| Gene Symbol | MAOA |
| Entrez ID | 4128 |
| Uniprot ID | P21397 |
| Description | monoamine oxidase A |
| Chromosomal Location | chrX: 43,654,907-43,746,824 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
BP | GO:0006576 | cellular biogenic amine metabolic process |
The chemical reactions and pathways occurring at the level of individual cells involving any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters. | TAS |
BP | GO:0042133 | neurotransmitter metabolic process |
The chemical reactions and pathways involving neurotransmitters, any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. | TAS |
BP | GO:0042135 | neurotransmitter catabolic process |
The chemical reactions and pathways resulting in the breakdown of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. | IEA |
BP | GO:0042420 | dopamine catabolic process |
The chemical reactions and pathways resulting in the breakdown of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline. | TAS |
BP | GO:0055114 | oxidation-reduction process |
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. | IEA |
CC | GO:0005739 | mitochondrion |
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. | IDA |
CC | GO:0005741 | mitochondrial outer membrane |
The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope. | TAS |
CC | GO:0016021 | integral component of membrane |
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. | IEA |
MF | GO:0008131 | primary amine oxidase activity |
Catalysis of the reaction: a primary amine + H2O + O2 = an aldehyde + NH3 + hydrogen peroxide. | TAS |
| Domain ID | Description |
|---|---|
IPR001613 | Flavin amine oxidase |
IPR002937 | Amine oxidase |
IPR023753 | FAD/NAD(P)-binding domain |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
hsa00260 | Glycine, serine and threonine metabolism | KEGG |
hsa00330 | Arginine and proline metabolism | KEGG |
hsa00340 | Histidine metabolism | KEGG |
hsa00350 | Tyrosine metabolism | KEGG |
hsa00360 | Phenylalanine metabolism | KEGG |
hsa00380 | Tryptophan metabolism | KEGG |
hsa00982 | Drug metabolism - cytochrome P450 | KEGG |
hsa01100 | Metabolic pathways | KEGG |
hsa04726 | Serotonergic synapse | KEGG |
hsa04728 | Dopaminergic synapse | KEGG |
hsa05030 | Cocaine addiction | KEGG |
hsa05031 | Amphetamine addiction | KEGG |
hsa05034 | Alcoholism | KEGG |
WP706 | Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways | WikiPathways |
WP3298 | Melatonin metabolism and effects | WikiPathways |
WP1455 | Serotonin Transporter Activity | WikiPathways |
WP3925 | Amino Acid metabolism | WikiPathways |
WP2436 | Dopamine metabolism | WikiPathways |
WP408 | Oxidative Stress | WikiPathways |
WP550 | Biogenic Amine Synthesis | WikiPathways |
| UMLS CUI | UMLS Term |
|---|---|
C0003431 | Antisocial Personality Disorder |
C0004352 | Autistic Disorder |
C0004936 | Mental Disorders |
C0014175 | Endometriosis |
C0019151 | Hepatic Encephalopathy |
C0020179 | Huntington Disease |
C0020649 | Hypotension |
C0026848 | Myopathy |
C0030567 | Parkinson Disease |
C0031511 | Pheochromocytoma |
C0033054 | Prenatal Exposure Delayed Effects |
C0745744 | End Stage Liver Disease |
C1136249 | Mental Retardation, X-Linked |
C1285261 | Fetal Nutrition Disorders |
| Tissue | Cell Type |
|---|---|
adrenal gland | glandular cells |
appendix | glandular cells |
cerebral cortex | endothelial cells |
colon | glandular cells |
duodenum | glandular cells |
endometrium | glandular cells |
esophagus | squamous epithelial cells |
fallopian tube | glandular cells |
gallbladder | glandular cells |
kidney | cells in tubules |
lung | pneumocytes |
nasopharynx | respiratory epithelial cells |
ovary | follicle cells |
pancreas | exocrine glandular cells |
pancreas | islets of Langerhans |
parathyroid gland | glandular cells |
placenta | decidual cells |
placenta | trophoblastic cells |
prostate | glandular cells |
rectum | glandular cells |
salivary gland | glandular cells |
seminal vesicle | glandular cells |
small intestine | glandular cells |
stomach | glandular cells |
thyroid gland | glandular cells |
urinary bladder | urothelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
22951915 | Haozi et al. | 2012 | Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
MAOA | 4128 | P21397 | 0.52 |
A2M | 2 | P01023 | 0.55 |
SLC25A5 | 292 | P05141 | 0.55 |
ATP6V1B2 | 526 | P21281 | 0.55 |
NDRG1 | 10397 | Q92597 | 0.73 |