0008289

lipid binding

Interacting selectively and non-covalently with a lipid.

IEA

MF

GO:0046872

metal ion binding

Interacting selectively and non-covalently with any metal ion.

IEA

Domain ID Description

IPR001564

Nucleoside diphosphate kinase

IPR023005

Nucleoside diphosphate kinase, active site

Pathway ID Pathway Term Pathway Source

hsa00230

Purine metabolism

KEGG

hsa00240

Pyrimidine metabolism

KEGG

hsa01100

Metabolic pathways

KEGG

No diseases found.

Tissue Cell Type

cervix, uterine

glandular cells

colon

glandular cells

fallopian tube

glandular cells

gallbladder

glandular cells

kidney

cells in tubules

liver

bile duct cells

placenta

decidual cells

placenta

trophoblastic cells

prostate

glandular cells

rectum

glandular cells

seminal vesicle

glandular cells

thyroid gland

glandular cells

No databases found.

Pubmed ID Author Year Title

22951915

Haozi et al.

2012

Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

Gene Symbol Entrez ID Uniprot ID Score

HTT

3064

P42858

0.63

NME2

4831

P22392

0.63

TRIP13

9319

Q15645

0.63

LSM8

51691

O95777

0.63

NME4

4833

O00746

0.95

BMI1

648

P35226

0.63

GRSF1

2926

Q12849

0.63

ITGB8

3696

P26012

0.63

MOV10

4343

Q9HCE1

0.63

TERF2

7014

Q15554

0.63

TP53

7157

P04637

0.63

SOCS3

9021

O14543

0.63

NXF1

10482

Q9UBU9

0.63

PAXIP1

22976

Q6ZW49

0.63

TNS4

84951

Q8IZW8

0.63

CLNK

116449

Q7Z7G1

0.63

ICT1

3396

Q14197

0.72

SUV39H2

79723

Q9H5I1

0.72

NME1

4830

P15531

0.79