Protein Description

Gene Symbol MCM2
Entrez ID 4171
Uniprot ID P49736
Description minichromosome maintenance complex component 2
Chromosomal Location chr3: 127,598,223-127,622,436
Ontology GO ID GO Term Definition Evidence

BP

GO:0000082

G1/S transition of mitotic cell cycle

The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated.

TAS

BP

GO:0006260

DNA replication

The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.

TAS

BP

GO:0006268

DNA unwinding involved in DNA replication

The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication.

IEA

BP

GO:0006270

DNA replication initiation

The process in which DNA-dependent DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action.

IMP

BP

GO:0006334

nucleosome assembly

The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA.

IEA

BP

GO:0007049

cell cycle

The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.

TAS

BP

GO:0071353

cellular response to interleukin-4

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-4 stimulus.

IEA

CC

GO:0000784

nuclear chromosome, telomeric region

The terminal region of a linear nuclear chromosome that includes the telomeric DNA repeats and associated proteins.

IDA

CC

GO:0000785

chromatin

The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.

IDA

CC

GO:0005634

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

IDA

CC

GO:0005654

nucleoplasm

That part of the nuclear content other than the chromosomes or the nucleolus.

IDA|TAS

CC

GO:0005664

nuclear origin of replication recognition complex

A multisubunit complex that is located at the replication origins of a chromosome in the nucleus.

IEA

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

IDA

CC

GO:0015630

microtubule cytoskeleton

The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.

IDA

CC

GO:0042555

MCM complex

A hexameric protein complex required for the initiation and regulation of DNA replication.

IDA

MF

GO:0003677

DNA binding

Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

TAS

MF

GO:0003678

DNA helicase activity

Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix.

IEA

MF

GO:0003688

DNA replication origin binding

Interacting selectively and non-covalently with the DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally.

IEA

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0005524

ATP binding

Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

IEA

MF

GO:0019899

enzyme binding

Interacting selectively and non-covalently with any enzyme.

IEA

MF

GO:0042393

histone binding

Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity.

IEA

MF

GO:0046872

metal ion binding

Interacting selectively and non-covalently with any metal ion.

IEA

Domain ID Description

IPR001208

MCM domain

IPR008045

DNA replication licensing factor Mcm2

IPR012340

Nucleic acid-binding, OB-fold

IPR018525

Mini-chromosome maintenance, conserved site

IPR027417

P-loop containing nucleoside triphosphate hydrolase

IPR027925

MCM N-terminal domain

IPR031327

Mini-chromosome maintenance protein

IPR033762

MCM OB domain

Pathway ID Pathway Term Pathway Source

hsa03030

DNA replication

KEGG

hsa04110

Cell cycle

KEGG

WP466

DNA Replication

WikiPathways

WP45

G1 to S cell cycle control

WikiPathways

WP179

Cell Cycle

WikiPathways

h_mcmPathway

CDK Regulation of DNA Replication

BioCarta

UMLS CUI UMLS Term

C0009375

Colonic Neoplasms

Tissue Cell Type

bone marrow

hematopoietic cells

lymph node

germinal center cells

Database Name

DisGeNET

Pubmed ID Author Year Title

19141577

Kim et al.

2009

Transcriptional Profiling with a Pathway-Oriented Analysis Identifies Dysregulated Molecular Phenotypes in the Endometrium of Patients with Polycystic Ovary Syndrome

22617121

Ouandaogo et al.

