BP

GO:0001525

angiogenesis

Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.

IEP

BP

GO:0002479

antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent

The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class I molecule. Class I here refers to classical class I molecules.

TAS

BP

GO:0007155

cell adhesion

The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.

IDA

BP

GO:0007160

cell-matrix adhesion

The binding of a cell to the extracellular matrix via adhesion molecules.

IDA|IMP|NAS

BP

GO:0007229

integrin-mediated signaling pathway

A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.

NAS

BP

GO:0008284

positive regulation of cell proliferation

Any process that activates or increases the rate or extent of cell proliferation.

IDA

BP

GO:0010745

negative regulation of macrophage derived foam cell differentiation

Any process that decreases the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions.

IMP

BP

GO:0010888

negative regulation of lipid storage

Any process that modulates the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development.

IMP

BP

GO:0016049

cell growth

The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present.

IMP

BP

GO:0016477

cell migration

The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.

IMP

BP

GO:0030198

extracellular matrix organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix.

TAS

BP

GO:0030335

positive regulation of cell migration

Any process that activates or increases the frequency, rate or extent of cell migration.

IEA

BP

GO:0031589

cell-substrate adhesion

The attachment of a cell to the underlying substrate via adhesion molecules.

IMP

BP

GO:0032369

negative regulation of lipid transport

Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

IMP

BP

GO:0033627

cell adhesion mediated by integrin

The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits.

IDA

BP

GO:0033690

positive regulation of osteoblast proliferation

Any process that activates or increases the rate or extent of osteoblast proliferation.

IEA

BP

GO:0034113

heterotypic cell-cell adhesion

The attachment of a cell to a cell of a different type via adhesion molecules.

IMP

BP

GO:0034446

substrate adhesion-dependent cell spreading

The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate.

IDA

BP

GO:0035987

endodermal cell differentiation

The process in which a relatively unspecialized cell acquires the specialized features of an endoderm cell, a cell of the inner of the three germ layers of the embryo.

IMP

BP

GO:0038027

apolipoprotein A-I-mediated signaling pathway

A series of molecular signals initiated by the binding of apolipoprotein A-I to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.

IMP

BP

GO:0043277

apoptotic cell clearance

The recognition and removal of an apoptotic cell by a neighboring cell or by a phagocyte.

IEA

BP

GO:0045715

negative regulation of low-density lipoprotein particle receptor biosynthetic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of low-density lipoprotein particle receptors.

IMP

BP

GO:0045785

positive regulation of cell adhesion

Any process that activates or increases the frequency, rate or extent of cell adhesion.

IDA

BP

GO:0046718

viral entry into host cell

The process that occurs after viral attachment by which a virus, or viral nucleic acid, breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the viral nucleic acid is released into the host cell cytoplasm.

IMP|TAS

BP

GO:0048010

vascular endothelial growth factor receptor signaling pathway

Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor (VEGFR) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription.

TAS

BP

GO:0050748

negative regulation of lipoprotein metabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids.

IMP

BP

GO:0050764

regulation of phagocytosis

Any process that modulates the frequency, rate or extent of phagocytosis, the process in which phagocytes engulf external particulate material.

IDA

BP

GO:0050900

leukocyte migration

The movement of a leukocyte within or between different tissues and organs of the body.

TAS

BP

GO:0050919

negative chemotaxis

The directed movement of a motile cell or organism towards a lower concentration of a chemical.

IMP

BP

GO:0052066

entry of symbiont into host cell by promotion of host phagocytosis

The invasion by an organism of a cell of its host organism by utilizing the host phagocytosis mechanism. The host is defined as the larger of the organisms involved in a symbiotic interaction.

NAS

BP

GO:0070371

ERK1 and ERK2 cascade

An intracellular protein kinase cascade containing at least ERK1 or ERK2 (MAPKs), a MEK (a MAPKK) and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.

ISS

BP

GO:0070588

calcium ion transmembrane transport

A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.

IDA

BP

GO:0097192

extrinsic apoptotic signaling pathway in absence of ligand

A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered.

ISS

BP

GO:2000425

regulation of apoptotic cell clearance

Any process that modulates the frequency, rate or extent of apoptotic cell clearance.

