BP

GO:0007044

cell-substrate junction assembly

The aggregation, arrangement and bonding together of a set of components to form a junction between a cell and its substrate.

TAS

BP

GO:0007160

cell-matrix adhesion

The binding of a cell to the extracellular matrix via adhesion molecules.

IEA

BP

GO:0007229

integrin-mediated signaling pathway

A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.

IEA

BP

GO:0010668

ectodermal cell differentiation

The process in which relatively unspecialized cells acquire specialized structural and/or functional features of an ectodermal cell. Differentiation includes the processes involved in commitment of a cell to a specific fate.

IEP

BP

GO:0010811

positive regulation of cell-substrate adhesion

Any process that increases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules.

IEA

BP

GO:0016337

single organismal cell-cell adhesion

The attachment of one cell to another cell via adhesion molecules, where both cells are part of the same organism.

IEA

BP

GO:0022409

positive regulation of cell-cell adhesion

Any process that activates or increases the rate or extent of cell adhesion to another cell.

IEA

BP

GO:0030198

extracellular matrix organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix.

TAS

BP

GO:0030335

positive regulation of cell migration

Any process that activates or increases the frequency, rate or extent of cell migration.

IMP

BP

GO:0031581

hemidesmosome assembly

Assembly of hemidesmosomes, integrin-containing protein complexes that bind to laminin in the basal lamina. Hemidesmosomes form the contact between the basal surface of epithelial cells and the underlying basal lamina.

TAS

BP

GO:0031589

cell-substrate adhesion

The attachment of a cell to the underlying substrate via adhesion molecules.

IMP

BP

GO:0031668

cellular response to extracellular stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus.

IEA

BP

GO:0033627

cell adhesion mediated by integrin

The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits.

IEA

BP

GO:0035878

nail development

The process whose specific outcome is the progression of a nail over time, from its formation to the mature structure. A nail is a horn-like envelope covering the outer end of a finger or toe, and consists of the nail plate, the nail matrix and the nail bed below it, and the grooves surrounding it.

IMP

BP

GO:0042327

positive regulation of phosphorylation

Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule.

IMP

BP

GO:0043065

positive regulation of apoptotic process

Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.

IGI

BP

GO:0043547

positive regulation of GTPase activity

Any process that activates or increases the activity of a GTPase.

IMP

BP

GO:0043588

skin development

The process whose specific outcome is the progression of the skin over time, from its formation to the mature structure. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner vascular dermis (cutis, corium or true skin) composed mostly of connective tissue.

IMP

BP

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.

IMP

BP

GO:0046847

filopodium assembly

The assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone.

IEA

BP

GO:0048565

digestive tract development

The process whose specific outcome is the progression of the digestive tract over time, from its formation to the mature structure. The digestive tract is the anatomical structure through which food passes and is processed.

IMP

BP

GO:0050873

brown fat cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria.

IEA

BP

GO:0050900

leukocyte migration

The movement of a leukocyte within or between different tissues and organs of the body.

TAS

BP

GO:0071407

cellular response to organic cyclic compound

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.

IEA

BP

GO:0072001

renal system development

The process whose specific outcome is the progression of the renal system over time, from its formation to the mature structure. The renal system maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels.

IMP

BP

GO:0097186

amelogenesis

The process whose specific outcome is the formation of tooth enamel, occurring in two stages: secretory stage and maturation stage.

IMP

BP

GO:2001237

negative regulation of extrinsic apoptotic signaling pathway

Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway.

IMP

CC

GO:0005604

basement membrane

A thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers.

IEA

CC

GO:0005886

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

IDA|TAS

CC

GO:0005913

cell-cell adherens junction

An adherens junction which connects a cell to another cell.

IDA

CC

GO:0005925

focal adhesion

Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.

IDA

CC

GO:0009897

external side of plasma membrane

The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.

IEA

CC

GO:0009925

basal plasma membrane

The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.

IEA

CC

GO:0009986

cell surface

The external part of the cell wall and/or plasma membrane.

IDA

CC

GO:0030056

hemidesmosome

A cell-substrate junction (attachment structure) found in epithelial cells that links intermediate filaments to extracellular matrices via transmembrane complexes. In vertebrates, hemidesmosomes mediate contact between the basal side of epithelial cells and the basal lamina. In C. elegans, hemidesmosomes connect epithelial cells to distinct extracellular matrices on both the apical and basal cell surfaces.

IEA

CC

GO:0030175

filopodium

Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft.

IEA

CC

GO:0034676

integrin alpha6-beta4 complex

An integrin complex that comprises one alpha6 subunit and one beta1 subunit.

IEA

MF

GO:0005178

integrin binding

Interacting selectively and non-covalently with an integrin.

IEA

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0031994

insulin-like growth factor I binding

Interacting selectively and non-covalently with insulin-like growth factor I.

IDA

MF

GO:0038132

neuregulin binding

Interacting selectively and non-covalently with a neuregulin, a member of the EGF family of growth factors.

IDA

MF

GO:0043236

laminin binding

Interacting selectively and non-covalently with laminins, glycoproteins that are major constituents of the basement membrane of cells.

IEA

MF

GO:0046872

metal ion binding

Interacting selectively and non-covalently with any metal ion.

IEA

MF

GO:0098641

cadherin binding involved in cell-cell adhesion

Any cadherin binding that occurs as part of the process of cell-cell adhesion.

IDA