Gene Symbol | LAMB1 |
Entrez ID | 3912 |
Uniprot ID | P07942 |
Description | laminin subunit beta 1 |
Chromosomal Location | chr7: 107,923,799-108,003,255 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0007155 |
cell adhesion |
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. |
TAS |
BP |
GO:0021812 |
neuronal-glial interaction involved in cerebral cortex radial glia guided migration |
The changes in adhesion between neuronal cells and glial cells as a component of the process of cerebral cortex glial-mediated radial cell migration. |
IMP |
BP |
GO:0030198 |
extracellular matrix organization |
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix. |
TAS |
BP |
GO:0030335 |
positive regulation of cell migration |
Any process that activates or increases the frequency, rate or extent of cell migration. |
IDA |
BP |
GO:0031175 |
neuron projection development |
The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). |
IDA |
BP |
GO:0034446 |
substrate adhesion-dependent cell spreading |
The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate. |
IDA |
BP |
GO:0035987 |
endodermal cell differentiation |
The process in which a relatively unspecialized cell acquires the specialized features of an endoderm cell, a cell of the inner of the three germ layers of the embryo. |
IEP |
BP |
GO:0042476 |
odontogenesis |
The process whose specific outcome is the progression of a tooth or teeth over time, from formation to the mature structure(s). A tooth is any hard bony, calcareous, or chitinous organ found in the mouth or pharynx of an animal and used in procuring or masticating food. |
IDA |
BP |
GO:0050679 |
positive regulation of epithelial cell proliferation |
Any process that activates or increases the rate or extent of epithelial cell proliferation. |
TAS |
CC |
GO:0005576 |
extracellular region |
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
TAS |
CC |
GO:0005604 |
basement membrane |
A thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers. |
IDA|TAS |
CC |
GO:0005606 |
laminin-1 complex |
A laminin complex composed of alpha1, beta1 and gamma1 polypeptide chains. |
IDA|IPI|TAS |
CC |
GO:0005607 |
laminin-2 complex |
A laminin complex composed of alpha2, beta1 and gamma1 polypeptide chains. |
IDA|TAS |
CC |
GO:0005615 |
extracellular space |
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. |
IDA |
CC |
GO:0031012 |
extracellular matrix |
A structure lying external to one or more cells, which provides structural support for cells or tissues. |
IDA|ISS |
CC |
GO:0043257 |
laminin-8 complex |
A laminin complex composed of alpha4, beta1 and gamma1 polypeptide chains. |
IDA|TAS |
CC |
GO:0043259 |
laminin-10 complex |
A laminin complex composed of alpha5, beta1 and gamma1 polypeptide chains. |
IDA |
CC |
GO:0048471 |
perinuclear region of cytoplasm |
Cytoplasm situated near, or occurring around, the nucleus. |
ISS |
CC |
GO:0070062 |
extracellular exosome |
A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. |
IDA |
MF |
GO:0005198 |
structural molecule activity |
The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. |
NAS |
MF |
GO:0005201 |
extracellular matrix structural constituent |
