Protein Description

Gene Symbol LIMS1
Entrez ID 3987
Uniprot ID P48059
Description LIM and senescent cell antigen-like domains 1
Chromosomal Location chr2: 108,534,355-108,687,246
Ontology GO ID GO Term Definition Evidence

BP

GO:0007569

cell aging

An aging process that has as participant a cell after a cell has stopped dividing. Cell aging may occur when a cell has temporarily stopped dividing through cell cycle arrest (GO:0007050) or when a cell has permanently stopped dividing, in which case it is undergoing cellular senescence (GO:0090398). May precede cell death (GO:0008219) and succeed cell maturation (GO:0048469).

TAS

BP

GO:0010628

positive regulation of gene expression

Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.

IMP

BP

GO:0010811

positive regulation of cell-substrate adhesion

Any process that increases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules.

IMP

BP

GO:0034329

cell junction assembly

A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a cell junction.

TAS

BP

GO:0043547

positive regulation of GTPase activity

Any process that activates or increases the activity of a GTPase.

IMP

BP

GO:0045184

establishment of protein localization

The directed movement of a protein to a specific location.

IMP

BP

GO:0045892

negative regulation of transcription, DNA-templated

Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.

IDA

BP

GO:0051291

protein heterooligomerization

The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers that are not all identical. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.

IEA

BP

GO:0051894

positive regulation of focal adhesion assembly

Any process that activates or increases the frequency, rate or extent of focal adhesion assembly, the establishment and maturation of focal adhesions.

IMP

BP

GO:0071560

cellular response to transforming growth factor beta stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus.

IEP

BP

GO:1900026

positive regulation of substrate adhesion-dependent cell spreading

Any process that activates or increases the frequency, rate or extent of substrate adhesion-dependent cell spreading.

IMP

CC

GO:0005829

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

TAS

CC

GO:0005886

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

IEA

CC

GO:0005911

cell-cell junction

A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals.

IMP

CC

GO:0005925

focal adhesion

Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.

IDA

CC

GO:0043234

protein complex

A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical.

IEA

CC

GO:0048471

perinuclear region of cytoplasm

Cytoplasm situated near, or occurring around, the nucleus.

IDA

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0008270

zinc ion binding

Interacting selectively and non-covalently with zinc (Zn) ions.

IDA

MF

GO:0019901

protein kinase binding

Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.

IPI

Domain ID Description

IPR001781

Zinc finger, LIM-type

IPR017351

LIM and senescent cell antigen-like-containing domain protein 1

Pathway ID Pathway Term Pathway Source

WP2572

Primary Focal Segmental Glomerulosclerosis FSGS

WikiPathways

No diseases found.

Tissue Cell Type

adrenal gland

glandular cells

bronchus

respiratory epithelial cells

duodenum

glandular cells

lymph node

germinal center cells

lymph node

non-germinal center cells

nasopharynx

respiratory epithelial cells

placenta

trophoblastic cells

seminal vesicle

glandular cells

small intestine

glandular cells

stomach

glandular cells

thyroid gland

glandular cells

tonsil

germinal center cells

tonsil

non-germinal center cells

No databases found.

Pubmed ID Author Year Title

22617121

Ouandaogo et al.

2012

Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

22951915

Haozi et al.

2012

Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

Gene Symbol Entrez ID Uniprot ID Score

TGFBR1

7046

P36897

0.52

TMSB4X

7114

P62328

0.52

SMURF1

57154

Q9HCE7

0.52

CTGF

1490

P29279

0.63

FMR1

2332

Q06787

0.63

MAPT

4137

P10636

0.63

MYH7

4625

P12883

0.63

PXN

5829

P49023

0.63

RBBP8

5932

Q99708

0.63

TRIO

7204

O75962

0.63

TRIP6

7205

Q15654

0.63

TYMS

7298

P04818

0.63

LPXN

9404

O60711

0.63

STUB1

10273

Q9UNE7

0.63

IPO7

10527

O95373

0.63

EHMT2

10919

Q96KQ7

0.63

RABGAP1

23637

Q9Y3P9

0.63

ATXN10

25814

Q9UBB4

0.63

PARVB

29780

Q9HBI1

0.63

MBIP

51562

Q9NS73

0.63

SRRT

51593

Q9BXP5

0.63

BMP2K

55589

Q9NSY1

0.63

CMAS

55907

Q8NFW8

0.63

ADAMTS9

56999

Q9P2N4

0.63

REPS1

85021

Q96D71

0.63

ZNF160

90338

Q9HCG1

0.63

MYO18A

399687

Q92614

0.63

HOXA1

3198

P49639

0.72

ILK

3611

Q13418

0.99

HNRNPU

3192

Q00839

0.49

CDC5L

988

Q99459

0.63

MYC

4609

P01106

0.63

NEB

4703

P20929

0.63

NEDD8

4738

Q15843

0.63

PEG3

5178

Q9GZU2

0.63

TTN

7273

Q8WZ42

0.63

SUMO1

7341

P63165

0.63

USP11

8237

P51784

0.63

ZMYM4

9202

Q5VZL5

0.63

SNW1

22938

Q13573

0.63

PLCE1

51196

Q9P212

0.63

PARVG

64098

Q9HBI0

0.63

OSR2

116039

Q8N2R0

0.63

CSRP3

8048

P50461

0.70

KIF22

3835

Q14807

0.72

STK11

6794

Q15831

0.72

XRCC5

7520

P13010

0.72

ACP6

51205

Q9NPH0

0.72

TMEM132A

54972

Q24JP5

0.72

SGO1

151648

Q5FBB7

0.72

ASPM

259266

Q8IZT6

0.72

NCK2

8440

O43639

0.90

PARVA

55742

Q9NVD7

0.90

RSU1

6251

Q15404

0.97