Gene Symbol | SMAD3 |
Entrez ID | 4088 |
Uniprot ID | P84022 |
Description | SMAD family member 3 |
Chromosomal Location | chr15: 67,063,763-67,195,195 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
IDA|IMP|TAS |
BP |
GO:0001657 |
ureteric bud development |
The process whose specific outcome is the progression of the ureteric bud over time, from its formation to the mature structure. |
IEA |
BP |
GO:0001666 |
response to hypoxia |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. |
IMP |
BP |
GO:0001701 |
in utero embryonic development |
The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus. |
IEA |
BP |
GO:0001707 |
mesoderm formation |
The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts. |
IEA |
BP |
GO:0001756 |
somitogenesis |
The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo. |
IEA |
BP |
GO:0001889 |
liver development |
The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes. |
IEA |
BP |
GO:0001947 |
heart looping |
The tube morphogenesis process in which the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceding their future integration. Heart looping begins with dextral-looping and ends when the main regional divisions of the mature heart and primordium of the great arterial trunks become established preceeding septation. |
IEA |
BP |
GO:0002076 |
osteoblast development |
The process whose specific outcome is the progression of an osteoblast over time, from its formation to the mature structure. Osteoblast development does not include the steps involved in committing a cranial neural crest cell or an osteoprogenitor cell to an osteoblast fate. An osteoblast is a cell that gives rise to bone. |
IEA |
BP |
GO:0002520 |
immune system development |
The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process. |
IEA |
BP |
GO:0006351 |
transcription, DNA-templated |
The cellular synthesis of RNA on a template of DNA. |
IEA |
BP |
GO:0006357 |
regulation of transcription from RNA polymerase II promoter |
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
IDA |
BP |
GO:0006810 |
transport |
The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter, pore or motor protein. |
IDA |
BP |
GO:0006919 |
activation of cysteine-type endopeptidase activity involved in apoptotic process |
Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process. |
IMP |
BP |
GO:0006955 |
immune response |
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. |
IMP |
BP |
GO:0007050 |
cell cycle arrest |
A regulatory process that halts progression through the cell cycle during one of the normal phases (G1, S, G2, M). |
IMP |
BP |
GO:0007179 |
transforming growth factor beta receptor signaling pathway |
A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. |
IDA|TAS |
BP |
GO:0007183 |
SMAD protein complex assembly |
The aggregation, arrangement and bonding together of a set of components to form a protein complex that contains SMAD proteins. |
IDA |
BP |
GO:0007492 |
endoderm development |
The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues. |
IEA |
BP |
GO:0009880 |
embryonic pattern specification |
The process that results in the patterns of cell differentiation that will arise in an embryo. |
IEA |
BP |
GO:0010628 |
positive regulation of gene expression |
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form. |
IDA |
BP |
GO:0010694 |
positive regulation of alkaline phosphatase activity |
Any process that increases the frequency, rate or extent of alkaline phosphatase activity, the catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum. |
IEA |
BP |
GO:0010718 |
positive regulation of epithelial to mesenchymal transition |
Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition is where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. |
IDA|IMP |
BP |
GO:0016202 |
regulation of striated muscle tissue development |
Any process that modulates the frequency, rate or extent of striated muscle development. |
IEA |
BP |
GO:0017015 |
regulation of transforming growth factor beta receptor signaling pathway |
Any process that modulates the frequency, rate or extent of activity of any TGF-beta receptor signaling pathway. |
IMP |
BP |
GO:0019049 |
evasion or tolerance of host defenses by virus |
Any process, either active or passive, by which a virus avoids or tolerates the effects of its host organism's defense(s). Host defenses may be induced by the presence of the virus or may be preformed (e.g. physical barriers). The host is defined as the larger of the organisms involved in a symbiotic interaction. |
