Protein Description

Gene Symbol MYO9B
Entrez ID 4650
Uniprot ID Q13459
Description myosin IXB
Chromosomal Location chr19: 17,075,781-17,214,537
Ontology GO ID GO Term Definition Evidence

BP

GO:0007266

Rho protein signal transduction

A series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state.

IC

BP

GO:0030048

actin filament-based movement

Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins.

IDA|TAS

BP

GO:0035023

regulation of Rho protein signal transduction

Any process that modulates the frequency, rate or extent of Rho protein signal transduction.

IMP

BP

GO:0035385

Roundabout signaling pathway

A series of molecular signals initiated by the binding of a SLIT protein to a Roundabout (ROBO) family receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.

IDA

BP

GO:0043547

positive regulation of GTPase activity

Any process that activates or increases the activity of a GTPase.

IEA

BP

GO:0051056

regulation of small GTPase mediated signal transduction

Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction.

TAS

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

IDA

CC

GO:0005829

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

TAS

CC

GO:0005884

actin filament

A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane.

IDA

CC

GO:0005938

cell cortex

The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.

IDA

CC

GO:0015629

actin cytoskeleton

The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.

TAS

CC

GO:0016020

membrane

A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

IDA

CC

GO:0016459

myosin complex

A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes.

IEA

CC

GO:0048471

perinuclear region of cytoplasm

Cytoplasm situated near, or occurring around, the nucleus.

IDA

MF

GO:0000146

microfilament motor activity

Catalysis of movement along a microfilament, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP).

IDA

MF

GO:0003779

actin binding

Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.

IDA

MF

GO:0005096

GTPase activator activity

Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.

IDA|TAS

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0005516

calmodulin binding

Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.

IDA

MF

GO:0005524

ATP binding

Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

IDA

MF

GO:0016887

ATPase activity

Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.

IDA

MF

GO:0017048

Rho GTPase binding

Interacting selectively and non-covalently with Rho protein, any member of the Rho subfamily of the Ras superfamily of monomeric GTPases. Proteins in the Rho subfamily are involved in relaying signals from cell-surface receptors to the actin cytoskeleton.

IPI

MF

GO:0043531

ADP binding

Interacting selectively and non-covalently with ADP, adenosine 5'-diphosphate.

IDA

MF

GO:0046872

metal ion binding

Interacting selectively and non-covalently with any metal ion.

IEA

MF

GO:0048495

Roundabout binding

Interacting selectively and non-covalently with the Roundabout (ROBO) receptor, a transmembrane receptor.

IPI

Domain ID Description

IPR000048

IQ motif, EF-hand binding site

IPR000159

Ras-associating (RA) domain

IPR000198

Rho GTPase-activating protein domain

IPR001609

Myosin head, motor domain

IPR002219

Protein kinase C-like, phorbol ester/diacylglycerol-binding domain

IPR008936

Rho GTPase activation protein

IPR027417

P-loop containing nucleoside triphosphate hydrolase

IPR028557

Unconventional myosin-IXb

IPR029071

Ubiquitin-related domain

No pathways found.

UMLS CUI UMLS Term

C0007570

Celiac Disease

Tissue Cell Type

adrenal gland

glandular cells

heart muscle

myocytes

kidney

cells in tubules

lymph node

germinal center cells

lymph node

non-germinal center cells

seminal vesicle

glandular cells

spleen

cells in red pulp

spleen

cells in white pulp

thyroid gland

glandular cells

tonsil

germinal center cells

tonsil

non-germinal center cells

tonsil

squamous epithelial cells

No databases found.

Pubmed ID Author Year Title

15291743

Diao et al.

2004

The molecular characteristics of polycystic ovary syndrome (PCOS) ovary defined by human ovary cDNA microarray

Gene Symbol Entrez ID Uniprot ID Score

ACTA1

58

P68133

0.52

RHOA

387

P61586

0.56

LRRC41

10489

Q15345

0.63

CALM2

805

P62158

0.73

CALM3

808

P62158

0.73

ARFGEF1

10565

Q9Y6D6

0.75

GRK5

2869

P34947

0.63

HLA-DPA1

3113

P20036

0.63

MCM2

4171

P49736

0.63

NTRK1

4914

P04629

0.63

PKN2

5586

Q16513

0.63

SKAP1

8631

Q86WV1

0.63

HERC2

8924

O95714

0.63

MOB4

25843

Q9Y3A3

0.63

SDF4

51150

Q9BRK5

0.63

CCDC8

83987

Q9H0W5

0.63

GPRASP2

114928

Q96D09

0.63

RBM33

155435

Q96EV2

0.63

LCN15

389812

Q6UWW0

0.63

FOXG1

2290

P55316

0.72

FOXL1

2300

Q12952

0.72

MYC

4609

P01106

0.72