| Gene Symbol | LMNB1 |
| Entrez ID | 4001 |
| Uniprot ID | P20700 |
| Description | lamin B1 |
| Chromosomal Location | chr5: 126,776,623-126,837,020 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
CC |
GO:0005635 |
nuclear envelope |
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). |
TAS |
|
CC |
GO:0005637 |
nuclear inner membrane |
The inner, i.e. lumen-facing, lipid bilayer of the nuclear envelope. |
IEA |
|
CC |
GO:0005638 |
lamin filament |
Any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope. They are classified as lamins A, B and C. |
IEA |
|
CC |
GO:0005654 |
nucleoplasm |
That part of the nuclear content other than the chromosomes or the nucleolus. |
TAS |
|
CC |
GO:0016020 |
membrane |
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
IDA |
|
CC |
GO:0016363 |
nuclear matrix |
The dense fibrillar network lying on the inner side of the nuclear membrane. |
IEA |
|
CC |
GO:0031965 |
nuclear membrane |
Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. |
IDA |
|
MF |
GO:0005198 |
structural molecule activity |
The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. |
IEA |
|
MF |
GO:0043274 |
phospholipase binding |
Interacting selectively and non-covalently with any phospholipase, enzymes that catalyze of the hydrolysis of a glycerophospholipid. |
IEA |
| Domain ID | Description |
|---|---|
|
IPR001322 |
Lamin Tail Domain |
|
IPR001664 |
Intermediate filament protein |
|
IPR018039 |
Intermediate filament protein, conserved site |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
|
hsa04210 |
Apoptosis |
KEGG |
|
WP314 |
Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation |
WikiPathways |
|
h_caspasePathway |
Caspase Cascade in Apoptosis |
BioCarta |
|
h_fasPathway |
FAS signaling pathway ( CD95 ) |
BioCarta |
|
h_HivnefPathway |
HIV-I Nef: negative effector of Fas and TNF |
BioCarta |
|
h_tnfr1Pathway |
TNFR1 Signaling Pathway |
BioCarta |
| UMLS CUI | UMLS Term |
|---|---|
|
C0017661 |
Iga Glomerulonephritis |
|
C0205711 |
Pelizaeus-Merzbacher Disease |
| Tissue | Cell Type |
|---|---|
|
adrenal gland |
glandular cells |
|
appendix |
glandular cells |
|
bone marrow |
hematopoietic cells |
|
breast |
glandular cells |
|
bronchus |
respiratory epithelial cells |
|
caudate |
glial cells |
|
caudate |
neuronal cells |
|
cerebellum |
cells in granular layer |
|
cerebellum |
cells in molecular layer |
|
cerebral cortex |
glial cells |
|
cerebral cortex |
neuronal cells |
|
cervix, uterine |
glandular cells |
|
cervix, uterine |
