BP

GO:0002026

regulation of the force of heart contraction

Any process that modulates the extent of heart contraction, changing the force with which blood is propelled.

IMP

BP

GO:0030049

muscle filament sliding

The sliding of actin thin filaments and myosin thick filaments past each other in muscle contraction. This involves a process of interaction of myosin located on a thick filament with actin located on a thin filament. During this process ATP is split and forces are generated.

TAS

BP

GO:0032781

positive regulation of ATPase activity

Any process that activates or increases the rate of ATP hydrolysis by an ATPase.

IMP

BP

GO:0060048

cardiac muscle contraction

Muscle contraction of cardiac muscle tissue.

IMP

CC

GO:0005829

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

TAS

CC

GO:0016459

myosin complex

A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes.

IEA

CC

GO:0031672

A band

The dark-staining region of a sarcomere, in which myosin thick filaments are present; the center is traversed by the paler H zone, which in turn contains the M line.

IMP

MF

GO:0003785

actin monomer binding

Interacting selectively and non-covalently with monomeric actin, also known as G-actin.

IDA

MF

GO:0005509

calcium ion binding

Interacting selectively and non-covalently with calcium ions (Ca2+).

IEA

MF

GO:0032038

myosin II heavy chain binding

Interacting selectively and non-covalently with a heavy chain of a myosin II complex.

NAS

MF

GO:0051015

actin filament binding

Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.

IMP