Gene Symbol | IMPA1 |
Entrez ID | 3612 |
Uniprot ID | P29218 |
Description | inositol(myo)-1(or 4)-monophosphatase 1 |
Chromosomal Location | chr8: 81,657,961-81,686,693 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0006020 |
inositol metabolic process |
The chemical reactions and pathways involving inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms. |
IBA |
BP |
GO:0006021 |
inositol biosynthetic process |
The chemical reactions and pathways resulting in the formation of inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms. |
IEA |
BP |
GO:0006661 |
phosphatidylinositol biosynthetic process |
The chemical reactions and pathways resulting in the formation of phosphatidylinositol, any glycophospholipid in which the sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. |
IMP |
BP |
GO:0006796 |
phosphate-containing compound metabolic process |
The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid. |
IMP |
BP |
GO:0007165 |
signal transduction |
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
IMP |
BP |
GO:0043647 |
inositol phosphate metabolic process |
The chemical reactions and pathways involving inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached. |
TAS |
BP |
GO:0046854 |
phosphatidylinositol phosphorylation |
The process of introducing one or more phosphate groups into a phosphatidylinositol, any glycerophosphoinositol having one phosphatidyl group esterified to one of the hydroxy groups of inositol. |
IEA |
BP |
GO:0046855 |
inositol phosphate dephosphorylation |
The process of removing a phosphate group from any mono- or polyphosphorylated inositol. |
IDA |
CC |
GO:0005737 |
cytoplasm |
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
IDA |
CC |
GO:0005829 |
cytosol |
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
TAS |
CC |
GO:0070062 |
extracellular exosome |
A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. |
IDA |
MF |
GO:0000287 |
magnesium ion binding |
Interacting selectively and non-covalently with magnesium (Mg) ions. |
IDA |
MF |
GO:0008934 |
inositol monophosphate 1-phosphatase activity |
Catalysis of the reaction: myo-inositol 1-phosphate + H2O = myo-inositol + phosphate. |
IDA|IMP|TAS |
MF |
GO:0030145 |
manganese ion binding |
Interacting selectively and non-covalently with manganese (Mn) ions. |
IDA |
MF |
GO:0031403 |
lithium ion binding |
Interacting selectively and non-covalently with lithium ions (Li+). |
IDA |
MF |
GO:0042803 |
protein homodimerization activity |
Interacting selectively and non-covalently with an identical protein to form a homodimer. |
IDA |
MF |
GO:0052832 |
inositol monophosphate 3-phosphatase activity |
Catalysis of the reaction: myo-inositol 3-phosphate + H2O = myo-inositol + phosphate. |
TAS |
MF |
GO:0052833 |
inositol monophosphate 4-phosphatase activity |
Catalysis of the reaction: myo-inositol 4-phosphate + H2O = myo-inositol + phosphate. |
TAS |
MF |
GO:0052834 |
inositol monophosphate phosphatase activity |
Catalysis of the reaction: myo-inositol phosphate + H2O = myo-inositol + phosphate. |
IDA |
Domain ID | Description |
---|---|
IPR000760 |
Inositol monophosphatase-like |
IPR020550 |
Inositol monophosphatase, conserved site |
IPR020552 |
Inositol monophosphatase, Lithium-sensitive |
IPR020583 |
Inositol monophosphatase, metal-binding site |
IPR033942 |
Inositol monophosphatase |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
hsa00562 |
Inositol phosphate metabolism |
KEGG |
hsa01100 |
Metabolic pathways |
KEGG |
hsa04070 |
Phosphatidylinositol signaling system |
KEGG |
WP1984 |
Integrated Breast Cancer Pathway |
WikiPathways |
UMLS CUI | UMLS Term |
---|---|
C0017661 |
Iga Glomerulonephritis |
C0036572 |
Seizures |
Tissue | Cell Type |
---|---|
adrenal gland |
glandular cells |
bronchus |
respiratory epithelial cells |
duodenum |
glandular cells |
stomach |
glandular cells |
testis |
cells in seminiferous ducts |
thyroid gland |
glandular cells |
Pubmed ID | Author | Year | Title |
---|---|---|---|
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
INPP1 |
3628 |
P49441 |
0.00 |
INPP4A |
3631 |
Q96PE3 |
0.00 |
PLCB2 |
5330 |
Q00722 |
0.00 |
PLCB3 |
5331 |
Q01970 |
0.00 |
PLCB4 |
5332 |
Q15147 |
0.00 |
PLCD1 |
5333 |
P51178 |
0.00 |
PLCG2 |
5336 |
P16885 |
0.00 |
PLCB1 |
23236 |
Q9NQ66 |
0.00 |
PLCD4 |
84812 |
Q9BRC7 |
0.00 |
PLCD3 |
113026 |
Q8N3E9 |
0.00 |
ARHGDIA |
396 |
P52565 |
0.49 |
DUT |
1854 |
P33316 |
0.49 |
TXN |
7295 |
P10599 |
0.49 |
UGDH |
7358 |
O60701 |
0.49 |
ISCU |
23479 |
Q9H1K1 |
0.49 |
PHPT1 |
29085 |
Q9NRX4 |
0.49 |
SCPEP1 |
59342 |
Q9HB40 |
0.49 |
S100B |
6285 |
P04271 |
0.62 |
CALB1 |
793 |
P05937 |
0.65 |
IMPA2 |
3613 |
O14732 |
0.73 |
IMPA1 |
3612 |
P29218 |
0.83 |
CDIPT |
10423 |
O14735 |
0.00 |
E2F3 |
1871 |
O00716 |
0.07 |
EIF6 |
3692 |
P56537 |
0.49 |
NUDT9 |
53343 |
Q9BW91 |
0.49 |
CYCS |
54205 |
P99999 |
0.49 |
PGLS |
25796 |
O95336 |
0.56 |
ELAVL1 |
1994 |
Q15717 |
0.63 |
NTRK1 |
4914 |
P04629 |
0.63 |
SUMO2 |
6613 |
P61956 |
0.63 |
NXF1 |
10482 |
Q9UBU9 |
0.63 |