Gene Symbol | KPNA4 |
Entrez ID | 3840 |
Uniprot ID | O00629 |
Description | karyopherin alpha 4 (importin alpha 3) |
Chromosomal Location | chr3: 160,494,995-160,565,588 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0006607 |
NLS-bearing protein import into nucleus |
The directed movement of a protein bearing a nuclear localization signal (NLS) from the cytoplasm into the nucleus, across the nuclear membrane. |
TAS |
BP |
GO:0019054 |
modulation by virus of host process |
The process in which a virus effects a change in the processes and activities of its host organism. |
TAS |
BP |
GO:0042542 |
response to hydrogen peroxide |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus. |
IEA |
BP |
GO:0075733 |
intracellular transport of virus |
The directed movement of a virus, or part of a virus, within the host cell. |
TAS |
CC |
GO:0005643 |
nuclear pore |
Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined. |
IBA |
CC |
GO:0005654 |
nucleoplasm |
That part of the nuclear content other than the chromosomes or the nucleolus. |
IBA|TAS |
CC |
GO:0005829 |
cytosol |
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
IBA|TAS |
CC |
GO:0070062 |
extracellular exosome |
A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. |
IDA |
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
MF |
GO:0008139 |
nuclear localization sequence binding |
Interacting selectively and non-covalently with a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus. |
IBA |
MF |
GO:0008565 |
protein transporter activity |
Enables the directed movement of proteins into, out of or within a cell, or between cells. |
IBA |
Domain ID | Description |
---|---|
IPR000225 |
Armadillo |
IPR002652 |
Importin-alpha, importin-beta-binding domain |
IPR011989 |
Armadillo-like helical |
IPR016024 |
Armadillo-type fold |
IPR024931 |
Importin subunit alpha |
IPR032413 |
Atypical Arm repeat |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
WP2034 |
Leptin signaling pathway |
WikiPathways |
Tissue | Cell Type |
---|---|
adrenal gland |
glandular cells |
appendix |
glandular cells |
bronchus |
respiratory epithelial cells |
caudate |
neuronal cells |
cerebellum |
cells in molecular layer |
cerebellum |
Purkinje cells |
cerebral cortex |
neuronal cells |
cervix, uterine |
glandular cells |
colon |
glandular cells |
duodenum |
glandular cells |
epididymis |
glandular cells |
esophagus |
squamous epithelial cells |
gallbladder |
glandular cells |
heart muscle |
myocytes |
hippocampus |
glial cells |
hippocampus |
neuronal cells |
kidney |
cells in glomeruli |
kidney |
cells in tubules |
liver |
hepatocytes |
lung |
pneumocytes |
oral mucosa |
squamous epithelial cells |
ovary |
follicle cells |
placenta |
trophoblastic cells |
rectum |
glandular cells |
skeletal muscle |
myocytes |
skin |
epidermal cells |
small intestine |
glandular cells |
smooth muscle |
smooth muscle cells |
stomach |
glandular cells |
testis |
cells in seminiferous ducts |
testis |
Leydig cells |
tonsil |
squamous epithelial cells |
urinary bladder |
urothelial cells |
Pubmed ID | Author | Year | Title |
---|---|---|---|
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |