BP

GO:0000184

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins.

IDA|IMP|TAS

BP

GO:0000398

mRNA splicing, via spliceosome

The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.

TAS

BP

GO:0006366

transcription from RNA polymerase II promoter

The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).

TAS

BP

GO:0006368

transcription elongation from RNA polymerase II promoter

The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II.

TAS

BP

GO:0006369

termination of RNA polymerase II transcription

The process in which the synthesis of an RNA molecule by RNA polymerase II using a DNA template is completed.

TAS

BP

GO:0006370

7-methylguanosine mRNA capping

Addition of the 7-methylguanosine cap to the 5' end of a nascent messenger RNA transcript.

IDA|TAS

BP

GO:0006405

RNA export from nucleus

The directed movement of RNA from the nucleus to the cytoplasm.

TAS

BP

GO:0006406

mRNA export from nucleus

The directed movement of mRNA from the nucleus to the cytoplasm.

IMP|TAS

BP

GO:0006446

regulation of translational initiation

Any process that modulates the frequency, rate or extent of translational initiation.

IDA

BP

GO:0008334

histone mRNA metabolic process

The chemical reactions and pathways involving an mRNA encoding a histone.

TAS

BP

GO:0008380

RNA splicing

The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.

TAS

BP

GO:0008543

fibroblast growth factor receptor signaling pathway

The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands.

TAS

BP

GO:0010467

gene expression

The process in which a gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.

TAS

BP

GO:0030307

positive regulation of cell growth

Any process that activates or increases the frequency, rate, extent or direction of cell growth.

IMP

BP

GO:0031047

gene silencing by RNA

Any process in which RNA molecules inactivate expression of target genes.

IEA

BP

GO:0031124

mRNA 3'-end processing

Any process involved in forming the mature 3' end of an mRNA molecule.

TAS

BP

GO:0031442

positive regulation of mRNA 3'-end processing

Any process that activates or increases the frequency, rate or extent of mRNA 3'-end processing.

IMP

BP

GO:0042795

snRNA transcription from RNA polymerase II promoter

The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase II (Pol II), originating at a Pol II promoter.

TAS

BP

GO:0045292

mRNA cis splicing, via spliceosome

The joining together, after removal of an intervening sequence composed of one or more introns, of two segments of the same RNA molecule via spliceosomal catalysis to produce an mRNA composed only of exon sequences that all came from the same primary transcript.

IEA

BP

GO:0051168

nuclear export

The directed movement of substances out of the nucleus.

TAS

BP

GO:0098789

pre-mRNA cleavage required for polyadenylation

The targeted, endonucleolytic cleavage of a pre-mRNA, required for polyadenylation of the 3' end. This cleavage is directed by binding sites near the 3' end of the mRNA and leaves a 3' hydoxyl end which then becomes a target for adenylation.

IMP

CC

GO:0005634

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

IDA

CC

GO:0005654

nucleoplasm

That part of the nuclear content other than the chromosomes or the nucleolus.

IDA|TAS

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

IDA

CC

GO:0005739

mitochondrion

A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

IDA

CC

GO:0005829

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

TAS

CC

GO:0005845

mRNA cap binding complex

Any protein complex that binds to an mRNA cap at any time in the lifetime of the mRNA.

IDA

CC

GO:0005846

nuclear cap binding complex

A conserved heterodimeric protein complex that binds to the 5' terminal cap structure m7G(5')ppp(5')N of nascent eukaryotic RNA polymerase II transcripts such as pre-mRNA and U snRNA. The consists of proteins known as CBP20 and CBP80, binds to cap structures in the nucleus, and is involved in pre-mRNA splicing, 3'-end formation, and RNA nuclear export.

IEA

CC

GO:0030529

intracellular ribonucleoprotein complex

An intracellular macromolecular complex containing both protein and RNA molecules.

IDA

CC

GO:0034518

RNA cap binding complex

Any protein complex that binds to a specialized RNA cap structure at any time in the lifetime of the RNA.

TAS

MF

GO:0000339

RNA cap binding

Interacting selectively and non-covalently with a 7-methylguanosine (m7G) group or derivative located at the 5' end of an RNA molecule.

IEA

MF

GO:0003723

RNA binding

Interacting selectively and non-covalently with an RNA molecule or a portion thereof.

TAS

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0044822

poly(A) RNA binding

Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases.

IDA