PCOSBase

Protein Description

Gene Symbol	LMNB1
Entrez ID	4001
Uniprot ID	P20700
Description	lamin B1
Chromosomal Location	chr5: 126,776,623-126,837,020

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Ontology	GO ID	GO Term	Definition	Evidence
CC	GO:0005635	nuclear envelope	The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).	TAS
CC	GO:0005637	nuclear inner membrane	The inner, i.e. lumen-facing, lipid bilayer of the nuclear envelope.	IEA
CC	GO:0005638	lamin filament	Any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope. They are classified as lamins A, B and C.	IEA
CC	GO:0005654	nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.	TAS
CC	GO:0016020	membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.	IDA
CC	GO:0016363	nuclear matrix	The dense fibrillar network lying on the inner side of the nuclear membrane.	IEA
CC	GO:0031965	nuclear membrane	Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.	IDA
MF	GO:0005198	structural molecule activity	The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell.	IEA
MF	GO:0043274	phospholipase binding	Interacting selectively and non-covalently with any phospholipase, enzymes that catalyze of the hydrolysis of a glycerophospholipid.	IEA

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Domain ID	Description
IPR001322	Lamin Tail Domain
IPR001664	Intermediate filament protein
IPR018039	Intermediate filament protein, conserved site

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Pathway ID	Pathway Term	Pathway Source
hsa04210	Apoptosis	KEGG
WP314	Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation	WikiPathways
h_caspasePathway	Caspase Cascade in Apoptosis	BioCarta
h_fasPathway	FAS signaling pathway ( CD95 )	BioCarta
h_HivnefPathway	HIV-I Nef: negative effector of Fas and TNF	BioCarta
h_tnfr1Pathway	TNFR1 Signaling Pathway	BioCarta

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UMLS CUI	UMLS Term
C0017661	Iga Glomerulonephritis
C0205711	Pelizaeus-Merzbacher Disease

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Tissue	Cell Type
adrenal gland	glandular cells
appendix	glandular cells
bone marrow	hematopoietic cells
breast	glandular cells
bronchus	respiratory epithelial cells
caudate	glial cells
caudate	neuronal cells
cerebellum	cells in granular layer
cerebellum	cells in molecular layer
cerebral cortex	glial cells
cerebral cortex	neuronal cells
cervix, uterine	glandular cells
cervix, uterine	squamous epithelial cells
colon	glandular cells
duodenum	glandular cells
endometrium	cells in endometrial stroma
endometrium	glandular cells
epididymis	glandular cells
esophagus	squamous epithelial cells
fallopian tube	glandular cells
gallbladder	glandular cells
hippocampus	glial cells
hippocampus	neuronal cells
kidney	cells in glomeruli
kidney	cells in tubules
liver	hepatocytes
lung	pneumocytes
nasopharynx	respiratory epithelial cells
oral mucosa	squamous epithelial cells
pancreas	exocrine glandular cells
pancreas	islets of Langerhans
parathyroid gland	glandular cells
placenta	decidual cells
placenta	trophoblastic cells
prostate	glandular cells
rectum	glandular cells
salivary gland	glandular cells
seminal vesicle	glandular cells
skin	fibroblasts
skin	keratinocytes
skin	Langerhans
skin	melanocytes
skin	epidermal cells
small intestine	glandular cells
soft tissue	fibroblasts
spleen	cells in red pulp
spleen	cells in white pulp
stomach	glandular cells
testis	cells in seminiferous ducts
testis	Leydig cells
thyroid gland	glandular cells
tonsil	non-germinal center cells
tonsil	squamous epithelial cells
urinary bladder	urothelial cells
vagina	squamous epithelial cells

No databases found.

