BP

GO:0001525

angiogenesis

Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.

TAS

BP

GO:0007044

cell-substrate junction assembly

The aggregation, arrangement and bonding together of a set of components to form a junction between a cell and its substrate.

IEA

BP

GO:0007155

cell adhesion

The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.

TAS

BP

GO:0007157

heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules

The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell.

IEA

BP

GO:0007159

leukocyte cell-cell adhesion

The attachment of a leukocyte to another cell via adhesion molecules.

IEA

BP

GO:0007229

integrin-mediated signaling pathway

A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.

IEA

BP

GO:0007613

memory

The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task).

IEA

BP

GO:0010811

positive regulation of cell-substrate adhesion

Any process that increases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules.

IEA

BP

GO:0030198

extracellular matrix organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix.

TAS

BP

GO:0030335

positive regulation of cell migration

Any process that activates or increases the frequency, rate or extent of cell migration.

IEA

BP

GO:0030949

positive regulation of vascular endothelial growth factor receptor signaling pathway

Any process that activates or increases the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity.

TAS

BP

GO:0031589

cell-substrate adhesion

The attachment of a cell to the underlying substrate via adhesion molecules.

IMP

BP

GO:0033627

cell adhesion mediated by integrin

The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits.

IDA

BP

GO:0033631

cell-cell adhesion mediated by integrin

The attachment of one cell to another cell via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits.

IEA

BP

GO:0034113

heterotypic cell-cell adhesion

The attachment of a cell to a cell of a different type via adhesion molecules.

IMP

BP

GO:0035313

wound healing, spreading of epidermal cells

The migration of an epidermal cell along or through a wound gap that contributes to the reestablishment of a continuous epidermis.

IEP

BP

GO:0035987

endodermal cell differentiation

The process in which a relatively unspecialized cell acquires the specialized features of an endoderm cell, a cell of the inner of the three germ layers of the embryo.

IMP

BP

GO:0046718

viral entry into host cell

The process that occurs after viral attachment by which a virus, or viral nucleic acid, breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the viral nucleic acid is released into the host cell cytoplasm.

IEA

BP

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.

IMP

BP

GO:0050900

leukocyte migration

The movement of a leukocyte within or between different tissues and organs of the body.

TAS

BP

GO:1903672

positive regulation of sprouting angiogenesis

Any process that activates or increases the frequency, rate or extent of sprouting angiogenesis.

IMP

BP

GO:2000811

negative regulation of anoikis

Any process that stops, prevents or reduces the frequency, rate or extent of anoikis.

IMP

CC

GO:0001726

ruffle

Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.

TAS

CC

GO:0005783

endoplasmic reticulum

The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).

IEA

CC

GO:0005794

Golgi apparatus

A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.

IEA

CC

GO:0005886

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

TAS

CC

GO:0005911

cell-cell junction

A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals.

IDA

CC

GO:0005925

focal adhesion

Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.

IDA

CC

GO:0008305

integrin complex

A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands.

IEA

CC

GO:0009897

external side of plasma membrane

The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.

IEA

CC

GO:0009986

cell surface

The external part of the cell wall and/or plasma membrane.

IDA

CC

GO:0031410

cytoplasmic vesicle

A vesicle found in the cytoplasm of a cell.

IEA

CC

GO:0032587

ruffle membrane

The portion of the plasma membrane surrounding a ruffle.

IDA

CC

GO:0045202

synapse

The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.

IEA

CC

GO:0071062

alphav-beta3 integrin-vitronectin complex

A protein complex that consists of an alphav-beta3 integrin complex bound to vitronectin.

TAS

MF

GO:0001618

virus receptor activity

Combining with a virus component and mediating entry of the virus into the cell.

IEA

MF

GO:0005154

epidermal growth factor receptor binding

Interacting selectively and non-covalently with the epidermal growth factor receptor.

IEA

MF

GO:0005161

platelet-derived growth factor receptor binding

Interacting selectively and non-covalently with the platelet-derived growth factor receptor.

TAS

MF

GO:0005178

integrin binding

Interacting selectively and non-covalently with an integrin.

IEA

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0043184

vascular endothelial growth factor receptor 2 binding

Interacting selectively and non-covalently with vascular endothelial growth factor receptor 2.

TAS

MF

GO:0046872

metal ion binding

Interacting selectively and non-covalently with any metal ion.

IEA