Gene Symbol | RPSA |
Entrez ID | 3921 |
Uniprot ID | P08865 |
Description | ribosomal protein SA |
Chromosomal Location | chr3: 39,406,689-39,412,542 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0000028 |
ribosomal small subunit assembly |
The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the small ribosomal subunit. |
IBA |
BP |
GO:0000184 |
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins. |
TAS |
BP |
GO:0000447 |
endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
Endonucleolytic cleavage between the SSU-rRNA and the 5.8S rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. |
IBA |
BP |
GO:0000461 |
endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
Endonucleolytic cleavage at the 3'-end of the SSU-rRNA from an originally tricistronic rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript, to produce the mature end of the SSU-rRNA. |
IBA |
BP |
GO:0006364 |
rRNA processing |
Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. |
TAS |
BP |
GO:0006407 |
rRNA export from nucleus |
The directed movement of rRNA from the nucleus to the cytoplasm; the rRNA is usually in the form of ribonucleoproteins. |
IBA |
BP |
GO:0006412 |
translation |
The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. |
IBA|IC |
BP |
GO:0006413 |
translational initiation |
The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. |
TAS |
BP |
GO:0006614 |
SRP-dependent cotranslational protein targeting to membrane |
The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. |
TAS |
BP |
GO:0007155 |
cell adhesion |
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. |
IEA |
BP |
GO:0019083 |
viral transcription |
The process by which a viral genome, or part of a viral genome, is transcribed within the host cell. |
TAS |
BP |
GO:0046718 |
viral entry into host cell |
The process that occurs after viral attachment by which a virus, or viral nucleic acid, breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the viral nucleic acid is released into the host cell cytoplasm. |
IEA |
CC |
GO:0005634 |
nucleus |
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
TAS |
CC |
GO:0005654 |
nucleoplasm |
That part of the nuclear content other than the chromosomes or the nucleolus. |
TAS |
CC |
GO:0005737 |
cytoplasm |
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
IDA|TAS |
CC |
GO:0005829 |
cytosol |
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
TAS |
CC |
GO:0005886 |
plasma membrane |
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
IDA |
CC |
GO:0016020 |
membrane |
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
IDA |
CC |
