PCOSBase

Protein Description

Gene Symbol	MET
Entrez ID	4233
Uniprot ID	P08581
Description	MET proto-oncogene, receptor tyrosine kinase
Chromosomal Location	chr7: 116,672,390-116,798,386

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Ontology	GO ID	GO Term	Definition	Evidence
BP	GO:0001886	endothelial cell morphogenesis	The change in form (cell shape and size) that occurs during the differentiation of an endothelial cell.	IDA
BP	GO:0007165	signal transduction	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.	TAS
BP	GO:0007166	cell surface receptor signaling pathway	A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.	NAS
BP	GO:0008283	cell proliferation	The multiplication or reproduction of cells, resulting in the expansion of a cell population.	TAS
BP	GO:0010507	negative regulation of autophagy	Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.	NAS
BP	GO:0018108	peptidyl-tyrosine phosphorylation	The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.	IEA
BP	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.	IDA
BP	GO:0048012	hepatocyte growth factor receptor signaling pathway	The series of molecular signals generated as a consequence of the hepatocyte growth factor receptor binding to one of its physiological ligands.	IEA
BP	GO:0048754	branching morphogenesis of an epithelial tube	The process in which the anatomical structures of branches in an epithelial tube are generated and organized. A tube is a long hollow cylinder.	IMP
BP	GO:0050918	positive chemotaxis	The directed movement of a motile cell or organism towards a higher concentration of a chemical.	IDA
BP	GO:0071526	semaphorin-plexin signaling pathway	A series of molecular signals generated as a consequence of a semaphorin receptor (composed of a plexin and a neurophilin) binding to a semaphorin ligand.	IDA
BP	GO:1901299	negative regulation of hydrogen peroxide-mediated programmed cell death	Any process that stops, prevents or reduces the frequency, rate or extent of hydrogen peroxide-mediated programmed cell death.	IMP
BP	GO:2001028	positive regulation of endothelial cell chemotaxis	Any process that activates or increases the frequency, rate or extent of endothelial cell chemotaxis.	IMP
CC	GO:0005576	extracellular region	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.	IEA
CC	GO:0005886	plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.	TAS
CC	GO:0005887	integral component of plasma membrane	The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.	TAS
CC	GO:0009925	basal plasma membrane	The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.	IDA
CC	GO:0009986	cell surface	The external part of the cell wall and/or plasma membrane.	IDA
CC	GO:0016021	integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.	NAS
MF	GO:0004713	protein tyrosine kinase activity	Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.	NAS\|TAS
MF	GO:0005008	hepatocyte growth factor-activated receptor activity	Combining with hepatocyte growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity.	TAS
MF	GO:0005515	protein binding	Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).	IPI
MF	GO:0005524	ATP binding	Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.	IEA
MF	GO:0019903	protein phosphatase binding	Interacting selectively and non-covalently with any protein phosphatase.	IPI

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Domain ID	Description
IPR000719	Protein kinase domain
IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain
IPR001627	Sema domain
IPR002165	Plexin repeat
IPR002909	IPT domain
IPR008266	Tyrosine-protein kinase, active site
IPR011009	Protein kinase-like domain
IPR013783	Immunoglobulin-like fold
IPR014756	Immunoglobulin E-set
IPR015943	WD40/YVTN repeat-like-containing domain
IPR016201	PSI domain
IPR016244	Tyrosine-protein kinase, HGF/MSP receptor
IPR017441	Protein kinase, ATP binding site
IPR020635	Tyrosine-protein kinase, catalytic domain

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Pathway ID	Pathway Term	Pathway Source
hsa01521	EGFR tyrosine kinase inhibitor resistance	KEGG
hsa04014	Ras signaling pathway	KEGG
hsa04015	Rap1 signaling pathway	KEGG
hsa04060	Cytokine-cytokine receptor interaction	KEGG
hsa04144	Endocytosis	KEGG
hsa04151	PI3K-Akt signaling pathway	KEGG
hsa04360	Axon guidance	KEGG
hsa04510	Focal adhesion	KEGG
hsa04520	Adherens junction	KEGG
hsa05100	Bacterial invasion of epithelial cells	KEGG
hsa05120	Epithelial cell signaling in Helicobacter pylori infection	KEGG
hsa05144	Malaria	KEGG
hsa05200	Pathways in cancer	KEGG
hsa05202	Transcriptional misregulation in cancer	KEGG
hsa05205	Proteoglycans in cancer	KEGG
hsa05206	MicroRNAs in cancer	KEGG
hsa05211	Renal cell carcinoma	KEGG
hsa05218	Melanoma	KEGG
hsa05230	Central carbon metabolism in cancer	KEGG
WP313	Signaling of Hepatocyte Growth Factor Receptor	WikiPathways
WP306	Focal Adhesion	WikiPathways
WP366	TGF-beta Signaling Pathway	WikiPathways
WP2870	Extracellular vesicle-mediated signaling in recipient cells	WikiPathways
WP2261	Signaling Pathways in Glioblastoma	WikiPathways
WP3932	Focal Adhesion-PI3K-Akt-mTOR-signaling pathway	WikiPathways
h_cblPathway	CBL mediated ligand-induced downregulation of EGF receptors	BioCarta
h_metPathway	Signaling of Hepatocyte Growth Factor Receptor	BioCarta

