Protein Description

Gene Symbol RPSA
Entrez ID 3921
Uniprot ID P08865
Description ribosomal protein SA
Chromosomal Location chr3: 39,406,689-39,412,542
Ontology GO ID GO Term Definition Evidence

BP

GO:0000028

ribosomal small subunit assembly

The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the small ribosomal subunit.

IBA

BP

GO:0000184

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins.

TAS

BP

GO:0000447

endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

Endonucleolytic cleavage between the SSU-rRNA and the 5.8S rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript.

IBA

BP

GO:0000461

endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

Endonucleolytic cleavage at the 3'-end of the SSU-rRNA from an originally tricistronic rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript, to produce the mature end of the SSU-rRNA.

IBA

BP

GO:0006364

rRNA processing

Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.

TAS

BP

GO:0006407

rRNA export from nucleus

The directed movement of rRNA from the nucleus to the cytoplasm; the rRNA is usually in the form of ribonucleoproteins.

IBA

BP

GO:0006412

translation

The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome.

IBA|IC

BP

GO:0006413

translational initiation

The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA.

TAS

BP

GO:0006614

SRP-dependent cotranslational protein targeting to membrane

The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane.

TAS

BP

GO:0007155

cell adhesion

The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.

IEA

BP

GO:0019083

viral transcription

The process by which a viral genome, or part of a viral genome, is transcribed within the host cell.

TAS

BP

GO:0046718

viral entry into host cell

The process that occurs after viral attachment by which a virus, or viral nucleic acid, breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the viral nucleic acid is released into the host cell cytoplasm.

IEA

CC

GO:0005634

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

TAS

CC

GO:0005654

nucleoplasm

That part of the nuclear content other than the chromosomes or the nucleolus.

TAS

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

IDA|TAS

CC

GO:0005829

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

TAS

CC

GO:0005886

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

IDA

CC

GO:0016020

membrane

A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

IDA

CC

GO:0022627

cytosolic small ribosomal subunit

The small subunit of a ribosome located in the cytosol.

IDA

CC

GO:0030686

90S preribosome

A large ribonucleoprotein complex considered to be the earliest preribosomal complex. In S. cerevisiae, it has a size of 90S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins.

IBA

CC

GO:0070062

extracellular exosome

A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.

IDA

MF

GO:0001618

virus receptor activity

Combining with a virus component and mediating entry of the virus into the cell.

IEA

MF

GO:0003735

structural constituent of ribosome

The action of a molecule that contributes to the structural integrity of the ribosome.

IBA

MF

GO:0005055

laminin receptor activity

Combining with a laminin, a glycoprotein that constitutes the majority of proteins in the basement membrane, to initiate a change in cell activity.

IEA

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0043022

ribosome binding

Interacting selectively and non-covalently with any part of a ribosome.

IPI

MF

GO:0043236

laminin binding

Interacting selectively and non-covalently with laminins, glycoproteins that are major constituents of the basement membrane of cells.

IEA

MF

GO:0044822

poly(A) RNA binding

Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases.

IDA

Domain ID Description

IPR001865

Ribosomal protein S2

IPR005707

Ribosomal protein S2, eukaryotic/archaeal

IPR018130

Ribosomal protein S2, conserved site

IPR023591

Ribosomal protein S2, flavodoxin-like domain

IPR027498

Ribosomal protein S2, eukaryotic

IPR027504

40S ribosomal protein SA

IPR032281

40S ribosomal protein SA, C-terminal domain

Pathway ID Pathway Term Pathway Source

hsa03010

Ribosome

KEGG

WP477

Cytoplasmic Ribosomal Proteins

WikiPathways

h_prionPathway

Prion Pathway

BioCarta

UMLS CUI UMLS Term

C0027626

Neoplasm Invasiveness

Tissue Cell Type

adrenal gland

glandular cells

appendix

glandular cells

bone marrow

hematopoietic cells

breast

glandular cells

breast

myoepithelial cells

bronchus

respiratory epithelial cells

cerebellum

cells in molecular layer

cerebellum

Purkinje cells

cerebral cortex

neuronal cells

colon

glandular cells

duodenum

glandular cells

endometrium

glandular cells

esophagus

squamous epithelial cells

gallbladder

glandular cells

hippocampus

neuronal cells

lung

macrophages

lymph node

non-germinal center cells

nasopharynx

respiratory epithelial cells

oral mucosa

squamous epithelial cells

pancreas

exocrine glandular cells

placenta

trophoblastic cells

rectum

glandular cells

salivary gland

glandular cells

seminal vesicle

glandular cells

skin

keratinocytes

skin

Langerhans

skin

melanocytes

skin

epidermal cells

small intestine

glandular cells

stomach

glandular cells

thyroid gland

glandular cells

tonsil

germinal center cells

tonsil

squamous epithelial cells

urinary bladder

urothelial cells

vagina

squamous epithelial cells

No databases found.

Pubmed ID Author Year Title

22617121

Ouandaogo et al.

