BP

GO:0006928

movement of cell or subcellular component

The directed, self-propelled movement of a cell or subcellular component without the involvement of an external agent such as a transporter or a pore.

TAS

BP

GO:0007162

negative regulation of cell adhesion

Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion.

TAS

BP

GO:0007275

multicellular organism development

The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

TAS

BP

GO:0035023

regulation of Rho protein signal transduction

Any process that modulates the frequency, rate or extent of Rho protein signal transduction.

IDA|IMP

BP

GO:0043547

positive regulation of GTPase activity

Any process that activates or increases the activity of a GTPase.

IEA

BP

GO:0051056

regulation of small GTPase mediated signal transduction

Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction.

TAS

BP

GO:0071461

cellular response to redox state

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating redox state. Redox state refers to the balance of oxidized versus reduced forms of electron donors and acceptors in an organelle, cell or organ; plastoquinone, glutathione (GSH/GSSG), and nicotinamide nucleotides (NAD+/NADH and NADP+/NADPH) are among the most important.

IEA

BP

GO:1901164

negative regulation of trophoblast cell migration

Any process that stops, prevents or reduces the frequency, rate or extent of trophoblast cell migration.

IDA

BP

GO:2000249

regulation of actin cytoskeleton reorganization

Any process that modulates the frequency, rate or extent of actin cytoskeleton reorganization.

IMP

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

TAS

CC

GO:0005829

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

IDA|TAS

CC

GO:0005856

cytoskeleton

Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.

TAS

CC

GO:0016020

membrane

A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

IEA

CC

GO:0016023

cytoplasmic, membrane-bounded vesicle

A membrane-bounded vesicle found in the cytoplasm of the cell.

TAS

CC

GO:0070062

extracellular exosome

A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.

IDA

MF

GO:0003924

GTPase activity

Catalysis of the reaction: GTP + H2O = GDP + phosphate.

IMP

MF

GO:0005094

Rho GDP-dissociation inhibitor activity

Prevents the dissociation of GDP from the small GTPase Rho, thereby preventing GTP from binding.

IDA

MF

GO:0005096

GTPase activator activity

Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.

IEA

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0048365

Rac GTPase binding

Interacting selectively and non-covalently with Rac protein, any member of the Rac subfamily of the Ras superfamily of monomeric GTPases.

IDA