GO:0022627 |
cytosolic small ribosomal subunit |
The small subunit of a ribosome located in the cytosol. |
IDA |
CC |
GO:0030686 |
90S preribosome |
A large ribonucleoprotein complex considered to be the earliest preribosomal complex. In S. cerevisiae, it has a size of 90S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins. |
IBA |
CC |
GO:0070062 |
extracellular exosome |
A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. |
IDA |
MF |
GO:0001618 |
virus receptor activity |
Combining with a virus component and mediating entry of the virus into the cell. |
IEA |
MF |
GO:0003735 |
structural constituent of ribosome |
The action of a molecule that contributes to the structural integrity of the ribosome. |
IBA |
MF |
GO:0005055 |
laminin receptor activity |
Combining with a laminin, a glycoprotein that constitutes the majority of proteins in the basement membrane, to initiate a change in cell activity. |
IEA |
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
MF |
GO:0043022 |
ribosome binding |
Interacting selectively and non-covalently with any part of a ribosome. |
IPI |
MF |
GO:0043236 |
laminin binding |
Interacting selectively and non-covalently with laminins, glycoproteins that are major constituents of the basement membrane of cells. |
IEA |
MF |
GO:0044822 |
poly(A) RNA binding |
Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases. |
IDA |
Domain ID | Description |
---|---|
IPR001865 |
Ribosomal protein S2 |
IPR005707 |
Ribosomal protein S2, eukaryotic/archaeal |
IPR018130 |
Ribosomal protein S2, conserved site |
IPR023591 |
Ribosomal protein S2, flavodoxin-like domain |
IPR027498 |
Ribosomal protein S2, eukaryotic |
IPR027504 |
40S ribosomal protein SA |
IPR032281 |
40S ribosomal protein SA, C-terminal domain |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
hsa03010 |
Ribosome |
KEGG |
WP477 |
Cytoplasmic Ribosomal Proteins |
WikiPathways |
h_prionPathway |
Prion Pathway |
BioCarta |
UMLS CUI | UMLS Term |
---|---|
C0027626 |
Neoplasm Invasiveness |
Tissue | Cell Type |
---|---|
adrenal gland |
glandular cells |
appendix |
glandular cells |
bone marrow |
hematopoietic cells |
breast |
glandular cells |
breast |
myoepithelial cells |
bronchus |
respiratory epithelial cells |
cerebellum |
cells in molecular layer |
cerebellum |
Purkinje cells |
cerebral cortex |
neuronal cells |
colon |
glandular cells |
duodenum |
glandular cells |
endometrium |
glandular cells |
esophagus |
squamous epithelial cells |
gallbladder |
glandular cells |
hippocampus |
neuronal cells |
lung |
macrophages |
lymph node |
non-germinal center cells |
nasopharynx |