2012

Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

Gene Symbol Entrez ID Uniprot ID Score

APP

351

P05067

0.56

ELL

8178

P55199

0.56

SF3B1

23451

O75533

0.59

ABCF1

23

Q8NE71

0.63

ACADVL

37

P49748

0.63

ACOX1

51

Q15067

0.63

ACP1

52

P24666

0.63

ACTA1

58

P68133

0.63

ACTA2

59

P62736

0.63

ACTC1

70

P68032

0.63

ACTG1

71

P63261

0.63

ACTG2

72

P63267

0.63

ACTN4

81

O43707

0.63

ACTN1

87

P12814

0.63

ADA

100

P00813

0.63

ADSL

158

P30566

0.63

AP2A1

160

O95782

0.63

AP2A2

161

O94973

0.63

AP2B1

163

P63010

0.63

AHCY

191

P23526

0.63

ALDH1A3

220

P47895

0.63

ALDOA

226

P04075

0.63

ALDOC

230

P09972

0.63

ANK3

288

Q12955

0.63

SLC25A4

291

P12235

0.63

SLC25A5

292

P05141

0.63

SLC25A6

293

P12236

0.63

ANXA1

301

P04083

0.63

ANXA2

302

P07355

0.63

ANXA2P2

304

A6NMY6

0.63

ARCN1

372

P48444

0.63

ARF4

378

P18085

0.63

ARG1

383

P05089

0.63

ATP5A1

498

P25705

0.63

ATP5B

506

P06576

0.63

ATP5C1

509

P36542

0.63

ATP5F1

515

P24539

0.63

ATP5O

539

P48047

0.63

AZGP1

563

P25311

0.63

BLMH

642

Q13867

0.63

DST

667

Q03001

0.63

BRDT

676

Q58F21

0.63

C1QBP

708

Q07021

0.63

C4A

720

P0C0L4

0.63

MRPL49

740

Q13405

0.63

CAD

790

P27708

0.63

CALM2

805

P62158

0.63

CALM3

808

P62158

0.63

CALR

811

P27797

0.63

CALU

813

O43852

0.63

CAPN1

823

P07384

0.63

CAPZA1

829

P52907

0.63

CAPZA2

830

P47755

0.63

CAPZB

832

P47756

0.63

CAT

847

P04040

0.63

SERPINH1

871

P50454

0.63

CCT6A

908

P40227

0.63

CDA

978

P32320

0.63

CDC42

998

P60953

0.63

CHD3

1107

Q12873

0.63

CLU

1191

P10909

0.63

TPP1

1200

O14773

0.63

CLTC

1213

Q00610

0.63

CNP

1267

P09543

0.63

COL8A1

1295

P27658

0.63

CPOX

1371

P36551

0.63

CRKL

1399

P46109

0.63

CS

1431

O75390

0.63

CSE1L

1434

P55060

0.63

CSK

1445

P41240

0.63

CSRP2

1466

Q16527

0.63

CSTA

1475

P01040

0.63

CSTB

1476

P04080

0.63

CTNNA1

1495

P35221

0.63

CTNNA2

1496

P26232

0.63

CTNNB1

1499

P35222

0.63

CTNND1

1500

O60716

0.63

CTNND2

1501

Q9UQB3

0.63

CTPS1

1503

P17812

0.63

DARS

1615

P14868

0.63

DDOST

1650

P39656

0.63

DDX1

1653

Q92499

0.63

DDX3X

1654

O00571

0.63

DDX5

1655

P17844

0.63

DDX6

1656

P26196

0.63

DHX9

1660

Q08211

0.63

DHX15

1665

O43143

0.63

DMD

1756

P11532

0.63

DYNC1H1

1778

Q14204

0.63

DOCK2

1794

Q92608

0.63

DPYSL2

1808

Q16555

0.63

DPYSL3

1809

Q14195

0.63

DSC1

1823

Q08554

0.63

DSC3

1825

Q14574

0.63

DSG1

1828

Q02413

0.63

DSP

1832

P15924

0.63

DUT

1854

P33316

0.63

EEF1A1

1915

P68104

0.63

EEF1A2

1917

Q05639

0.63

EEF1B2

1933

P24534

0.63

EEF1D

1936

P29692

0.63

EEF1G

1937

P26641

0.63

EEF2

1938

P13639

0.63

EIF4G1

1981

Q04637

0.63

EIF4G2

1982

P78344

0.63

EIF5A

1984

P63241

0.63

SERPINB1

1992

P30740

0.63

ENO1

2023

P06733

0.63

FBL

2091

P22087

0.63

EWSR1

2130

Q01844

0.63

FABP5

2171

Q01469

0.63

ACSL3

2181

O95573

0.63

FARSA

2193

Q9Y285

0.63

FASN

2194

P49327

0.63

FHL2

2274

Q14192

0.63

FKBP1A

2280

P62942

0.63

FKBP4

2288

Q02790

0.63

FLNA

2316

P21333

0.63

FLNB

2317

O75369

0.63

FLNC

2318

Q14315

0.63

FUS

2521

P35637

0.63

G6PD

2539

P11413

0.63

XRCC6

2547

P12956

0.63

GAPDH

2597

P04406

0.63

GART

2618

P22102

0.63

GDI2

2665

P50395

0.63

GFPT1

2673

Q06210

0.63

GJA3

2700

Q9Y6H8

0.63

GLS

2744

O94925

0.63

GLRX

2745

P35754

0.63

GLUD1

