PCOSBase

Protein Description

Gene Symbol	HNRNPM
Entrez ID	4670
Uniprot ID	P52272
Description	heterogeneous nuclear ribonucleoprotein M
Chromosomal Location	chr19: 8,444,767-8,489,114

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Ontology	GO ID	GO Term	Definition	Evidence
BP	GO:0000380	alternative mRNA splicing, via spliceosome	The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition.	IMP
BP	GO:0000398	mRNA splicing, via spliceosome	The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.	IC\|TAS
BP	GO:0008543	fibroblast growth factor receptor signaling pathway	The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands.	TAS
BP	GO:0010467	gene expression	The process in which a gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.	TAS
CC	GO:0005654	nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.	IDA\|TAS
CC	GO:0005681	spliceosomal complex	Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA.	IDA
CC	GO:0005730	nucleolus	A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.	IEA
CC	GO:0005887	integral component of plasma membrane	The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.	TAS
CC	GO:0016020	membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.	IDA
CC	GO:0016363	nuclear matrix	The dense fibrillar network lying on the inner side of the nuclear membrane.	IDA
CC	GO:0031012	extracellular matrix	A structure lying external to one or more cells, which provides structural support for cells or tissues.	IDA
CC	GO:0042382	paraspeckles	Discrete subnuclear bodies in the interchromatin nucleoplasmic space, often located adjacent to nuclear specks. 10-20 paraspeckles are typically found in human cell nuclei.	IDA
CC	GO:0070062	extracellular exosome	A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.	IDA
CC	GO:0071013	catalytic step 2 spliceosome	A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs.	IDA
MF	GO:0000166	nucleotide binding	Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.	IEA
MF	GO:0003723	RNA binding	Interacting selectively and non-covalently with an RNA molecule or a portion thereof.	NAS
MF	GO:0005515	protein binding	Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).	IPI
MF	GO:0019904	protein domain specific binding	Interacting selectively and non-covalently with a specific domain of a protein.	IPI
MF	GO:0044822	poly(A) RNA binding	Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases.	IDA

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Domain ID	Description
IPR000504	RNA recognition motif domain
IPR024666	Heterogeneous nuclear ribonucleoprotein M, PY nuclear localisation signal
IPR024667	Heterogeneous nuclear ribonucleoprotein M

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Pathway ID	Pathway Term	Pathway Source
hsa03040	Spliceosome	KEGG
WP411	mRNA Processing	WikiPathways

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No diseases found.

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Tissue	Cell Type
adrenal gland	glandular cells
appendix	glandular cells
appendix	lymphoid tissue
bone marrow	hematopoietic cells
breast	adipocytes
breast	glandular cells
breast	myoepithelial cells
bronchus	respiratory epithelial cells
caudate	glial cells
caudate	neuronal cells
cerebellum	cells in granular layer
cerebellum	cells in molecular layer
cerebellum	Purkinje cells
cerebral cortex	endothelial cells
cerebral cortex	glial cells
cerebral cortex	neuronal cells
cervix, uterine	glandular cells
cervix, uterine	squamous epithelial cells
colon	endothelial cells
colon	glandular cells
colon	peripheral nerve/ganglion
duodenum	glandular cells
endometrium	cells in endometrial stroma
endometrium	glandular cells
epididymis	glandular cells
esophagus	squamous epithelial cells
fallopian tube	glandular cells
gallbladder	glandular cells
heart muscle	myocytes
hippocampus	glial cells
hippocampus	neuronal cells
kidney	cells in glomeruli
kidney	cells in tubules
liver	bile duct cells
liver	hepatocytes
lung	macrophages
lung	pneumocytes
lymph node	germinal center cells
lymph node	non-germinal center cells
nasopharynx	respiratory epithelial cells
oral mucosa	squamous epithelial cells
ovary	follicle cells
ovary	ovarian stroma cells
pancreas	exocrine glandular cells
pancreas	islets of Langerhans
parathyroid gland	glandular cells
placenta	trophoblastic cells
prostate	glandular cells
rectum	glandular cells
salivary gland	glandular cells
seminal vesicle	glandular cells
skeletal muscle	myocytes
skin	fibroblasts
skin	keratinocytes
skin	Langerhans
skin	melanocytes
skin	epidermal cells
small intestine	glandular cells
smooth muscle	smooth muscle cells
soft tissue	adipocytes
soft tissue	fibroblasts
soft tissue	peripheral nerve
soft tissue	chondrocytes
spleen	cells in red pulp
spleen	cells in white pulp
stomach	glandular cells
testis	cells in seminiferous ducts
testis	Leydig cells
thyroid gland	glandular cells
tonsil	germinal center cells
tonsil	non-germinal center cells
tonsil	squamous epithelial cells
urinary bladder	urothelial cells
vagina	squamous epithelial cells

No databases found.