IDA |
BP |
GO:0023019 |
signal transduction involved in regulation of gene expression |
Any process that modulates the frequency, rate or extent of gene expression as a consequence of a process in which a signal is released and/or conveyed from one location to another. |
IEA |
BP |
GO:0030308 |
negative regulation of cell growth |
Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth. |
IDA |
BP |
GO:0030335 |
positive regulation of cell migration |
Any process that activates or increases the frequency, rate or extent of cell migration. |
IEA |
BP |
GO:0030501 |
positive regulation of bone mineralization |
Any process that activates or increases the frequency, rate or extent of bone mineralization. |
IEA |
BP |
GO:0030512 |
negative regulation of transforming growth factor beta receptor signaling pathway |
Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway. |
TAS |
BP |
GO:0030878 |
thyroid gland development |
The process whose specific outcome is the progression of the thyroid gland over time, from its formation to the mature structure. The thyroid gland is an endoderm-derived gland that produces thyroid hormone. |
IEA |
BP |
GO:0031053 |
primary miRNA processing |
Any process involved in the conversion of a primary microRNA transcript into a pre-microRNA molecule. |
TAS |
BP |
GO:0032332 |
positive regulation of chondrocyte differentiation |
Any process that activates or increases the frequency, rate or extent of chondrocyte differentiation. |
IEA |
BP |
GO:0032731 |
positive regulation of interleukin-1 beta production |
Any process that activates or increases the frequency, rate, or extent of interleukin-1 beta production. |
IEA |
BP |
GO:0032909 |
regulation of transforming growth factor beta2 production |
Any process that modulates the frequency, rate, or extent of production of transforming growth factor-beta2. |
IMP |
BP |
GO:0032916 |
positive regulation of transforming growth factor beta3 production |
Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta3. |
IEA |
BP |
GO:0032924 |
activin receptor signaling pathway |
A series of molecular signals initiated by the binding of an extracellular ligand to an activin receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. |
IMP |
BP |
GO:0033689 |
negative regulation of osteoblast proliferation |
Any process that stops, prevents or reduces the rate or extent of osteoblast proliferation. |
IEA |
BP |
GO:0035413 |
positive regulation of catenin import into nucleus |
Any process that increases the rate, frequency or extent of the directed movement of a catenin protein from the cytoplasm into the nucleus. |
IEA |
BP |
GO:0038092 |
nodal signaling pathway |
A series of molecular signals initiated by the binding of a nodal protein to an activin receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. |
IMP |
BP |
GO:0042060 |
wound healing |
The series of events that restore integrity to a damaged tissue, following an injury. |
TAS |
BP |
GO:0042110 |
T cell activation |
The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. |
IEA |
BP |
GO:0042177 |
negative regulation of protein catabolic process |
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. |
IEA |
BP |
GO:0042993 |
positive regulation of transcription factor import into nucleus |
Any process that activates or increases the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus. |
IDA |
BP |
GO:0043066 |
negative regulation of apoptotic process |
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. |
IEA |
BP |
GO:0045216 |
cell-cell junction organization |
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-cell junction. A cell-cell junction is a specialized region of connection between two cells. |
IMP |
BP |
GO:0045429 |
positive regulation of nitric oxide biosynthetic process |
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide. |
IDA |
BP |
GO:0045599 |
negative regulation of fat cell differentiation |
Any process that stops, prevents, or reduces the frequency, rate or extent of adipocyte differentiation. |
IDA |
BP |
GO:0045668 |
negative regulation of osteoblast differentiation |
Any process that stops, prevents, or reduces the frequency, rate or extent of osteoblast differentiation. |
IEA |
BP |
GO:0045893 |
positive regulation of transcription, DNA-templated |