squamous epithelial cells |
|
colon |
glandular cells |
|
duodenum |
glandular cells |
|
endometrium |
cells in endometrial stroma |
|
endometrium |
glandular cells |
|
epididymis |
glandular cells |
|
esophagus |
squamous epithelial cells |
|
fallopian tube |
glandular cells |
|
gallbladder |
glandular cells |
|
hippocampus |
glial cells |
|
hippocampus |
neuronal cells |
|
kidney |
cells in glomeruli |
|
kidney |
cells in tubules |
|
liver |
hepatocytes |
|
lung |
pneumocytes |
|
nasopharynx |
respiratory epithelial cells |
|
oral mucosa |
squamous epithelial cells |
|
pancreas |
exocrine glandular cells |
|
pancreas |
islets of Langerhans |
|
parathyroid gland |
glandular cells |
|
placenta |
decidual cells |
|
placenta |
trophoblastic cells |
|
prostate |
glandular cells |
|
rectum |
glandular cells |
|
salivary gland |
glandular cells |
|
seminal vesicle |
glandular cells |
|
skin |
fibroblasts |
|
skin |
keratinocytes |
|
skin |
Langerhans |
|
skin |
melanocytes |
|
skin |
epidermal cells |
|
small intestine |
glandular cells |
|
soft tissue |
fibroblasts |
|
spleen |
cells in red pulp |
|
spleen |
cells in white pulp |
|
stomach |
glandular cells |
|
testis |
cells in seminiferous ducts |
|
testis |
Leydig cells |
|
thyroid gland |
glandular cells |
|
tonsil |
non-germinal center cells |
|
tonsil |
squamous epithelial cells |
|
urinary bladder |
urothelial cells |
|
vagina |
squamous epithelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
|
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
RPA1 |
6117 |
P27694 |
0.49 |
|
RPA3 |
6119 |
P35244 |
0.49 |
|
SRSF6 |
6431 |
Q13247 |
0.49 |
|
NCSTN |
23385 |
Q92542 |
0.49 |
|
SF3B3 |
23450 |
Q15393 |
0.49 |
|
MAGT1 |
84061 |
Q9H0U3 |
0.49 |
|
KPNA3 |
3840 |
O00505 |
0.56 |
|
SERPINA3 |
12 |
P01011 |
0.63 |
|
EGF |
1950 |
P01133 |
0.63 |
|
PCGF2 |
7703 |
P35227 |
0.63 |
|
PIAS2 |
9063 |
O75928 |
0.63 |
|
GIT2 |
9815 |
Q14161 |
0.63 |
|
ZZEF1 |
23140 |
O43149 |
0.63 |
|
PASK |
23178 |
Q96RG2 |
0.63 |
|
MBIP |
51562 |
Q9NS73 |
0.63 |
|
AIRE |
326 |
O43918 |
0.72 |
|
NDEL1 |
81565 |
Q9GZM8 |
0.72 |
|
POU2F1 |
5451 |
P14859 |
0.73 |
|
LMNB1 |
4001 |
P20700 |
0.79 |
|
LMNA |
4000 |
P02545 |
0.84 |
|
HSPA8 |
3312 |
P11142 |
0.49 |
|
ILF3 |
3609 |
Q12906 |
0.49 |
|
EIF6 |
3692 |
P56537 |
0.49 |
|
HNRNPM |
4670 |
P52272 |
0.49 |
|
SMARCA4 |
6597 |
P51532 |
0.49 |
|
DDX21 |
9188 |
Q9NR30 |
0.49 |
|
RNF13 |
11342 |
O43567 |
0.49 |
|
HP1BP3 |
50809 |
Q5SSJ5 |
0.49 |
|
CDK1 |
983 |
P06493 |
0.52 |
|
GZMB |
