Protein Description

Gene Symbol LAMA4
Entrez ID 3910
Uniprot ID Q16363
Description laminin subunit alpha 4
Chromosomal Location chr6: 112,108,760-112,254,939
Ontology GO ID GO Term Definition Evidence

BP

GO:0007155

cell adhesion

The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.

IEA

BP

GO:0030155

regulation of cell adhesion

Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix.

IEA

BP

GO:0030198

extracellular matrix organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix.

TAS

BP

GO:0030334

regulation of cell migration

Any process that modulates the frequency, rate or extent of cell migration.

IEA

BP

GO:0045995

regulation of embryonic development

Any process that modulates the frequency, rate or extent of embryonic development.

IEA

CC

GO:0005576

extracellular region

The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

TAS

CC

GO:0005604

basement membrane

A thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers.

IDA

CC

GO:0005605

basal lamina

A thin sheet of proteoglycans and glycoproteins, especially laminin, secreted by cells as an extracellular matrix.

TAS

CC

GO:0031012

extracellular matrix

A structure lying external to one or more cells, which provides structural support for cells or tissues.

ISS

CC

GO:0070062

extracellular exosome

A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.

IDA

MF

GO:0005102

receptor binding

Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

IEA

MF

GO:0005201

extracellular matrix structural constituent

The action of a molecule that contributes to the structural integrity of the extracellular matrix.

TAS

Domain ID Description

IPR000742

EGF-like domain

IPR001791

Laminin G domain

IPR002049

Laminin EGF domain

IPR009254

Laminin alpha, domain I

IPR010307

Laminin domain II

IPR013320

Concanavalin A-like lectin/glucanase domain

Pathway ID Pathway Term Pathway Source

hsa04151

PI3K-Akt signaling pathway

KEGG

hsa04510

Focal adhesion

KEGG

hsa04512

ECM-receptor interaction

KEGG

hsa05143

African trypanosomiasis

KEGG

hsa05145

Toxoplasmosis

KEGG

hsa05146

Amoebiasis

KEGG

hsa05200

Pathways in cancer

KEGG

hsa05222

Small cell lung cancer

KEGG

WP306

Focal Adhesion

WikiPathways

WP2911

miRNA targets in ECM and membrane receptors

WikiPathways

WP3932

Focal Adhesion-PI3K-Akt-mTOR-signaling pathway

WikiPathways

h_agrPathway

Agrin in Postsynaptic Differentiation

BioCarta

UMLS CUI UMLS Term

C0000786

Spontaneous Abortion

Tissue Cell Type

smooth muscle

smooth muscle cells

No databases found.

Pubmed ID Author Year Title

19141577

Kim et al.

2009

Transcriptional Profiling with a Pathway-Oriented Analysis Identifies Dysregulated Molecular Phenotypes in the Endometrium of Patients with Polycystic Ovary Syndrome

Gene Symbol Entrez ID Uniprot ID Score

LAMB1

3912

P07942

0.52

LAMB2

3913

P55268

0.52

LAMC1

3915

P11047

0.52

LAMC3

10319

Q9Y6N6

0.52

CNN3

1266

Q15417

0.63

FHL1

2273

Q13642

0.63

NUP98

4928

P52948

0.63

SUMO2

6613

P61956

0.63

TUBB2A

7280

Q13885

0.63

UNC119

9094

Q13432

0.63

COPS6

10980

Q7L5N1

0.63

BRD7

29117

Q9NPI1

0.63

MED31

51003

Q9Y3C7

0.63

RIF1

55183

Q5UIP0

0.63

ATF7IP

55729

Q6VMQ6

0.63

LRIF1

55791

Q5T3J3

0.63

UBR1

197131

Q8IWV7

0.63

TUBB2B

347733

Q9BVA1

0.63

ZHX1

11244

Q9UKY1

0.73

APC

324

P25054

0.63

EEF1A1

1915

P68104

0.63

LGALS3

3958

P17931

0.63

LGALS8

3964

O00214

0.63

LGALS9

3965

O00182

0.63

MCAM

4162

P43121

0.63

STX1A

6804

Q16623

0.63

PILRA

29992

Q9UKJ1

0.63

IFT57

55081

Q9NWB7

0.63

RTN4

57142

Q9NQC3

0.63

GAPDH

2597

P04406

0.73

PTN

5764

P21246

0.73

TP53

7157

P04637

0.76