Protein Description

Gene Symbol MKLN1
Entrez ID 4289
Uniprot ID Q9UL63
Description muskelin 1
Chromosomal Location chr7: 131,110,096-131,496,636
Ontology GO ID GO Term Definition Evidence

BP

GO:0007160

cell-matrix adhesion

The binding of a cell to the extracellular matrix via adhesion molecules.

ISS

BP

GO:0007165

signal transduction

The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

NAS

BP

GO:0008360

regulation of cell shape

Any process that modulates the surface configuration of a cell.

ISS

BP

GO:0031532

actin cytoskeleton reorganization

A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins.

ISS

CC

GO:0001726

ruffle

Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.

ISS

CC

GO:0005829

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

ISS

CC

GO:0005938

cell cortex

The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.

ISS

Domain ID Description

IPR006594

LIS1 homology motif

IPR006595

CTLH, C-terminal LisH motif

IPR006652

Kelch repeat type 1

IPR008979

Galactose-binding domain-like

IPR010565

Muskelin, N-terminal

IPR011043

Galactose oxidase/kelch, beta-propeller

IPR015915

Kelch-type beta propeller

IPR015916

Galactose oxidase, beta-propeller

No pathways found.

No diseases found.

Tissue Cell Type

appendix

glandular cells

caudate

neuronal cells

cerebellum

cells in granular layer

cerebellum

Purkinje cells

cerebral cortex

neuropil

colon

glandular cells

duodenum

glandular cells

gallbladder

glandular cells

kidney

cells in tubules

parathyroid gland

glandular cells

stomach

glandular cells

No databases found.

Pubmed ID Author Year Title

22617121

Ouandaogo et al.

2012

Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

22951915

Haozi et al.

2012

Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

Gene Symbol Entrez ID Uniprot ID Score

NUDCD2

134492

Q8WVJ2

0.49

MKLN1

4289

Q9UL63

0.63

MAEA

10296

Q7L5Y9

0.63

GID8

54994

Q9NWU2

0.68

RMND5A

64795

Q9H871

0.73

ADCYAP1

116

P18509

0.63

ELAVL1

1994

Q15717

0.63

GDNF

2668

P39905

0.63

GPS2

2874

Q13227

0.63

HLA-DPB1

3115

P04440

0.63

MMP7

4316

P09237

0.63

PRG2

5553

P13727

0.63

SFRP2

6423

Q96HF1

0.63

SOX2

6657

P48431

0.63

TDGF1

6997

P13385

0.63

GGH

8836

Q92820

0.63

NR1H3

10062

Q13133

0.63

IFI30

10437

P13284

0.63

LAMTOR5

10542

O43504

0.63

ARMC8

25852

Q8IUR7

0.63

MRPL4

51073

Q9BYD3

0.63

SLX4

84464

Q8IY92

0.63

UNK

85451

Q9C0B0

0.63

GLIPR1L2

144321

Q4G1C9

0.63

PTGER3

5733

P43115

0.68

DYNC1H1

1778

Q14204

0.72

MYC

4609

P01106

0.76

RNPS1

10921

Q15287

0.76

RANBP9

10048

Q96S59

0.87