Gene Symbol | NME4 |
Entrez ID | 4833 |
Uniprot ID | O00746 |
Description | NME/NM23 nucleoside diphosphate kinase 4 |
Chromosomal Location | chr16: 396,725-410,367 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0006163 |
purine nucleotide metabolic process |
The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. |
IBA |
BP |
GO:0006165 |
nucleoside diphosphate phosphorylation |
The process of introducing a phosphate group into a nucleoside diphosphate to produce a nucleoside triphosphate. |
IEA |
BP |
GO:0006183 |
GTP biosynthetic process |
The chemical reactions and pathways resulting in the formation of GTP, guanosine triphosphate. |
IEA |
BP |
GO:0006220 |
pyrimidine nucleotide metabolic process |
The chemical reactions and pathways involving a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. |
IBA |
BP |
GO:0006228 |
UTP biosynthetic process |
The chemical reactions and pathways resulting in the formation of UTP, uridine (5'-)triphosphate. |
IEA |
BP |
GO:0006241 |
CTP biosynthetic process |
The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate. |
IEA |
BP |
GO:0006869 |
lipid transport |
The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. |
IEA |
BP |
GO:0009116 |
nucleoside metabolic process |
The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine). |
TAS |
BP |
GO:0009142 |
nucleoside triphosphate biosynthetic process |
The chemical reactions and pathways resulting in the formation of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar. |
IBA |
BP |
GO:0015949 |
nucleobase-containing small molecule interconversion |
The chemical reactions and pathways by which a nucleobase, nucleoside or nucleotide small molecule is synthesized from another nucleobase, nucleoside or nucleotide small molecule. |
TAS |
BP |
GO:0042981 |
regulation of apoptotic process |
Any process that modulates the occurrence or rate of cell death by apoptotic process. |
IBA |
CC |
GO:0005739 |
mitochondrion |
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
IDA |
CC |
GO:0005743 |
mitochondrial inner membrane |
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. |
TAS |
CC |
GO:0005758 |
mitochondrial intermembrane space |
The region between the inner and outer lipid bilayers of the mitochondrial envelope. |
IEA |
CC |
GO:0005759 |
mitochondrial matrix |
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. |
IEA |
MF |
GO:0004550 |
nucleoside diphosphate kinase activity |
Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate. |
EXP |
MF |
GO:0005524 |
ATP binding |
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
IEA |
MF |
GO:0008289 |
lipid binding |
Interacting selectively and non-covalently with a lipid. |
IEA |
MF |
GO:0046872 |
metal ion binding |
Interacting selectively and non-covalently with any metal ion. |
IEA |
Domain ID | Description |
---|---|
IPR001564 |
Nucleoside diphosphate kinase |
IPR023005 |
Nucleoside diphosphate kinase, active site |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
hsa00230 |
Purine metabolism |
KEGG |
hsa00240 |
Pyrimidine metabolism |
KEGG |
hsa01100 |
Metabolic pathways |
KEGG |
Tissue | Cell Type |
---|---|
cervix, uterine |
glandular cells |
colon |
glandular cells |
fallopian tube |
glandular cells |
gallbladder |
glandular cells |
kidney |
cells in tubules |
liver |
bile duct cells |
placenta |
decidual cells |
placenta |
trophoblastic cells |
prostate |
glandular cells |
rectum |
glandular cells |
seminal vesicle |
glandular cells |
thyroid gland |
glandular cells |
Pubmed ID | Author | Year | Title |
---|---|---|---|
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
HTT |
3064 |
P42858 |
0.63 |
NME2 |
4831 |
P22392 |
0.63 |
TRIP13 |
9319 |
Q15645 |
0.63 |
LSM8 |
51691 |
O95777 |
0.63 |
NME4 |
4833 |
O00746 |
0.95 |
BMI1 |
648 |
P35226 |
0.63 |
GRSF1 |
2926 |
Q12849 |
0.63 |
ITGB8 |
3696 |
P26012 |
0.63 |
MOV10 |
4343 |
Q9HCE1 |
0.63 |
TERF2 |
7014 |
Q15554 |
0.63 |
TP53 |
7157 |
P04637 |
0.63 |
SOCS3 |
9021 |
O14543 |
0.63 |
NXF1 |
10482 |
Q9UBU9 |
0.63 |
PAXIP1 |
22976 |
Q6ZW49 |
0.63 |
TNS4 |
84951 |
Q8IZW8 |
0.63 |
CLNK |
116449 |
Q7Z7G1 |
0.63 |
ICT1 |
3396 |
Q14197 |
0.72 |
SUV39H2 |
79723 |
Q9H5I1 |
0.72 |
NME1 |
4830 |
P15531 |
0.79 |