| Gene Symbol | ITGAX |
| Entrez ID | 3687 |
| Uniprot ID | P20702 |
| Description | integrin subunit alpha X |
| Chromosomal Location | chr16: 31,355,134-31,382,997 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
BP | GO:0007155 | cell adhesion |
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. | TAS |
BP | GO:0007229 | integrin-mediated signaling pathway |
A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. | IEA |
BP | GO:0009887 | animal organ morphogenesis |
Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. | TAS |
BP | GO:0030198 | extracellular matrix organization |
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix. | TAS |
BP | GO:0034113 | heterotypic cell-cell adhesion |
The attachment of a cell to a cell of a different type via adhesion molecules. | IMP |
BP | GO:0050900 | leukocyte migration |
The movement of a leukocyte within or between different tissues and organs of the body. | TAS |
BP | GO:1903955 | positive regulation of protein targeting to mitochondrion |
Any process that activates or increases the frequency, rate or extent of protein targeting to mitochondrion. | IMP |
CC | GO:0005886 | plasma membrane |
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. | TAS |
CC | GO:0008305 | integrin complex |
A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. | IEA |
CC | GO:0009986 | cell surface |
The external part of the cell wall and/or plasma membrane. | IC|IDA |
CC | GO:0016020 | membrane |
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. | IDA |
MF | GO:0004872 | receptor activity |
Combining with an extracellular or intracellular messenger to initiate a change in cell activity. | TAS |
MF | GO:0005515 | protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). | IPI |
MF | GO:0046872 | metal ion binding |
Interacting selectively and non-covalently with any metal ion. | IEA |
| Domain ID | Description |
|---|---|
IPR000413 | Integrin alpha chain |
IPR002035 | von Willebrand factor, type A |
IPR013517 | FG-GAP repeat |
IPR013519 | Integrin alpha beta-propellor |
IPR013649 | Integrin alpha-2 |
IPR018184 | Integrin alpha chain, C-terminal cytoplasmic region, conserved site |
IPR032695 | Integrin domain |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
hsa04610 | Complement and coagulation cascades | KEGG |
hsa04810 | Regulation of actin cytoskeleton | KEGG |
hsa05152 | Tuberculosis | KEGG |
WP306 | Focal Adhesion | WikiPathways |
WP3945 | TYROBP Causal Network | WikiPathways |
WP185 | Integrin-mediated Cell Adhesion | WikiPathways |
WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway | WikiPathways |
h_dcPathway | Dendritic cells in regulating TH1 and TH2 Development | BioCarta |
| UMLS CUI | UMLS Term |
|---|---|
C0017661 | Iga Glomerulonephritis |
C0023487 | Acute Promyelocytic Leukemia |
C0024141 | Lupus Erythematosus, Systemic |
| Database Name |
|---|
DisGeNET |
DGA |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
PTK2 | 5747 | Q05397 | 0.0 |
FCER2 | 2208 | P06734 | 0.62 |
C3 | 718 | P01024 | 0.86 |
CRK | 1398 | P46108 | 0.0 |
CRKL | 1399 | P46109 | 0.0 |
CD209 | 30835 | Q9NNX6 | 0.0 |
JAM3 | 83700 | Q9BX67 | 0.52 |
ITGB2 | 3689 | P05107 | 0.85 |