| Gene Symbol | TRIM23 |
| Entrez ID | 373 |
| Uniprot ID | P36406 |
| Description | tripartite motif containing 23 |
| Chromosomal Location | chr5: 65,589,680-65,625,975 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0007264 |
small GTPase mediated signal transduction |
Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. |
IEA |
|
BP |
GO:0016032 |
viral process |
A multi-organism process in which a virus is a participant. The other participant is the host. Includes infection of a host cell, replication of the viral genome, and assembly of progeny virus particles. In some cases the viral genetic material may integrate into the host genome and only subsequently, under particular circumstances, 'complete' its life cycle. |
IEA |
|
BP |
GO:0016567 |
protein ubiquitination |
The process in which one or more ubiquitin groups are added to a protein. |
IDA|IEA |
|
BP |
GO:0043085 |
positive regulation of catalytic activity |
Any process that activates or increases the activity of an enzyme. |
IEA |
|
CC |
GO:0000139 |
Golgi membrane |
The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
IDA |
|
CC |
GO:0005634 |
nucleus |
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
IEA |
|
CC |
GO:0005765 |
lysosomal membrane |
The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. |
IDA |
|
CC |
GO:0070062 |
extracellular exosome |
A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. |
IDA |
|
MF |
GO:0003924 |
GTPase activity |
Catalysis of the reaction: GTP + H2O = GDP + phosphate. |
IDA |
|
MF |
GO:0004842 |
ubiquitin-protein transferase activity |
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages. |
IDA |
|
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
|
MF |
GO:0005525 |
GTP binding |
Interacting selectively and non-covalently with GTP, guanosine triphosphate. |
IDA |
|
MF |
GO:0008047 |
enzyme activator activity |
Binds to and increases the activity of an enzyme. |
TAS |
|
MF |
GO:0008270 |
zinc ion binding |
Interacting selectively and non-covalently with zinc (Zn) ions. |
IEA |
|
MF |
GO:0016874 |
ligase activity |
Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. |
IEA |
|
MF |
GO:0019003 |
GDP binding |
Interacting selectively and non-covalently with GDP, guanosine 5'-diphosphate. |
IDA |
|
MF |
GO:0042802 |
identical protein binding |
Interacting selectively and non-covalently with an identical protein or proteins. |
IPI |
| Domain ID | Description |
|---|---|
|
IPR000315 |
B-box-type zinc finger |
|
IPR001841 |
Zinc finger, RING-type |
|
IPR003649 |
B-box, C-terminal |
|
IPR005225 |
Small GTP-binding protein domain |
|
IPR006689 |
Small GTPase superfamily, ARF/SAR type |
|
IPR013083 |
Zinc finger, RING/FYVE/PHD-type |
|
IPR013087 |
Zinc finger C2H2-type |
|
IPR017907 |
Zinc finger, RING-type, conserved site |
|
IPR024156 |
Small GTPase superfamily, ARF type |
|
IPR027417 |
P-loop containing nucleoside triphosphate hydrolase |
| Tissue | Cell Type |
|---|---|
|
adrenal gland |
glandular cells |
|
bone marrow |
hematopoietic cells |