2746

P00367

0.63

GLUD2

2747

P49448

0.63

SFN

2810

P31947

0.63

GRB2

2885

P62993

0.63

PDIA3

2923

P30101

0.63

GSR

2936

P00390

0.63

GSTP1

2950

P09211

0.63

HIST1H1C

3006

P16403

0.63

HIST1H1E

3008

P10412

0.63

HIST1H1T

3010

P22492

0.63

HIST1H2AD

3013

P20671

0.63

H2AFX

3014

P16104

0.63

H2AFZ

3015

P0C0S5

0.63

HIST1H2BD

3017

P58876

0.63

HIST1H2BB

3018

P33778

0.63

H3F3A; H3F3B

3020

P84243

0.63

HIST1H1A

3024

Q02539

0.63

HSD17B10

3028

Q99714

0.63

HADHA

3030

P40939

0.63

HADHB

3032

P55084

0.63

HAL

3034

P42357

0.63

HARS

3035

P12081

0.63

HAS1

3036

Q92839

0.63

HBB

3043

P68871

0.63

HBD

3045

P02042

0.63

HBG1

3047

P69891

0.63

HBG2

3048

P69892

0.63

HDAC2

3066

Q92769

0.63

HNRNPA1

3178

P09651

0.63

HNRNPA2B1

3181

P22626

0.63

HNRNPAB

3182

Q99729

0.63

HNRNPC

3183

P07910

0.63

HNRNPD

3184

Q14103

0.63

HNRNPF

3185

P52597

0.63

HNRNPH1

3187

P31943

0.63

HNRNPH2

3188

P55795

0.63

HNRNPK

3190

P61978

0.63

HNRNPL

3191

P14866

0.63

HNRNPU

3192

Q00839

0.63

HPRT1

3251

P00492

0.63

PRMT1

3276

Q99873

0.63

DNAJA1

3301

P31689

0.63

HSPA1A

3303

P0DMV8

0.63

HSPA1B

3304

P0DMV9

0.63

HSPA1L

3305

P34931

0.63

HSPA2

3306

P54652

0.63

HSPA5

3309

P11021

0.63

HSPA6

3310

P17066

0.63

HSPA7

3311

P48741

0.63

HSPA8

3312

P11142

0.63

HSPA9

3313

P38646

0.63

HSPB1

3315

P04792

0.63

HSP90AA1

3320

P07900

0.63

HSPD1

3329

P10809

0.63

HSPG2

3339

P98160

0.63

IGHG1

3500

P01857

0.63

IGHG3

3502

P01860

0.63

IGHG4

3503

P01861

0.63

IL2RB

3560

P14784

0.63

ILF3

3609

Q12906

0.63

IMPDH2

3615

P12268

0.63

JUP

3728

P14923

0.63

KARS

3735

Q15046

0.63

KPNA1

3836

P52294

0.63

KPNB1

3837

Q14974

0.63

KPNA2

3838

P52292

0.63

KPNA5

3841

O15131

0.63

KRT2

3849

P35908

0.63

KRT5

3852

P13647

0.63

KRT6B

3854

P04259

0.63

KRT18

3875

P05783

0.63

KRT32

3882

Q14532

0.63

RPSA

3921

P08865

0.63

LDHA

3939

P00338

0.63

LDHB

3945

P07195

0.63

LGALS1

3956

P09382

0.63

LGALS3BP

3959

Q08380

0.63

LMNA

4000

P02545

0.63

LMNB1

4001

P20700

0.63

LYZ

4069

P61626

0.63

MAGOH

4116

P61326

0.63

MARS

4141

P56192

0.63

MAT2A

4144

P31153

0.63

MBD1

4152

Q9UIS9

0.63

ME2

4200

P23368

0.63

MAP3K1

4214

Q13233

0.63

MGST3

4259

O14880

0.63

MIF

4282

P14174

0.63

MKI67

4288

P46013

0.63

MPP3

4356

Q13368

0.63

MSN

4478

P26038

0.63

MTAP

4507

Q13126

0.63

MTHFD1

4522

P11586

0.63

MYH1

4619

P12882

0.63

MYH2

4620

Q9UKX2

0.63

MYH4

4622

Q9Y623

0.63

MYH6

4624

P13533

0.63

MYH8

4626

P13535

0.63

MYH9

4627

P35579

0.63

MYL6

4637

P60660

0.63

MYO9A

4649

B2RTY4

0.63

MYO9B

4650

Q13459

0.63

NACA

4666

Q13765

0.63

HNRNPM

4670

P52272

0.63

NAP1L1

4673

P55209

0.63

NEB

4703

P20929

0.63

NDUFS1

4719

P28331

0.63

RPL10A

4736

P62906

0.63

NEFM

4741

P07197

0.63

NEU2

4759

Q9Y3R4

0.63

SNU13

4809

P55769

0.63

NME1

4830

P15531

0.63

NME2

4831

P22392

0.63

NMT1

4836

P30419

0.63

CNOT4

4850

O95628

0.63

PNP

4860

P00491

0.63

NPM1

4869

P06748

0.63

OPA1

4976

O60313

0.63

P2RX4

5025

Q99571

0.63

P4HB

5034

P07237

0.63

PA2G4

5036

Q9UQ80

0.63

PABPC3

5042

Q9H361

0.63

PRDX1

5052

Q06830

0.63

PCBP1

5093

Q15365

0.63

PCBP2

5094

Q15366

0.63

PCMT1

5110

P22061

0.63

CHMP1A

5119

Q9HD42

0.63

PFDN2

5202

Q9UHV9

0.63

PFKP

5214

Q01813

0.63

PFN1

5216

P07737

0.63

