Gene Symbol | NEK3 |
Entrez ID | 4752 |
Uniprot ID | P51956 |
Description | NIMA-related kinase 3 |
Chromosomal Location | chr13: 52,132,639-52,159,861 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0006468 |
protein phosphorylation |
The process of introducing a phosphate group on to a protein. |
IBA|ISS |
BP |
GO:0007017 |
microtubule-based process |
Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. |
IBA |
BP |
GO:0007059 |
chromosome segregation |
The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles. |
IBA |
BP |
GO:0007067 |
mitotic nuclear division |
A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell. |
NAS |
BP |
GO:0030010 |
establishment of cell polarity |
The specification and formation of anisotropic intracellular organization or cell growth patterns. |
IEA |
BP |
GO:0048812 |
neuron projection morphogenesis |
The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites. |
IEA |
BP |
GO:0051301 |
cell division |
The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. |
IEA |
BP |
GO:0090043 |
regulation of tubulin deacetylation |
Any process that modulates the frequency, rate or extent of tubulin deacetylation. Tubulin deacetylation is the removal of an acetyl group from a protein amino acid. |
IEA |
CC |
GO:0005634 |
nucleus |
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
IBA|NAS |
CC |
GO:0005737 |
cytoplasm |
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
IBA |
CC |
GO:0005813 |
centrosome |
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle. |
IBA |
CC |
GO:0030424 |
axon |
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. |
IEA |
MF |
GO:0004674 |
protein serine/threonine kinase activity |
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
NAS |
MF |
GO:0005524 |
ATP binding |
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
IEA |
MF |
GO:0046872 |
metal ion binding |
Interacting selectively and non-covalently with any metal ion. |
IEA |
Domain ID | Description |
---|---|
IPR000719 |
Protein kinase domain |
IPR008271 |
Serine/threonine-protein kinase, active site |
IPR011009 |
Protein kinase-like domain |
IPR017441 |
Protein kinase, ATP binding site |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
WP2037 |
Prolactin Signaling Pathway |
WikiPathways |
Tissue | Cell Type |
---|---|
cerebral cortex |
endothelial cells |
colon |
endothelial cells |
heart muscle |
myocytes |
kidney |
cells in tubules |
skeletal muscle |
myocytes |
smooth muscle |
smooth muscle cells |
Pubmed ID | Author | Year | Title |
---|---|---|---|
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
26459919 |
Lan et al. |
2015 |
Functional microarray analysis of differentially expressed genes in granulosa cells from women with polycystic ovary syndrome related to MAPK/ERK signaling |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
VAV1 |
7409 |
P15498 |
0.52 |
BPGM |
669 |
P07738 |
0.63 |
CDCA8 |
55143 |
Q53HL2 |
0.63 |
NMNAT1 |
64802 |
Q9HAN9 |
0.63 |
PRLR |
5618 |
P16471 |
0.65 |
VAV2 |
7410 |
P52735 |
0.73 |
CDK13 |
8621 |
Q14004 |
0.63 |
HDAC6 |
10013 |
Q9UBN7 |
0.63 |
VSIG4 |
11326 |
Q9Y279 |
0.63 |