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. |
IDA |
BP |
GO:0045930 |
negative regulation of mitotic cell cycle |
Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle. |
IMP |
BP |
GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
IDA|IMP|TAS |
BP |
GO:0048340 |
paraxial mesoderm morphogenesis |
The process in which the anatomical structures of the paraxial mesoderm are generated and organized. |
IEA |
BP |
GO:0048589 |
developmental growth |
The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another. |
IEA |
BP |
GO:0048617 |
embryonic foregut morphogenesis |
The process in which the anatomical structures of the foregut are generated and organized, during the embryonic phase. |
IEA |
BP |
GO:0048701 |
embryonic cranial skeleton morphogenesis |
The process in which the anatomical structures of the cranial skeleton are generated and organized during the embryonic phase. |
IEA |
BP |
GO:0050678 |
regulation of epithelial cell proliferation |
Any process that modulates the frequency, rate or extent of epithelial cell proliferation. |
IEA |
BP |
GO:0050728 |
negative regulation of inflammatory response |
Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response. |
IEA |
BP |
GO:0050776 |
regulation of immune response |
Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. |
IEA |
BP |
GO:0050821 |
protein stabilization |
Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation. |
IEA |
BP |
GO:0050927 |
positive regulation of positive chemotaxis |
Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical. |
IEA |
BP |
GO:0051098 |
regulation of binding |
Any process that modulates the frequency, rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule. |
IEA |
BP |
GO:0051481 |
negative regulation of cytosolic calcium ion concentration |
Any process that decreases the concentration of calcium ions in the cytosol. |
IDA |
BP |
GO:0051496 |
positive regulation of stress fiber assembly |
Any process that activates or increases the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts. |
IEA |
BP |
GO:0051894 |
positive regulation of focal adhesion assembly |
Any process that activates or increases the frequency, rate or extent of focal adhesion assembly, the establishment and maturation of focal adhesions. |
IEA |
BP |
GO:0060039 |
pericardium development |
The process whose specific outcome is the progression of the pericardium over time, from its formation to the mature structure. The pericardium is a double-walled sac that contains the heart and the roots of the aorta, vena cava and the pulmonary artery. |
IEA |
BP |
GO:0060070 |
canonical Wnt signaling pathway |
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes. |
IEA |
BP |
GO:0060290 |
transdifferentiation |
The conversion of a differentiated cell of one fate into a differentiated cell of another fate without first undergoing cell division or reversion to a more primitive or stem cell-like fate. |
IEA |
BP |
GO:0060395 |
SMAD protein signal transduction |
The cascade of processes by which a signal interacts with a receptor, causing a change in the activity of a SMAD protein, and ultimately effecting a change in the functioning of the cell. |
IEA |
BP |
GO:0061045 |
negative regulation of wound healing |
Any process that decreases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury. |
IEA |
BP |
GO:0070306 |
lens fiber cell differentiation |
The process in which a relatively unspecialized cell acquires specialized features of a lens fiber cell, any of the elongated, tightly packed cells that make up the bulk of the mature lens in the camera-type eye. The cytoplasm of a lens fiber cell is devoid of most intracellular organelles including the cell nucleus, and contains primarily crystallins, a group of water-soluble proteins expressed in vary large quantities. |
IEA |
BP |
GO:0097191 |
extrinsic apoptotic signaling pathway |
A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered. |
IMP |
BP |
GO:0097296 |
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway |
Any process that initiates the activity of an inactive cysteine-type endopeptidase involved in the apoptotic signaling pathway. |
IEA |
BP |
GO:1901203 |
positive regulation of extracellular matrix assembly |
Any process that activates or increases the frequency, rate or extent of extracellular matrix assembly. |
IDA |
BP |
GO:1902895 |
positive regulation of pri-miRNA transcription from RNA polymerase II promoter |