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Pubmed ID	Author	Year	Title
22617121	Ouandaogo et al.	2012	Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation
22951915	Haozi et al.	2012	Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

Gene Symbol	Entrez ID	Uniprot ID	Score
RPA1	6117	P27694	0.49
RPA3	6119	P35244	0.49
SRSF6	6431	Q13247	0.49
NCSTN	23385	Q92542	0.49
SF3B3	23450	Q15393	0.49
MAGT1	84061	Q9H0U3	0.49
KPNA3	3840	O00505	0.56
SERPINA3	12	P01011	0.63
EGF	1950	P01133	0.63
PCGF2	7703	P35227	0.63
PIAS2	9063	O75928	0.63
GIT2	9815	Q14161	0.63
ZZEF1	23140	O43149	0.63
PASK	23178	Q96RG2	0.63
MBIP	51562	Q9NS73	0.63
AIRE	326	O43918	0.72
NDEL1	81565	Q9GZM8	0.72
POU2F1	5451	P14859	0.73
LMNB1	4001	P20700	0.79
LMNA	4000	P02545	0.84
HSPA8	3312	P11142	0.49
ILF3	3609	Q12906	0.49
EIF6	3692	P56537	0.49
HNRNPM	4670	P52272	0.49
SMARCA4	6597	P51532	0.49
DDX21	9188	Q9NR30	0.49
RNF13	11342	O43567	0.49
HP1BP3	50809	Q5SSJ5	0.49
CDK1	983	P06493	0.52
GZMB	3002	P10144	0.52
PRKCD	5580	Q05655	0.52
SNAI1	6615	O95863	0.52
SRPK2	6733	P78362	0.52
TOR1AIP1	26092	Q5JTV8	0.52
MCM10	55388	Q7L590	0.52
GZMA	3001	P12544	0.55
MELK	9833	Q14680	0.55
URB2	9816	Q14146	0.59
CASP3	836	P42574	0.62
LBR	3930	Q14739	0.62
PRPH	5630	P41219	0.62
ADRB2	154	P07550	0.63
ATF4	468	P18848	0.63
ELAVL1	1994	Q15717	0.63
ESR1	2099	P03372	0.63
FN1	2335	P02751	0.63
GJA1	2697	P17302	0.63
HLA-B	3106	P30480	0.63
HNRNPA1	3178	P09651	0.63
ITGA4	3676	P13612	0.63
JUN	3725	P05412	0.63
MCM2	4171	P49736	0.63
MCM7	4176	P33993	0.63
MDM2	4193	Q00987	0.63
NFKB1	4790	P19838	0.63
NTRK1	4914	P04629	0.63
PARK2	5071	O60260	0.63
RAC1	5879	P63000	0.63
ABCE1	6059	P61221	0.63
SUMO3	6612	P55854	0.63
TMPO	7112	P42167	0.63
WHSC1	7468	O96028	0.63
YY1	7528	P25490	0.63
RTCA	8634	O00442	0.63
EED	8726	O75530	0.63
ATG12	9140	O94817	0.63
KIAA0101	9768	Q15004	0.63
CUL7	9820	Q14999	0.63
ACTR1B	10120	P42025	0.63
ACTR1A	10121	P61163	0.63
DCTN2	10540	Q13561	0.63
DCTN3	11258	O75935	0.63
OBSL1	23363	O75147	0.63
NCAPH	23397	Q15003	0.63
FBXO6	26270	Q9NRD1	0.63
IFT57	55081	Q9NWB7	0.63
ACTR10	55860	Q9NZ32	0.63
SMARCAD1	56916	Q9H4L7	0.63
HECW2	57520	Q9P2P5	0.63
ABCG8	64241	Q9H221	0.63
SPRTN	83932	Q9H040	0.63
CCDC8	83987	Q9H0W5	0.63
LRRK2	120892	Q5S007	0.63
BAP18	124944	Q8IXM2	0.63
SCARNA22	677770		0.63
SEPT12	124404	Q8IYM1	0.65
SUMO4	387082	Q6EEV6	0.65
CASP6	839	P55212	0.66
YWHAZ	7534	P63104	0.68
YWHAQ	10971	P27348	0.68
BCAR3	8412	O75815	0.7
ILK	3611	Q13418	0.72
KPNA1	3836	P52294	0.72
SPTAN1	6709	Q13813	0.72
VIM	7431	P08670	0.72
NES	10763	P48681	0.72
ZWINT	11130	O95229	0.72
SPG20	23111	Q8N0X7	0.72
TMEM63B	55362	Q5T3F8	0.72
SUMO2	6613	P61956	0.73
EMD	2010	P50402	0.82
VCAM1	7412	P19320	0.82
PRKCB	5579	P05771	0.85
PRKCA	5578	P17252	0.86
TMPO	7112	P42166	0.89