PFN2

5217

P35080

0.63

PGK1

5230

P00558

0.63

SLC25A3

5250

Q00325

0.63

SERPINB6

5269

P35237

0.63

SERPINB8

5271

P50452

0.63

SERPINB9

5272

P50453

0.63

PIP

5304

P12273

0.63

PKM

5315

P14618

0.63

PKP1

5317

Q13835

0.63

PLEC

5339

Q15149

0.63

PPIA

5478

P62937

0.63

PPIB

5479

P23284

0.63

PPP2R1A

5518

P30153

0.63

PPP2R2A

5520

P63151

0.63

PPP2R2B

5521

Q00005

0.63

PRKAA1

5562

Q13131

0.63

MAPK3

5595

P27361

0.63

EIF2AK2

5610

P19525

0.63

PRSS3

5646

P35030

0.63

PSMA7

5688

O14818

0.63

PSMB1

5689

P20618

0.63

PSMB2

5690

P49721

0.63

PSMB3

5691

P49720

0.63

PSMB5

5693

P28074

0.63

PSMB6

5694

P28072

0.63

PSMD2

5708

Q13200

0.63

PSMD3

5709

O43242

0.63

PSME1

5720

Q06323

0.63

PSME2

5721

Q9UL46

0.63

PTBP1

5725

P26599

0.63

QSOX1

5768

O00391

0.63

PYGB

5834

P11216

0.63

PYGL

5836

P06737

0.63

PYGM

5837

P11217

0.63

QARS

5859

P47897

0.63

RANBP2

5903

P49792

0.63

RARS

5917

P54136

0.63

RBM3

5935

P98179

0.63

RCN2

5955

Q14257

0.63

RNH1

6050

P13489

0.63

ABCE1

6059

P61221

0.63

RPL3

6122

P39023

0.63

RPL5

6125

P46777

0.63

RPL7

6129

P18124

0.63

RPL7A

6130

P62424

0.63

RPL10

6134

P27635

0.63

RPL11

6135

P62913

0.63

RPL12

6136

P30050

0.63

RPL13

6137

P26373

0.63

RPL15

6138

P61313

0.63

RPL17

6139

P18621

0.63

RPL18

6141

Q07020

0.63

RPL18A

6142

Q02543

0.63

RPL22

6146

P35268

0.63

RPL23A

6147

P62750

0.63

RPL24

6152

P83731

0.63

RPL26

6154

P61254

0.63

RPL27

6155

P61353

0.63

RPL30

6156

P62888

0.63

RPL27A

6157

P46776

0.63

RPL28

6158

P46779

0.63

RPL31

6160

P62899

0.63

RPL32

6161

P62910

0.63

RPL34

6164

P49207

0.63

RPL35A

6165

P18077

0.63

RPL37A

6168

P61513

0.63

RPL38

6169

P63173

0.63

RPLP0

6175

P05388

0.63

RPLP2

6181

P05387

0.63

RPN1

6184

P04843

0.63

RPN2

6185

P04844

0.63

RPS3

6188

P23396

0.63

RPS3A

6189

P61247

0.63

RPS5

6193

P46782

0.63

RPS7

6201

P62081

0.63

RPS8

6202

P62241

0.63

RPS9

6203

P46781

0.63

RPS10

6204

P46783

0.63

RPS11

6205

P62280

0.63

RPS12

6206

P25398

0.63

RPS13

6207

P62277

0.63

RPS14

6208

P62263

0.63

RPS15A

6210

P62244

0.63

RPS16

6217

P62249

0.63

RPS17

6218

P08708

0.63

RPS18

6222

P62269

0.63

RPS19

6223

P39019

0.63

RPS20

6224

P60866

0.63

RPS23

6228

P62266

0.63

RPS25

6230

P62851

0.63

RPS26

6231

P62854

0.63

RPS27

6232

P42677

0.63

RPS27A

6233

P62979

0.63

RPS28

6234

P62857

0.63

RPS29

6235

P62273

0.63

S100A3

6274

P33764

0.63

S100A8

6279

P05109

0.63

S100A9

6280

P06702

0.63

S100A11

6282

P31949

0.63

SARS

6301

P49591

0.63

SERPINB3

6317

P29508

0.63

SEC13

6396

P55735

0.63

SET

6418

Q01105

0.63

SFPQ

6421

P23246

0.63

SRSF3

6428

P84103

0.63

SIAH1

6477

Q8IUQ4

0.63

SIAH2

6478

O43255

0.63

SLC1A5

6510

Q15758

0.63

SLC3A2

6520

P08195

0.63

SLC25A1

6576

P53007

0.63

FSCN1

6624

Q16658

0.63

SNRPA1

6627

P09661

0.63

SNRPD2

6633

P62316

0.63

SNRPD3

6634

P62318

0.63

SNX1

6642

Q13596

0.63

SRP14

6727

P37108

0.63

SRP68

6730

Q9UHB9

0.63

SRP72

6731

O76094

0.63

SSR4

6748

P51571

0.63

STAU1

6780

O95793

0.63

SYCP1

6847

Q15431

0.63

MAP3K7

6885

O43318

0.63

TARS

6897

P26639

0.63

TCEB2

6923

Q15370

0.63

TCP1

6950

P17987

0.63

PRDX2

7001

P32119

0.63

TGM1

7051

P22735

0.63

TGM2

7052

P21980

0.63

TGM3

7053

Q08188

0.63

TCHH

7062

Q07283

0.63

