Gene Symbol | CHST6 |
Entrez ID | 4166 |
Uniprot ID | Q9GZX3 |
Description | carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6 |
Chromosomal Location | chr16: 75,472,052-75,495,384 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0005975 |
carbohydrate metabolic process |
The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. |
IEA |
BP |
GO:0006044 |
N-acetylglucosamine metabolic process |
The chemical reactions and pathways involving N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein. |
IC|IDA |
BP |
GO:0006790 |
sulfur compound metabolic process |
The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione. |
IDA |
BP |
GO:0018146 |
keratan sulfate biosynthetic process |
The chemical reactions and pathways resulting in the formation of keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues. |
IDA|TAS |
CC |
GO:0000139 |
Golgi membrane |
The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
TAS |
CC |
GO:0005794 |
Golgi apparatus |
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. |
TAS |
CC |
GO:0016021 |
integral component of membrane |
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
IBA |
MF |
GO:0001517 |
N-acetylglucosamine 6-O-sulfotransferase activity |
Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-acetyl-D-glucosamine = adenosine 3',5'-bisphosphate + N-acetyl-D-glucosamine 6-sulfate. |
IDA|TAS |
Domain ID | Description |
---|---|
IPR000863 |
Sulfotransferase domain |
IPR016469 |
Carbohydrate sulfotransferase |
IPR027417 |
P-loop containing nucleoside triphosphate hydrolase |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
hsa00533 |
Glycosaminoglycan biosynthesis - keratan sulfate |
KEGG |
WP702 |
Metapathway biotransformation |
WikiPathways |
UMLS CUI | UMLS Term |
---|---|
C0024439 |
Macular Corneal Dystrophy |
Pubmed ID | Author | Year | Title |
---|---|---|---|
22904171 |
Kaur et al. |
2012 |
Differential Gene Expression in Granulosa Cells from Polycystic Ovary Syndrome Patients with and without Insulin Resistance: Identification of Susceptibility Gene Sets through Network Analysis |