Protein Description

Gene Symbol ITGAM
Entrez ID 3684
Uniprot ID P11215
Description integrin subunit alpha M
Chromosomal Location chr16: 31,259,990-31,332,892
Ontology GO ID GO Term Definition Evidence

BP

GO:0007155

cell adhesion

The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.

IEA

BP

GO:0007229

integrin-mediated signaling pathway

A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.

IEA

BP

GO:0010668

ectodermal cell differentiation

The process in which relatively unspecialized cells acquire specialized structural and/or functional features of an ectodermal cell. Differentiation includes the processes involved in commitment of a cell to a specific fate.

IEP

BP

GO:0030198

extracellular matrix organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix.

TAS

BP

GO:0034142

toll-like receptor 4 signaling pathway

Any series of molecular signals generated as a consequence of binding to toll-like receptor 4.

TAS

BP

GO:0050900

leukocyte migration

The movement of a leukocyte within or between different tissues and organs of the body.

TAS

CC

GO:0005615

extracellular space

That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

IDA

CC

GO:0005886

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

TAS

CC

GO:0008305

integrin complex

A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands.

IEA

CC

GO:0009986

cell surface

The external part of the cell wall and/or plasma membrane.

IDA

CC

GO:0070062

extracellular exosome

A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.

IDA

MF

GO:0001948

glycoprotein binding

Interacting selectively and non-covalently with a glycoprotein, a protein that contains covalently bound glycose (monosaccharide) residues. These also include proteoglycans.

IPI

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0046872

metal ion binding

Interacting selectively and non-covalently with any metal ion.

IEA

MF

GO:0046982

protein heterodimerization activity

Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.

IEA

Domain ID Description

IPR000413

Integrin alpha chain

IPR002035

von Willebrand factor, type A

IPR013517

FG-GAP repeat

IPR013519

Integrin alpha beta-propellor

IPR013649

Integrin alpha-2

IPR018184

Integrin alpha chain, C-terminal cytoplasmic region, conserved site

IPR032695

Integrin domain

Pathway ID Pathway Term Pathway Source

hsa04015

Rap1 signaling pathway

KEGG

hsa04145

Phagosome

KEGG

hsa04514

Cell adhesion molecules (CAMs)

KEGG

hsa04610

Complement and coagulation cascades

KEGG

hsa04640

Hematopoietic cell lineage

KEGG

hsa04670

Leukocyte transendothelial migration

KEGG

hsa04810

Regulation of actin cytoskeleton

KEGG

hsa05133

Pertussis

KEGG

hsa05134

Legionellosis

KEGG

hsa05140

Leishmaniasis

KEGG

hsa05146

Amoebiasis

KEGG

hsa05150

Staphylococcus aureus infection

KEGG

hsa05152

Tuberculosis

KEGG

hsa05202

Transcriptional misregulation in cancer

KEGG

WP306

Focal Adhesion

WikiPathways

WP3945

TYROBP Causal Network

WikiPathways

WP185

Integrin-mediated Cell Adhesion

WikiPathways

WP3937

Microglia Pathogen Phagocytosis Pathway

WikiPathways

h_granulocytesPathway

Adhesion and Diapedesis of Granulocytes

BioCarta

h_monocytePathway

Monocyte and its Surface Molecules

BioCarta

h_neutrophilPathway

Neutrophil and Its Surface Molecules

BioCarta

UMLS CUI UMLS Term

C0017661

Iga Glomerulonephritis

C0020877

Ileitis

C0023487

Acute Promyelocytic Leukemia

C0024141

Lupus Erythematosus, Systemic

C0036421

Systemic Scleroderma

C0162820

Dermatitis, Allergic Contact

Tissue Cell Type

bone marrow

hematopoietic cells

No databases found.

Pubmed ID Author Year Title

22904171

Kaur et al.

2012

Differential Gene Expression in Granulosa Cells from Polycystic Ovary Syndrome Patients with and without Insulin Resistance: Identification of Susceptibility Gene Sets through Network Analysis

Gene Symbol Entrez ID Uniprot ID Score

PLG

5340

P00747

0.00

PTPRC

5788

P08575

0.00

SHARPIN

81858

Q9H0F6

0.49

ELANE

1991

P08246

0.52

ICAM4

3386

Q14773

0.52

THY1

7070

P04216

0.52

C3

718

P01024

0.65

BCAP31

10134

P51572

0.70

CRKL

1399

P46109

0.00

BCAR1

9564

P56945

0.00

GP1BA

2811

P07359

0.52

CFH

3075

P08603

0.52

HP

3240

P00738

0.52

ICAM2

3384

P13598

0.52

CD209

30835

Q9NNX6

0.52

FGG

2266

P02679

0.62

AUP1

550

Q9Y679

0.63

RAD21

5885

O60216

0.63

CLEC4M

10332

Q9H2X3

0.65

ITGB2

3689

P05107

0.71

PRTN3

5657

P24158

0.72

IRAK1

3654

P51617

0.73

PLAUR

5329

Q03405

0.76

JAM3

83700

Q9BX67

0.76

ICAM1

3383

P05362

0.87