TKT

7086

P29401

0.63

TLN1

7094

Q9Y490

0.63

TPI1

7167

P60174

0.63

TPM3

7170

P06753

0.63

TPM4

7171

P67936

0.63

TPR

7175

P12270

0.63

HSP90B1

7184

P14625

0.63

CCT3

7203

P49368

0.63

DNAJC7

7266

Q99615

0.63

TTN

7273

Q8WZ42

0.63

TUBA4A

7277

P68366

0.63

TUBB2A

7280

Q13885

0.63

TUFM

7284

P49411

0.63

TXN

7295

P10599

0.63

UBA52

7311

P62987

0.63

UBB

7314

P0CG47

0.63

UBE2D1

7321

P51668

0.63

UBE2D2

7322

P62837

0.63

UBE2D3

7323

P61077

0.63

UBE2L3

7332

P68036

0.63

UGP2

7360

Q16851

0.63

UPP1

7378

Q16831

0.63

UQCRC1

7384

P31930

0.63

UTRN

7402

P46939

0.63

VCP

7415

P55072

0.63

EZR

7430

P15311

0.63

VIM

7431

P08670

0.63

XBP1

7494

P17861

0.63

XPO1

7514

O14980

0.63

XRCC5

7520

P13010

0.63

YWHAB

7529

P31946

0.63

YWHAE

7531

P62258

0.63

YWHAG

7532

P61981

0.63

YWHAH

7533

Q04917

0.63

YWHAZ

7534

P63104

0.63

ZNF142

7701

P52746

0.63

TRIM25

7706

Q14258

0.63

MOGS

7841

Q13724

0.63

TUBA1A

7846

Q71U36

0.63

TAF15

8148

Q92804

0.63

USP9X

8239

Q93008

0.63

PICALM

8301

Q13492

0.63

HIST1H2AJ

8331

Q99878

0.63

HIST1H2AC

8334

Q93077

0.63

HIST2H2AC

8338

Q16777

0.63

HIST1H2BC; HIST1H2BE; HIST1H2BF; HIST1H2BG; HIST1H2BI

8339

P62807

0.63

HIST1H2BL

8340

Q99880

0.63

HIST1H2BN

8341

Q99877

0.63

HIST1H2BM

8342

Q99879

0.63

HIST1H2BH

8345

Q93079

0.63

HIST1H2BO

8348

P23527

0.63

HIST2H2BE

8349

Q16778

0.63

SLC25A11

8402

Q02978

0.63

TAGLN2

8407

P37802

0.63

CUL4B

8450

Q13620

0.63

CUL4A

8451

Q13619

0.63

PKP4

8502

Q99569

0.63

AGPS

8540

O00116

0.63

YARS

8565

P54577

0.63

KHSRP

8570

Q92945

0.63

DDX3Y

8653

O15523

0.63

DYNLL1

8655

P63167

0.63

EIF3B

8662

P55884

0.63

EIF3C

8663

Q99613

0.63

EIF3D

8664

O15371

0.63

EIF3F

8665

O00303

0.63

RNMT

8731

O43148

0.63

PABPC4

8761

Q13310

0.63

DPM1

8813

O60762

0.63

IQGAP1

8826

P46940

0.63

GMPS

8833

P49915

0.63

GGH

8836

Q92820

0.63

FUBP1

8880

Q96AE4

0.63

CPNE3

8895

O75131

0.63

FUBP3

8939

Q96I24

0.63

HIST1H2BJ

8970

P06899

0.63

BUB3

9184

O43684

0.63

DDX21

9188

Q9NR30

0.63

VAPA

9218

Q9P0L0

0.63

NOLC1

9221

Q14978

0.63

TBRG4

9238

Q969Z0

0.63

UBE2L6

9246

O14933

0.63

PTER

9317

Q96BW5

0.63

RPL23

9349

P62829

0.63

CPNE6

9362

O95741

0.63

EEF1E1

9521

O43324

0.63

BAG4

9530

O95429

0.63

BAG2

9532

O95816

0.63

ATP5J2

9551

P56134

0.63

SEC22B

9554

O75396

0.63

GDA

9615

Q9Y2T3

0.63

TBKBP1

9755

A7MCY6

0.63

MLEC

9761

Q14165

0.63

SPCS2

9789

Q15005

0.63

TOMM70

9868

O94826

0.63

SEC16A

9919

O15027

0.63

KIF14

9928

Q15058

0.63

MVP

9961

Q14764

0.63

HDAC6

10013

Q9UBN7

0.63

PDCD6

10016

O75340

0.63

SLC17A4

10050

Q9Y2C5

0.63

FARSB

10056

Q9NSD9

0.63

ARPC4

10093

P59998

0.63

ACTR3

10096

P61158

0.63

LRPPRC

10128

P42704

0.63

PDIA6

10130

Q15084

0.63

G3BP1

10146

Q13283

0.63

SLC25A13

10165

Q9UJS0

0.63

DHRS2

10202

Q13268

0.63

HNRNPR

10236

O43390

0.63

PRSS16

10279

Q9NQE7

0.63

DNAJA2

10294

O60884

0.63

LANCL1

10314

O43813

0.63

TFG

10342

Q92734

0.63

NPM3

10360

O75607

0.63

TUBB3

10381

Q13509

0.63

TUBB4A

10382

P04350

0.63

TUBB4B

10383

P68371

0.63

MYL9

10398

P24844

0.63

RACK1

10399

P63244

0.63

SEC24B

10427

O95487

0.63

RBM14

10432

Q96PK6

0.63

TAB1

10454

Q15750

0.63

SEC23B

10483

Q15437

0.63

SEC23A

10484

Q15436

0.63

SYNCRIP

10492

O60506

0.63

