Gene Symbol | MYO9B |
Entrez ID | 4650 |
Uniprot ID | Q13459 |
Description | myosin IXB |
Chromosomal Location | chr19: 17,075,781-17,214,537 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0007266 |
Rho protein signal transduction |
A series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state. |
IC |
BP |
GO:0030048 |
actin filament-based movement |
Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins. |
IDA|TAS |
BP |
GO:0035023 |
regulation of Rho protein signal transduction |
Any process that modulates the frequency, rate or extent of Rho protein signal transduction. |
IMP |
BP |
GO:0035385 |
Roundabout signaling pathway |
A series of molecular signals initiated by the binding of a SLIT protein to a Roundabout (ROBO) family receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. |
IDA |
BP |
GO:0043547 |
positive regulation of GTPase activity |
Any process that activates or increases the activity of a GTPase. |
IEA |
BP |
GO:0051056 |
regulation of small GTPase mediated signal transduction |
Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction. |
TAS |
CC |
GO:0005737 |
cytoplasm |
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
IDA |
CC |
GO:0005829 |
cytosol |
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
TAS |
CC |
GO:0005884 |
actin filament |
A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane. |
IDA |
CC |
GO:0005938 |
cell cortex |
The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins. |
IDA |
CC |
GO:0015629 |
actin cytoskeleton |
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. |
TAS |
CC |
GO:0016020 |
membrane |
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
IDA |
CC |
GO:0016459 |
myosin complex |
A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. |
IEA |
CC |
GO:0048471 |
perinuclear region of cytoplasm |
Cytoplasm situated near, or occurring around, the nucleus. |
IDA |
MF |
GO:0000146 |
microfilament motor activity |
Catalysis of movement along a microfilament, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). |
IDA |
MF |
GO:0003779 |
actin binding |
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. |
IDA |
MF |
GO:0005096 |
GTPase activator activity |
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. |
IDA|TAS |
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
MF |
GO:0005516 |
calmodulin binding |
Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. |
IDA |
MF |
GO:0005524 |
ATP binding |
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
IDA |
MF |
GO:0016887 |
ATPase activity |
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction. |
IDA |
MF |
GO:0017048 |
Rho GTPase binding |
Interacting selectively and non-covalently with Rho protein, any member of the Rho subfamily of the Ras superfamily of monomeric GTPases. Proteins in the Rho subfamily are involved in relaying signals from cell-surface receptors to the actin cytoskeleton. |
IPI |
MF |
GO:0043531 |
ADP binding |
Interacting selectively and non-covalently with ADP, adenosine 5'-diphosphate. |
IDA |
MF |
GO:0046872 |
metal ion binding |
Interacting selectively and non-covalently with any metal ion. |
IEA |
MF |
GO:0048495 |
Roundabout binding |
Interacting selectively and non-covalently with the Roundabout (ROBO) receptor, a transmembrane receptor. |
IPI |
Domain ID | Description |
---|---|
IPR000048 |
IQ motif, EF-hand binding site |
IPR000159 |
Ras-associating (RA) domain |
IPR000198 |
Rho GTPase-activating protein domain |
IPR001609 |
Myosin head, motor domain |
IPR002219 |
Protein kinase C-like, phorbol ester/diacylglycerol-binding domain |
IPR008936 |
Rho GTPase activation protein |
IPR027417 |
P-loop containing nucleoside triphosphate hydrolase |
IPR028557 |
Unconventional myosin-IXb |
IPR029071 |
Ubiquitin-related domain |
UMLS CUI | UMLS Term |
---|---|
C0007570 |
Celiac Disease |
Tissue | Cell Type |
---|---|
adrenal gland |
glandular cells |
heart muscle |
myocytes |
kidney |
cells in tubules |
lymph node |
germinal center cells |
lymph node |
non-germinal center cells |
seminal vesicle |
glandular cells |
spleen |
cells in red pulp |
spleen |
cells in white pulp |
thyroid gland |
glandular cells |
tonsil |
germinal center cells |
tonsil |
non-germinal center cells |
tonsil |
squamous epithelial cells |
Pubmed ID | Author | Year | Title |
---|---|---|---|
15291743 |
Diao et al. |
2004 |
The molecular characteristics of polycystic ovary syndrome (PCOS) ovary defined by human ovary cDNA microarray |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
ACTA1 |
58 |
P68133 |
0.52 |
RHOA |
387 |
P61586 |
0.56 |
LRRC41 |
10489 |
Q15345 |
0.63 |
CALM2 |
805 |
P62158 |
0.73 |
CALM3 |
808 |
P62158 |
0.73 |
ARFGEF1 |
10565 |
Q9Y6D6 |
0.75 |
GRK5 |
2869 |
P34947 |
0.63 |
HLA-DPA1 |
3113 |
P20036 |
0.63 |
MCM2 |
4171 |
P49736 |
0.63 |
NTRK1 |
4914 |
P04629 |
0.63 |
PKN2 |
5586 |
Q16513 |
0.63 |
SKAP1 |
8631 |
Q86WV1 |
0.63 |
HERC2 |
8924 |
O95714 |
0.63 |
MOB4 |
25843 |
Q9Y3A3 |
0.63 |
SDF4 |
51150 |
Q9BRK5 |
0.63 |
CCDC8 |
83987 |
Q9H0W5 |
0.63 |
GPRASP2 |
114928 |
Q96D09 |
0.63 |
RBM33 |
155435 |
Q96EV2 |
0.63 |
LCN15 |
389812 |
Q6UWW0 |
0.63 |
FOXG1 |
2290 |
P55316 |
0.72 |
FOXL1 |
2300 |
Q12952 |
0.72 |
MYC |
4609 |
P01106 |
0.72 |