Gene Symbol | LAMA4 |
Entrez ID | 3910 |
Uniprot ID | Q16363 |
Description | laminin subunit alpha 4 |
Chromosomal Location | chr6: 112,108,760-112,254,939 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0007155 |
cell adhesion |
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. |
IEA |
BP |
GO:0030155 |
regulation of cell adhesion |
Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix. |
IEA |
BP |
GO:0030198 |
extracellular matrix organization |
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix. |
TAS |
BP |
GO:0030334 |
regulation of cell migration |
Any process that modulates the frequency, rate or extent of cell migration. |
IEA |
BP |
GO:0045995 |
regulation of embryonic development |
Any process that modulates the frequency, rate or extent of embryonic development. |
IEA |
CC |
GO:0005576 |
extracellular region |
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
TAS |
CC |
GO:0005604 |
basement membrane |
A thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers. |
IDA |
CC |
GO:0005605 |
basal lamina |
A thin sheet of proteoglycans and glycoproteins, especially laminin, secreted by cells as an extracellular matrix. |
TAS |
CC |
GO:0031012 |
extracellular matrix |
A structure lying external to one or more cells, which provides structural support for cells or tissues. |
ISS |
CC |
GO:0070062 |
extracellular exosome |
A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. |
IDA |
MF |
GO:0005102 |
receptor binding |
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. |
IEA |
MF |
GO:0005201 |
extracellular matrix structural constituent |
The action of a molecule that contributes to the structural integrity of the extracellular matrix. |
TAS |
Domain ID | Description |
---|---|
IPR000742 |
EGF-like domain |
IPR001791 |
Laminin G domain |
IPR002049 |
Laminin EGF domain |
IPR009254 |
Laminin alpha, domain I |
IPR010307 |
Laminin domain II |
IPR013320 |
Concanavalin A-like lectin/glucanase domain |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
hsa04151 |
PI3K-Akt signaling pathway |
KEGG |
hsa04510 |
Focal adhesion |
KEGG |
hsa04512 |
ECM-receptor interaction |
KEGG |
hsa05143 |
African trypanosomiasis |
KEGG |
hsa05145 |
Toxoplasmosis |
KEGG |
hsa05146 |
Amoebiasis |
KEGG |
hsa05200 |
Pathways in cancer |
KEGG |
hsa05222 |
Small cell lung cancer |
KEGG |
WP306 |
Focal Adhesion |
WikiPathways |
WP2911 |
miRNA targets in ECM and membrane receptors |
WikiPathways |
WP3932 |
Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
WikiPathways |
h_agrPathway |
Agrin in Postsynaptic Differentiation |
BioCarta |
UMLS CUI | UMLS Term |
---|---|
C0000786 |
Spontaneous Abortion |
Tissue | Cell Type |
---|---|
smooth muscle |
smooth muscle cells |
Pubmed ID | Author | Year | Title |
---|---|---|---|
19141577 |
Kim et al. |
2009 |
Transcriptional Profiling with a Pathway-Oriented Analysis Identifies Dysregulated Molecular Phenotypes in the Endometrium of Patients with Polycystic Ovary Syndrome |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
LAMB1 |
3912 |
P07942 |
0.52 |
LAMB2 |
3913 |
P55268 |
0.52 |
LAMC1 |
3915 |
P11047 |
0.52 |
LAMC3 |
10319 |
Q9Y6N6 |
0.52 |
CNN3 |
1266 |
Q15417 |
0.63 |
FHL1 |
2273 |
Q13642 |
0.63 |
NUP98 |
4928 |
P52948 |
0.63 |
SUMO2 |
6613 |
P61956 |
0.63 |
TUBB2A |
7280 |
Q13885 |
0.63 |
UNC119 |
9094 |
Q13432 |
0.63 |
COPS6 |
10980 |
Q7L5N1 |
0.63 |
BRD7 |
29117 |
Q9NPI1 |
0.63 |
MED31 |
51003 |
Q9Y3C7 |
0.63 |
RIF1 |
55183 |
Q5UIP0 |
0.63 |
ATF7IP |
55729 |
Q6VMQ6 |
0.63 |
LRIF1 |
55791 |
Q5T3J3 |
0.63 |
UBR1 |
197131 |
Q8IWV7 |
0.63 |
TUBB2B |
347733 |
Q9BVA1 |
0.63 |
ZHX1 |
11244 |
Q9UKY1 |
0.73 |
APC |
324 |
P25054 |
0.63 |
EEF1A1 |
1915 |
P68104 |
0.63 |
LGALS3 |
3958 |
P17931 |
0.63 |
LGALS8 |
3964 |
O00214 |
0.63 |
LGALS9 |
3965 |
O00182 |
0.63 |
MCAM |
4162 |
P43121 |
0.63 |
STX1A |
6804 |
Q16623 |
0.63 |
PILRA |
29992 |
Q9UKJ1 |
0.63 |
IFT57 |
55081 |
Q9NWB7 |
0.63 |
RTN4 |
57142 |
Q9NQC3 |
0.63 |
GAPDH |
2597 |
P04406 |
0.73 |
PTN |
5764 |
P21246 |
0.73 |
TP53 |
7157 |
P04637 |
0.76 |