DDX17

10521

Q92841

0.63

IPO7

10527

O95373

0.63

CCT7

10574

Q99832

0.63

CCT4

10575

P50991

0.63

CCT2

10576

P78371

0.63

PAICS

10606

P22234

0.63

MYL12A

10627

P19105

0.63

IGF2BP2

10644

Q9Y6M1

0.63

GNB5

10681

O14775

0.63

CCT6B

10693

Q92526

0.63

CCT8

10694

P50990

0.63

PTGES3

10728

Q15185

0.63

HSPH1

10808

Q92598

0.63

CLPX

10845

O76031

0.63

MAGED2

10916

Q9UNF1

0.63

SUB1

10923

P53999

0.63

PRDX3

10935

P30048

0.63

KDELR1

10945

P24390

0.63

STIP1

10963

P31948

0.63

CKAP4

10970

Q07065

0.63

YWHAQ

10971

P27348

0.63

GCN1

10985

Q92616

0.63

KDELR2

11014

P33947

0.63

KDELR3

11015

O43731

0.63

HNRNPUL1

11100

Q9BUJ2

0.63

PROSC

11212

O94903

0.63

LYPLA2

11313

O95372

0.63

PARK7

11315

Q99497

0.63

PHB2

11331

Q99623

0.63

CBX3

11335

Q13185

0.63

U2AF2

11338

P26368

0.63

XRN2

22803

Q9H0D6

0.63

COPG1

22820

Q9Y678

0.63

PUF60

22827

Q9UHX1

0.63

FASTKD2

22868

Q9NYY8

0.63

CCT5

22948

P48643

0.63

TRIM32

22954

Q13049

0.63

RAB21

23011

Q9UL25

0.63

SNRNP200

23020

O75643

0.63

PALLD

23022

Q8WX93

0.63

ERP44

23071

Q9BS26

0.63

TAB2

23118

Q9NYJ8

0.63

GANAB

23193

Q14697

0.63

FAM168A

23201

Q92567

0.63

FBXO28

23219

Q9NVF7

0.63

SCFD1

23256

Q8WVM8

0.63

FKBP15

23307

Q5T1M5

0.63

SYNE1

23345

Q8NF91

0.63

UBR4

23352

Q5T4S7

0.63

COTL1

23406

Q14019

0.63

TARDBP

23435

Q13148

0.63

SEC11A

23478

P67812

0.63

MACF1

23499

Q9UPN3

0.63

RPL13A

23521

P40429

0.63

DNPEP

23549

Q9ULA0

0.63

CASP14

23581

P31944

0.63

CARHSP1

23589

Q9Y2V2

0.63

KPNA6

23633

O60684

0.63

NUP62

23636

P37198

0.63

UBBP4

23666

N/A

0.63

SDF2L1

23753

Q9HCN8

0.63

MTCH2

23788

Q9Y6C9

0.63

ZNF318

24149

Q5VUA4

0.63

FAM98A

25940

Q8NCA5

0.63

SPATS2L

26010

Q9NUQ6

0.63

PTCD1

26024

O75127

0.63

GIGYF2

26058

Q6Y7W6

0.63

POLDIP2

26073

Q9Y2S7

0.63

SERBP1

26135

Q8NC51

0.63

PHGDH

26227

O43175

0.63

FBXO3

26273

Q9UK99

0.63

AGO1

26523

Q9UL18

0.63

COPG2

26958

Q9UBF2

0.63

CHORDC1

26973

Q9UHD1

0.63

PABPC1

26986

P11940

0.63

SND1

27044

Q7KZF4

0.63

CPNE7

27132

Q9UBL6

0.63

RBMX

27316

P38159

0.63

STK39

27347

Q9UEW8

0.63

APOBEC3C

27350

Q9NRW3

0.63

MAT2B

27430

Q9NZL9

0.63

TBK1

29110

Q9UHD2

0.63

EHD4

30844

Q9H223

0.63

RRM2B

50484

Q7LG56

0.63

UBXN1

51035

Q04323

0.63

RPS27L

51065

Q71UM5

0.63

NOSIP

51070

Q9Y314

0.63

RPL26L1

51121

Q9UNX3

0.63

SLC22A17

51310

Q8WUG5

0.63

EIF3L

51386

Q9Y262

0.63

SNX9

51429

Q9Y5X1

0.63

YTHDF2

51441

Q9Y5A9

0.63

UBE2D4

51619

Q9Y2X8

0.63

C14orf166

51637

Q9Y224

0.63

FAM96B

51647

Q9Y3D0

0.63

RSF1

51773

Q96T23

0.63

CALML5

51806

Q9NZT1

0.63

MYO3A

53904

Q8NEV4

0.63

H2BFS

54145

P57053

0.63

DNAJC10

54431

Q8IXB1

0.63

TMCO1

54499

Q9UM00

0.63

YTHDF1

54915

Q9BYJ9

0.63

MAGOHB

55110

Q96A72

0.63

TMEM33

55161

P57088

0.63

ATAD3A

55210

Q9NVI7

0.63

CPPED1

55313

Q9BRF8

0.63

TCP11L1

55346

Q9NUJ3

0.63

LRRC59

55379

Q96AG4

0.63

NPLOC4

55666

Q8TAT6

0.63

DHX32

55760

Q7L7V1

0.63

H2AFJ

55766

Q9BTM1

0.63

PPP2R2D

55844

Q66LE6

0.63

LANCL2

55915

Q9NS86

0.63

RCC2

55920

Q9P258

0.63

IL36G

56300

Q9NZH8

0.63

NCLN

56926

Q969V3

0.63

ARNTL2

56938

Q8WYA1

0.63

PRDM8

56978

Q9NQV8

0.63

ACTR3B

57180

Q9P1U1

0.63

S100A14

57402

Q9HCY8

0.63

RNF213

57674

Q63HN8

0.63

SPCS3

60559

P61009

0.63

MMS19

64210

Q96T76

0.63

NOM1

64434

Q5C9Z4