ISS

BP

GO:2000536

negative regulation of entry of bacterium into host cell

Any process that stops, prevents or reduces the frequency, rate or extent of entry of bacterium into host cell.

IDA

BP

GO:2001237

negative regulation of extrinsic apoptotic signaling pathway

Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway.

IMP

CC

GO:0005886

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

IDA|TAS

CC

GO:0005887

integral component of plasma membrane

The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

NAS

CC

GO:0005925

focal adhesion

Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.

IDA

CC

GO:0008305

integrin complex

A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands.

IDA|NAS

CC

GO:0009897

external side of plasma membrane

The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.

IEA

CC

GO:0009986

cell surface

The external part of the cell wall and/or plasma membrane.

IDA|ISS

CC

GO:0016020

membrane

A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

ISS

CC

GO:0031258

lamellipodium membrane

The portion of the plasma membrane surrounding a lamellipodium.

IDA

CC

GO:0031527

filopodium membrane

The portion of the plasma membrane surrounding a filopodium.

IDA

CC

GO:0031528

microvillus membrane

The portion of the plasma membrane surrounding a microvillus.

IDA

CC

GO:0032587

ruffle membrane

The portion of the plasma membrane surrounding a ruffle.

IDA

CC

GO:0034683

integrin alphav-beta3 complex

An integrin complex that comprises one alphav subunit and one beta3 subunit.

IDA

CC

GO:0034684

integrin alphav-beta5 complex

An integrin complex that comprises one alphav subunit and one beta5 subunit.

IDA

CC

GO:0034686

integrin alphav-beta8 complex

An integrin complex that comprises one alphav subunit and one beta8 subunit.

IDA

CC

GO:0035867

alphav-beta3 integrin-IGF-1-IGF1R complex

A protein complex that consists of an alphav-beta3 integrin complex bound to insulin-like growth factor-1 (IGF-1) and type I insulin-like growth factor receptor (IGF1R). IGF1R is a heterotetramer that consists of two alpha-subunits and two beta-subunits.

IDA

CC

GO:0045335

phagocytic vesicle

A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.

TAS

CC

GO:0070062

extracellular exosome

A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.

IDA

MF

GO:0001618

virus receptor activity

Combining with a virus component and mediating entry of the virus into the cell.

IEA

MF

GO:0001846

opsonin binding

Interacting selectively and non-covalently with an opsonin, such as a complement component or antibody, deposited on the surface of a bacteria, virus, immune complex, or other particulate material.

ISS

MF

GO:0001968

fibronectin binding

Interacting selectively and non-covalently with a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids.

IDA

MF

GO:0002020

protease binding

Interacting selectively and non-covalently with any protease or peptidase.

IDA

MF

GO:0005080

protein kinase C binding

Interacting selectively and non-covalently with protein kinase C.

ISS

MF

GO:0005245

voltage-gated calcium channel activity

Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.

IDA

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0015026

coreceptor activity

Combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity.

TAS

MF

GO:0017134

fibroblast growth factor binding

Interacting selectively and non-covalently with a fibroblast growth factor.

IDA

MF

GO:0019960

C-X3-C chemokine binding

Interacting selectively and non-covalently with a C-X3-C chemokine; C-X3-C chemokines have three amino acids between the first two cysteines of the characteristic four-cysteine motif.

IDA

MF

GO:0031994

insulin-like growth factor I binding

Interacting selectively and non-covalently with insulin-like growth factor I.

IDA

MF

GO:0038132

neuregulin binding

Interacting selectively and non-covalently with a neuregulin, a member of the EGF family of growth factors.

IDA

MF

GO:0046872

metal ion binding

Interacting selectively and non-covalently with any metal ion.

IEA

MF

GO:0050431

transforming growth factor beta binding

Interacting selectively and non-covalently with TGF-beta, transforming growth factor beta, a multifunctional peptide that controls proliferation, differentiation and other functions in many cell types.

ISS

MF

GO:0050840

extracellular matrix binding

Interacting selectively and non-covalently with a component of the extracellular matrix.

IDA

MF

GO:1990430

extracellular matrix protein binding

Interacting selectively and non-covalently with a protein that is part of an extracellular matrix.

IDA