Gene Symbol | LIMS1 |
Entrez ID | 3987 |
Uniprot ID | P48059 |
Description | LIM and senescent cell antigen-like domains 1 |
Chromosomal Location | chr2: 108,534,355-108,687,246 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0007569 |
cell aging |
An aging process that has as participant a cell after a cell has stopped dividing. Cell aging may occur when a cell has temporarily stopped dividing through cell cycle arrest (GO:0007050) or when a cell has permanently stopped dividing, in which case it is undergoing cellular senescence (GO:0090398). May precede cell death (GO:0008219) and succeed cell maturation (GO:0048469). |
TAS |
BP |
GO:0010628 |
positive regulation of gene expression |
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form. |
IMP |
BP |
GO:0010811 |
positive regulation of cell-substrate adhesion |
Any process that increases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules. |
IMP |
BP |
GO:0034329 |
cell junction assembly |
A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a cell junction. |
TAS |
BP |
GO:0043547 |
positive regulation of GTPase activity |
Any process that activates or increases the activity of a GTPase. |
IMP |
BP |
GO:0045184 |
establishment of protein localization |
The directed movement of a protein to a specific location. |
IMP |
BP |
GO:0045892 |
negative regulation of transcription, DNA-templated |
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. |
IDA |
BP |
GO:0051291 |
protein heterooligomerization |
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers that are not all identical. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. |
IEA |
BP |
GO:0051894 |
positive regulation of focal adhesion assembly |
Any process that activates or increases the frequency, rate or extent of focal adhesion assembly, the establishment and maturation of focal adhesions. |
IMP |
BP |
GO:0071560 |
cellular response to transforming growth factor beta stimulus |
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus. |
IEP |
BP |
GO:1900026 |
positive regulation of substrate adhesion-dependent cell spreading |
Any process that activates or increases the frequency, rate or extent of substrate adhesion-dependent cell spreading. |
IMP |
CC |
GO:0005829 |
cytosol |
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
TAS |
CC |
GO:0005886 |
plasma membrane |
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
IEA |
CC |
GO:0005911 |
cell-cell junction |
A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals. |
IMP |
CC |
GO:0005925 |
focal adhesion |
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. |
IDA |
CC |
GO:0043234 |
protein complex |
A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical. |
IEA |
CC |
GO:0048471 |
perinuclear region of cytoplasm |
Cytoplasm situated near, or occurring around, the nucleus. |
IDA |
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
MF |
GO:0008270 |
zinc ion binding |
Interacting selectively and non-covalently with zinc (Zn) ions. |
IDA |
MF |
GO:0019901 |
protein kinase binding |
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. |
IPI |
Domain ID | Description |
---|---|
IPR001781 |
Zinc finger, LIM-type |
IPR017351 |
LIM and senescent cell antigen-like-containing domain protein 1 |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
WP2572 |
Primary Focal Segmental Glomerulosclerosis FSGS |
WikiPathways |
Tissue | Cell Type |
---|---|
adrenal gland |
glandular cells |
bronchus |
respiratory epithelial cells |
duodenum |
glandular cells |
lymph node |
germinal center cells |
lymph node |
non-germinal center cells |
nasopharynx |
respiratory epithelial cells |
placenta |
trophoblastic cells |
seminal vesicle |
glandular cells |
small intestine |
glandular cells |
stomach |
glandular cells |
thyroid gland |
glandular cells |
tonsil |
germinal center cells |
tonsil |
non-germinal center cells |
Pubmed ID | Author | Year | Title |
---|---|---|---|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
TGFBR1 |
7046 |
P36897 |
0.52 |
TMSB4X |
7114 |
P62328 |
0.52 |
SMURF1 |
57154 |
Q9HCE7 |
0.52 |
CTGF |
1490 |
P29279 |
0.63 |
FMR1 |
2332 |
Q06787 |
0.63 |
MAPT |
4137 |
P10636 |
0.63 |
MYH7 |
4625 |
P12883 |
0.63 |
PXN |
5829 |
P49023 |
0.63 |
RBBP8 |
5932 |
Q99708 |
0.63 |
TRIO |
7204 |
O75962 |
0.63 |
TRIP6 |
7205 |
Q15654 |
0.63 |
TYMS |
7298 |
P04818 |
0.63 |
LPXN |
9404 |
O60711 |
0.63 |
STUB1 |
10273 |
Q9UNE7 |
0.63 |
IPO7 |
10527 |
O95373 |
0.63 |
EHMT2 |
10919 |
Q96KQ7 |
0.63 |
RABGAP1 |
23637 |
Q9Y3P9 |
0.63 |
ATXN10 |
25814 |
Q9UBB4 |
0.63 |
PARVB |
29780 |
Q9HBI1 |
0.63 |
MBIP |
51562 |
Q9NS73 |
0.63 |
SRRT |
51593 |
Q9BXP5 |
0.63 |
BMP2K |
55589 |
Q9NSY1 |
0.63 |
CMAS |
55907 |
Q8NFW8 |
0.63 |
ADAMTS9 |
56999 |
Q9P2N4 |
0.63 |
REPS1 |
85021 |
Q96D71 |
0.63 |
ZNF160 |
90338 |
Q9HCG1 |
0.63 |
MYO18A |
399687 |
Q92614 |
0.63 |
HOXA1 |
3198 |
P49639 |
0.72 |
ILK |
3611 |
Q13418 |
0.99 |
HNRNPU |
3192 |
Q00839 |
0.49 |
CDC5L |
988 |
Q99459 |
0.63 |
MYC |
4609 |
P01106 |
0.63 |
NEB |
4703 |
P20929 |
0.63 |
NEDD8 |
4738 |
Q15843 |
0.63 |
PEG3 |
5178 |
Q9GZU2 |
0.63 |
TTN |
7273 |
Q8WZ42 |
0.63 |
SUMO1 |
7341 |
P63165 |
0.63 |
USP11 |
8237 |
P51784 |
0.63 |
ZMYM4 |
9202 |
Q5VZL5 |
0.63 |
SNW1 |
22938 |
Q13573 |
0.63 |
PLCE1 |
51196 |
Q9P212 |
0.63 |
PARVG |
64098 |
Q9HBI0 |
0.63 |
OSR2 |
116039 |
Q8N2R0 |
0.63 |
CSRP3 |
8048 |
P50461 |
0.70 |
KIF22 |
3835 |
Q14807 |
0.72 |
STK11 |
6794 |
Q15831 |
0.72 |
XRCC5 |
7520 |
P13010 |
0.72 |
ACP6 |
51205 |
Q9NPH0 |
0.72 |
TMEM132A |
54972 |
Q24JP5 |
0.72 |
SGO1 |
151648 |
Q5FBB7 |
0.72 |
ASPM |
259266 |
Q8IZT6 |
0.72 |
NCK2 |
8440 |
O43639 |
0.90 |
PARVA |
55742 |
Q9NVD7 |
0.90 |
RSU1 |
6251 |
Q15404 |
0.97 |