| Gene Symbol | MAOA |
| Entrez ID | 4128 |
| Uniprot ID | P21397 |
| Description | monoamine oxidase A |
| Chromosomal Location | chrX: 43,654,907-43,746,824 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0006576 |
cellular biogenic amine metabolic process |
The chemical reactions and pathways occurring at the level of individual cells involving any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters. |
TAS |
|
BP |
GO:0042133 |
neurotransmitter metabolic process |
The chemical reactions and pathways involving neurotransmitters, any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. |
TAS |
|
BP |
GO:0042135 |
neurotransmitter catabolic process |
The chemical reactions and pathways resulting in the breakdown of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. |
IEA |
|
BP |
GO:0042420 |
dopamine catabolic process |
The chemical reactions and pathways resulting in the breakdown of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline. |
TAS |
|
BP |
GO:0055114 |
oxidation-reduction process |
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. |
IEA |
|
CC |
GO:0005739 |
mitochondrion |
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
IDA |
|
CC |
GO:0005741 |
mitochondrial outer membrane |
The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope. |
TAS |
|
CC |
GO:0016021 |
integral component of membrane |
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
IEA |
|
MF |
GO:0008131 |
primary amine oxidase activity |
Catalysis of the reaction: a primary amine + H2O + O2 = an aldehyde + NH3 + hydrogen peroxide. |
TAS |
| Domain ID | Description |
|---|---|
|
IPR001613 |
Flavin amine oxidase |
|
IPR002937 |
Amine oxidase |
|
IPR023753 |
FAD/NAD(P)-binding domain |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
|
hsa00260 |
Glycine, serine and threonine metabolism |
KEGG |
|
hsa00330 |
Arginine and proline metabolism |
KEGG |
|
hsa00340 |
Histidine metabolism |
KEGG |
|
hsa00350 |
Tyrosine metabolism |
KEGG |
|
hsa00360 |
Phenylalanine metabolism |
KEGG |
|
hsa00380 |
Tryptophan metabolism |
KEGG |
|
hsa00982 |
Drug metabolism - cytochrome P450 |
KEGG |
|
hsa01100 |
Metabolic pathways |
KEGG |
|
hsa04726 |
Serotonergic synapse |
KEGG |
|
hsa04728 |
Dopaminergic synapse |
KEGG |
|
hsa05030 |
Cocaine addiction |
KEGG |
|
hsa05031 |
Amphetamine addiction |
KEGG |
|
hsa05034 |
Alcoholism |
KEGG |
|
WP706 |
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways |
WikiPathways |
|
WP3298 |
Melatonin metabolism and effects |
WikiPathways |
|
WP1455 |
Serotonin Transporter Activity |
WikiPathways |
|
WP3925 |
Amino Acid metabolism |
WikiPathways |
|
WP2436 |
Dopamine metabolism |
WikiPathways |
|
WP408 |
Oxidative Stress |
WikiPathways |
|
WP550 |
Biogenic Amine Synthesis |
WikiPathways |
| UMLS CUI | UMLS Term |
|---|---|
|
C0003431 |
Antisocial Personality Disorder |
|
C0004352 |
Autistic Disorder |
|
C0004936 |
Mental Disorders |
|
C0014175 |
Endometriosis |
|
C0019151 |
Hepatic Encephalopathy |
|
C0020179 |
Huntington Disease |
|
C0020649 |
Hypotension |
|
C0026848 |
Myopathy |
|
C0030567 |
Parkinson Disease |
|
C0031511 |
Pheochromocytoma |
|
C0033054 |
Prenatal Exposure Delayed Effects |
|
C0745744 |
End Stage Liver Disease |
|
C1136249 |
Mental Retardation, X-Linked |
|
C1285261 |
Fetal Nutrition Disorders |
| Tissue | Cell Type |
|---|---|
|
adrenal gland |
glandular cells |
|
appendix |
glandular cells |
|
cerebral cortex |
endothelial cells |
|
colon |
glandular cells |
|
duodenum |
glandular cells |
|
endometrium |
glandular cells |
|
esophagus |
squamous epithelial cells |
|
fallopian tube |
glandular cells |
|
gallbladder |
glandular cells |
|
kidney |
cells in tubules |
|
lung |
pneumocytes |
|
nasopharynx |
respiratory epithelial cells |
|
ovary |
follicle cells |
|
pancreas |
exocrine glandular cells |
|
pancreas |
islets of Langerhans |
|
parathyroid gland |
glandular cells |
|
placenta |
decidual cells |
|
placenta |
trophoblastic cells |
|
prostate |
glandular cells |
|
rectum |
glandular cells |
|
salivary gland |
glandular cells |
|
seminal vesicle |
glandular cells |
|
small intestine |
glandular cells |
|
stomach |
glandular cells |
|
thyroid gland |
glandular cells |
|
urinary bladder |
urothelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
MAOA |
4128 |
P21397 |
0.52 |
|
A2M |
2 |
P01023 |
0.55 |
|
SLC25A5 |
292 |
P05141 |
0.55 |
|
ATP6V1B2 |
526 |
P21281 |
0.55 |
|
NDRG1 |
10397 |
Q92597 |
0.73 |