Any process that activates or increases the frequency, rate or extent of pri-miRNA transcription from RNA polymerase II promoter. |
IMP |
CC |
GO:0000790 |
nuclear chromatin |
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus. |
IDA |
CC |
GO:0005634 |
nucleus |
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
IDA |
CC |
GO:0005637 |
nuclear inner membrane |
The inner, i.e. lumen-facing, lipid bilayer of the nuclear envelope. |
IDA |
CC |
GO:0005654 |
nucleoplasm |
That part of the nuclear content other than the chromosomes or the nucleolus. |
IDA|TAS |
CC |
GO:0005667 |
transcription factor complex |
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription. |
IDA |
CC |
GO:0005737 |
cytoplasm |
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
IDA |
CC |
GO:0005829 |
cytosol |
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
TAS |
CC |
GO:0005886 |
plasma membrane |
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
IEA |
CC |
GO:0043235 |
receptor complex |
Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. |
IMP |
CC |
GO:0071141 |
SMAD protein complex |
A protein complex that consists of SMAD proteins; may be homomeric or heteromeric. |
IDA |
CC |
GO:0071144 |
SMAD2-SMAD3 protein complex |
A heteromeric SMAD protein complex that contains SMAD2 and SMAD3. |
IDA |
MF |
GO:0000978 |
RNA polymerase II core promoter proximal region sequence-specific DNA binding |
Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II. |
IDA |
MF |
GO:0000983 |
transcription factor activity, RNA polymerase II core promoter sequence-specific |
Interacting selectively and non-covalently with a specific DNA sequence in an RNA polymerase II (Pol II) core promoter, the region composed of the transcription start site and binding sites for transcription factors of the Pol II basal transcription machinery, in order to modulate transcription by Pol II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. |
IDA|IMP |
MF |
GO:0000987 |
core promoter proximal region sequence-specific DNA binding |
Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to the core promoter. The transcribed region might be described as a gene, cistron, or operon. |
IDA |
MF |
GO:0000988 |
transcription factor activity, protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well. |
IDA |
MF |
GO:0001102 |
RNA polymerase II activating transcription factor binding |
Interacting selectively and non-covalently with an RNA polymerase II transcription activating factor, a protein involved in positive regulation of transcription. |
IPI |
MF |
GO:0003700 |
transcription factor activity, sequence-specific DNA binding |
Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. |
IDA |
MF |
GO:0005160 |
transforming growth factor beta receptor binding |
Interacting selectively and non-covalently with the transforming growth factor beta receptor. |
IPI |
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
MF |
GO:0005518 |
collagen binding |
Interacting selectively and non-covalently with collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%). |
IEA |
MF |
GO:0008013 |
beta-catenin binding |
Interacting selectively and non-covalently with the beta subunit of the catenin complex. |
IEA |
MF |
GO:0008134 |
transcription factor binding |
Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription. |
IPI |
MF |
GO:0008270 |
zinc ion binding |
Interacting selectively and non-covalently with zinc (Zn) ions. |
IDA |
MF |
GO:0019901 |
protein kinase binding |
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. |
IPI |
MF |
GO:0019902 |
phosphatase binding |
Interacting selectively and non-covalently with any phosphatase. |
IPI |
MF |
GO:0030618 |
transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity |
A TGF-beta cytoplasmic mediator that is phosphorylated by a TGFbeta receptor and complexes with a common-partner mediator. The- heterocomplex translocates to the nucleus to regulate transcription. |
IDA |
MF |
GO:0031490 |
chromatin DNA binding |
Interacting selectively and non-covalently with DNA that is assembled into chromatin. |
IEA |
MF |
GO:0031625 |
ubiquitin protein ligase binding |
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins. |
IPI |
MF |
GO:0035326 |
enhancer binding |
Interacting selectively and non-covalently with an enhancer, a transcription regulatory region that is somewhat distal from the core promoter and which enhances transcription from that promoter. |
