BP

GO:0001974

blood vessel remodeling

The reorganization or renovation of existing blood vessels.

IEA

BP

GO:0006955

immune response

Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.

IEA

BP

GO:0007275

multicellular organism development

The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

TAS

BP

GO:0007566

embryo implantation

Attachment of the blastocyst to the uterine lining.

IEA

BP

GO:0008284

positive regulation of cell proliferation

Any process that activates or increases the rate or extent of cell proliferation.

IDA

BP

GO:0008285

negative regulation of cell proliferation

Any process that stops, prevents or reduces the rate or extent of cell proliferation.

IEA

BP

GO:0019827

stem cell population maintenance

The process by which an organism or tissue maintains a population of stem cells of a single type. This can be achieved by a number of mechanisms: stem cell asymmetric division maintains stem cell numbers; stem cell symmetric division increases them; maintenance of a stem cell niche maintains the conditions for commitment to the stem cell fate for some types of stem cell; stem cells may arise de novo from other cell types.

IEA

BP

GO:0033138

positive regulation of peptidyl-serine phosphorylation

Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine.

IDA

BP

GO:0033141

positive regulation of peptidyl-serine phosphorylation of STAT protein

Any process that activates or increases the frequency, rate or extent of the phosphorylation of a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein.

IDA

BP

GO:0042503

tyrosine phosphorylation of Stat3 protein

The process of introducing a phosphate group to a tyrosine residue of a Stat3 protein.

IEA

BP

GO:0042511

positive regulation of tyrosine phosphorylation of Stat1 protein

Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat1 protein.

IDA

BP

GO:0042517

positive regulation of tyrosine phosphorylation of Stat3 protein

Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat3 protein.

IDA

BP

GO:0043410

positive regulation of MAPK cascade

Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.

IDA

BP

GO:0045651

positive regulation of macrophage differentiation

Any process that activates or increases the frequency, rate or extent of macrophage differentiation.

IDA

BP

GO:0045835

negative regulation of meiotic nuclear division

Any process that stops, prevents, or reduces the frequency, rate or extent of meiosis.

IEA

BP

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.

IDA

BP

GO:0046697

decidualization

The cellular and vascular changes occurring in the endometrium of the pregnant uterus just after the onset of blastocyst implantation. This process involves the proliferation and differentiation of the fibroblast-like endometrial stromal cells into large, polyploid decidual cells that eventually form the maternal component of the placenta.

IEA

BP

GO:0046888

negative regulation of hormone secretion

Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a hormone from a cell.

IDA

BP

GO:0048286

lung alveolus development

The process whose specific outcome is the progression of the alveolus over time, from its formation to the mature structure. The alveolus is a sac for holding air in the lungs; formed by the terminal dilation of air passageways.

IEA

BP

GO:0048644

muscle organ morphogenesis

The process in which the anatomical structures of muscle are generated and organized.

IEA

BP

GO:0048666

neuron development

The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.

IEA

BP

GO:0048711

positive regulation of astrocyte differentiation

Any process that activates or increases the frequency, rate or extent of astrocyte differentiation.

IEA

BP

GO:0048861

leukemia inhibitory factor signaling pathway

Any series of molecular signals initiated by the binding of leukemia inhibitory factor to a receptor on the surface of the target cell, and ending with regulation of a downstream cellular process, e.g. transcription.

IDA

BP

GO:0048863

stem cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.

IEA

BP

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.

IDA

BP

GO:0060426

lung vasculature development

The biological process whose specific outcome is the progression of a lung vasculature from an initial condition to its mature state. This process begins with the formation of the lung vasculature and ends with the mature structure. The lung vasculature is composed of the tubule structures that carry blood or lymph in the lungs.

IEA

BP

GO:0060463

lung lobe morphogenesis

The process in which the anatomical structures of a lung lobe are generated and organized. A lung lobe is a projection that extends from the lung.

IEA

BP

GO:0060707

trophoblast giant cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of a trophoblast giant cell of the placenta. Trophoblast giant cells are the cell of the placenta that line the maternal decidua.

IEA

BP

GO:0060708

spongiotrophoblast differentiation

The process in which a relatively unspecialized cell of the ectoplacental cone acquires specialized features of a spongiotrophoblast of the placenta. A spongiotrophoblast cell is a basophilic cell.

IEA

BP

GO:0070373

negative regulation of ERK1 and ERK2 cascade

Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.

IEA

BP

GO:0072108

positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis

Any process that increases the rate, frequency or extent of the transition where a mesenchymal cell establishes apical/basolateral polarity, forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros.

IDA

BP

GO:0072307

regulation of metanephric nephron tubule epithelial cell differentiation

Any process that modulates the frequency, rate or extent of metanephric nephron tubule epithelial cell differentiation.

IDA

BP

GO:1900182

positive regulation of protein localization to nucleus

Any process that activates or increases the frequency, rate or extent of protein localization to nucleus.

IDA

BP

GO:1901676

positive regulation of histone H3-K27 acetylation

Any process that activates or increases the frequency, rate or extent of histone H3-K27 acetylation.

IDA

BP

GO:1903025

regulation of RNA polymerase II regulatory region sequence-specific DNA binding

Any process that modulates the frequency, rate or extent of RNA polymerase II regulatory region sequence-specific DNA binding.

IEA

CC

GO:0005576

extracellular region

The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

TAS

CC

GO:0005615

extracellular space

That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

IC

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

IDA

MF

GO:0001135

transcription factor activity, RNA polymerase II transcription factor recruiting

The function of binding to an RNA polymerase II (RNAP II) transcription factor and recruiting it to the transcription machinery complex in order to modulate transcription by RNAP II.

IDA

MF

GO:0005102

receptor binding

Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

IPI

MF

GO:0005125

cytokine activity

Functions to control the survival, growth, differentiation and effector function of tissues and cells.

IDA

MF

GO:0005146

leukemia inhibitory factor receptor binding

Interacting selectively and non-covalently with the leukemia inhibitory factor receptor.

IDA|IPI

MF

GO:0008083

growth factor activity

The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.

IDA