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UMLS CUI	UMLS Term
C0001418	Adenocarcinoma
C0004352	Autistic Disorder
C0007131	Non-Small Cell Lung Carcinoma
C0007134	Renal Cell Carcinoma
C0007137	Squamous Cell Carcinoma
C0009241	Cognition Disorders
C0014859	Esophageal Neoplasms
C0017636	Glioblastoma
C0019189	Hepatitis, Chronic
C0023467	Leukemia, Myelocytic, Acute
C0023904	Liver Neoplasms, Experimental
C0024121	Lung Neoplasms
C0027626	Neoplasm Invasiveness
C0027627	Neoplasm Metastasis
C0027672	Neoplastic Syndromes, Hereditary
C0027819	Neuroblastoma
C0029463	Osteosarcoma
C0036341	Schizophrenia
C0037199	Sinusitis
C0038356	Stomach Neoplasms
C0919267	Ovarian Neoplasm
C2239176	Liver Carcinoma

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Tissue	Cell Type
cerebral cortex	neuronal cells
cervix, uterine	glandular cells
duodenum	glandular cells
gallbladder	glandular cells
lung	macrophages
rectum	glandular cells
small intestine	glandular cells
soft tissue	peripheral nerve

Database Name
GWASdb

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No sources found.

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Gene Symbol	Entrez ID	Uniprot ID	Score
TNC	3371	P24821	0.00
NEDD4	4734	P46934	0.00
PDGFA	5154	P04085	0.00
PDGFB	5155	P01127	0.00
PIK3CB	5291	P42338	0.00
PIK3CG	5294	P48736	0.00
PLG	5340	P00747	0.00
SH3GL1	6455	Q99961	0.00
SP1	6667	P08047	0.00
VEGFA	7422	P15692	0.00
VEGFB	7423	P49765	0.00
VEGFC	7424	P49767	0.00
RNF41	10193	Q9H4P4	0.00
SEMA4D	10507	Q92854	0.00
RND1	27289	Q92730	0.00
SH3GLB1	51100	Q9Y371	0.00
PDGFC	56034	Q9NRA1	0.00
SMURF1	57154	Q9HCE7	0.00
PDGFD	80310	Q9GZP0	0.00
CNR1	1268	P21554	0.52
CTTN	2017	Q14247	0.55
DAPK3	1613	O43293	0.63
HSPA4	3308	P34932	0.63
SNX2	6643	O60749	0.63
VAV1	7409	P15498	0.63
SMC1A	8243	Q14683	0.63
STUB1	10273	Q9UNE7	0.63
PASK	23178	Q96RG2	0.63
SNAPIN	23557	O95295	0.63
CBLC	23624	Q9ULV8	0.63
PCBD2	84105	Q9H0N5	0.63
SPSB2	84727	Q99619	0.63
SPSB3	90864	Q6PJ21	0.63
SPSB4	92369	Q96A44	0.63
GGA3	23163	Q9NZ52	0.65
LAPTM4B	55353	Q86VI4	0.65
SPSB1	80176	Q96BD6	0.65
MET	4233	P08581	0.66
CASP3	836	P42574	0.68
DCN	1634	P07585	0.68
PKM	5315	P14618	0.68
PTPRC	5788	P08575	0.68
ABL2	27	P42684	0.72
BTK	695	Q06187	0.72
FES	2242	P07332	0.72
FGR	2268	P09769	0.72
GRB7	2886	Q14451	0.72
HCK	3055	P08631	0.72
ITK	3702	Q08881	0.72
MATK	4145	P42679	0.72
PLCG2	5336	P16885	0.72
PLXNB3	5365	Q9ULL4	0.72
