Protein Description

Gene Symbol ITGAX
Entrez ID 3687
Uniprot ID P20702
Descriptionintegrin subunit alpha X
Chromosomal Locationchr16: 31,355,134-31,382,997
OntologyGO IDGO TermDefinitionEvidence

BP

GO:0007155

cell adhesion

The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.

TAS

BP

GO:0007229

integrin-mediated signaling pathway

A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.

IEA

BP

GO:0009887

animal organ morphogenesis

Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

TAS

BP

GO:0030198

extracellular matrix organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix.

TAS

BP

GO:0034113

heterotypic cell-cell adhesion

The attachment of a cell to a cell of a different type via adhesion molecules.

IMP

BP

GO:0050900

leukocyte migration

The movement of a leukocyte within or between different tissues and organs of the body.

TAS

BP

GO:1903955

positive regulation of protein targeting to mitochondrion

Any process that activates or increases the frequency, rate or extent of protein targeting to mitochondrion.

IMP

CC

GO:0005886

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

TAS

CC

GO:0008305

integrin complex

A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands.

IEA

CC

GO:0009986

cell surface

The external part of the cell wall and/or plasma membrane.

IC|IDA

CC

GO:0016020

membrane

A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

IDA

MF

GO:0004872

receptor activity

Combining with an extracellular or intracellular messenger to initiate a change in cell activity.

TAS

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0046872

metal ion binding

Interacting selectively and non-covalently with any metal ion.

IEA

Domain IDDescription

IPR000413

Integrin alpha chain

IPR002035

von Willebrand factor, type A

IPR013517

FG-GAP repeat

IPR013519

Integrin alpha beta-propellor

IPR013649

Integrin alpha-2

IPR018184

Integrin alpha chain, C-terminal cytoplasmic region, conserved site

IPR032695

Integrin domain

Pathway IDPathway TermPathway Source

hsa04610

Complement and coagulation cascades

KEGG

hsa04810

Regulation of actin cytoskeleton

KEGG

hsa05152

Tuberculosis

KEGG

WP306

Focal Adhesion

WikiPathways

WP3945

TYROBP Causal Network

WikiPathways

WP185

Integrin-mediated Cell Adhesion

WikiPathways

WP3932

Focal Adhesion-PI3K-Akt-mTOR-signaling pathway

WikiPathways

h_dcPathway

Dendritic cells in regulating TH1 and TH2 Development

BioCarta

UMLS CUIUMLS Term

C0017661

Iga Glomerulonephritis

C0023487

Acute Promyelocytic Leukemia

C0024141

Lupus Erythematosus, Systemic

No tissues found.

Database Name

DisGeNET

DGA

No sources found.

Gene SymbolEntrez IDUniprot IDScore

PTK2

5747

Q05397

0.0

FCER2

2208

P06734

0.62

C3

718

P01024

0.86

CRK

1398

P46108

0.0

CRKL

1399

P46109

0.0

CD209

30835

Q9NNX6

0.0

JAM3

83700

Q9BX67

0.52

ITGB2

3689

P05107

0.85