3002 |
P10144 |
0.52 |
|
PRKCD |
5580 |
Q05655 |
0.52 |
|
SNAI1 |
6615 |
O95863 |
0.52 |
|
SRPK2 |
6733 |
P78362 |
0.52 |
|
TOR1AIP1 |
26092 |
Q5JTV8 |
0.52 |
|
MCM10 |
55388 |
Q7L590 |
0.52 |
|
GZMA |
3001 |
P12544 |
0.55 |
|
MELK |
9833 |
Q14680 |
0.55 |
|
URB2 |
9816 |
Q14146 |
0.59 |
|
CASP3 |
836 |
P42574 |
0.62 |
|
LBR |
3930 |
Q14739 |
0.62 |
|
PRPH |
5630 |
P41219 |
0.62 |
|
ADRB2 |
154 |
P07550 |
0.63 |
|
ATF4 |
468 |
P18848 |
0.63 |
|
ELAVL1 |
1994 |
Q15717 |
0.63 |
|
ESR1 |
2099 |
P03372 |
0.63 |
|
FN1 |
2335 |
P02751 |
0.63 |
|
GJA1 |
2697 |
P17302 |
0.63 |
|
HLA-B |
3106 |
P30480 |
0.63 |
|
HNRNPA1 |
3178 |
P09651 |
0.63 |
|
ITGA4 |
3676 |
P13612 |
0.63 |
|
JUN |
3725 |
P05412 |
0.63 |
|
MCM2 |
4171 |
P49736 |
0.63 |
|
MCM7 |
4176 |
P33993 |
0.63 |
|
MDM2 |
4193 |
Q00987 |
0.63 |
|
NFKB1 |
4790 |
P19838 |
0.63 |
|
NTRK1 |
4914 |
P04629 |
0.63 |
|
PARK2 |
5071 |
O60260 |
0.63 |
|
RAC1 |
5879 |
P63000 |
0.63 |
|
ABCE1 |
6059 |
P61221 |
0.63 |
|
SUMO3 |
6612 |
P55854 |
0.63 |
|
TMPO |
7112 |
P42167 |
0.63 |
|
WHSC1 |
7468 |
O96028 |
0.63 |
|
YY1 |
7528 |
P25490 |
0.63 |
|
RTCA |
8634 |
O00442 |
0.63 |
|
EED |
8726 |
O75530 |
0.63 |
|
ATG12 |
9140 |
O94817 |
0.63 |
|
KIAA0101 |
9768 |
Q15004 |
0.63 |
|
CUL7 |
9820 |
Q14999 |
0.63 |
|
ACTR1B |
10120 |
P42025 |
0.63 |
|
ACTR1A |
10121 |
P61163 |
0.63 |
|
DCTN2 |
10540 |
Q13561 |
0.63 |
|
DCTN3 |
11258 |
O75935 |
0.63 |
|
OBSL1 |
23363 |
O75147 |
0.63 |
|
NCAPH |
23397 |
Q15003 |
0.63 |
|
FBXO6 |
26270 |
Q9NRD1 |
0.63 |
|
IFT57 |
55081 |
Q9NWB7 |
0.63 |
|
ACTR10 |
55860 |
Q9NZ32 |
0.63 |
|
SMARCAD1 |
56916 |
Q9H4L7 |
0.63 |
|
HECW2 |
57520 |
Q9P2P5 |
0.63 |
|
ABCG8 |
64241 |
Q9H221 |
0.63 |
|
SPRTN |
83932 |
Q9H040 |
0.63 |
|
CCDC8 |
83987 |
Q9H0W5 |
0.63 |
|
LRRK2 |
120892 |
Q5S007 |
0.63 |
|
BAP18 |
124944 |
Q8IXM2 |
0.63 |
|
SCARNA22 |
677770 |
N/A |
0.63 |
|
SEPT12 |
124404 |
Q8IYM1 |
0.65 |
|
SUMO4 |
387082 |
Q6EEV6 |
0.65 |
|
CASP6 |
839 |
P55212 |
0.66 |
|
YWHAZ |
7534 |
P63104 |
0.68 |
|
YWHAQ |
10971 |
P27348 |
0.68 |
|
BCAR3 |
8412 |
O75815 |
0.70 |
|
ILK |
3611 |
Q13418 |
0.72 |
|
KPNA1 |
3836 |
P52294 |
0.72 |
|
SPTAN1 |
6709 |
Q13813 |
0.72 |
|
VIM |
7431 |
P08670 |
0.72 |
|
NES |
10763 |
P48681 |
0.72 |
|
ZWINT |
11130 |
O95229 |
0.72 |
|
SPG20 |
23111 |
Q8N0X7 |
0.72 |
|
TMEM63B |
55362 |
Q5T3F8 |
0.72 |
|
SUMO2 |
6613 |
P61956 |
0.73 |
|
EMD |
2010 |
P50402 |
0.82 |
|
VCAM1 |
7412 |
P19320 |
0.82 |
|
PRKCB |
5579 |
P05771 |
0.85 |
|
PRKCA |
5578 |
P17252 |
0.86 |
|
TMPO |
7112 |
P42166 |
0.89 |