IC |
MF |
GO:0042803 |
protein homodimerization activity |
Interacting selectively and non-covalently with an identical protein to form a homodimer. |
IPI |
MF |
GO:0043130 |
ubiquitin binding |
Interacting selectively and non-covalently with ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation. |
IDA |
MF |
GO:0043425 |
bHLH transcription factor binding |
Interacting selectively and non-covalently with any of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways. |
IPI |
MF |
GO:0043565 |
sequence-specific DNA binding |
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. |
IDA |
MF |
GO:0044212 |
transcription regulatory region DNA binding |
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors. |
IDA |
MF |
GO:0046982 |
protein heterodimerization activity |
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer. |
IEA |
MF |
GO:0070410 |
co-SMAD binding |
Interacting selectively and non-covalently with a common mediator SMAD signaling protein. |
IPI |
MF |
GO:0070412 |
R-SMAD binding |
Interacting selectively and non-covalently with a receptor-regulated SMAD signaling protein. |
IPI |
Domain ID | Description |
---|---|
IPR001132 |
SMAD domain, Dwarfin-type |
IPR003619 |
MAD homology 1, Dwarfin-type |
IPR008984 |
SMAD/FHA domain |
IPR013019 |
MAD homology, MH1 |
IPR013790 |
Dwarfin |
IPR017855 |
SMAD domain-like |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
hsa04068 |
FoxO signaling pathway |
KEGG |
hsa04110 |
Cell cycle |
KEGG |
hsa04144 |
Endocytosis |
KEGG |
hsa04310 |
Wnt signaling pathway |
KEGG |
hsa04350 |
TGF-beta signaling pathway |
KEGG |
hsa04371 |
Apelin signaling pathway |
KEGG |
hsa04390 |
Hippo signaling pathway |
KEGG |
hsa04520 |
Adherens junction |
KEGG |
hsa04550 |
Signaling pathways regulating pluripotency of stem cells |
KEGG |
hsa04659 |
Th17 cell differentiation |
KEGG |
hsa04933 |
AGE-RAGE signaling pathway in diabetic complications |
KEGG |
hsa05142 |
Chagas disease (American trypanosomiasis) |
KEGG |
hsa05161 |
Hepatitis B |
KEGG |
hsa05166 |
HTLV-I infection |
KEGG |
hsa05200 |
Pathways in cancer |
KEGG |
hsa05210 |
Colorectal cancer |
KEGG |
hsa05212 |
Pancreatic cancer |
KEGG |
hsa05220 |
Chronic myeloid leukemia |
KEGG |
hsa05321 |
Inflammatory bowel disease (IBD) |
KEGG |
WP560 |
TGF-beta Receptor Signaling |
WikiPathways |
WP3859 |
TGF-B Signaling in Thyroid Cells for Epithelial-Mesenchymal Transition |
WikiPathways |
WP3646 |
Hepatitis C and Hepatocellular Carcinoma |
WikiPathways |
WP2324 |
AGE/RAGE pathway |
WikiPathways |
WP366 |
TGF-beta Signaling Pathway |
WikiPathways |
WP34 |
Ovarian Infertility Genes |
WikiPathways |
WP710 |
DNA Damage Response (only ATM dependent) |
WikiPathways |
WP236 |
Adipogenesis |
WikiPathways |
WP2870 |
Extracellular vesicle-mediated signaling in recipient cells |
WikiPathways |
WP2857 |
Mesodermal Commitment Pathway |
WikiPathways |
WP3850 |
Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling |
WikiPathways |
WP2853 |
Endoderm Differentiation |
WikiPathways |
WP615 |
Senescence and Autophagy in Cancer |
WikiPathways |
WP1971 |
Integrated Cancer Pathway |
WikiPathways |
WP179 |
Cell Cycle |
WikiPathways |
WP3874 |
Canonical and Non-Canonical TGF-B signaling |
WikiPathways |
WP138 |
Androgen receptor signaling pathway |
WikiPathways |
WP3668 |
Hypothesized Pathways in Pathogenesis of Cardiovascular Disease |
WikiPathways |
h_g1Pathway |
Cell Cycle: G1/S Check Point |
BioCarta |
h_nthiPathway |
NFkB activation by Nontypeable Hemophilus influenzae |
BioCarta |
h_tob1Pathway |
Role of Tob in T-cell activation |
BioCarta |
h_tgfbPathway |
TGF beta signaling pathway |
BioCarta |
UMLS CUI | UMLS Term |
---|---|
C0002949 |
Aneurysm, Dissecting |
C0003486 |
Aortic Aneurysm |
C0004096 |
Asthma |
C0010068 |
Coronary Heart Disease |
C0010346 |
Crohn Disease |
C0018621 |
Hay Fever |
C0021390 |
Inflammatory Bowel Diseases |
C0023267 |
Fibroid Tumor |
C0023890 |
Liver Cirrhosis |
C0023891 |
Liver Cirrhosis, Alcoholic |
C0029408 |
Degenerative Polyarthritis |
C0042138 |
Uterine Neoplasms |
C0376634 |
Craniofacial Abnormalities |
C0600519 |
Ventricular Remodeling |
C2697932 |
Loeys-Dietz Syndrome |
C3495559 |
Juvenile Arthritis |
Tissue | Cell Type |
---|---|
adrenal gland |
glandular cells |
appendix |
glandular cells |
bone marrow |
hematopoietic cells |
bronchus |
respiratory epithelial cells |
caudate |
neuronal cells |
cerebellum |