|
breast |
glandular cells |
|
breast |
myoepithelial cells |
|
bronchus |
respiratory epithelial cells |
|
cerebral cortex |
neuronal cells |
|
cervix, uterine |
glandular cells |
|
cervix, uterine |
squamous epithelial cells |
|
colon |
glandular cells |
|
duodenum |
glandular cells |
|
endometrium |
glandular cells |
|
gallbladder |
glandular cells |
|
hippocampus |
glial cells |
|
lung |
macrophages |
|
nasopharynx |
respiratory epithelial cells |
|
placenta |
trophoblastic cells |
|
salivary gland |
glandular cells |
|
skin |
fibroblasts |
|
skin |
keratinocytes |
|
skin |
Langerhans |
|
skin |
melanocytes |
|
small intestine |
glandular cells |
|
smooth muscle |
smooth muscle cells |
|
testis |
cells in seminiferous ducts |
|
thyroid gland |
glandular cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
UBA1 |
7317 |
P22314 |
0.49 |
|
UBE2N |
7334 |
P61088 |
0.49 |
|
UBE2V1 |
387522 |
Q13404 |
0.49 |
|
CYTH2 |
9266 |
Q99418 |
0.56 |
|
CDR2 |
1039 |
Q01850 |
0.63 |
|
DCX |
1641 |
O43602 |
0.63 |
|
DOCK2 |
1794 |
Q92608 |
0.63 |
|
GATA2 |
2624 |
P23769 |
0.63 |
|
HOXA1 |
3198 |
P49639 |
0.63 |
|
HOXB5 |
3215 |
P09067 |
0.63 |
|
KIFC3 |
3801 |
Q9BVG8 |
0.63 |
|
KRT6A |
3853 |
P02538 |
0.63 |
|
LGALS8 |
3964 |
O00214 |
0.63 |
|
LMO2 |
4005 |
P25791 |
0.63 |
|
PDE4D |
5144 |
Q08499 |
0.63 |
|
PHF1 |
5252 |
O43189 |
0.63 |
|
PIK3R2 |
5296 |
O00459 |
0.63 |
|
SIAH1 |
6477 |
Q8IUQ4 |
0.63 |
|
SNAI2 |
6591 |
O43623 |
0.63 |
|
SNAI1 |
6615 |
O95863 |
0.63 |
|
SNRPB |
6628 |
P14678 |
0.63 |
|
TMSB4X |
7114 |
P62328 |
0.63 |
|
TNFAIP3 |
7128 |
P21580 |
0.63 |
|
TRAF1 |
7185 |
Q13077 |
0.63 |
|
TSG101 |
7251 |
Q99816 |
0.63 |
|
UBE2E2 |
7325 |
Q96LR5 |
0.63 |
|
UBE2H |
7328 |
P62256 |
0.63 |
|
SF1 |
7536 |
Q15637 |
0.63 |
|
GPANK1 |
7918 |
O95872 |
0.63 |
|
PKP4 |
8502 |
Q99569 |
0.63 |
|
STK19 |
8859 |
P49842 |
0.63 |
|
PIAS2 |
9063 |
O75928 |
0.63 |
|
CXCL14 |
9547 |
O95715 |
0.63 |
|
CREB5 |
9586 |
Q02930 |
0.63 |
|
POM121 |
9883 |
Q96HA1 |
0.63 |
|
RNF10 |
9921 |
Q8N5U6 |
0.63 |
|
JOSD1 |
9929 |
Q15040 |
0.63 |
|
SORBS3 |
10174 |
O60504 |
0.63 |
|
KAT5 |
10524 |
Q92993 |
0.63 |
|
NEK6 |
10783 |
Q9HC98 |
0.63 |
|
USP20 |
10868 |
Q9Y2K6 |
0.63 |
|
DEPP |
11067 |
Q9NTK1 |
0.63 |
|
DMC1 |
11144 |
Q14565 |
0.63 |
|
GGA2 |
23062 |
Q9UJY4 |
0.63 |
|
PPIL2 |
23759 |
Q13356 |
0.63 |
|
GPSM1 |
26086 |
Q86YR5 |
0.63 |
|
RIBC2 |
26150 |
Q9H4K1 |
0.63 |
|
HSPB7 |
27129 |
Q9UBY9 |
0.63 |
|
GPKOW |
27238 |
Q92917 |
0.63 |
|
NFU1 |
27247 |
Q9UMS0 |
0.63 |
|
POLL |
27343 |
Q9UGP5 |
0.63 |
|
ARHGEF3 |
50650 |
Q9NR81 |
0.63 |
|
MRPL4 |
51073 |
Q9BYD3 |
0.63 |
|
SPG21 |
51324 |
Q9NZD8 |
0.63 |
|
FAM208B |
54906 |
Q5VWN6 |
0.63 |
|
FAM90A1 |
55138 |
Q86YD7 |
0.63 |
|
CCDC25 |
55246 |
Q86WR0 |
0.63 |
|
TBC1D22B |
55633 |
Q9NU19 |
0.63 |
|
RNF126 |
55658 |
Q9BV68 |
0.63 |
|
ARFGAP1 |
55738 |
Q8N6T3 |
0.63 |
|
EAF2 |
55840 |
Q96CJ1 |
0.63 |
|
NXT2 |
55916 |
Q9NPJ8 |
0.63 |
|
SMG9 |
56006 |
Q9H0W8 |
0.63 |
|
RAD18 |
56852 |
Q9NS91 |
0.63 |
|
KLHL42 |
57542 |
Q9P2K6 |
0.63 |
|
