Protein Description

Gene Symbol INPP1
Entrez ID 3628
Uniprot ID P49441
Description inositol polyphosphate-1-phosphatase
Chromosomal Location chr2: 190,343,470-190,371,665
Ontology GO ID GO Term Definition Evidence

BP

GO:0006796

phosphate-containing compound metabolic process

The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid.

TAS

BP

GO:0007165

signal transduction

The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

TAS

BP

GO:0043647

inositol phosphate metabolic process

The chemical reactions and pathways involving inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached.

TAS

BP

GO:0046854

phosphatidylinositol phosphorylation

The process of introducing one or more phosphate groups into a phosphatidylinositol, any glycerophosphoinositol having one phosphatidyl group esterified to one of the hydroxy groups of inositol.

IEA

BP

GO:0046855

inositol phosphate dephosphorylation

The process of removing a phosphate group from any mono- or polyphosphorylated inositol.

IBA

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

IBA

CC

GO:0005829

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

TAS

MF

GO:0000287

magnesium ion binding

Interacting selectively and non-covalently with magnesium (Mg) ions.

IBA

MF

GO:0004441

inositol-1,4-bisphosphate 1-phosphatase activity

Catalysis of the reaction: 1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate.

TAS

MF

GO:0052829

inositol-1,3,4-trisphosphate 1-phosphatase activity

Catalysis of the reaction: D-myo-inositol 1,3,4-trisphosphate + H2O = myo-inositol 3,4-bisphosphate + phosphate.

TAS

Domain ID Description

IPR000760

Inositol monophosphatase-like

IPR020550

Inositol monophosphatase, conserved site

IPR020583

Inositol monophosphatase, metal-binding site

Pathway ID Pathway Term Pathway Source

hsa00562

Inositol phosphate metabolism

KEGG

hsa01100

Metabolic pathways

KEGG

hsa04070

Phosphatidylinositol signaling system

KEGG

UMLS CUI UMLS Term

C0004352

Autistic Disorder

Tissue Cell Type

colon

endothelial cells

No databases found.

Pubmed ID Author Year Title

22951915

Haozi et al.

2012

Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

Gene Symbol Entrez ID Uniprot ID Score

INPPL1

3636

O15357

0.00

PLCB2

5330

Q00722

0.00

PLCB3

5331

Q01970

0.00

PLCB4

5332

Q15147

0.00

PLCD1

5333

P51178

0.00

PLCG1

5335

P19174

0.00

PLCG2

5336

P16885

0.00

INPP4B

8821

O15327

0.00

PLCB1

23236

Q9NQ66

0.00

PLCD3

113026

Q8N3E9

0.00

TLK1

9874

Q9UKI8

0.49

WDR12

55759

Q9GZL7

0.49

LIG1

3978

P18858

0.63

MEOX2

4223

P50222

0.63

DYNLL1

8655

P63167

0.63

NR1D1

9572

P20393

0.63

NDC80

10403

O14777

0.63

LDOC1

23641

O95751

0.63

NECAB2

54550

Q7Z6G3

0.63

C9orf16

79095

Q9BUW7

0.63

USHBP1

83878

Q8N6Y0

0.63

SYCE3

644186

A1L190

0.63

IMPA1

3612

P29218

0.00

IMPA2

3613

O14732

0.00

BRCA1

672

P38398

0.72