respiratory epithelial cells |
oral mucosa |
squamous epithelial cells |
pancreas |
exocrine glandular cells |
placenta |
trophoblastic cells |
rectum |
glandular cells |
salivary gland |
glandular cells |
seminal vesicle |
glandular cells |
skin |
keratinocytes |
skin |
Langerhans |
skin |
melanocytes |
skin |
epidermal cells |
small intestine |
glandular cells |
stomach |
glandular cells |
thyroid gland |
glandular cells |
tonsil |
germinal center cells |
tonsil |
squamous epithelial cells |
urinary bladder |
urothelial cells |
vagina |
squamous epithelial cells |
Pubmed ID | Author | Year | Title |
---|---|---|---|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
CCT6A |
908 |
P40227 |
0.49 |
EIF4A2 |
1974 |
Q14240 |
0.49 |
IL7R |
3575 |
P16871 |
0.49 |
RPL35A |
6165 |
P18077 |
0.49 |
RPL38 |
6169 |
P63173 |
0.49 |
RPS27 |
6232 |
P42677 |
0.49 |
SSR4 |
6748 |
P51571 |
0.49 |
TCP1 |
6950 |
P17987 |
0.49 |
UQCRC2 |
7385 |
P22695 |
0.49 |
VCL |
7414 |
P18206 |
0.49 |
VDAC2 |
7417 |
P45880 |
0.49 |
LAGE3 |
8270 |
Q14657 |
0.49 |
CCT4 |
10575 |
P50991 |
0.49 |
RPL13A |
23521 |
P40429 |
0.49 |
BRCA1 |
672 |
P38398 |
0.52 |
ITGA6 |
3655 |
P23229 |
0.52 |
ACADVL |
37 |
P49748 |
0.63 |
CDR2 |
1039 |
Q01850 |
0.63 |
XRCC6 |
2547 |
P12956 |
0.63 |
HBG2 |
3048 |
P69892 |
0.63 |
NEDD4 |
4734 |
P46934 |
0.63 |
PURB |
5814 |
Q96QR8 |
0.63 |
SOD1 |
6647 |
P00441 |
0.63 |
TFAP2A |
7020 |
P05549 |
0.63 |
ZNF121 |
7675 |
P58317 |
0.63 |
ZNF146 |
7705 |
Q15072 |
0.63 |
BMS1 |
9790 |
Q14692 |
0.63 |
SYNCRIP |
10492 |
O60506 |
0.63 |
CHERP |
10523 |
Q8IWX8 |
0.63 |
DCTN6 |
10671 |
O00399 |
0.63 |
SRSF10 |
10772 |
O75494 |
0.63 |
SF3B2 |
10992 |
Q13435 |
0.63 |
U2SURP |
23350 |
O15042 |
0.63 |
ZNF629 |
23361 |
Q9UEG4 |
0.63 |
SF3B1 |
23451 |
O75533 |
0.63 |
ZBTB11 |
27107 |
O95625 |
0.63 |
ZNF777 |
27153 |
Q9ULD5 |
0.63 |
GNMT |
27232 |
Q14749 |
0.63 |
CDR2L |
30850 |
Q86X02 |
0.63 |
RPL26L1 |
51121 |
Q9UNX3 |
0.63 |
LARP7 |
51574 |
Q4G0J3 |
0.63 |
IMP3 |
55272 |
Q9NV31 |
0.63 |
RNF114 |
55905 |
Q9Y508 |
0.63 |
ZNF335 |
63925 |
Q9H4Z2 |
0.63 |
GZF1 |
64412 |
Q9H116 |
0.63 |
ZNF574 |
64763 |
Q6ZN55 |
0.63 |
C6orf106 |
64771 |
Q9H6K1 |
0.63 |
KRI1 |
65095 |
Q8N9T8 |
0.63 |
ZNF768 |
79724 |
Q9H5H4 |
0.63 |
UTP23 |
84294 |
Q9BRU9 |
0.63 |
LTV1 |
84946 |
Q96GA3 |
0.63 |
ZCRB1 |
85437 |
Q8TBF4 |
0.63 |
DHX57 |
90957 |
Q6P158 |
0.63 |
ZNF358 |
140467 |
Q9NW07 |
0.63 |
CLEC4G |
339390 |
Q6UXB4 |
0.63 |
RPSAP58 |
388524 |
N/A |
0.63 |
KRR1 |
11103 |
Q13601 |
0.70 |
PCNA |
5111 |
P12004 |
0.72 |
TSR1 |
55720 |
Q2NL82 |
0.73 |
RPS21 |
100291837 |
P63220 |
0.91 |
SLC25A4 |
291 |
P12235 |
0.49 |
