BP

GO:0002090

regulation of receptor internalization

Any process that modulates the frequency, rate or extent of receptor internalization.

ISS

BP

GO:0006661

phosphatidylinositol biosynthetic process

The chemical reactions and pathways resulting in the formation of phosphatidylinositol, any glycophospholipid in which the sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.

TAS

BP

GO:0006878

cellular copper ion homeostasis

Any process involved in the maintenance of an internal steady state of copper ions at the level of a cell.

IMP

BP

GO:0006892

post-Golgi vesicle-mediated transport

The directed movement of substances from the Golgi to other parts of the cell, including organelles and the plasma membrane, mediated by small transport vesicles.

TAS

BP

GO:0007015

actin filament organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking.

IEA

BP

GO:0007264

small GTPase mediated signal transduction

Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals.

IEA

BP

GO:0015031

protein transport

The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

IEA

BP

GO:0019886

antigen processing and presentation of exogenous peptide antigen via MHC class II

The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein.

TAS

BP

GO:0034315

regulation of Arp2/3 complex-mediated actin nucleation

Any process that modulates the frequency, rate or extent of actin nucleation mediated by the Arp2/3 complex and interacting proteins.

ISS

BP

GO:0034379

very-low-density lipoprotein particle assembly

The aggregation and arrangement of proteins and lipids in the liver to form a very-low-density lipoprotein particle.

IEA

BP

GO:0043085

positive regulation of catalytic activity

Any process that activates or increases the activity of an enzyme.

IEA

BP

GO:0045807

positive regulation of endocytosis

Any process that activates or increases the frequency, rate or extent of endocytosis.

IEA

BP

GO:0045956

positive regulation of calcium ion-dependent exocytosis

Any process that activates or increases the frequency, rate or extent of calcium ion-dependent exocytosis.

IEA

BP

GO:0050690

regulation of defense response to virus by virus

Any viral process that modulates the frequency, rate, or extent of the antiviral response of the host cell or organism.

TAS

BP

GO:0050714

positive regulation of protein secretion

Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell.

IEA

BP

GO:0055108

Golgi to transport vesicle transport

The directed movement of proteins from the Golgi to a transport vesicle. Continuously secreted proteins are sorted into transport vesicles that fuse with the plasma membrane, releasing their contents by exocytosis.

IEA

BP

GO:0060292

long term synaptic depression

A process that modulates synaptic plasticity such that synapses are changed resulting in the decrease in the rate, or frequency of synaptic transmission at the synapse.

ISS

BP

GO:0060999

positive regulation of dendritic spine development

Any process that increases the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure.

IEA

BP

GO:0070142

synaptic vesicle budding

Evagination of a membrane to form a synaptic vesicle.

IEA

BP

GO:0097061

dendritic spine organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a dendritic spine. A dendritic spine is a specialized protrusion from a neuronal dendrite and is involved in synaptic transmission.

ISS

BP

GO:0097212

lysosomal membrane organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosomal membrane. A lysosomal membrane is the lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.

IEA

BP

GO:1902307

positive regulation of sodium ion transmembrane transport

Any process that activates or increases the frequency, rate or extent of sodium ion transmembrane transport.

IEA

BP

GO:1902824

positive regulation of late endosome to lysosome transport

Any process that activates or increases the frequency, rate or extent of late endosome to lysosome transport.

IEA

BP

GO:1902953

positive regulation of ER to Golgi vesicle-mediated transport

Any process that activates or increases the frequency, rate or extent of ER to Golgi vesicle-mediated transport.

IEA

BP

GO:1903725

regulation of phospholipid metabolic process

Any process that modulates the frequency, rate or extent of phospholipid metabolic process.

IEA

CC

GO:0000139

Golgi membrane

The lipid bilayer surrounding any of the compartments of the Golgi apparatus.

TAS

CC

GO:0005770

late endosome

A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.

IEA

CC

GO:0005778

peroxisomal membrane

The lipid bilayer surrounding a peroxisome.

IEA

CC

GO:0005802

trans-Golgi network

The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination.

IEA

CC

GO:0005829

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

TAS

CC

GO:0005886

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

TAS

CC

GO:0005925

focal adhesion

Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.

IDA

CC

GO:0014069

postsynaptic density

The postsynaptic density is a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at an excitatory synapse. It forms an electron-dense disc that consists of a range of proteins with different functions, some of which contact the cytoplasmic domains of ion channels in the postsynaptic membrane. The proteins making up the disc include structural proteins linked to the actin cytoskeleton and signalling machinery, such as protein kinases and phosphatases.

IEA

CC

GO:0030017

sarcomere

The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.

IEA

CC

GO:0030137

COPI-coated vesicle

A vesicle with a coat formed of the COPI coat complex proteins. COPI-coated vesicles are found associated with Golgi membranes at steady state, are involved in Golgi to endoplasmic reticulum (retrograde) vesicle transport, and possibly also in intra-Golgi transport.

IEA

CC

GO:0031252

cell leading edge

The area of a motile cell closest to the direction of movement.

IDA

CC

GO:0043005

neuron projection

A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.

IEA

CC

GO:0045211

postsynaptic membrane

A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane.

IEA

CC

GO:0048471

perinuclear region of cytoplasm

Cytoplasm situated near, or occurring around, the nucleus.

IEA

CC

GO:0070062

extracellular exosome

A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.

IDA

MF

GO:0000287

magnesium ion binding

Interacting selectively and non-covalently with magnesium (Mg) ions.

IEA

MF

GO:0003924

GTPase activity

Catalysis of the reaction: GTP + H2O = GDP + phosphate.

TAS

MF

GO:0005057

receptor signaling protein activity

Conveys a signal from an upstream receptor or intracellular signal transducer, converting the signal into a form where it can ultimately trigger a change in the state or activity of a cell.

TAS

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0005525

GTP binding

Interacting selectively and non-covalently with GTP, guanosine triphosphate.

IEA

MF

GO:0019003

GDP binding

Interacting selectively and non-covalently with GDP, guanosine 5'-diphosphate.

IEA

MF

GO:0044822

poly(A) RNA binding

Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases.

IDA

MF

GO:1990583

phospholipase D activator activity

Increases the activity of the enzyme phospholipase D.

IEA