The action of a molecule that contributes to the structural integrity of the extracellular matrix. |
IDA |
Domain ID | Description |
---|---|
IPR000742 |
EGF-like domain |
IPR002049 |
Laminin EGF domain |
IPR008211 |
Laminin, N-terminal |
IPR008979 |
Galactose-binding domain-like |
IPR013015 |
Laminin IV type B |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
hsa04151 |
PI3K-Akt signaling pathway |
KEGG |
hsa04510 |
Focal adhesion |
KEGG |
hsa04512 |
ECM-receptor interaction |
KEGG |
hsa05145 |
Toxoplasmosis |
KEGG |
hsa05146 |
Amoebiasis |
KEGG |
hsa05200 |
Pathways in cancer |
KEGG |
hsa05222 |
Small cell lung cancer |
KEGG |
WP306 |
Focal Adhesion |
WikiPathways |
WP244 |
Alpha 6 Beta 4 signaling pathway |
WikiPathways |
WP453 |
Inflammatory Response Pathway |
WikiPathways |
WP3932 |
Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
WikiPathways |
h_prionPathway |
Prion Pathway |
BioCarta |
UMLS CUI | UMLS Term |
---|---|
C0004352 |
Autistic Disorder |
C0009324 |
Ulcerative Colitis |
C0009363 |
Congenital Ocular Coloboma (Disorder) |
C0014175 |
Endometriosis |
Tissue | Cell Type |
---|---|
gallbladder |
glandular cells |
placenta |
decidual cells |
placenta |
trophoblastic cells |
Pubmed ID | Author | Year | Title |
---|---|---|---|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
NQO1 |
1728 |
P15559 |
0.49 |
COL6A1 |
1291 |
P12109 |
0.62 |
POLR2E |
5434 |
P19388 |
0.63 |
RPL31 |
6160 |
P62899 |
0.63 |
GFI1B |
8328 |
Q5VTD9 |
0.63 |
KIAA1033 |
23325 |
Q2M389 |
0.63 |
BRD1 |
23774 |
O95696 |
0.63 |
ATXN7L2 |
127002 |
Q5T6C5 |
0.63 |
ACHE |
43 |
P22303 |
0.67 |
KARS |
3735 |
Q15046 |
0.72 |
EGF |
1950 |
P01133 |
0.00 |
ITGA6 |
3655 |
P23229 |
0.00 |
ITGA2 |
3673 |
P17301 |
0.00 |
ITGA2B |
3674 |
P08514 |
0.00 |
ITGA3 |
3675 |
P26006 |
0.00 |
ITGA4 |
3676 |
P13612 |
0.00 |
ITGA5 |
3678 |
P08648 |
0.00 |
ITGA7 |
3679 |
Q13683 |
0.00 |
ITGA9 |
3680 |
Q13797 |
0.00 |
ITGAV |
3685 |
P06756 |
0.00 |
ITGB1 |
3688 |
P05556 |
0.00 |
ITGB3 |
3690 |
P05106 |
0.00 |
ITGB4 |
3691 |
P16144 |
0.00 |
ITGB5 |
3693 |
P18084 |
0.00 |
ITGA11 |
22801 |
Q9UKX5 |
0.00 |
HSPD1 |
3329 |
P10809 |
0.49 |
PSMD5 |
5711 |
Q16401 |
0.49 |
ERBB2IP |
55914 |
Q96RT1 |
0.49 |
DPY30 |
84661 |
Q9C005 |
0.49 |
LAMA2 |
3908 |
P24043 |
0.52 |
LAMA3 |
3909 |
Q16787 |
0.52 |
LAMA4 |
3910 |
Q16363 |
0.52 |
SEPT12 |
124404 |
Q8IYM1 |
0.52 |
LAMA1 |
284217 |
P25391 |
0.52 |
ESR2 |
2100 |
Q92731 |
0.55 |
ANTXR2 |
118429 |
P58335 |
0.56 |
LAMA5 |
3911 |
O15230 |
0.59 |
LGALS3 |
3958 |
P17931 |
0.63 |
LGALS9 |
3965 |
O00182 |
0.63 |
NTF3 |
4908 |
P20783 |
0.63 |
NTRK1 |
4914 |
P04629 |
0.63 |
OGN |
4969 |
P20774 |
0.63 |
PA2G4 |
5036 |
Q9UQ80 |
0.63 |
PSMC5 |
5705 |
P62195 |
0.63 |
PTPRK |
5796 |
Q15262 |
0.63 |
TGFB1 |
7040 |
P01137 |
0.63 |
EIF3I |
8668 |
Q13347 |
0.63 |
IFT140 |
9742 |
Q96RY7 |
0.63 |
CD96 |
10225 |
P40200 |
0.63 |
FBXO6 |
26270 |
Q9NRD1 |
0.63 |
HECW2 |
57520 |
Q9P2P5 |
0.63 |
TMEM25 |
84866 |
Q86YD3 |
0.63 |
PYHIN1 |
149628 |
Q6K0P9 |
0.63 |
ATXN7 |
6314 |
O15265 |
0.68 |
PDIA3 |
2923 |
P30101 |
0.72 |
KIF11 |
3832 |
P52732 |
0.72 |
FGFR1OP |
11116 |
O95684 |
0.72 |
CACNA1A |
773 |
O00555 |
0.75 |
LAMC1 |
3915 |
P11047 |
0.87 |