Protein Description

Gene Symbol IMPA1
Entrez ID 3612
Uniprot ID P29218
Description inositol(myo)-1(or 4)-monophosphatase 1
Chromosomal Location chr8: 81,657,961-81,686,693
Ontology GO ID GO Term Definition Evidence

BP

GO:0006020

inositol metabolic process

The chemical reactions and pathways involving inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms.

IBA

BP

GO:0006021

inositol biosynthetic process

The chemical reactions and pathways resulting in the formation of inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms.

IEA

BP

GO:0006661

phosphatidylinositol biosynthetic process

The chemical reactions and pathways resulting in the formation of phosphatidylinositol, any glycophospholipid in which the sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.

IMP

BP

GO:0006796

phosphate-containing compound metabolic process

The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid.

IMP

BP

GO:0007165

signal transduction

The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

IMP

BP

GO:0043647

inositol phosphate metabolic process

The chemical reactions and pathways involving inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached.

TAS

BP

GO:0046854

phosphatidylinositol phosphorylation

The process of introducing one or more phosphate groups into a phosphatidylinositol, any glycerophosphoinositol having one phosphatidyl group esterified to one of the hydroxy groups of inositol.

IEA

BP

GO:0046855

inositol phosphate dephosphorylation

The process of removing a phosphate group from any mono- or polyphosphorylated inositol.

IDA

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

IDA

CC

GO:0005829

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

TAS

CC

GO:0070062

extracellular exosome

A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.

IDA

MF

GO:0000287

magnesium ion binding

Interacting selectively and non-covalently with magnesium (Mg) ions.

IDA

MF

GO:0008934

inositol monophosphate 1-phosphatase activity

Catalysis of the reaction: myo-inositol 1-phosphate + H2O = myo-inositol + phosphate.

IDA|IMP|TAS

MF

GO:0030145

manganese ion binding

Interacting selectively and non-covalently with manganese (Mn) ions.

IDA

MF

GO:0031403

lithium ion binding

Interacting selectively and non-covalently with lithium ions (Li+).

IDA

MF

GO:0042803

protein homodimerization activity

Interacting selectively and non-covalently with an identical protein to form a homodimer.

IDA

MF

GO:0052832

inositol monophosphate 3-phosphatase activity

Catalysis of the reaction: myo-inositol 3-phosphate + H2O = myo-inositol + phosphate.

TAS

MF

GO:0052833

inositol monophosphate 4-phosphatase activity

Catalysis of the reaction: myo-inositol 4-phosphate + H2O = myo-inositol + phosphate.

TAS

MF

GO:0052834

inositol monophosphate phosphatase activity

Catalysis of the reaction: myo-inositol phosphate + H2O = myo-inositol + phosphate.

IDA

Domain ID Description

IPR000760

Inositol monophosphatase-like

IPR020550

Inositol monophosphatase, conserved site

IPR020552

Inositol monophosphatase, Lithium-sensitive

IPR020583

Inositol monophosphatase, metal-binding site

IPR033942

Inositol monophosphatase

Pathway ID Pathway Term Pathway Source

hsa00562

Inositol phosphate metabolism

KEGG

hsa01100

Metabolic pathways

KEGG

hsa04070

Phosphatidylinositol signaling system

KEGG

WP1984

Integrated Breast Cancer Pathway

WikiPathways

UMLS CUI UMLS Term

C0017661

Iga Glomerulonephritis

C0036572

Seizures

Tissue Cell Type

adrenal gland

glandular cells

bronchus

respiratory epithelial cells

duodenum

glandular cells

stomach

glandular cells

testis

cells in seminiferous ducts

thyroid gland

glandular cells

No databases found.

Pubmed ID Author Year Title

22951915

Haozi et al.

2012

Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

Gene Symbol Entrez ID Uniprot ID Score

INPP1

3628

P49441

0.00

INPP4A

3631

Q96PE3

0.00

PLCB2

5330

Q00722

0.00

PLCB3

5331

Q01970

0.00

PLCB4

5332

Q15147

0.00

PLCD1

5333

P51178

0.00

PLCG2

5336

P16885

0.00

PLCB1

23236

Q9NQ66

0.00

PLCD4

84812

Q9BRC7

0.00

PLCD3

113026

Q8N3E9

0.00

ARHGDIA

396

P52565

0.49

DUT

1854

P33316

0.49

TXN

7295

P10599

0.49

UGDH

7358

O60701

0.49

ISCU

23479

Q9H1K1

0.49

PHPT1

29085

Q9NRX4

0.49

SCPEP1

59342

Q9HB40

0.49

S100B

6285

P04271

0.62

CALB1

793

P05937

0.65

IMPA2

3613

O14732

0.73

IMPA1

3612

P29218

0.83

CDIPT

10423

O14735

0.00

E2F3

1871

O00716

0.07

EIF6

3692

P56537

0.49

NUDT9

53343

Q9BW91

0.49

CYCS

54205

P99999

0.49

PGLS

25796

O95336

0.56

ELAVL1

1994

Q15717

0.63

NTRK1

4914

P04629

0.63

SUMO2

6613

P61956

0.63

NXF1

10482

Q9UBU9

0.63