2012

Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

Gene Symbol Entrez ID Uniprot ID Score

CCT6A

908

P40227

0.49

EIF4A2

1974

Q14240

0.49

IL7R

3575

P16871

0.49

RPL35A

6165

P18077

0.49

RPL38

6169

P63173

0.49

RPS27

6232

P42677

0.49

SSR4

6748

P51571

0.49

TCP1

6950

P17987

0.49

UQCRC2

7385

P22695

0.49

VCL

7414

P18206

0.49

VDAC2

7417

P45880

0.49

LAGE3

8270

Q14657

0.49

CCT4

10575

P50991

0.49

RPL13A

23521

P40429

0.49

BRCA1

672

P38398

0.52

ITGA6

3655

P23229

0.52

ACADVL

37

P49748

0.63

CDR2

1039

Q01850

0.63

XRCC6

2547

P12956

0.63

HBG2

3048

P69892

0.63

NEDD4

4734

P46934

0.63

PURB

5814

Q96QR8

0.63

SOD1

6647

P00441

0.63

TFAP2A

7020

P05549

0.63

ZNF121

7675

P58317

0.63

ZNF146

7705

Q15072

0.63

BMS1

9790

Q14692

0.63

SYNCRIP

10492

O60506

0.63

CHERP

10523

Q8IWX8

0.63

DCTN6

10671

O00399

0.63

SRSF10

10772

O75494

0.63

SF3B2

10992

Q13435

0.63

U2SURP

23350

O15042

0.63

ZNF629

23361

Q9UEG4

0.63

SF3B1

23451

O75533

0.63

ZBTB11

27107

O95625

0.63

ZNF777

27153

Q9ULD5

0.63

GNMT

27232

Q14749

0.63

CDR2L

30850

Q86X02

0.63

RPL26L1

51121

Q9UNX3

0.63

LARP7

51574

Q4G0J3

0.63

IMP3

55272

Q9NV31

0.63

RNF114

55905

Q9Y508

0.63

ZNF335

63925

Q9H4Z2

0.63

GZF1

64412

Q9H116

0.63

ZNF574

64763

Q6ZN55

0.63

C6orf106

64771

Q9H6K1

0.63

KRI1

65095

Q8N9T8

0.63

ZNF768

79724

Q9H5H4

0.63

UTP23

84294

Q9BRU9

0.63

LTV1

84946

Q96GA3

0.63

ZCRB1

85437

Q8TBF4

0.63

DHX57

90957

Q6P158

0.63

ZNF358

140467

Q9NW07

0.63

CLEC4G

339390

Q6UXB4

0.63

RPSAP58

388524

N/A

0.63

KRR1

11103

Q13601

0.70

PCNA

5111

P12004

0.72

TSR1

55720

Q2NL82

0.73

RPS21

100291837

P63220

0.91

SLC25A4

291

P12235

0.49

SLC25A5

292

P05141

0.49

CLTC

1213

Q00610

0.49

DHX9

1660

Q08211

0.49

ECE1

1889

P42892

0.49

EEF1A2

1917

Q05639

0.49

EIF4A1

1973

P60842

0.49

EWSR1

2130

Q01844

0.49

HNRNPA1

3178

P09651

0.49

HSPA4

3308

P34932

0.49

HSPA5

3309

P11021

0.49

HNRNPM

4670

P52272

0.49

SNU13

4809

P55769

0.49

RPL13

6137

P26373

0.49

RPL17

6139

P18621

0.49

RPL27A

6157

P46776

0.49

RPL29

6159

P47914

0.49

RPL32

6161

P62910

0.49

RPL34

6164

P49207

0.49

RPN1

6184

P04843

0.49

RPS24

6229

P62847

0.49

RPS25

6230

P62851

0.49

RPS29

6235

P62273

0.49

RBM8A

9939

Q9Y5S9

0.49

HNRNPA0

10949

Q13151

0.49

RPL36

25873

Q9Y3U8

0.49

PABPC1

26986

P11940

0.49

RBMX

27316

P38159

0.49

NENF

29937

Q9UMX5

0.49

RPS27L

51065

Q71UM5

0.49

PNO1

56902

Q9NRX1

0.49

CCDC68

80323

Q9H2F9

0.49

RPLP0P6

220717

Q8NHW5

0.49

HIST1H2AA

221613

Q96QV6

0.49

CSF2RA

1438

P15509

0.52

LAMA2

3908

P24043

0.52

DKC1

1736

O60832

0.56

PDHB

5162

P11177

0.56

RPS11

6205

P62280

0.56

RPL10A

4736

P62906

0.59

RPL3

6122

P39023

0.59

RPL5

6125

P46777

0.59

RPL6

6128

Q02878

0.59

RPL7

6129

P18124

0.59

RPL7A

6130

P62424

0.59

RPL8

6132

P62917

0.59

RPL11

6135

P62913

0.59

RPL12

6136

P30050

0.59

RPL15

6138

P61313

0.59

RPL18A

6142

Q02543

0.59

RPL19

6143

P84098

0.59

RPL21

6144

