Gene Symbol | MAN2A2 |
Entrez ID | 4122 |
Uniprot ID | P49641 |
Description | mannosidase, alpha, class 2A, member 2 |
Chromosomal Location | chr15: 90,902,218-90,922,584 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0006013 |
mannose metabolic process |
The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins. |
IBA |
BP |
GO:0006491 |
N-glycan processing |
The conversion of N-linked glycan (N = nitrogen) structures from the initially transferred oligosaccharide to a mature form, by the actions of glycosidases and glycosyltransferases. The early processing steps are conserved and play roles in glycoprotein folding and trafficking. |
IBA |
BP |
GO:0006517 |
protein deglycosylation |
The removal of sugar residues from a glycosylated protein. |
IBA |
CC |
GO:0000139 |
Golgi membrane |
The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
IBA|TAS |
CC |
GO:0016021 |
integral component of membrane |
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
IEA |
MF |
GO:0004559 |
alpha-mannosidase activity |
Catalysis of the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. |
IBA |
MF |
GO:0004572 |
mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity |
Catalysis of the hydrolysis of the terminal (1->3)- and (1->6)-linked alpha-D-mannose residues in the mannosyl-oligosaccharide Man(5)(GlcNAc)(3). |
TAS |
MF |
GO:0008270 |
zinc ion binding |
Interacting selectively and non-covalently with zinc (Zn) ions. |
IEA |
MF |
GO:0016799 |
hydrolase activity, hydrolyzing N-glycosyl compounds |
Catalysis of the hydrolysis of any N-glycosyl bond. |
IEA |
MF |
GO:0030246 |
carbohydrate binding |
Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. |
IEA |
Domain ID | Description |
---|---|
IPR000602 |
Glycoside hydrolase family 38, N-terminal domain |
IPR011013 |
Galactose mutarotase-like domain |
IPR011330 |
Glycoside hydrolase/deacetylase, beta/alpha-barrel |
IPR011682 |
Glycosyl hydrolase family 38, C-terminal |
IPR015341 |
Glycoside hydrolase family 38, central domain |
IPR027291 |
Glycoside hydrolase 38/57, N-terminal domain |
IPR028995 |
Glycoside hydrolase families 57/38, central domain |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
hsa00510 |
N-Glycan biosynthesis |
KEGG |
hsa01100 |
Metabolic pathways |
KEGG |
h_eradPathway |
ER�associated degradation (ERAD) Pathway |
BioCarta |
h_aMANpathway |
Steps in the Glycosylation of Mammalian N-linked Oligosaccarides |
BioCarta |
UMLS CUI | UMLS Term |
---|---|
C1263846 |
Attention Deficit Hyperactivity Disorder |
Tissue | Cell Type |
---|---|
caudate |
neuronal cells |
colon |
glandular cells |
duodenum |
glandular cells |
epididymis |
glandular cells |
lung |
macrophages |
seminal vesicle |
glandular cells |
small intestine |
glandular cells |
Pubmed ID | Author | Year | Title |
---|---|---|---|
25393639 |
Ambekar et al. |
2014 |
Proteomics of follicular fluid from women with polycystic ovary syndrome suggests molecular defects in follicular development |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
CAPN2 |
824 |
P17655 |
0.49 |
CHD3 |
1107 |
Q12873 |
0.63 |
IKBKAP |
8518 |
O95163 |
0.63 |
GIT1 |
28964 |
Q9Y2X7 |
0.63 |
LUC7L2 |
51631 |
Q9Y383 |
0.63 |
ENO3 |
2027 |
P13929 |
0.63 |
HLA-DRA |
3122 |
P01903 |
0.63 |
HLA-E |
3133 |
P13747 |
0.63 |
PLAUR |
5329 |
Q03405 |
0.63 |
PTPRK |
5796 |
Q15262 |
0.63 |
VIM |
7431 |
P08670 |
0.63 |
FBXO6 |
26270 |
Q9NRD1 |
0.63 |
SUSD4 |
55061 |
Q5VX71 |
0.63 |
SLC39A4 |
55630 |
Q6P5W5 |
0.63 |
TMEM25 |
84866 |
Q86YD3 |
0.63 |
CLEC12A |
160364 |
Q5QGZ9 |
0.63 |