| Gene Symbol | INPP1 |
| Entrez ID | 3628 |
| Uniprot ID | P49441 |
| Description | inositol polyphosphate-1-phosphatase |
| Chromosomal Location | chr2: 190,343,470-190,371,665 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0006796 |
phosphate-containing compound metabolic process |
The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid. |
TAS |
|
BP |
GO:0007165 |
signal transduction |
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
TAS |
|
BP |
GO:0043647 |
inositol phosphate metabolic process |
The chemical reactions and pathways involving inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached. |
TAS |
|
BP |
GO:0046854 |
phosphatidylinositol phosphorylation |
The process of introducing one or more phosphate groups into a phosphatidylinositol, any glycerophosphoinositol having one phosphatidyl group esterified to one of the hydroxy groups of inositol. |
IEA |
|
BP |
GO:0046855 |
inositol phosphate dephosphorylation |
The process of removing a phosphate group from any mono- or polyphosphorylated inositol. |
IBA |
|
CC |
GO:0005737 |
cytoplasm |
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
IBA |
|
CC |
GO:0005829 |
cytosol |
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
TAS |
|
MF |
GO:0000287 |
magnesium ion binding |
Interacting selectively and non-covalently with magnesium (Mg) ions. |
IBA |
|
MF |
GO:0004441 |
inositol-1,4-bisphosphate 1-phosphatase activity |
Catalysis of the reaction: 1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate. |
TAS |
|
MF |
GO:0052829 |
inositol-1,3,4-trisphosphate 1-phosphatase activity |
Catalysis of the reaction: D-myo-inositol 1,3,4-trisphosphate + H2O = myo-inositol 3,4-bisphosphate + phosphate. |
TAS |
| Domain ID | Description |
|---|---|
|
IPR000760 |
Inositol monophosphatase-like |
|
IPR020550 |
Inositol monophosphatase, conserved site |
|
IPR020583 |
Inositol monophosphatase, metal-binding site |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
|
hsa00562 |
Inositol phosphate metabolism |
KEGG |
|
hsa01100 |
Metabolic pathways |
KEGG |
|
hsa04070 |
Phosphatidylinositol signaling system |
KEGG |
| UMLS CUI | UMLS Term |
|---|---|
|
C0004352 |
Autistic Disorder |
| Tissue | Cell Type |
|---|---|
|
colon |
endothelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
INPPL1 |
3636 |
O15357 |
0.00 |
|
PLCB2 |
5330 |
Q00722 |
0.00 |
|
PLCB3 |
5331 |
Q01970 |
0.00 |
|
PLCB4 |
5332 |
Q15147 |
0.00 |
|
PLCD1 |
5333 |
P51178 |
0.00 |
|
PLCG1 |
5335 |
P19174 |
0.00 |
|
PLCG2 |
5336 |
P16885 |
0.00 |
|
INPP4B |
8821 |
O15327 |
0.00 |
|
PLCB1 |
23236 |
Q9NQ66 |
0.00 |
|
PLCD3 |
113026 |
Q8N3E9 |
0.00 |
|
TLK1 |
9874 |
Q9UKI8 |
0.49 |
|
WDR12 |
55759 |
Q9GZL7 |
0.49 |
|
LIG1 |
3978 |
P18858 |
0.63 |
|
MEOX2 |
4223 |
P50222 |
0.63 |
|
DYNLL1 |
8655 |
P63167 |
0.63 |
|
NR1D1 |
9572 |
P20393 |
0.63 |
|
NDC80 |
10403 |
O14777 |
0.63 |
|
LDOC1 |
23641 |
O95751 |
0.63 |
|
NECAB2 |
54550 |
Q7Z6G3 |
0.63 |
|
C9orf16 |
79095 |
Q9BUW7 |
0.63 |
|
USHBP1 |
83878 |
Q8N6Y0 |
0.63 |
|
SYCE3 |
644186 |
A1L190 |
0.63 |
|
IMPA1 |
3612 |
P29218 |
0.00 |
|
IMPA2 |
3613 |
O14732 |
0.00 |
|
BRCA1 |
672 |
P38398 |
0.72 |