Protein Description

Gene Symbol MDK
Entrez ID 4192
Uniprot ID P21741
Description midkine (neurite growth-promoting factor 2)
Chromosomal Location chr11: 46,380,756-46,383,837
Ontology GO ID GO Term Definition Evidence

BP

GO:0001662

behavioral fear response

An acute behavioral change resulting from a perceived external threat.

IEA

BP

GO:0007165

signal transduction

The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

NAS

BP

GO:0007219

Notch signaling pathway

A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.

TAS

BP

GO:0007399

nervous system development

The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.

NAS

BP

GO:0007614

short-term memory

The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation.

IEA

BP

GO:0009611

response to wounding

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.

ISS

BP

GO:0016477

cell migration

The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.

IEA

BP

GO:0021542

dentate gyrus development

The process whose specific outcome is the progression of the dentate gyrus over time, from its formation to the mature structure. The dentate gyrus is one of two interlocking gyri of the hippocampus. It contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus.

IEA

BP

GO:0021681

cerebellar granular layer development

The process whose specific outcome is the progression of the cerebellar granule layer over time, from its formation to the mature structure. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer.

IEA

BP

GO:0021987

cerebral cortex development

The progression of the cerebral cortex over time from its initial formation until its mature state. The cerebral cortex is the outer layered region of the telencephalon.

IEA

BP

GO:0030154

cell differentiation

The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.

NAS

BP

GO:0030325

adrenal gland development

The process whose specific outcome is the progression of the adrenal gland over time, from its formation to the mature structure. This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the adrenal gland. In either case, this organ consists of two cells types, aminergic chromaffin cells and steroidogenic cortical cells.

ISS

BP

GO:0030421

defecation

The expulsion of feces from the rectum.

IEA

BP

GO:0042493

response to drug

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.

IEA

BP

GO:0043524

negative regulation of neuron apoptotic process

Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.

IEA

BP

GO:0045893

positive regulation of transcription, DNA-templated

Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.

IEA

BP

GO:0050795

regulation of behavior

Any process that modulates the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli.

IEA

BP

GO:0051384

response to glucocorticoid

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.

IEA

BP

GO:0051781

positive regulation of cell division

Any process that activates or increases the frequency, rate or extent of cell division.

IEA

CC

GO:0005576

extracellular region

The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

TAS

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

IEA

CC

GO:0042995

cell projection

A prolongation or process extending from a cell, e.g. a flagellum or axon.

IEA

MF

GO:0008083

growth factor activity

The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.

NAS

MF

GO:0008201

heparin binding

Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.

IDA

Domain ID Description

IPR000762

Midkine heparin-binding growth factor

IPR020089

Pleiotrophin/Midkine, N-terminal domain

IPR020090

Pleiotrophin/Midkine, C-terminal domain

IPR020091

Pleiotrophin/Midkine disulphide-rich domain

IPR020092

Pleiotrophin/Midkine heparin-binding growth factor, conserved site

No pathways found.

UMLS CUI UMLS Term

C0003469

Anxiety Disorders

C0011881

Diabetic Nephropathy

C0017638

Glioma

C0025261

Memory Disorders

Tissue Cell Type

duodenum

glandular cells

small intestine

glandular cells

No databases found.

Pubmed ID Author Year Title

12734205

Wood et al.

2003

The Molecular Phenotype of Polycystic Ovary Syndrome (PCOS) Theca Cells and New Candidate PCOS Genes Defined by Microarray Analysis

22951915

Haozi et al.

2012

Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

Gene Symbol Entrez ID Uniprot ID Score

PTPRB

5787

P23467

0.49

ALK

238

Q9UM73

0.52

MDK

4192

P21741

0.52

JAK1

3716

P23458

0.62

JAK2

3717

O60674

0.62

UBQLN4

56893

Q9NRR5

0.63

TSPAN1

10103

O60635

0.67

ACTG1

71

P63261

0.72

NCAM1

4684

P13591

0.72

NID1

4811

P14543

0.72

TUBA1A

7846

Q71U36

0.72

NID2

22795

Q14112

0.72

TUBB2B

347733

Q9BVA1

0.72

RPL18A

6142

Q02543

0.73

LRP1

4035

Q07954

0.84

LRP2

4036

P98164

0.62

SDC4

6385

P31431

0.62

TGM1

7051

P22735

0.62

MAPK6

5597

Q16659

0.63

SDC1

6382

P18827

0.63

STAT1

6772

P42224

0.63

SDC3

9672

O75056

0.63

SRPK2

6733

P78362

0.70

NCL

4691

P19338

0.86

PTPRZ1

5803

P23471

0.86