| Gene Symbol | LSS |
| Entrez ID | 4047 |
| Uniprot ID | P48449 |
| Description | lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) |
| Chromosomal Location | chr21: 46,188,141-46,228,824 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
BP | GO:0006694 | steroid biosynthetic process |
The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification. | IMP |
BP | GO:0006695 | cholesterol biosynthetic process |
The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. | IMP|TAS |
BP | GO:0031647 | regulation of protein stability |
Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation. | IMP |
CC | GO:0005789 | endoplasmic reticulum membrane |
The lipid bilayer surrounding the endoplasmic reticulum. | TAS |
CC | GO:0005811 | lipid particle |
An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins. | IDA |
CC | GO:0016020 | membrane |
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. | IDA |
MF | GO:0000250 | lanosterol synthase activity |
Catalysis of the reaction: (S)-2,3-epoxysqualene = lanosterol. This is a cyclization reaction that forms the sterol nucleus. | IGI|IMP|TAS |
| Domain ID | Description |
|---|---|
IPR002365 | Terpene synthase, conserved site |
IPR008930 | Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid |
IPR018333 | Squalene cyclase |
IPR032696 | Squalene cyclase, C-terminal |
IPR032697 | Squalene cyclase, N-terminal |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
hsa00100 | Steroid biosynthesis | KEGG |
hsa01100 | Metabolic pathways | KEGG |
WP1982 | Sterol Regulatory Element-Binding Proteins (SREBP) signalling | WikiPathways |
WP197 | Cholesterol Biosynthesis | WikiPathways |
| UMLS CUI | UMLS Term |
|---|---|
C0023794 | Lipoidosis |
| Tissue | Cell Type |
|---|---|
adrenal gland | glandular cells |
appendix | glandular cells |
bronchus | respiratory epithelial cells |
colon | endothelial cells |
colon | glandular cells |
colon | peripheral nerve/ganglion |
duodenum | glandular cells |
esophagus | squamous epithelial cells |
gallbladder | glandular cells |
kidney | cells in tubules |
liver | hepatocytes |
lung | macrophages |
nasopharynx | respiratory epithelial cells |
oral mucosa | squamous epithelial cells |
ovary | follicle cells |
parathyroid gland | glandular cells |
placenta | trophoblastic cells |
rectum | glandular cells |
stomach | glandular cells |
testis | Leydig cells |
tonsil | squamous epithelial cells |
urinary bladder | urothelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
22617121 | Ouandaogo et al. | 2012 | Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
NR4A1 | 3164 | P22736 | 0.63 |
ATP4A | 495 | P20648 | 0.63 |
NEDD8 | 4738 | Q15843 | 0.63 |
NTRK1 | 4914 | P04629 | 0.63 |
SUMO1 | 7341 | P63165 | 0.63 |
XPO1 | 7514 | O14980 | 0.63 |
PNKD | 25953 | Q8N490 | 0.63 |
MYH9 | 4627 | P35579 | 0.72 |
MYO5C | 55930 | Q9NQX4 | 0.72 |
FIP1L1 | 81608 | Q6UN15 | 0.72 |