Gene Symbol | MDK |
Entrez ID | 4192 |
Uniprot ID | P21741 |
Description | midkine (neurite growth-promoting factor 2) |
Chromosomal Location | chr11: 46,380,756-46,383,837 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0001662 |
behavioral fear response |
An acute behavioral change resulting from a perceived external threat. |
IEA |
BP |
GO:0007165 |
signal transduction |
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
NAS |
BP |
GO:0007219 |
Notch signaling pathway |
A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. |
TAS |
BP |
GO:0007399 |
nervous system development |
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state. |
NAS |
BP |
GO:0007614 |
short-term memory |
The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation. |
IEA |
BP |
GO:0009611 |
response to wounding |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism. |
ISS |
BP |
GO:0016477 |
cell migration |
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms. |
IEA |
BP |
GO:0021542 |
dentate gyrus development |
The process whose specific outcome is the progression of the dentate gyrus over time, from its formation to the mature structure. The dentate gyrus is one of two interlocking gyri of the hippocampus. It contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus. |
IEA |
BP |
GO:0021681 |
cerebellar granular layer development |
The process whose specific outcome is the progression of the cerebellar granule layer over time, from its formation to the mature structure. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer. |
IEA |
BP |
GO:0021987 |
cerebral cortex development |
The progression of the cerebral cortex over time from its initial formation until its mature state. The cerebral cortex is the outer layered region of the telencephalon. |
IEA |
BP |
GO:0030154 |
cell differentiation |
The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
NAS |
BP |
GO:0030325 |
adrenal gland development |
The process whose specific outcome is the progression of the adrenal gland over time, from its formation to the mature structure. This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the adrenal gland. In either case, this organ consists of two cells types, aminergic chromaffin cells and steroidogenic cortical cells. |
ISS |
BP |
GO:0030421 |
defecation |
The expulsion of feces from the rectum. |
IEA |
BP |
GO:0042493 |
response to drug |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease. |
IEA |
BP |
GO:0043524 |
negative regulation of neuron apoptotic process |
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons. |
IEA |
BP |
GO:0045893 |
positive regulation of transcription, DNA-templated |
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. |
IEA |
BP |
GO:0050795 |
regulation of behavior |
Any process that modulates the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. |
IEA |
BP |
GO:0051384 |
response to glucocorticoid |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects. |
IEA |
BP |
GO:0051781 |
positive regulation of cell division |
Any process that activates or increases the frequency, rate or extent of cell division. |
IEA |
CC |
GO:0005576 |
extracellular region |
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
TAS |
CC |
GO:0005737 |
cytoplasm |
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
IEA |
CC |
GO:0042995 |
cell projection |
A prolongation or process extending from a cell, e.g. a flagellum or axon. |
IEA |
MF |
GO:0008083 |
growth factor activity |
The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation. |
NAS |
MF |
GO:0008201 |
heparin binding |
Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues. |
IDA |
Domain ID | Description |
---|---|
IPR000762 |
Midkine heparin-binding growth factor |
IPR020089 |
Pleiotrophin/Midkine, N-terminal domain |
IPR020090 |
Pleiotrophin/Midkine, C-terminal domain |
IPR020091 |
Pleiotrophin/Midkine disulphide-rich domain |
IPR020092 |
Pleiotrophin/Midkine heparin-binding growth factor, conserved site |
UMLS CUI | UMLS Term |
---|---|
C0003469 |
Anxiety Disorders |
C0011881 |
Diabetic Nephropathy |
C0017638 |
Glioma |
C0025261 |
Memory Disorders |
Tissue | Cell Type |
---|---|
duodenum |
glandular cells |
small intestine |
glandular cells |
Pubmed ID | Author | Year | Title |
---|---|---|---|
12734205 |
Wood et al. |
2003 |
The Molecular Phenotype of Polycystic Ovary Syndrome (PCOS) Theca Cells and New Candidate PCOS Genes Defined by Microarray Analysis |
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
PTPRB |
5787 |
P23467 |
0.49 |
ALK |
238 |
Q9UM73 |
0.52 |
MDK |
4192 |
P21741 |
0.52 |
JAK1 |
3716 |
P23458 |
0.62 |
JAK2 |
3717 |
O60674 |
0.62 |
UBQLN4 |
56893 |
Q9NRR5 |
0.63 |
TSPAN1 |
10103 |
O60635 |
0.67 |
ACTG1 |
71 |
P63261 |
0.72 |
NCAM1 |
4684 |
P13591 |
0.72 |
NID1 |
4811 |
P14543 |
0.72 |
TUBA1A |
7846 |
Q71U36 |
0.72 |
NID2 |
22795 |
Q14112 |
0.72 |
TUBB2B |
347733 |
Q9BVA1 |
0.72 |
RPL18A |
6142 |
Q02543 |
0.73 |
LRP1 |
4035 |
Q07954 |
0.84 |
LRP2 |
4036 |
P98164 |
0.62 |
SDC4 |
6385 |
P31431 |
0.62 |
TGM1 |
7051 |
P22735 |
0.62 |
MAPK6 |
5597 |
Q16659 |
0.63 |
SDC1 |
6382 |
P18827 |
0.63 |
STAT1 |
6772 |
P42224 |
0.63 |
SDC3 |
9672 |
O75056 |
0.63 |
SRPK2 |
6733 |
P78362 |
0.70 |
NCL |
4691 |
P19338 |
0.86 |
PTPRZ1 |
5803 |
P23471 |
0.86 |