0.63

CRTC3

64784

Q6UUV7

0.63

GNPNAT1

64841

Q96EK6

0.63

NT5DC2

64943

Q9H857

0.63

ZFP69B

65243

Q9UJL9

0.63

AHNAK

79026

Q09666

0.63

TMEM109

79073

Q9BVC6

0.63

DERL1

79139

Q9BUN8

0.63

C2orf47

79568

Q8WWC4

0.63

FN3KRP

79672

Q9HA64

0.63

ISOC2

79763

Q96AB3

0.63

MYH14

79784

Q7Z406

0.63

DCAKD

79877

Q8WVC6

0.63

PLEKHH3

79990

Q7Z736

0.63

TUBA4B

80086

Q9H853

0.63

CLPB

81570

Q9H078

0.63

KRTAP9-9

81870

Q9BYP9

0.63

EPPK1

83481

P58107

0.63

HMCN1

83872

Q96RW7

0.63

KRTAP3-2

83897

Q9BYR7

0.63

KRTAP9-2

83899

Q9BYQ4

0.63

KRTAP9-3

83900

Q9BYQ3

0.63

KRTAP9-8

83901

Q9BYQ0

0.63

HDAC10

83933

Q969S8

0.63

NUDT16L1

84309

Q9BRJ7

0.63

TUBB6

84617

Q9BUF5

0.63

MYPN

84665

Q86TC9

0.63

TUBA1C

84790

Q9BQE3

0.63

ABHD14B

84836

Q96IU4

0.63

PHF5A

84844

Q7RTV0

0.63

TNS4

84951

Q8IZW8

0.63

HIST1H2AH

85235

Q96KK5

0.63

HIST1H2BK

85236

O60814

0.63

KRTAP9-4

85280

Q9BYQ2

0.63

KRTAP3-3

85293

Q9BYR6

0.63

TNKS1BP1

85456

Q9C0C2

0.63

SERPINB12

89777

Q96P63

0.63

TIMM50

92609

Q3ZCQ8

0.63

HIST3H2A

92815

Q7L7L0

0.63

IMP4

92856

Q96G21

0.63

MUC16

94025

Q8WXI7

0.63

H2AFV

94239

Q71UI9

0.63

MYL12B

103910

O14950

0.63

TUBA3E

112714

Q6PEY2

0.63

DTX2

113878

Q86UW9

0.63

PHACTR3

116154

Q96KR7

0.63

DCD

117159

P81605

0.63

KRBA2

124751

Q6ZNG9

0.63

TRAPPC5

126003

Q8IUR0

0.63

HIST3H2BB

128312

Q8N257

0.63

CPNE4

131034

Q96A23

0.63

OCIAD2

132299

Q56VL3

0.63

MTPN

136319

P58546

0.63

DYNLL2

140735

Q96FJ2

0.63

RPL10L

140801

Q96L21

0.63

PSMA8

143471

Q8TAA3

0.63

CPNE8

144402

Q86YQ8

0.63

HNRNPA1L2

144983

Q32P51

0.63

FAM81A

145773

Q8TBF8

0.63

TTBK2

146057

Q6IQ55

0.63

ASPRV1

151516

Q53RT3

0.63

CPNE9

151835

Q8IYJ1

0.63

C8orf37

157657

Q96NL8

0.63

EEF1A1P5

158078

Q5VTE0

0.63

TTC39B

158219

Q5VTQ0

0.63

TDRD5

163589

Q8NAT2

0.63

DCP1B

196513

Q8IZD4

0.63

RPL22L1

200916

Q6P5R6

0.63

CMYA5

202333

Q8N3K9

0.63

TUBB

203068

P07437

0.63

ATAD3C

219293

Q5T2N8

0.63

RPLP0P6

220717

Q8NHW5

0.63

HNRNPA3

220988

P51991

0.63

CPNE2

221184

Q96FN4

0.63

HIST1H2AA

221613

Q96QV6

0.63

YTHDF3

253943

Q7Z739

0.63

SNX33

257364

Q8WV41

0.63

FAM98B

283742

Q52LJ0

0.63

GSDMA

284110

Q96QA5

0.63

VSIG8

284677

Q5VU13

0.63

IAH1

285148

Q2TAA2

0.63

RGPD4

285190

Q7Z3J3

0.63

HIST2H2AB

317772

Q8IUE6

0.63

KRTAP11-1

337880

Q8IUC1

0.63

SMTNL2

342527

Q2TAL5

0.63

NCCRP1

342897

Q6ZVX7

0.63

ACTBL2

345651

Q562R1

0.63

TUBB2B

347733

Q9BVA1

0.63

SBSN

374897

Q6UWP8

0.63

RPSAP58

388524

N/A

0.63

HRNR

388697

Q86YZ3

0.63

HSP90AB2P

391634

Q58FF8

0.63

RGPD1

400966

P0DJD0

0.63

RGS7BP

401190

Q6MZT1

0.63

USP17L1

401447

Q7RTZ2

0.63

C8orf82

414919

Q6P1X6

0.63

HIST2H3PS2

440686

N/A

0.63

HIST2H2BF

440689

Q5QNW6

0.63

RPS26P11

441502

Q5JNZ5

0.63

RBMXL1

494115

Q96E39

0.63

BOLA2

552900

Q9H3K6

0.63

RGPD3

653489

A6NKT7

0.63

RGPD8

727851

O14715

0.63

KRTAP9-1

728318

A8MXZ3

0.63

USP17L5

728386

A8MUK1

0.63

EIF3CL

728689

B5ME19

0.63

RGPD5

729540

Q99666

0.63

TDRD15

100129278

B5MCY1

0.63

TIMM23

100287932

O14925

0.63

C4B; C4B_2

721

P0C0L5

0.63

HIST1H2AB; HIST1H2AE

3012

P04908

0.63

LGALS7; LGALS7B

3963

P47929

0.63

RPL9; RPL9P7; RPL9P8; RPL9P9

6133

P32969

0.63

HIST1H2AG; HIST1H2AI; HIST1H2AK; HIST1H2AL; HIST1H2AM

8329

P0C0S8

0.63

TUBA3C; TUBA3D

113457

Q13748

0.63

HIST2H3A; HIST2H3C; HIST2H3D