TSHZ3 |
57616 |
Q63HK5 |
0.63 |
|
CCDC146 |
57639 |
Q8IYE0 |
0.63 |
|
RNF213 |
57674 |
Q63HN8 |
0.63 |
|
ZNF250 |
58500 |
P15622 |
0.63 |
|
DMRT3 |
58524 |
Q9NQL9 |
0.63 |
|
SH2D4A |
63898 |
Q9H788 |
0.63 |
|
CARD9 |
64170 |
Q9H257 |
0.63 |
|
GMCL1P1 |
64396 |
Q8NEA9 |
0.63 |
|
RSRC2 |
65117 |
Q7L4I2 |
0.63 |
|
C8orf33 |
65265 |
Q9H7E9 |
0.63 |
|
WDR25 |
79446 |
Q64LD2 |
0.63 |
|
ZC2HC1C |
79696 |
Q53FD0 |
0.63 |
|
FLAD1 |
80308 |
Q8NFF5 |
0.63 |
|
TXNDC5 |
81567 |
Q8NBS9 |
0.63 |
|
FAM110A |
83541 |
Q9BQ89 |
0.63 |
|
FAM103A1 |
83640 |
Q9BTL3 |
0.63 |
|
UTP23 |
84294 |
Q9BRU9 |
0.63 |
|
MRPL45 |
84311 |
Q9BRJ2 |
0.63 |
|
SYVN1 |
84447 |
Q86TM6 |
0.63 |
|
TRIM55 |
84675 |
Q9BYV6 |
0.63 |
|
LNX1 |
84708 |
Q8TBB1 |
0.63 |
|
ANKRD36BP1 |
84832 |
Q96IX9 |
0.63 |
|
FAM83A |
84985 |
Q86UY5 |
0.63 |
|
FBF1 |
85302 |
Q8TES7 |
0.63 |
|
ATPAF2 |
91647 |
Q8N5M1 |
0.63 |
|
MTFR2 |
113115 |
Q6P444 |
0.63 |
|
HAUS1 |
115106 |
Q96CS2 |
0.63 |
|
EXOC3-AS1 |
116349 |
Q8N2X6 |
0.63 |
|
MORN4 |
118812 |
Q8NDC4 |
0.63 |
|
LINC00526 |
147525 |
Q96FQ7 |
0.63 |
|
UBE2U |
148581 |
Q5VVX9 |
0.63 |
|
IQUB |
154865 |
Q8NA54 |
0.63 |
|
ZNF564 |
163050 |
Q8TBZ8 |
0.63 |
|
CDC20B |
166979 |
Q86Y33 |
0.63 |
|
PPP1R18 |
170954 |
Q6NYC8 |
0.63 |
|
CFAP53 |
220136 |
Q96M91 |
0.63 |
|
LINC01018 |
255167 |
N/A |
0.63 |
|
RTP5 |
285093 |
Q14D33 |
0.63 |
|
FAM133A |
286499 |
Q8N9E0 |
0.63 |
|
TRIM42 |
287015 |
Q8IWZ5 |
0.63 |
|
SUMO1P1 |
391257 |
N/A |
0.63 |
|
GCC2-AS1 |
644903 |
N/A |
0.63 |
|
LOC729603 |
729603 |
N/A |
0.63 |
|
UBE2D1 |
7321 |
P51668 |
0.66 |
|
UBE2D2 |
7322 |
P62837 |
0.66 |
|
UBE2D3 |
7323 |
P61077 |
0.66 |
|
UBE2E1 |
7324 |
P51965 |
0.70 |
|
BAG1 |
573 |
Q99933 |
0.73 |
|
GEM |
2669 |
P55040 |
0.73 |
|
PSMA1 |
5682 |
P25786 |
0.73 |
|
TROAP |
10024 |
Q12815 |
0.73 |
|
ZNF581 |
51545 |
Q9P0T4 |
0.73 |
|
C19orf57 |
79173 |
Q0VDD7 |
0.73 |
|
TRIM23 |
373 |
P36406 |
0.86 |
|
E2F3 |
1871 |
O00716 |
0.07 |
|
TRIM28 |
10155 |
Q13263 |
0.49 |
|
FAM193B |
54540 |
Q96PV7 |
0.49 |
|
TRIM6 |
117854 |
Q9C030 |
0.49 |
|
SLC25A6 |
293 |
P12236 |
0.63 |
|
AQP1 |
358 |
P29972 |
0.63 |
|
ARF6 |
382 |
P62330 |
0.63 |
|
FHIT |
2272 |
P49789 |
0.63 |
|
MDM2 |
4193 |
Q00987 |
0.63 |
|
MLH1 |
4292 |
P40692 |
0.63 |
|
PITX1 |
5307 |
P78337 |
0.63 |
|
ATXN7 |
6314 |
O15265 |
0.63 |
|
MKRN3 |
7681 |
Q13064 |
0.63 |
|
IKBKG |
8517 |
Q9Y6K9 |
0.63 |
|
USP2 |
9099 |
O75604 |
0.63 |
|
FXR2 |
9513 |
P51116 |
0.63 |
|
ARNT2 |
9915 |
Q9HBZ2 |
0.63 |
|
TRAIP |
10293 |
Q9BWF2 |
0.63 |
|
TRIM31 |
11074 |
Q9BZY9 |
0.63 |
|
POLI |
11201 |
Q9UNA4 |
0.63 |
|
UBOX5 |
22888 |
O94941 |
0.63 |
|
TRIM32 |
22954 |
Q13049 |
0.63 |
|
IQCE |
23288 |
Q6IPM2 |
0.63 |
|
USP21 |
27005 |
Q9UK80 |
0.63 |
|
BAZ2B |
29994 |
Q9UIF8 |
0.63 |
|
AKTIP |
64400 |
Q9H8T0 |
0.63 |
|
RNF34 |
80196 |
Q969K3 |
0.63 |
|
RNF32 |
140545 |
Q9H0A6 |
0.63 |
|
GLIDR |
389741 |
N/A |
0.63 |
|
CYTH1 |
9267 |
Q15438 |
0.68 |
|
COX5B |
1329 |
P10606 |
0.73 |
|
TRIM27 |
5987 |
P14373 |
0.73 |
|
TRIM29 |
23650 |
Q14134 |
0.73 |
|
UBE2I |
7329 |
P63279 |
0.74 |