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Pubmed ID	Author	Year	Title
22951915	Haozi et al.	2012	Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

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Gene Symbol	Entrez ID	Uniprot ID	Score
RCC1	1104	P18754	0.49
DHODH	1723	Q02127	0.49
STOM	2040	P27105	0.49
GTF3C1	2975	Q12789	0.49
KRT16	3868	P08779	0.49
RPSA	3921	P08865	0.49
LMNA	4000	P02545	0.49
LMNB1	4001	P20700	0.49
MYH10	4628	P35580	0.49
SEPT2	4735	Q15019	0.49
RPL10A	4736	P62906	0.49
SNU13	4809	P55769	0.49
NONO	4841	Q15233	0.49
RANBP2	5903	P49792	0.49
RAP1A	5906	P62834	0.49
RPL5	6125	P46777	0.49
RPL6	6128	Q02878	0.49
RPL7	6129	P18124	0.49
RPL7A	6130	P62424	0.49
RPL10	6134	P27635	0.49
RPL11	6135	P62913	0.49
RPL12	6136	P30050	0.49
RPL18	6141	Q07020	0.49
RPL22	6146	P35268	0.49
RPL23A	6147	P62750	0.49
MRPL23	6150	Q16540	0.49
RPL30	6156	P62888	0.49
RPL31	6160	P62899	0.49
RPLP0	6175	P05388	0.49
RPS2	6187	P15880	0.49
RPS4X	6191	P62701	0.49
RPS5	6193	P46782	0.49
RPS6	6194	P62753	0.49
RPS7	6201	P62081	0.49
RPS8	6202	P62241	0.49
RPS11	6205	P62280	0.49
RPS13	6207	P62277	0.49
RPS14	6208	P62263	0.49
RPS15A	6210	P62244	0.49
RPS16	6217	P62249	0.49
RPS23	6228	P62266	0.49
RPS24	6229	P62847	0.49
RPS25	6230	P62851	0.49
RPS26	6231	P62854	0.49
RPS28	6234	P62857	0.49
RRBP1	6238	Q9P2E9	0.49
SFPQ	6421	P23246	0.49
SRSF1	6426	Q07955	0.49
SRSF3	6428	P84103	0.49
SRSF5	6430	Q13243	0.49
SNRPA1	6627	P09661	0.49
SNRPD1	6632	P62314	0.49
SNRPD3	6634	P62318	0.49
SON	6651	P18583	0.49
SSR1	6745	P43307	0.49
TOP1	7150	P11387	0.49
U2AF1	7307	Q01081	0.49
UQCRC2	7385	P22695	0.49
VTN	7448	P04004	0.49
SMARCA5	8467	O60264	0.49
RPL14	9045	P50914	0.49
SMC3	9126	Q9UQE7	0.49
PRPF3	9129	O43395	0.49
MTA2	9219	O94776	0.49
EFTUD2	9343	Q15029	0.49
RPL23	9349	P62829	0.49
TOMM70	9868	O94826	0.49
RBM8A	9939	Q9Y5S9	0.49
THRAP3	9967	Q9Y2W1	0.49
ALYREF	10189	Q86V81	0.49
HNRNPR	10236	O43390	0.49
SF3A1	10291	Q15459	0.49
RBM14	10432	Q96PK6	0.49
SYNCRIP	10492	O60506	0.49
PRPF8	10594	Q6P2Q9	0.49
RNPS1	10921	Q15287	0.49
HNRNPA0	10949	Q13151	0.49
RAB31	11031	Q13636	0.49
SUPT16H	11198	Q9Y5B9	0.49
U2AF2	11338	P26368	0.49
PUF60	22827	Q9UHX1	0.49
RALY	22913	Q9UKM9	0.49
RRS1	23212	Q15050	0.49
SF3B3	23450	Q15393	0.49
SF3B1	23451	O75533	0.49
PRPF6	24148	O94906	0.49
SAMM50	25813	Q9Y512	0.49