SLC25A5 |
292 |
P05141 |
0.49 |
CLTC |
1213 |
Q00610 |
0.49 |
DHX9 |
1660 |
Q08211 |
0.49 |
ECE1 |
1889 |
P42892 |
0.49 |
EEF1A2 |
1917 |
Q05639 |
0.49 |
EIF4A1 |
1973 |
P60842 |
0.49 |
EWSR1 |
2130 |
Q01844 |
0.49 |
HNRNPA1 |
3178 |
P09651 |
0.49 |
HSPA4 |
3308 |
P34932 |
0.49 |
HSPA5 |
3309 |
P11021 |
0.49 |
HNRNPM |
4670 |
P52272 |
0.49 |
SNU13 |
4809 |
P55769 |
0.49 |
RPL13 |
6137 |
P26373 |
0.49 |
RPL17 |
6139 |
P18621 |
0.49 |
RPL27A |
6157 |
P46776 |
0.49 |
RPL29 |
6159 |
P47914 |
0.49 |
RPL32 |
6161 |
P62910 |
0.49 |
RPL34 |
6164 |
P49207 |
0.49 |
RPN1 |
6184 |
P04843 |
0.49 |
RPS24 |
6229 |
P62847 |
0.49 |
RPS25 |
6230 |
P62851 |
0.49 |
RPS29 |
6235 |
P62273 |
0.49 |
RBM8A |
9939 |
Q9Y5S9 |
0.49 |
HNRNPA0 |
10949 |
Q13151 |
0.49 |
RPL36 |
25873 |
Q9Y3U8 |
0.49 |
PABPC1 |
26986 |
P11940 |
0.49 |
RBMX |
27316 |
P38159 |
0.49 |
NENF |
29937 |
Q9UMX5 |
0.49 |
RPS27L |
51065 |
Q71UM5 |
0.49 |
PNO1 |
56902 |
Q9NRX1 |
0.49 |
CCDC68 |
80323 |
Q9H2F9 |
0.49 |
RPLP0P6 |
220717 |
Q8NHW5 |
0.49 |
HIST1H2AA |
221613 |
Q96QV6 |
0.49 |
CSF2RA |
1438 |
P15509 |
0.52 |
LAMA2 |
3908 |
P24043 |
0.52 |
DKC1 |
1736 |
O60832 |
0.56 |
PDHB |
5162 |
P11177 |
0.56 |
RPS11 |
6205 |
P62280 |
0.56 |
RPL10A |
4736 |
P62906 |
0.59 |
RPL3 |
6122 |
P39023 |
0.59 |
RPL5 |
6125 |
P46777 |
0.59 |
RPL6 |
6128 |
Q02878 |
0.59 |
RPL7 |
6129 |
P18124 |
0.59 |
RPL7A |
6130 |
P62424 |
0.59 |
RPL8 |
6132 |
P62917 |
0.59 |
RPL11 |
6135 |
P62913 |
0.59 |
RPL12 |
6136 |
P30050 |
0.59 |
RPL15 |
6138 |
P61313 |
0.59 |
RPL18A |
6142 |
Q02543 |
0.59 |
RPL19 |
6143 |
P84098 |
0.59 |
RPL21 |
6144 |
P46778 |
0.59 |
RPL22 |
6146 |
P35268 |
0.59 |
RPL23A |
6147 |
P62750 |
0.59 |
RPL27 |
6155 |
P61353 |
0.59 |
RPL30 |
6156 |
P62888 |
0.59 |
RPL31 |
6160 |
P62899 |
0.59 |
RPL37A |
6168 |
P61513 |
0.59 |
RPLP0 |
6175 |
P05388 |
0.59 |
RPLP1 |
6176 |
P05386 |
0.59 |
RPLP2 |
6181 |
P05387 |
0.59 |
RPS6 |
6194 |
P62753 |
0.59 |
RPS7 |
6201 |
P62081 |
0.59 |
RPS10 |
6204 |
P46783 |
0.59 |
RPS14 |
6208 |
P62263 |
0.59 |
RPS15 |
6209 |
P62841 |
0.59 |
RPS26 |
6231 |
P62854 |
0.59 |
RPL14 |
9045 |
P50914 |
0.59 |
RPL35 |
11224 |
P42766 |
0.59 |
RPL10L |
140801 |
Q96L21 |
0.59 |
RPL9; RPL9P7; RPL9P8; RPL9P9 |
6133 |
P32969 |
0.59 |
ACTB |
60 |
P60709 |
0.62 |
ABCD1 |
215 |
P33897 |
0.63 |
APEX1 |
328 |
P27695 |
0.63 |
CD4 |
920 |
P01730 |
0.63 |
CTNNB1 |
1499 |
P35222 |
0.63 |
DYNC1LI2 |
1783 |
O43237 |
0.63 |
ESR1 |
2099 |
P03372 |
0.63 |
FAU |
2197 |
P62861 |
0.63 |
FN1 |
2335 |
P02751 |
0.63 |
GJA1 |
2697 |
P17302 |
0.63 |
SFN |
2810 |
P31947 |
0.63 |
HIST1H1A |
3024 |
Q02539 |
0.63 |
HNRNPD |
3184 |
Q14103 |
0.63 |