RASA1	5921	P20936	0.72
SH3BP2	6452	P78314	0.72
SOS1	6654	Q07889	0.72
SYK	6850	P43405	0.72
TNS1	7145	Q9HBL0	0.72
VAV2	7410	P52735	0.72
YES1	7525	P07947	0.72
ZAP70	7535	P43403	0.72
PIK3R3	8503	Q92569	0.72
SOCS2	8835	O14508	0.72
SOCS5	9655	O75159	0.72
SH2D3C	10044	Q8N5H7	0.72
TNS2	23371	Q63HR2	0.72
SH2B1	25970	Q9NRF2	0.72
STAP1	26228	Q9ULZ2	0.72
SHC3	53358	Q92529	0.72
SHD	56961	Q96IW2	0.72
TNS3	64759	Q68CZ2	0.72
HSH2D	84941	Q96JZ2	0.72
HSP90AA1	3320	P07900	0.73
STAT3	6774	P40763	0.73
PIK3R1	5295	P27986	0.83
PLCG1	5335	P19174	0.84
DNAJA3	9093	Q96EY1	0.85
CRK	1398	P46108	0.86
PTPN1	5770	P18031	0.88
GRB2	2885	P62993	0.90
HGF	3082	P14210	0.90
GAB1	2549	Q13480	0.95
CBLB	868	Q13191	0.00
CDC42	998	P60953	0.00
CRKL	1399	P46109	0.00
EGF	1950	P01133	0.00
FIGF	2277	O43915	0.00
IGF1	3479	P05019	0.00
MDM2	4193	Q00987	0.00
BCAR1	9564	P56945	0.00
EPN2	22905	O95208	0.00
EPN1	29924	Q9Y6I3	0.00
GNG12	55970	Q9UBI6	0.49
BAG1	573	Q99933	0.52
HGFAC	3083	Q04756	0.52
FAS	355	P25445	0.55
ITGB4	3691	P16144	0.62
CD44	960	P16070	0.63
HSP90AB1	3326	P08238	0.63
INPP5D	3635	Q92835	0.63
KDR	3791	P35968	0.63
LGALS9	3965	O00182	0.63
MUC1	4582	P15941	0.63
PCBP1	5093	Q15365	0.63
YWHAZ	7534	P63104	0.63
FBXO6	26270	Q9NRD1	0.63
CEACAM21	90273	Q3KPI0	0.63
MUC20	200958	Q8N307	0.67
PTPN3	5774	P26045	0.68
PTPN12	5782	Q05209	0.68
PTPRG	5793	P23470	0.68
PTPRK	5796	Q15262	0.68
PTPRO	5800	Q16827	0.68
PTPRB	5787	P23467	0.70
BLK	640	P51451	0.72
CDH1	999	P12830	0.72
GRB14	2888	Q14449	0.72
LCK	3932	P06239	0.72
LYN	4067	P07948	0.72
SH2D1A	4068	O60880	0.72
NCK1	4690	P16333	0.72
PIK3R2	5296	O00459	0.72
PTK6	5753	Q13882	0.72
SHB	6461	Q15464	0.72
TEC	7006	P42680	0.72
TXK	7294	P42681	0.72
BCAR3	8412	O75815	0.72
NCK2	8440	O43639	0.72
SOCS3	9021	O14543	0.72
SH2D2A	9047	Q9NP31	0.72
SOCS6	9306	O14544	0.72
GAB2	9846	Q9UQC2	0.72
SH2B3	10019	Q9UQQ2	0.72
VAV3	10451	Q9UKW4	0.72
SH2B2	10603	O14492	0.72
PLXNB2	23654	O15031	0.72
SHC2	25759	P98077	0.72
SH3KBP1	30011	Q96B97	0.72
SLA2	84174	Q9H6Q3	0.72
TNS4	84951	Q8IZW8	0.72
SH2D1B	117157	O14796	0.72
SHC4	399694	Q6S5L8	0.72
HGS	9146	O14964	0.76
RANBP9	10048	Q96S59	0.79
GLMN	11146	Q92990	0.79
RANBP10	57610	Q6VN20	0.79
CTNNB1	1499	P35222	0.83
LRIG1	26018	Q96JA1	0.83
EGFR	1956	P00533	0.85
SOCS1	8651	O15524	0.87
PTPN11	5781	Q06124	0.88
INPPL1	3636	O15357	0.89
PTPRJ	5795	Q12913	0.89
SHC1	6464	P29353	0.89
CBL	867	P22681	0.90
SRC	6714	P12931	0.90
PLXNB1	5364	O43157	0.92