TOR1AIP1	26092	Q5JTV8	0.49
TIMM9	26520	Q9Y5J7	0.49
SND1	27044	Q7KZF4	0.49
PRPF19	27339	Q9UMS4	0.49
RRP7A	27341	Q9Y3A4	0.49
MRPS28	28957	Q9Y2Q9	0.49
UQCR10	29796	Q9UDW1	0.49
TRA2A	29896	Q13595	0.49
SLC25A24	29957	Q6NUK1	0.49
MRPL37	51253	Q9BZE1	0.49
SRRT	51593	Q9BXP5	0.49
MBD3	53615	O95983	0.49
LRRC59	55379	Q96AG4	0.49
PRPF40A	55660	O75400	0.49
RCC2	55920	Q9P258	0.49
PCDHA2	56146	Q9Y5H9	0.49
RTN4	57142	Q9NQC3	0.49
RBM25	58517	P49756	0.49
MRPS9	64965	P82933	0.49
MRPL55	128308	Q7Z7F7	0.49
RPLP0P6	220717	Q8NHW5	0.49
ZNF326	284695	Q5BKZ1	0.49
RPS21	100291837	P63220	0.49
SRSF2	6427	Q01130	0.52
RPL18A	6142	Q02543	0.56
EEF1G	1937	P26641	0.63
MRE11A	4361	P49959	0.63
AKAP9	10142	Q99996	0.63
ECM29	23392	Q5VYK3	0.63
GMCL1P1	64396	Q8NEA9	0.63
RBM4B	83759	Q9BQ04	0.63
TEKT4	150483	Q8WW24	0.63
NFKB2	4791	Q00653	0.72
MAP3K14	9020	Q99558	0.72
RPL19	6143	P84098	0.73
LMO3	55885	Q8TAP4	0.73
CEACAM5	1048	P06731	0.75
PLRG1	5356	O43660	0.76
TNPO1	3842	Q92973	0.78
ADAR	103	P55265	0.49
DDX5	1655	P17844	0.49
FLNB	2317	O75369	0.49
HNRNPC	3183	P07910	0.49
HNRNPL	3191	P14866	0.49
HNRNPDL	9987	O14979	0.49
RBMX	27316	P38159	0.49
B9D2	80776	Q9BPU9	0.49
YWHAG	7532	P61981	0.52
HSPA8	3312	P11142	0.55
HNRNPK	3190	P61978	0.56
UBE2I	7329	P63279	0.62
ABCF1	23	Q8NE71	0.63
APC	324	P25054	0.63
ARF6	382	P62330	0.63
CD81	975	P60033	0.63
CDK2	1017	P24941	0.63
CRY2	1408	Q49AN0	0.63
CSNK1E	1454	P49674	0.63
CTNNB1	1499	P35222	0.63
DHX9	1660	Q08211	0.63
ENO1	2023	P06733	0.63
ERG	2078	P11308	0.63
FLII	2314	Q13045	0.63
FN1	2335	P02751	0.63
NR5A1	2516	Q13285	0.63
SFN	2810	P31947	0.63
HLA-B	3106	P30480	0.63
ITGA4	3676	P13612	0.63
MAGEB2	4113	O15479	0.63
MCM2	4171	P49736	0.63
MOV10	4343	Q9HCE1	0.63
NFKBIB	4793	Q15653	0.63
NFX1	4799	Q12986	0.63
NMT1	4836	P30419	0.63
NPM1	4869	P06748	0.63
NTRK1	4914	P04629	0.63
PARK2	5071	O60260	0.63
PHKG2	5261	P15735	0.63
EIF2AK2	5610	P19525	0.63
PSMB8	5696	P28062	0.63
RBM4	5936	Q9BWF3	0.63
RFC4	5984	P35249	0.63
RPA1	6117	P27694	0.63
RPA2	6118	P15927	0.63
RPA3	6119	P35244	0.63
RPL27	6155	P61353	0.63
RPS6KB2	6199	Q9UBS0	0.63
SGK1	6446	O00141	0.63
SHMT2	6472	P34897	0.63
SKI	6497	P12755	0.63
SUMO3	6612	P55854	0.63
STAT3	6774	P40763	0.63
STAU1	6780	O95793	0.63
TADA2A	6871	O75478	0.63
VHL	7428	P40337	0.63
WHSC1	7468	O96028	0.63
XPO1	7514	O14980	0.63
YWHAZ	7534	P63104	0.63
