Protein Description

Gene Symbol NEK3
Entrez ID 4752
Uniprot ID P51956
Description NIMA-related kinase 3
Chromosomal Location chr13: 52,132,639-52,159,861
Ontology GO ID GO Term Definition Evidence

BP

GO:0006468

protein phosphorylation

The process of introducing a phosphate group on to a protein.

IBA|ISS

BP

GO:0007017

microtubule-based process

Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins.

IBA

BP

GO:0007059

chromosome segregation

The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.

IBA

BP

GO:0007067

mitotic nuclear division

A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell.

NAS

BP

GO:0030010

establishment of cell polarity

The specification and formation of anisotropic intracellular organization or cell growth patterns.

IEA

BP

GO:0048812

neuron projection morphogenesis

The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites.

IEA

BP

GO:0051301

cell division

The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.

IEA

BP

GO:0090043

regulation of tubulin deacetylation

Any process that modulates the frequency, rate or extent of tubulin deacetylation. Tubulin deacetylation is the removal of an acetyl group from a protein amino acid.

IEA

CC

GO:0005634

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

IBA|NAS

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

IBA

CC

GO:0005813

centrosome

A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.

IBA

CC

GO:0030424

axon

The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.

IEA

MF

GO:0004674

protein serine/threonine kinase activity

Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

NAS

MF

GO:0005524

ATP binding

Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

IEA

MF

GO:0046872

metal ion binding

Interacting selectively and non-covalently with any metal ion.

IEA

Domain ID Description

IPR000719

Protein kinase domain

IPR008271

Serine/threonine-protein kinase, active site

IPR011009

Protein kinase-like domain

IPR017441

Protein kinase, ATP binding site

Pathway ID Pathway Term Pathway Source

WP2037

Prolactin Signaling Pathway

WikiPathways

No diseases found.

Tissue Cell Type

cerebral cortex

endothelial cells

colon

endothelial cells

heart muscle

myocytes

kidney

cells in tubules

skeletal muscle

myocytes

smooth muscle

smooth muscle cells

No databases found.

Pubmed ID Author Year Title

22951915

Haozi et al.

2012

Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

26459919

Lan et al.

2015

Functional microarray analysis of differentially expressed genes in granulosa cells from women with polycystic ovary syndrome related to MAPK/ERK signaling

Gene Symbol Entrez ID Uniprot ID Score

VAV1

7409

P15498

0.52

BPGM

669

P07738

0.63

CDCA8

55143

Q53HL2

0.63

NMNAT1

64802

Q9HAN9

0.63

PRLR

5618

P16471

0.65

VAV2

7410

P52735

0.73

CDK13

8621

Q14004

0.63

HDAC6

10013

Q9UBN7

0.63

VSIG4

11326

Q9Y279

0.63