Protein Description

Gene Symbol MAN2A2
Entrez ID 4122
Uniprot ID P49641
Description mannosidase, alpha, class 2A, member 2
Chromosomal Location chr15: 90,902,218-90,922,584
Ontology GO ID GO Term Definition Evidence

BP

GO:0006013

mannose metabolic process

The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins.

IBA

BP

GO:0006491

N-glycan processing

The conversion of N-linked glycan (N = nitrogen) structures from the initially transferred oligosaccharide to a mature form, by the actions of glycosidases and glycosyltransferases. The early processing steps are conserved and play roles in glycoprotein folding and trafficking.

IBA

BP

GO:0006517

protein deglycosylation

The removal of sugar residues from a glycosylated protein.

IBA

CC

GO:0000139

Golgi membrane

The lipid bilayer surrounding any of the compartments of the Golgi apparatus.

IBA|TAS

CC

GO:0016021

integral component of membrane

The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

IEA

MF

GO:0004559

alpha-mannosidase activity

Catalysis of the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.

IBA

MF

GO:0004572

mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity

Catalysis of the hydrolysis of the terminal (1->3)- and (1->6)-linked alpha-D-mannose residues in the mannosyl-oligosaccharide Man(5)(GlcNAc)(3).

TAS

MF

GO:0008270

zinc ion binding

Interacting selectively and non-covalently with zinc (Zn) ions.

IEA

MF

GO:0016799

hydrolase activity, hydrolyzing N-glycosyl compounds

Catalysis of the hydrolysis of any N-glycosyl bond.

IEA

MF

GO:0030246

carbohydrate binding

Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates.

IEA

Domain ID Description

IPR000602

Glycoside hydrolase family 38, N-terminal domain

IPR011013

Galactose mutarotase-like domain

IPR011330

Glycoside hydrolase/deacetylase, beta/alpha-barrel

IPR011682

Glycosyl hydrolase family 38, C-terminal

IPR015341

Glycoside hydrolase family 38, central domain

IPR027291

Glycoside hydrolase 38/57, N-terminal domain

IPR028995

Glycoside hydrolase families 57/38, central domain

Pathway ID Pathway Term Pathway Source

hsa00510

N-Glycan biosynthesis

KEGG

hsa01100

Metabolic pathways

KEGG

h_eradPathway

ER�associated degradation (ERAD) Pathway

BioCarta

h_aMANpathway

Steps in the Glycosylation of Mammalian N-linked Oligosaccarides

BioCarta

UMLS CUI UMLS Term

C1263846

Attention Deficit Hyperactivity Disorder

Tissue Cell Type

caudate

neuronal cells

colon

glandular cells

duodenum

glandular cells

epididymis

glandular cells

lung

macrophages

seminal vesicle

glandular cells

small intestine

glandular cells

No databases found.

Pubmed ID Author Year Title

25393639

Ambekar et al.

2014

Proteomics of follicular fluid from women with polycystic ovary syndrome suggests molecular defects in follicular development

Gene Symbol Entrez ID Uniprot ID Score

CAPN2

824

P17655

0.49

CHD3

1107

Q12873

0.63

IKBKAP

8518

O95163

0.63

GIT1

28964

Q9Y2X7

0.63

LUC7L2

51631

Q9Y383

0.63

ENO3

2027

P13929

0.63

HLA-DRA

3122

P01903

0.63

HLA-E

3133

P13747

0.63

PLAUR

5329

Q03405

0.63

PTPRK

5796

Q15262

0.63

VIM

7431

P08670

0.63

FBXO6

26270

Q9NRD1

0.63

SUSD4

55061

Q5VX71

0.63

SLC39A4

55630

Q6P5W5

0.63

TMEM25

84866

Q86YD3

0.63

CLEC12A

160364

Q5QGZ9

0.63