ZNF207	7756	O43670	0.63
PRRC2A	7916	P48634	0.63
GAN	8139	Q9H2C0	0.63
UBL4A	8266	P11441	0.63
CUL3	8452	Q13618	0.63
CUL2	8453	Q13617	0.63
CUL1	8454	Q13616	0.63
EED	8726	O75530	0.63
TNFRSF10D	8793	Q9UBN6	0.63
EIF2B3	8891	Q9NR50	0.63
EIF2B2	8892	P49770	0.63
MED26	9441	O95402	0.63
IKBKE	9641	Q14164	0.63
MORF4L2	9643	Q15014	0.63
KIAA0101	9768	Q15004	0.63
PAN2	9924	Q504Q3	0.63
TOPORS	10210	Q9NS56	0.63
SRRM1	10250	Q8IYB3	0.63
NXF1	10482	Q9UBU9	0.63
NOP56	10528	O00567	0.63
IVNS1ABP	10625	Q9Y6Y0	0.63
IGF2BP3	10643	O00425	0.63
MORF4L1	10933	Q9UBU8	0.63
COPS5	10987	Q92905	0.63
ERLIN2	11160	O94905	0.63
CEP250	11190	Q9BV73	0.63
GABARAP	11337	O95166	0.63
GABARAPL2	11345	P60520	0.63
SNW1	22938	Q13573	0.63
PRAME	23532	P78395	0.63
GABARAPL1	23710	Q9H0R8	0.63
FBXO6	26270	Q9NRD1	0.63
RPL26L1	51121	Q9UNX3	0.63
DDX41	51428	Q9UJV9	0.63
MRGBP	55257	Q9NV56	0.63
MED29	55588	Q9NX70	0.63
RIOK2	55781	Q9BVS4	0.63
CAND1	55832	Q86VP6	0.63
C20orf24	55969	Q9BUV8	0.63
SMARCAD1	56916	Q9H4L7	0.63
AICDA	57379	Q9GZX7	0.63
WDR77	79084	Q9BQA1	0.63
MAP1LC3B	81631	Q9GZQ8	0.63
DOT1L	84444	Q8TEK3	0.63
IGSF8	93185	Q969P0	0.63
HAUS1	115106	Q96CS2	0.63
MED19	219541	A0JLT2	0.63
UBAC2	337867	Q8NBM4	0.63
SCARNA22	677770	N/A	0.63
LYST	1130	Q99698	0.65
BAG2	9532	O95816	0.67
TARDBP	23435	Q13148	0.70
ABL1	25	P00519	0.72
ARRB1	408	P49407	0.72
ARRB2	409	P32121	0.72
CLK2	1196	P49760	0.72
ILK	3611	Q13418	0.72
MAGOH	4116	P61326	0.72
MAP3K1	4214	Q13233	0.72
RELA	5970	Q04206	0.72
SRPK1	6732	Q96SB4	0.72
SRPK2	6733	P78362	0.72
EIF4A3	9775	P38919	0.72
MATR3	9782	P43243	0.72
SEC16A	9919	O15027	0.72
TANK	10010	Q92844	0.72
CDC37	11140	Q16543	0.72
MAST3	23031	O60307	0.72
SRPK3	26576	Q9UPE1	0.72
TBK1	29110	Q9UHD2	0.72
MYEF2	50804	Q9P2K5	0.72
DDX1	1653	Q92499	0.73
MDM2	4193	Q00987	0.73
TP53	7157	P04637	0.73
UBD	10537	O15205	0.73
SRRM2	23524	Q9UQ35	0.73
RTCB	51493	Q9Y3I0	0.73
LMO2	4005	P25791	0.74
SUMO2	6613	P61956	0.74
CDC5L	988	Q99459	0.76
RFXANK	8625	O14593	0.76
TSC22D1	8848	Q15714	0.76
PTP4A3	11156	O75365	0.76
PHLDA3	23612	Q9Y5J5	0.76
GSTK1	373156	Q9Y2Q3	0.76
ESR1	2099	P03372	0.77
HNRNPF	3185	P52597	0.79
HNRNPH1	3187	P31943	0.79
HNRNPH2	3188	P55795	0.79
SUMO1	7341	P63165	0.81
NFKB1	4790	P19838	0.82
VCAM1	7412	P19320	0.82
MAP1LC3A	84557	Q9H492	0.82
TCERG1	10915	O14776	0.83
JUN	3725	P05412	0.86
HNRNPA1	3178	P09651	0.94