Protein Description

Gene Symbol LAMB1
Entrez ID 3912
Uniprot ID P07942
Description laminin subunit beta 1
Chromosomal Location chr7: 107,923,799-108,003,255
Ontology GO ID GO Term Definition Evidence

BP

GO:0007155

cell adhesion

The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.

TAS

BP

GO:0021812

neuronal-glial interaction involved in cerebral cortex radial glia guided migration

The changes in adhesion between neuronal cells and glial cells as a component of the process of cerebral cortex glial-mediated radial cell migration.

IMP

BP

GO:0030198

extracellular matrix organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix.

TAS

BP

GO:0030335

positive regulation of cell migration

Any process that activates or increases the frequency, rate or extent of cell migration.

IDA

BP

GO:0031175

neuron projection development

The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).

IDA

BP

GO:0034446

substrate adhesion-dependent cell spreading

The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate.

IDA

BP

GO:0035987

endodermal cell differentiation

The process in which a relatively unspecialized cell acquires the specialized features of an endoderm cell, a cell of the inner of the three germ layers of the embryo.

IEP

BP

GO:0042476

odontogenesis

The process whose specific outcome is the progression of a tooth or teeth over time, from formation to the mature structure(s). A tooth is any hard bony, calcareous, or chitinous organ found in the mouth or pharynx of an animal and used in procuring or masticating food.

IDA

BP

GO:0050679

positive regulation of epithelial cell proliferation

Any process that activates or increases the rate or extent of epithelial cell proliferation.

TAS

CC

GO:0005576

extracellular region

The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

TAS

CC

GO:0005604

basement membrane

A thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers.

IDA|TAS

CC

GO:0005606

laminin-1 complex

A laminin complex composed of alpha1, beta1 and gamma1 polypeptide chains.

IDA|IPI|TAS

CC

GO:0005607

laminin-2 complex

A laminin complex composed of alpha2, beta1 and gamma1 polypeptide chains.

IDA|TAS

CC

GO:0005615

extracellular space

That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

IDA

CC

GO:0031012

extracellular matrix

A structure lying external to one or more cells, which provides structural support for cells or tissues.

IDA|ISS

CC

GO:0043257

laminin-8 complex

A laminin complex composed of alpha4, beta1 and gamma1 polypeptide chains.

IDA|TAS

CC

GO:0043259

laminin-10 complex

A laminin complex composed of alpha5, beta1 and gamma1 polypeptide chains.

IDA

CC

GO:0048471

perinuclear region of cytoplasm

Cytoplasm situated near, or occurring around, the nucleus.

ISS

CC

GO:0070062

extracellular exosome

A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.

IDA

MF

GO:0005198

structural molecule activity

The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell.

NAS

MF

GO:0005201

extracellular matrix structural constituent

The action of a molecule that contributes to the structural integrity of the extracellular matrix.

IDA

Domain ID Description

IPR000742

EGF-like domain

IPR002049

Laminin EGF domain

IPR008211

Laminin, N-terminal

IPR008979

Galactose-binding domain-like

IPR013015

Laminin IV type B

Pathway ID Pathway Term Pathway Source

hsa04151

PI3K-Akt signaling pathway

KEGG

hsa04510

Focal adhesion

KEGG

hsa04512

ECM-receptor interaction

KEGG

hsa05145

Toxoplasmosis

KEGG

hsa05146

Amoebiasis

KEGG

hsa05200

Pathways in cancer

KEGG

hsa05222

Small cell lung cancer

KEGG

WP306

Focal Adhesion

WikiPathways

WP244

Alpha 6 Beta 4 signaling pathway

WikiPathways

WP453

Inflammatory Response Pathway

WikiPathways

WP3932

Focal Adhesion-PI3K-Akt-mTOR-signaling pathway

WikiPathways

h_prionPathway

Prion Pathway

BioCarta

UMLS CUI UMLS Term

C0004352

Autistic Disorder

C0009324

Ulcerative Colitis

C0009363

Congenital Ocular Coloboma (Disorder)

C0014175

Endometriosis

Tissue Cell Type

gallbladder

glandular cells

placenta

decidual cells

placenta

trophoblastic cells

No databases found.

Pubmed ID Author Year Title

22617121

Ouandaogo et al.

2012

Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

22951915

Haozi et al.

2012

Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

Gene Symbol Entrez ID Uniprot ID Score

NQO1

1728

P15559

0.49

COL6A1

1291

P12109

0.62

POLR2E

5434

P19388

0.63

RPL31

6160

P62899

0.63

GFI1B

8328

Q5VTD9

0.63

KIAA1033

23325

Q2M389

0.63

BRD1

23774

O95696

0.63

ATXN7L2

127002

Q5T6C5

0.63

ACHE

43

P22303

0.67

KARS

3735

Q15046

0.72

EGF

1950

P01133

0.00

ITGA6

3655

P23229

0.00

ITGA2

3673

P17301

0.00

ITGA2B

3674

P08514

0.00

ITGA3

3675

P26006

0.00

ITGA4

3676

P13612

0.00

ITGA5

3678

P08648

0.00

ITGA7

3679

Q13683

0.00

ITGA9

3680

Q13797

0.00

ITGAV

3685

P06756

0.00

ITGB1

3688

P05556

0.00

ITGB3

3690

P05106

0.00

ITGB4

3691

P16144

0.00

ITGB5

3693

P18084

0.00

ITGA11

22801

Q9UKX5

0.00

HSPD1

3329

P10809

0.49

PSMD5

5711

Q16401

0.49

ERBB2IP

55914

Q96RT1

0.49

DPY30

84661

Q9C005

0.49

LAMA2

3908

P24043

0.52

LAMA3

3909

Q16787

0.52

LAMA4

3910

Q16363

0.52

SEPT12

124404

Q8IYM1

0.52

LAMA1

284217

P25391

0.52

ESR2

2100

Q92731

0.55

ANTXR2

118429

P58335

0.56

LAMA5

3911

O15230

0.59

LGALS3

3958

P17931

0.63

LGALS9

3965

O00182

0.63

NTF3

4908

P20783

0.63

NTRK1

4914

P04629

0.63

OGN

4969

P20774

0.63

PA2G4

5036

Q9UQ80

0.63

PSMC5

5705

P62195

0.63

PTPRK

5796

Q15262

0.63

TGFB1

7040

P01137

0.63

EIF3I

8668

Q13347

0.63

IFT140

9742

Q96RY7

0.63

CD96

10225

P40200

0.63

FBXO6

26270

Q9NRD1

0.63

HECW2

57520

Q9P2P5

0.63

TMEM25

84866

Q86YD3

0.63

PYHIN1

149628

Q6K0P9

0.63

ATXN7

6314

O15265

0.68

PDIA3

2923

P30101

0.72

KIF11

3832

P52732

0.72

FGFR1OP

11116

O95684

0.72

CACNA1A

773

O00555

0.75

LAMC1

3915

P11047

0.87