cells in molecular layer |
cerebral cortex |
neuronal cells |
cervix, uterine |
glandular cells |
cervix, uterine |
squamous epithelial cells |
colon |
glandular cells |
duodenum |
glandular cells |
endometrium |
glandular cells |
esophagus |
squamous epithelial cells |
fallopian tube |
glandular cells |
gallbladder |
glandular cells |
lung |
macrophages |
lymph node |
germinal center cells |
lymph node |
non-germinal center cells |
pancreas |
islets of Langerhans |
rectum |
glandular cells |
seminal vesicle |
glandular cells |
skin |
epidermal cells |
small intestine |
glandular cells |
soft tissue |
chondrocytes |
spleen |
cells in white pulp |
stomach |
glandular cells |
testis |
cells in seminiferous ducts |
testis |
Leydig cells |
tonsil |
germinal center cells |
tonsil |
squamous epithelial cells |
urinary bladder |
urothelial cells |
Database Name |
---|
GWASdb |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
SMAD7 |
4092 |
O15105 |
0.00 |
DVL2 |
1856 |
O14641 |
0.14 |
UBC |
7316 |
P0CG48 |
0.14 |
BMP7 |
655 |
P18075 |
0.52 |
GLI3 |
2737 |
P10071 |
0.52 |
TGFBR2 |
7048 |
P37173 |
0.52 |
MIR140 |
406932 |
N/A |
0.52 |
PAX8 |
7849 |
Q06710 |
0.55 |
AGL |
178 |
P35573 |
0.56 |
APP |
351 |
P05067 |
0.56 |
CRK |
1398 |
P46108 |
0.56 |
EIF4B |
1975 |
P23588 |
0.56 |
BPTF |
2186 |
Q12830 |
0.56 |
NF1 |
4763 |
P21359 |
0.56 |
NFIA |
4774 |
Q12857 |
0.56 |
ODC1 |
4953 |
P11926 |
0.56 |
PYGL |
5836 |
P06737 |
0.56 |
RANBP3 |
8498 |
Q9H6Z4 |
0.56 |
STUB1 |
10273 |
Q9UNE7 |
0.56 |
XPO6 |
23214 |
Q96QU8 |
0.56 |
SIN3A |
25942 |
Q96ST3 |
0.56 |
IL36RN |
26525 |
Q9UBH0 |
0.56 |
UCHL5 |
51377 |
Q9Y5K5 |
0.56 |
CCDC186 |
55088 |
Q7Z3E2 |
0.56 |
KLHL9 |
55958 |
Q9P2J3 |
0.56 |
JPH1 |
56704 |
Q9HDC5 |
0.56 |
RSPH3 |
83861 |
Q86UC2 |
0.56 |
TPM3 |
7170 |
P06753 |
0.59 |
VIM |
7431 |
P08670 |
0.59 |
WEE1 |
7465 |
P30291 |
0.59 |
NUP153 |
9972 |
P49790 |
0.59 |
ZDHHC4 |
55146 |
Q9NPG8 |
0.59 |
MYOD1 |
4654 |
P15172 |
0.62 |
PARP4 |
143 |
Q9UKK3 |
0.63 |
ANK3 |
288 |
Q12955 |
0.63 |
APOB |
338 |
P04114 |
0.63 |
BACH1 |
571 |
O14867 |
0.63 |
DDX3X |
1654 |
O00571 |
0.63 |
FLNA |
2316 |
P21333 |
0.63 |
XRCC6 |
2547 |
P12956 |
0.63 |
KAT2A |
2648 |
Q92830 |
0.63 |
GRB2 |
2885 |
P62993 |
0.63 |
CFH |
3075 |
P08603 |
0.63 |
NR4A1 |
3164 |
P22736 |
0.63 |
HNRNPK |
3190 |
P61978 |
0.63 |
HSPA1A |
3303 |
P0DMV8 |
0.63 |
HSPA1B |
3304 |
P0DMV9 |
0.63 |
ISL1 |
3670 |
P61371 |
0.63 |
LBP |
3929 |
P18428 |
0.63 |
SMAD5 |
4090 |
Q99717 |
0.63 |
MEOX2 |
4223 |
P50222 |
0.63 |
PAPPA |
5069 |
Q13219 |
0.63 |
PAX6 |
5080 |
P26367 |
0.63 |
PITX1 |
5307 |
P78337 |
0.63 |
PITX2 |
5308 |
Q99697 |
0.63 |
PLAG1 |
5324 |
Q6DJT9 |
0.63 |
PLAGL1 |
5325 |
Q9UM63 |
0.63 |
PLG |
5340 |
P00747 |
0.63 |
PROX1 |
5629 |
Q92786 |
0.63 |
PSMD11 |
5717 |
O00231 |
0.63 |
RCVRN |
5957 |
P35243 |
0.63 |
RELA |
5970 |
Q04206 |
0.63 |
SMARCA4 |
6597 |
P51532 |
0.63 |
SMARCC1 |
6599 |
Q92922 |
0.63 |
SMARCC2 |
6601 |
Q8TAQ2 |
0.63 |
SNRNP70 |
6625 |
P08621 |
0.63 |
SOX9 |
6662 |
P48436 |
0.63 |
SRC |
6714 |
P12931 |
0.63 |
SUV39H1 |
6839 |
O43463 |
0.63 |
TLR4 |
7099 |
O00206 |
0.63 |
ZNF184 |
7738 |
Q99676 |
0.63 |
MAFK |
7975 |
O60675 |
0.63 |
NCOA3 |
8202 |
Q9Y6Q9 |
0.63 |
USP9X |
8239 |
Q93008 |
0.63 |
ARID1A |
8289 |
O14497 |
0.63 |
BLZF1 |
8548 |
Q9H2G9 |
0.63 |
TP63 |
8626 |
Q9H3D4 |
0.63 |
NCOA1 |
8648 |
Q15788 |
0.63 |
DDX3Y |
8653 |
O15523 |
0.63 |
ARHGEF7 |
8874 |
Q14155 |
0.63 |
MCM3AP |
8888 |
O60318 |
0.63 |
GIT2 |
9815 |
Q14161 |
0.63 |
MED24 |
9862 |
O75448 |
0.63 |
MED6 |
10001 |
O75586 |
0.63 |
TANK |
10010 |
Q92844 |
0.63 |
RANBP9 |
10048 |
Q96S59 |
0.63 |
YAP1 |
10413 |
P46937 |
0.63 |
ST6GALNAC2 |
10610 |
Q9UJ37 |
0.63 |
ZMYND11 |
10771 |
Q15326 |
0.63 |
DNAJB4 |
11080 |
Q9UDY4 |
0.63 |
CORO1A |
11151 |
P31146 |
0.63 |
PDZRN3 |
23024 |
Q9UPQ7 |
0.63 |
NCOA6 |
23054 |
Q14686 |
0.63 |
GRIP1 |
23426 |
Q9Y3R0 |
0.63 |
SS18L1 |
26039 |
O75177 |
0.63 |
RGCC |
28984 |
Q9H4X1 |
0.63 |
TDP2 |
51567 |
O95551 |
0.63 |
DDX4 |
54514 |
Q9NQI0 |
0.63 |
ZNF83 |
55769 |
P51522 |
0.63 |
RIOK2 |
55781 |
Q9BVS4 |
0.63 |
APMAP |
57136 |
Q9HDC9 |
0.63 |
KIAA1522 |
57648 |
Q9P206 |
0.63 |
TRIB3 |
57761 |
Q96RU7 |
0.63 |
ELAC2 |
60528 |
Q9BQ52 |
0.63 |
ZNF329 |
79673 |
Q86UD4 |
0.63 |
ZBTB3 |
79842 |
Q9H5J0 |
0.63 |
CPSF7 |
79869 |
Q8N684 |
0.63 |
SVEP1 |
79987 |
Q4LDE5 |
0.63 |
CCDC33 |
80125 |
Q8N5R6 |
0.63 |
CPTP |
80772 |
Q5TA50 |
0.63 |
LACRT |
90070 |
Q9GZZ8 |
0.63 |
TEKT4 |
150483 |