126961

Q71DI3

0.63

HIST2H2AA3; HIST2H2AA4

723790

Q6FI13

0.63

CFL1

1072

P23528

0.70

EIF4A1

1973

P60842

0.70

EIF4A2

1974

Q14240

0.70

GLUL

2752

P15104

0.70

NARS

4677

O43776

0.70

MAPK1

5594

P28482

0.70

SKP1

6500

P63208

0.70

DSTN

11034

P60981

0.70

HEATR1

55127

Q9H583

0.70

NCL

4691

P19338

0.73

HIST1H3A

8350

P68431

0.73

CCNC

892

P24863

0.75

SNF8

11267

Q96H20

0.77

RPS4X

6191

P62701

0.82

MCMBP

79892

Q9BTE3

0.88

MCM2

4171

P49736

0.93

BUB1B

701

O60566

0.00

CHEK1

1111

O14757

0.00

POLR2A

5430

P24928

0.49

TCEA1

6917

P23193

0.49

CPSF7

79869

Q8N684

0.49

POC5

134359

Q8NA72

0.49

GTF2B

2959

Q00403

0.52

GTF2H1

2965

P32780

0.52

KAT7

11143

O95251

0.52

CPSF1

29894

Q10570

0.52

RAD52

5893

P43351

0.55

MCPH1

79648

Q8NEM0

0.56

ACLY

47

P53396

0.63

AIRE

326

O43918

0.63

APEX1

328

P27695

0.63

CCND1

595

P24385

0.63

CYP1A1

1543

P04798

0.63

EMD

2010

P50402

0.63

ESR1

2099

P03372

0.63

ESR2

2100

Q92731

0.63

ITGA4

3676

P13612

0.63

JUN

3725

P05412

0.63

MDM2

4193

Q00987

0.63

MGMT

4255

P16455

0.63

NTRK1

4914

P04629

0.63

POLA1

5422

P09884

0.63

RAD21

5885

O60216

0.63

CCL2

6347

P13500

0.63

CNTN2

6900

Q02246

0.63

SUMO1

7341

P63165

0.63

CCNA1

8900

P78396

0.63

IKBKE

9641

Q14164

0.63

KDM4A

9682

O75164

0.63

HDAC5

10014

Q9UQL6

0.63

HUWE1

10075

Q7Z6Z7

0.63

HYOU1

10525

Q9Y4L1

0.63

AHSA1

10598

O95433

0.63

SPIN1

10927

Q9Y657

0.63

FAF2

23197

Q96CS3

0.63

OBSL1

23363

O75147

0.63

MOB4

25843

Q9Y3A3

0.63

L3MBTL1

26013

Q9Y468

0.63

TIPIN

54962

Q9BVW5

0.63

CHFR

55743

Q96EP1

0.63

CAND1

55832

Q86VP6

0.63

TXNDC16

57544

Q9P2K2

0.63

GINS3

64785

Q9BRX5

0.63

CDT1

81620

Q9H211

0.63

CCDC8

83987

Q9H0W5

0.63

ATRIP

84126

Q8WXE1

0.63

PRRC1

133619

Q96M27

0.63

PYHIN1

149628

Q6K0P9

0.63

MMS22L

253714

Q6ZRQ5

0.63

SPIN2B

474343

Q9BPZ2

0.63

ATM

472

Q13315

0.65

ATR

545

Q13535

0.65

PLK1

5347

P53350

0.65

EP300

2033

Q09472

0.68

CDKN2A

1029

P42771

0.70

CSNK2A1

1457

P68400

0.70

CCNB2

9133

O95067

0.70

ORC6

23594

Q9Y5N6

0.70

FN1

2335

P02751

0.72

PRKAG1

5571

P54619

0.72

DDA1

79016

Q9BW61

0.72

UBA5

79876

Q9GZZ9

0.72

ING5

84289

Q8WYH8

0.72

PHC2

1912

Q8IXK0

0.73

HSP90AB1

3326

P08238

0.73

ILF2

3608

Q12905

0.73

PRKDC

5591

P78527

0.73

RPA2

6118

P15927

0.73

TERF1

7013

P54274

0.73

CAP1

10487

Q01518

0.73

ASF1A

25842

Q9Y294

0.73

HIST1H2BA

255626

Q96A08

0.73

SUMO2

6613

P61956

0.74

ASF1B

55723

Q9NVP2

0.74

CDK2

1017

P24941

0.75

TCEA2

6919

Q15560

0.75

TERF2IP

54386

Q9NYB0

0.75

CDC6

990

Q99741

0.76

BRCC3

79184

P46736

0.76

HIST3H3

8290

Q16695

0.77

ORC1

4998

Q13415

0.79

ORC4

5000

O43929

0.79

RPA3

6119

P35244

0.79

AKAP8

10270

O43823

0.79

CDK4

1019

P11802

0.80

CDK6

1021

Q00534

0.81

SSRP1

6749

Q08945

0.82

VCAM1

7412

P19320

0.82

TONSL

4796

Q96HA7

0.83

DBF4

10926

Q9UBU7

0.83

TBP

6908

P20226

0.85

HIST1H4A; HIST1H4B; HIST1H4C; HIST1H4D; HIST1H4E; HIST1H4F; HIST1H4H; HIST1H4I; HIST1H4J; HIST1H4K; HIST1H4L; HIST2H4A; HIST2H4B; HIST4H4

121504

P62805

0.86

MCM10

55388

Q7L590

0.87

RPA1

6117

P27694

0.91

ORC5

5001

O43913

0.94

CDC7

8317

O00311

0.95

ORC2

4999

Q13416

0.96

MCM3

4172

P25205

0.99

MCM5

4174

P33992

0.99

MCM7

4176

P33993

0.99

MCM4

4173

P33991

1.00

MCM6

4175

Q14566

1.00