Gene Symbol | ITGAM |
Entrez ID | 3684 |
Uniprot ID | P11215 |
Description | integrin subunit alpha M |
Chromosomal Location | chr16: 31,259,990-31,332,892 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0007155 |
cell adhesion |
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. |
IEA |
BP |
GO:0007229 |
integrin-mediated signaling pathway |
A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. |
IEA |
BP |
GO:0010668 |
ectodermal cell differentiation |
The process in which relatively unspecialized cells acquire specialized structural and/or functional features of an ectodermal cell. Differentiation includes the processes involved in commitment of a cell to a specific fate. |
IEP |
BP |
GO:0030198 |
extracellular matrix organization |
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix. |
TAS |
BP |
GO:0034142 |
toll-like receptor 4 signaling pathway |
Any series of molecular signals generated as a consequence of binding to toll-like receptor 4. |
TAS |
BP |
GO:0050900 |
leukocyte migration |
The movement of a leukocyte within or between different tissues and organs of the body. |
TAS |
CC |
GO:0005615 |
extracellular space |
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. |
IDA |
CC |
GO:0005886 |
plasma membrane |
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
TAS |
CC |
GO:0008305 |
integrin complex |
A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. |
IEA |
CC |
GO:0009986 |
cell surface |
The external part of the cell wall and/or plasma membrane. |
IDA |
CC |
GO:0070062 |
extracellular exosome |
A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. |
IDA |
MF |
GO:0001948 |
glycoprotein binding |
Interacting selectively and non-covalently with a glycoprotein, a protein that contains covalently bound glycose (monosaccharide) residues. These also include proteoglycans. |
IPI |
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
MF |
GO:0046872 |
metal ion binding |
Interacting selectively and non-covalently with any metal ion. |
IEA |
MF |
GO:0046982 |
protein heterodimerization activity |
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer. |
IEA |
Domain ID | Description |
---|---|
IPR000413 |
Integrin alpha chain |
IPR002035 |
von Willebrand factor, type A |
IPR013517 |
FG-GAP repeat |
IPR013519 |
Integrin alpha beta-propellor |
IPR013649 |
Integrin alpha-2 |
IPR018184 |
Integrin alpha chain, C-terminal cytoplasmic region, conserved site |
IPR032695 |
Integrin domain |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
hsa04015 |
Rap1 signaling pathway |
KEGG |
hsa04145 |
Phagosome |
KEGG |
hsa04514 |
Cell adhesion molecules (CAMs) |
KEGG |
hsa04610 |
Complement and coagulation cascades |
KEGG |
hsa04640 |
Hematopoietic cell lineage |
KEGG |
hsa04670 |
Leukocyte transendothelial migration |
KEGG |
hsa04810 |
Regulation of actin cytoskeleton |
KEGG |
hsa05133 |
Pertussis |
KEGG |
hsa05134 |
Legionellosis |
KEGG |
hsa05140 |
Leishmaniasis |
KEGG |
hsa05146 |
Amoebiasis |
KEGG |
hsa05150 |
Staphylococcus aureus infection |
KEGG |
hsa05152 |
Tuberculosis |
KEGG |
hsa05202 |
Transcriptional misregulation in cancer |
KEGG |
WP306 |
Focal Adhesion |
WikiPathways |
WP3945 |
TYROBP Causal Network |
WikiPathways |
WP185 |
Integrin-mediated Cell Adhesion |
WikiPathways |
WP3937 |
Microglia Pathogen Phagocytosis Pathway |
WikiPathways |
h_granulocytesPathway |
Adhesion and Diapedesis of Granulocytes |
BioCarta |
h_monocytePathway |
Monocyte and its Surface Molecules |
BioCarta |
h_neutrophilPathway |
Neutrophil and Its Surface Molecules |
BioCarta |
UMLS CUI | UMLS Term |
---|---|
C0017661 |
Iga Glomerulonephritis |
C0020877 |
Ileitis |
C0023487 |
Acute Promyelocytic Leukemia |
C0024141 |
Lupus Erythematosus, Systemic |
C0036421 |
Systemic Scleroderma |
C0162820 |
Dermatitis, Allergic Contact |
Tissue | Cell Type |
---|---|
bone marrow |
hematopoietic cells |
Pubmed ID | Author | Year | Title |
---|---|---|---|
22904171 |
Kaur et al. |
2012 |
Differential Gene Expression in Granulosa Cells from Polycystic Ovary Syndrome Patients with and without Insulin Resistance: Identification of Susceptibility Gene Sets through Network Analysis |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
PLG |
5340 |
P00747 |
0.00 |
PTPRC |
5788 |
P08575 |
0.00 |
SHARPIN |
81858 |
Q9H0F6 |
0.49 |
ELANE |
1991 |
P08246 |
0.52 |
ICAM4 |
3386 |
Q14773 |
0.52 |
THY1 |
7070 |
P04216 |
0.52 |
C3 |
718 |
P01024 |
0.65 |
BCAP31 |
10134 |
P51572 |
0.70 |
CRKL |
1399 |
P46109 |
0.00 |
BCAR1 |
9564 |
P56945 |
0.00 |
GP1BA |
2811 |
P07359 |
0.52 |
CFH |
3075 |
P08603 |
0.52 |
HP |
3240 |
P00738 |
0.52 |
ICAM2 |
3384 |
P13598 |
0.52 |
CD209 |
30835 |
Q9NNX6 |
0.52 |
FGG |
2266 |
P02679 |
0.62 |
AUP1 |
550 |
Q9Y679 |
0.63 |
RAD21 |
5885 |
O60216 |
0.63 |
CLEC4M |
10332 |
Q9H2X3 |
0.65 |
ITGB2 |
3689 |
P05107 |
0.71 |
PRTN3 |
5657 |
P24158 |
0.72 |
IRAK1 |
3654 |
P51617 |
0.73 |
PLAUR |
5329 |
Q03405 |
0.76 |
JAM3 |
83700 |
Q9BX67 |
0.76 |
ICAM1 |
3383 |
P05362 |
0.87 |