Q8WW24 |
0.63 |
RPSAP15 |
220885 |
N/A |
0.63 |
KANSL1 |
284058 |
Q7Z3B3 |
0.63 |
CAMK2G |
818 |
Q13555 |
0.65 |
ZMYM2 |
7750 |
Q9UBW7 |
0.65 |
ZNF8 |
7554 |
P17098 |
0.67 |
HGS |
9146 |
O14964 |
0.67 |
CHUK |
1147 |
O15111 |
0.68 |
FOXM1 |
2305 |
Q08050 |
0.68 |
MAPK8 |
5599 |
P45983 |
0.68 |
SH2D2A |
9047 |
Q9NP31 |
0.68 |
HDAC4 |
9759 |
P56524 |
0.68 |
HDAC5 |
10014 |
Q9UQL6 |
0.68 |
CITED2 |
10370 |
Q99967 |
0.68 |
MYOCD |
93649 |
Q8IZQ8 |
0.68 |
ACTB |
60 |
P60709 |
0.70 |
IRF7 |
3665 |
Q92985 |
0.70 |
PRTN3 |
5657 |
P24158 |
0.70 |
HNF4A |
3172 |
P41235 |
0.71 |
DHX8 |
1659 |
Q14562 |
0.72 |
DYRK1A |
1859 |
Q13627 |
0.72 |
IRS1 |
3667 |
P35568 |
0.72 |
ITGB4 |
3691 |
P16144 |
0.72 |
OPA1 |
4976 |
O60313 |
0.72 |
PTPN6 |
5777 |
P29350 |
0.72 |
RPL3 |
6122 |
P39023 |
0.72 |
RPL4 |
6124 |
P36578 |
0.72 |
TCP1 |
6950 |
P17987 |
0.72 |
VAV2 |
7410 |
P52735 |
0.72 |
KDM5C |
8242 |
P41229 |
0.72 |
SLC25A12 |
8604 |
O75746 |
0.72 |
MTMR4 |
9110 |
Q9NYA4 |
0.72 |
BUB3 |
9184 |
O43684 |
0.72 |
SLC9A3R2 |
9351 |
Q15599 |
0.72 |
DCAF7 |
10238 |
P61962 |
0.72 |
DNAJA2 |
10294 |
O60884 |
0.72 |
ATXN2L |
11273 |
Q8WWM7 |
0.72 |
U2AF2 |
11338 |
P26368 |
0.72 |
LRCH1 |
23143 |
Q9Y2L9 |
0.72 |
SIK3 |
23387 |
Q9Y2K2 |
0.72 |
RAB11FIP5 |
26056 |
Q9BXF6 |
0.72 |
PABPC1 |
26986 |
P11940 |
0.72 |
YTHDF2 |
51441 |
Q9Y5A9 |
0.72 |
PSPC1 |
55269 |
Q8WXF1 |
0.72 |
EPB41L5 |
57669 |
Q9HCM4 |
0.72 |
CHD8 |
57680 |
Q9HCK8 |
0.72 |
SQRDL |
58472 |
Q9Y6N5 |
0.72 |
PJA1 |
64219 |
Q8NG27 |
0.72 |
SARG |
79098 |
Q9BW04 |
0.72 |
FAM83G |
644815 |
A6ND36 |
0.72 |
CDK11A |
728642 |
Q9UQ88 |
0.72 |
CSH1|CSH2 |
1442 |
P0DML2|P0DML3 |
0.73 |
CYP11A1 |
1583 |
P05108 |
0.73 |
PCDH1 |
5097 |
Q08174 |
0.73 |
RPLP0 |
6175 |
P05388 |
0.73 |
TGM2 |
7052 |
P21980 |
0.73 |
ZBTB16 |
7704 |
Q05516 |
0.73 |
SECISBP2L |
9728 |
Q93073 |
0.73 |
EBI3 |
10148 |
Q14213 |
0.73 |
CFDP1 |
10428 |
Q9UEE9 |
0.73 |
GMEB1 |
10691 |
Q9Y692 |
0.73 |
TMED1 |
11018 |
Q13445 |
0.73 |
PRDM4 |
11108 |
Q9UKN5 |
0.73 |
MTF2 |
22823 |
Q9Y483 |
0.73 |
HEY1 |
23462 |
Q9Y5J3 |
0.73 |
C10orf54 |
64115 |
Q9H7M9 |
0.73 |
SAP130 |
79595 |
Q9H0E3 |
0.73 |
FOXO1 |
2308 |
Q12778 |
0.74 |
HIVEP1 |
3096 |
P15822 |
0.74 |
FOXO4 |
4303 |
P98177 |
0.74 |
SPTBN1 |
6711 |
Q01082 |
0.74 |
ZEB1 |
6935 |
P37275 |
0.74 |
RBX1 |
9978 |
P62877 |
0.74 |
CEBPA |
1050 |
P49715 |
0.75 |
HSPA4 |
3308 |
P34932 |
0.75 |
SREBF2 |
6721 |
Q12772 |
0.75 |
CUL1 |
8454 |
Q13616 |
0.75 |
HIPK2 |
28996 |
Q9H2X6 |
0.75 |
EPAS1 |
2034 |
Q99814 |
0.76 |
MDM4 |
4194 |
O15151 |
0.76 |
PCK2 |
5106 |
Q16822 |
0.76 |
CHRD |
8646 |
Q9H2X0 |
0.76 |
DOCK9 |
23348 |
Q9BZ29 |
0.76 |
SETD2 |
29072 |
Q9BYW2 |
0.76 |
RNF31 |
55072 |
Q96EP0 |
0.76 |
PARD3 |
56288 |
Q8TEW0 |
0.76 |
ZC3H12A |
80149 |
Q5D1E8 |
0.76 |
TSC22D4 |
81628 |
Q9Y3Q8 |
0.76 |
CSNK1G2 |
1455 |
P78368 |
0.77 |
PARD3B |
117583 |
Q8TEW8 |
0.77 |
CEBPD |
1052 |
P49716 |
0.78 |
HDAC1 |
3065 |
Q13547 |
0.78 |
TGFBR1 |
7046 |
P36897 |
0.78 |
BRCA2 |
675 |
P51587 |
0.79 |
ATF2 |
1386 |
P15336 |
0.79 |
E2F4 |
1874 |
Q16254 |
0.79 |
KPNB1 |
3837 |
Q14974 |
0.79 |
MYC |
4609 |
P01106 |
0.79 |
CTCF |
10664 |
P49711 |
0.80 |
NEDD4 |
4734 |
P46934 |
0.81 |
USP15 |
9958 |
Q9Y4E8 |
0.81 |
RUNX1 |
861 |
Q01196 |
0.82 |
SMAD9 |
4093 |
O15198 |
0.82 |
KAT2B |
8850 |
Q92831 |
0.82 |
CDC27 |
996 |
P30260 |
0.83 |
CSNK1D |
1453 |
P48730 |
0.83 |
MEN1 |
4221 |
O00255 |
0.83 |
BTRC |
8945 |
Q9Y297 |
0.83 |
WWP1 |
11059 |
Q9H0M0 |
0.83 |
RUNX3 |
864 |
Q13761 |
0.84 |
CTNNB1 |
1499 |
P35222 |
0.84 |
YY1 |
7528 |
P25490 |
0.84 |
SMURF1 |
57154 |
Q9HCE7 |
0.84 |
CEBPB |
1051 |
P17676 |
0.85 |
LEMD3 |
23592 |
Q9Y2U8 |
0.85 |
TRIM33 |
51592 |
Q9UPN9 |
0.85 |
TFE3 |
7030 |
P19532 |
0.86 |
USP7 |
7874 |
Q93009 |
0.86 |
MAX |
4149 |
P61244 |
0.87 |
SQSTM1 |
8878 |
Q13501 |
0.87 |
DDX5 |
1655 |
P17844 |
0.88 |
MECOM |
2122 |
Q03112 |
0.88 |
FOXO3 |
2309 |
O43524 |
0.88 |
RBL1 |
5933 |
P28749 |
0.88 |
PIAS3 |
10401 |
Q9Y6X2 |
0.88 |
LEF1 |
51176 |
Q9UJU2 |
0.88 |
RUNX2 |
860 |
Q13950 |
0.89 |
NR3C1 |
2908 |
P04150 |
0.89 |
JUNB |
3726 |
P17275 |
0.89 |
SMAD2 |
4087 |
Q15796 |
0.89 |
SKIL |
6498 |
P12757 |
0.89 |
SNW1 |
22938 |
Q13573 |
0.89 |
AR |
367 |
P10275 |
0.90 |
DAB2 |
1601 |
P98082 |
0.90 |
JUN |
3725 |
P05412 |
0.90 |
SMAD3 |
4088 |
P84022 |
0.90 |
SMAD4 |
4089 |
Q13485 |
0.90 |
SKI |
6497 |
P12755 |
0.90 |
WWP2 |
11060 |
O00308 |
0.90 |
NOTCH1 |
4851 |
P46531 |
0.95 |
ACVR2B |
93 |
Q13705 |
0.00 |
CDKN2B |
1030 |
P42772 |
