Protein Description

Gene Symbol KPNA4
Entrez ID 3840
Uniprot ID O00629
Description karyopherin alpha 4 (importin alpha 3)
Chromosomal Location chr3: 160,494,995-160,565,588
Ontology GO ID GO Term Definition Evidence

BP

GO:0006607

NLS-bearing protein import into nucleus

The directed movement of a protein bearing a nuclear localization signal (NLS) from the cytoplasm into the nucleus, across the nuclear membrane.

TAS

BP

GO:0019054

modulation by virus of host process

The process in which a virus effects a change in the processes and activities of its host organism.

TAS

BP

GO:0042542

response to hydrogen peroxide

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.

IEA

BP

GO:0075733

intracellular transport of virus

The directed movement of a virus, or part of a virus, within the host cell.

TAS

CC

GO:0005643

nuclear pore

Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined.

IBA

CC

GO:0005654

nucleoplasm

That part of the nuclear content other than the chromosomes or the nucleolus.

IBA|TAS

CC

GO:0005829

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

IBA|TAS

CC

GO:0070062

extracellular exosome

A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.

IDA

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0008139

nuclear localization sequence binding

Interacting selectively and non-covalently with a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus.

IBA

MF

GO:0008565

protein transporter activity

Enables the directed movement of proteins into, out of or within a cell, or between cells.

IBA

Domain ID Description

IPR000225

Armadillo

IPR002652

Importin-alpha, importin-beta-binding domain

IPR011989

Armadillo-like helical

IPR016024

Armadillo-type fold

IPR024931

Importin subunit alpha

IPR032413

Atypical Arm repeat

Pathway ID Pathway Term Pathway Source

WP2034

Leptin signaling pathway

WikiPathways

No diseases found.

Tissue Cell Type

adrenal gland

glandular cells

appendix

glandular cells

bronchus

respiratory epithelial cells

caudate

neuronal cells

cerebellum

cells in molecular layer

cerebellum

Purkinje cells

cerebral cortex

neuronal cells

cervix, uterine

glandular cells

colon

glandular cells

duodenum

glandular cells

epididymis

glandular cells

esophagus

squamous epithelial cells

gallbladder

glandular cells

heart muscle

myocytes

hippocampus

glial cells

hippocampus

neuronal cells

kidney

cells in glomeruli

kidney

cells in tubules

liver

hepatocytes

lung

pneumocytes

oral mucosa

squamous epithelial cells

ovary

follicle cells

placenta

trophoblastic cells

rectum

glandular cells

skeletal muscle

myocytes

skin

epidermal cells

small intestine

glandular cells

smooth muscle

smooth muscle cells

stomach

glandular cells

testis

cells in seminiferous ducts

testis

Leydig cells

tonsil

squamous epithelial cells

urinary bladder

urothelial cells

No databases found.

Pubmed ID Author Year Title

22951915

Haozi et al.

2012

Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

No partners found.