P46778

0.59

RPL22

6146

P35268

0.59

RPL23A

6147

P62750

0.59

RPL27

6155

P61353

0.59

RPL30

6156

P62888

0.59

RPL31

6160

P62899

0.59

RPL37A

6168

P61513

0.59

RPLP0

6175

P05388

0.59

RPLP1

6176

P05386

0.59

RPLP2

6181

P05387

0.59

RPS6

6194

P62753

0.59

RPS7

6201

P62081

0.59

RPS10

6204

P46783

0.59

RPS14

6208

P62263

0.59

RPS15

6209

P62841

0.59

RPS26

6231

P62854

0.59

RPL14

9045

P50914

0.59

RPL35

11224

P42766

0.59

RPL10L

140801

Q96L21

0.59

RPL9; RPL9P7; RPL9P8; RPL9P9

6133

P32969

0.59

ACTB

60

P60709

0.62

ABCD1

215

P33897

0.63

APEX1

328

P27695

0.63

CD4

920

P01730

0.63

CTNNB1

1499

P35222

0.63

DYNC1LI2

1783

O43237

0.63

ESR1

2099

P03372

0.63

FAU

2197

P62861

0.63

FN1

2335

P02751

0.63

GJA1

2697

P17302

0.63

SFN

2810

P31947

0.63

HIST1H1A

3024

Q02539

0.63

HNRNPD

3184

Q14103

0.63

HNRNPU

3192

Q00839

0.63

HSPB1

3315

P04792

0.63

HSP90AA1

3320

P07900

0.63

ITGA4

3676

P13612

0.63

JUN

3725

P05412

0.63

MCM2

4171

P49736

0.63

MDM2

4193

Q00987

0.63

NKX3-1

4824

Q99801

0.63

NPM1

4869

P06748

0.63

NTRK1

4914

P04629

0.63

PPP2R1A

5518

P30153

0.63

PROS1

5627

P07225

0.63

PTBP1

5725

P26599

0.63

RNF2

6045

Q99496

0.63

SLC2A5

6518

P22732

0.63

VHL

7428

P40337

0.63

XPO1

7514

O14980

0.63

YWHAZ

7534

P63104

0.63

GAN

8139

Q9H2C0

0.63

UBL4A

8266

P11441

0.63

CUL1

8454

Q13616

0.63

DYNLL1

8655

P63167

0.63

BAG3

9531

O95817

0.63

CUL7

9820

Q14999

0.63

HDAC5

10014

Q9UQL6

0.63

RACK1

10399

P63244

0.63

UBD

10537

O15205

0.63

COPS5

10987

Q92905

0.63

ZBTB1

22890

Q9Y2K1

0.63

FBXW11

23291

Q9UKB1

0.63

OBSL1

23363

O75147

0.63

LARP1

23367

Q6PKG0

0.63

TARDBP

23435

Q13148

0.63

LUZP4

51213

Q9P127

0.63

LIMA1

51474

Q9UHB6

0.63

SIRT7

51547

Q9NRC8

0.63

CAND1

55832

Q86VP6

0.63

USE1

55850

Q9NZ43

0.63

ANKH

56172

Q9HCJ1

0.63

TRIB3

57761

Q96RU7

0.63

NOM1

64434

Q5C9Z4

0.63

WDR76

79968

Q9H967

0.63

LRRK2

120892

Q5S007

0.63

UBE2U

148581

Q5VVX9

0.63

PRUNE2

158471

Q8WUY3

0.63

EEF1A1

1915

P68104

0.65

RPL4

6124

P36578

0.65

RPL18

6141

Q07020

0.65

RPL24

6152

P83731

0.65

RPS15A

6210

P62244

0.65

RPS19

6223

P39019

0.65

RPL23

9349

P62829

0.65

SUMO4

387082

Q6EEV6

0.65

PRND

23627

Q9UKY0

0.67

CALM2

805

P62158

0.70

CALM3

808

P62158

0.70

HSP90AB1

3326

P08238

0.72

TP63

8626

Q9H3D4

0.72

RPS3A

6189

P61247

0.73

RPS12

6206

P25398

0.73

RPS18

6222

P62269

0.73

RPS27A

6233

P62979

0.73

RPS28

6234

P62857

0.73

RNF8

9025

O76064

0.73

POT1

25913

Q9NUX5

0.73

ACD

65057

Q96AP0

0.73

RPL10

6134

P27635

0.74

RPS3

6188

P23396

0.74

RPS4X

6191

P62701

0.74

RPS13

6207

P62277

0.74

RPS20

6224

P60866

0.74

RPS23

6228

P62266

0.74

SUMO2

6613

P61956

0.74

TINF2

26277

Q9BSI4

0.75

RPS17

6218

P08708

0.79

RPS2

6187

P15880

0.80

RPS5

6193

P46782

0.80

RPS8

6202

P62241

0.80

RPS9

6203

P46781

0.80

RPS16

6217

P62249

0.80

VCAM1

7412

P19320

0.82

CBX5

23468

P45973

0.83

SUMO1

7341

P63165

0.85

KARS

3735

Q15046

0.89