HNRNPU |
3192 |
Q00839 |
0.63 |
HSPB1 |
3315 |
P04792 |
0.63 |
HSP90AA1 |
3320 |
P07900 |
0.63 |
ITGA4 |
3676 |
P13612 |
0.63 |
JUN |
3725 |
P05412 |
0.63 |
MCM2 |
4171 |
P49736 |
0.63 |
MDM2 |
4193 |
Q00987 |
0.63 |
NKX3-1 |
4824 |
Q99801 |
0.63 |
NPM1 |
4869 |
P06748 |
0.63 |
NTRK1 |
4914 |
P04629 |
0.63 |
PPP2R1A |
5518 |
P30153 |
0.63 |
PROS1 |
5627 |
P07225 |
0.63 |
PTBP1 |
5725 |
P26599 |
0.63 |
RNF2 |
6045 |
Q99496 |
0.63 |
SLC2A5 |
6518 |
P22732 |
0.63 |
VHL |
7428 |
P40337 |
0.63 |
XPO1 |
7514 |
O14980 |
0.63 |
YWHAZ |
7534 |
P63104 |
0.63 |
GAN |
8139 |
Q9H2C0 |
0.63 |
UBL4A |
8266 |
P11441 |
0.63 |
CUL1 |
8454 |
Q13616 |
0.63 |
DYNLL1 |
8655 |
P63167 |
0.63 |
BAG3 |
9531 |
O95817 |
0.63 |
CUL7 |
9820 |
Q14999 |
0.63 |
HDAC5 |
10014 |
Q9UQL6 |
0.63 |
RACK1 |
10399 |
P63244 |
0.63 |
UBD |
10537 |
O15205 |
0.63 |
COPS5 |
10987 |
Q92905 |
0.63 |
ZBTB1 |
22890 |
Q9Y2K1 |
0.63 |
FBXW11 |
23291 |
Q9UKB1 |
0.63 |
OBSL1 |
23363 |
O75147 |
0.63 |
LARP1 |
23367 |
Q6PKG0 |
0.63 |
TARDBP |
23435 |
Q13148 |
0.63 |
LUZP4 |
51213 |
Q9P127 |
0.63 |
LIMA1 |
51474 |
Q9UHB6 |
0.63 |
SIRT7 |
51547 |
Q9NRC8 |
0.63 |
CAND1 |
55832 |
Q86VP6 |
0.63 |
USE1 |
55850 |
Q9NZ43 |
0.63 |
ANKH |
56172 |
Q9HCJ1 |
0.63 |
TRIB3 |
57761 |
Q96RU7 |
0.63 |
NOM1 |
64434 |
Q5C9Z4 |
0.63 |
WDR76 |
79968 |
Q9H967 |
0.63 |
LRRK2 |
120892 |
Q5S007 |
0.63 |
UBE2U |
148581 |
Q5VVX9 |
0.63 |
PRUNE2 |
158471 |
Q8WUY3 |
0.63 |
EEF1A1 |
1915 |
P68104 |
0.65 |
RPL4 |
6124 |
P36578 |
0.65 |
RPL18 |
6141 |
Q07020 |
0.65 |
RPL24 |
6152 |
P83731 |
0.65 |
RPS15A |
6210 |
P62244 |
0.65 |
RPS19 |
6223 |
P39019 |
0.65 |
RPL23 |
9349 |
P62829 |
0.65 |
SUMO4 |
387082 |
Q6EEV6 |
0.65 |
PRND |
23627 |
Q9UKY0 |
0.67 |
CALM2 |
805 |
P62158 |
0.70 |
CALM3 |
808 |
P62158 |
0.70 |
HSP90AB1 |
3326 |
P08238 |
0.72 |
TP63 |
8626 |
Q9H3D4 |
0.72 |
RPS3A |
6189 |
P61247 |
0.73 |
RPS12 |
6206 |
P25398 |
0.73 |
RPS18 |
6222 |
P62269 |
0.73 |
RPS27A |
6233 |
P62979 |
0.73 |
RPS28 |
6234 |
P62857 |
0.73 |
RNF8 |
9025 |
O76064 |
0.73 |
POT1 |
25913 |
Q9NUX5 |
0.73 |
ACD |
65057 |
Q96AP0 |
0.73 |
RPL10 |
6134 |
P27635 |
0.74 |
RPS3 |
6188 |
P23396 |
0.74 |
RPS4X |
6191 |
P62701 |
0.74 |
RPS13 |
6207 |
P62277 |
0.74 |
RPS20 |
6224 |
P60866 |
0.74 |
RPS23 |
6228 |
P62266 |
0.74 |
SUMO2 |
6613 |
P61956 |
0.74 |
TINF2 |
26277 |
Q9BSI4 |
0.75 |
RPS17 |
6218 |
P08708 |
0.79 |
RPS2 |
6187 |
P15880 |
0.80 |
RPS5 |
6193 |
P46782 |
0.80 |
RPS8 |
6202 |
P62241 |
0.80 |
RPS9 |
6203 |
P46781 |
0.80 |
RPS16 |
6217 |
P62249 |
0.80 |
VCAM1 |
7412 |
P19320 |
0.82 |
CBX5 |
23468 |
P45973 |
0.83 |
SUMO1 |
7341 |
P63165 |
0.85 |
KARS |
3735 |
Q15046 |
0.89 |