0.00 |
COL1A2 |
1278 |
P08123 |
0.00 |
PPARD |
5467 |
Q03181 |
0.00 |
AXIN1 |
8312 |
O15169 |
0.00 |
AXIN2 |
8313 |
Q9Y2T1 |
0.00 |
ACVR1C |
130399 |
Q8NER5 |
0.00 |
CDK8 |
1024 |
P49336 |
0.52 |
CDK9 |
1025 |
P50750 |
0.52 |
ESR2 |
2100 |
Q92731 |
0.52 |
PRKAR1B |
5575 |
P31321 |
0.52 |
PRKAR2A |
5576 |
P13861 |
0.52 |
RIT1 |
6016 |
Q92963 |
0.52 |
TGFB1 |
7040 |
P01137 |
0.52 |
TP73 |
7161 |
O15350 |
0.52 |
HMGA2 |
8091 |
P52926 |
0.52 |
ARHGEF6 |
9459 |
Q15052 |
0.52 |
RRAS2 |
22800 |
P62070 |
0.52 |
RASD2 |
23551 |
Q96D21 |
0.52 |
RAB38 |
23682 |
P57729 |
0.52 |
RASL12 |
51285 |
Q9NYN1 |
0.52 |
GSC |
145258 |
P56915 |
0.52 |
SKOR2 |
652991 |
Q2VWA4 |
0.52 |
MAPK14 |
1432 |
Q16539 |
0.55 |
E2F5 |
1875 |
Q15329 |
0.55 |
FOXG1 |
2290 |
P55316 |
0.55 |
YBX1 |
4904 |
P67809 |
0.55 |
MAPK9 |
5601 |
P45984 |
0.55 |
MAGI2 |
9863 |
Q86UL8 |
0.55 |
PRMT5 |
10419 |
O14744 |
0.55 |
LCK |
3932 |
P06239 |
0.56 |
PIK3CA |
5290 |
P42336 |
0.56 |
PIAS2 |
9063 |
O75928 |
0.56 |
ITCH |
83737 |
Q96J02 |
0.56 |
EPB41 |
2035 |
P11171 |
0.59 |
KRT2 |
3849 |
P35908 |
0.59 |
KRT10 |
3858 |
P13645 |
0.59 |
LMNA |
4000 |
P02545 |
0.59 |
MYO5B |
4645 |
Q9ULV0 |
0.59 |
PAEP |
5047 |
P09466 |
0.59 |
GTF2IRD1 |
9569 |
Q9UHL9 |
0.59 |
SF3A1 |
10291 |
Q15459 |
0.59 |
JPH3 |
57338 |
Q8WXH2 |
0.59 |
PPM1A |
5494 |
P35813 |
0.62 |
AES |
166 |
Q08117 |
0.63 |
FOXL2 |
668 |
P58012 |
0.63 |
KLF5 |
688 |
Q13887 |
0.63 |
LDLRAD4 |
753 |
O15165 |
0.63 |
CBL |
867 |
P22681 |
0.63 |
CDKN1A |
1026 |
P38936 |
0.63 |
CR1 |
1378 |
P17927 |
0.63 |
PHC2 |
1912 |
Q8IXK0 |
0.63 |
FBLN1 |
2192 |
P23142 |
0.63 |
FLI1 |
2313 |
Q01543 |
0.63 |
HOXC11 |
3227 |
O43248 |
0.63 |
HP |
3240 |
P00738 |
0.63 |
NEDD8 |
4738 |
Q15843 |
0.63 |
NFIC |
4782 |
P08651 |
0.63 |
PPARG |
5468 |
P37231 |
0.63 |
RPA1 |
6117 |
P27694 |
0.63 |
TF |
7018 |
P02787 |
0.63 |
CFLAR |
8837 |
O15519 |
0.63 |
BAG3 |
9531 |
O95817 |
0.63 |
KDM2A |
22992 |
Q9Y2K7 |
0.63 |
KDM6B |
23135 |
O15054 |
0.63 |
ZCCHC14 |
23174 |
Q8WYQ9 |
0.63 |
DNAJB5 |
25822 |
O75953 |
0.63 |
GGA1 |
26088 |
Q9UJY5 |
0.63 |
AATF |
26574 |
Q9NY61 |
0.63 |
UBQLN4 |
56893 |
Q9NRR5 |
0.63 |
MKL1 |
57591 |
Q969V6 |
0.63 |
PRDM16 |
63976 |
Q9HAZ2 |
0.63 |
RARG |
5916 |
P13631 |
0.65 |
MAP3K7 |
6885 |
O43318 |
0.65 |
SF3B2 |
10992 |
Q13435 |
0.65 |
SERTAD1 |
29950 |
Q9UHV2 |
0.65 |
OTUB1 |
55611 |
Q96FW1 |
0.65 |
CCNT1 |
904 |
O60563 |
0.68 |
FHL1 |
2273 |
Q13642 |
0.68 |
FHL2 |
2274 |
Q14192 |
0.68 |
FHL3 |
2275 |
Q13643 |
0.68 |
S100A4 |
6275 |
P26447 |
0.68 |
ZMIZ1 |
57178 |
Q9ULJ6 |
0.68 |
ETS1 |
2113 |
P14921 |
0.69 |
SRY |
6736 |
Q05066 |
0.70 |
NUP214 |
8021 |
P35658 |
0.70 |
TRIM62 |
55223 |
Q9BVG3 |
0.70 |
CDK2 |
1017 |
P24941 |
0.71 |
CDK4 |
1019 |
P11802 |
0.71 |
TSC2 |
7249 |
P49815 |
0.71 |
ACVR1B |
91 |
P36896 |
0.72 |
GLI2 |
2736 |
P10070 |
0.72 |
PEX6 |
5190 |
Q13608 |
0.72 |
TCF12 |
6938 |
Q99081 |
0.72 |
DACH1 |
1602 |
Q9UI36 |
0.73 |
MBD1 |
4152 |
Q9UIS9 |
0.73 |
NFYC |
4802 |
Q13952 |
0.73 |
PPP2R1A |
5518 |
P30153 |
0.73 |
CDC16 |
8881 |
Q13042 |
0.73 |
KMT2B |
9757 |
Q9UMN6 |
0.73 |
HEYL |
26508 |
Q9NQ87 |
0.73 |
CXXC5 |
51523 |
Q7LFL8 |
0.73 |
MED15 |
51586 |
Q96RN5 |
0.73 |
TGIF2 |
60436 |
Q9GZN2 |
0.73 |
NOTCH4 |
4855 |
Q99466 |
0.74 |
JUND |
3727 |
P17535 |
0.75 |
TOB1 |
10140 |
P50616 |
0.76 |
PPP1R12C |
54776 |
Q9BZL4 |
0.76 |
ESR1 |
2099 |
P03372 |
0.77 |
MYD88 |
4615 |
Q99836 |
0.77 |
DEDD |
9191 |
O75618 |
0.77 |
TGFB1I1 |
7041 |
O43294 |
0.78 |
EID2 |
163126 |
Q8N6I1 |
0.79 |
HIF1A |
3091 |
Q16665 |
0.80 |
IL37 |
27178 |
Q9NZH6 |
0.80 |
BRCA1 |
672 |
P38398 |
0.81 |
VDR |
7421 |
P11473 |
0.81 |
NEDD4L |
23327 |
Q96PU5 |
0.81 |
CDC25A |
993 |
P30304 |
0.83 |
PML |
5371 |
P29590 |
0.83 |
TP53 |
7157 |
P04637 |
0.83 |
ZEB2 |
9839 |
O60315 |
0.83 |
EIF4ENIF1 |
56478 |
Q9NRA8 |
0.83 |
DVL1 |
1855 |
O14640 |
0.84 |
SMAD1 |
4086 |
Q15797 |
0.84 |
TGIF1 |
7050 |
Q15583 |
0.84 |
STRAP |
11171 |
Q9Y3F4 |
0.84 |
RNF111 |
54778 |
Q6ZNA4 |
0.84 |
EP300 |
2033 |
Q09472 |
0.86 |
MAPK1 |
5594 |
P28482 |
0.86 |
FOS |
2353 |
P01100 |
0.88 |
GSK3B |
2932 |
P49841 |
0.88 |
ANAPC10 |
10393 |
Q9UM13 |
0.88 |
PIAS4 |
51588 |
Q8N2W9 |
0.88 |
ATF3 |
467 |
P18847 |
0.89 |
SP1 |
6667 |
P08047 |
0.89 |
AKT1 |
207 |
P31749 |
0.90 |
NEDD9 |
4739 |
Q14511 |
0.90 |
PIN1 |
5300 |
Q13526 |
0.90 |
ZFYVE9 |
9372 |
O95405 |
0.90 |
SMURF2 |
64750 |
Q9HAU4 |
0.90 |
CREBBP |
1387 |
Q92793 |
0.94 |
FOXH1 |
8928 |
O75593 |
0.95 |
ERBB2IP |
55914 |
Q96RT1 |
0.96 |