BP

GO:0001916

positive regulation of T cell mediated cytotoxicity

Any process that activates or increases the frequency, rate or extent of T cell mediated cytotoxicity.

ISS

BP

GO:0002230

positive regulation of defense response to virus by host

Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication.

IDA|ISS

BP

GO:0002827

positive regulation of T-helper 1 type immune response

Any process that activates or increases the frequency, rate, or extent of a T-helper 1 type immune response.

IDA|ISS

BP

GO:0007165

signal transduction

The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

IC

BP

GO:0018108

peptidyl-tyrosine phosphorylation

The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.

IEA

BP

GO:0019221

cytokine-mediated signaling pathway

A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.

TAS

BP

GO:0032729

positive regulation of interferon-gamma production

Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.

IDA|IMP

BP

GO:0035722

interleukin-12-mediated signaling pathway

A series of molecular signals initiated by the binding of interleukin-12 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.

IEA

BP

GO:0038155

interleukin-23-mediated signaling pathway

A series of molecular signals initiated by the binding of interleukin-23 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.

IEA

BP

GO:0042104

positive regulation of activated T cell proliferation

Any process that activates or increases the rate or extent of activated T cell proliferation.

IDA

BP

GO:0043382

positive regulation of memory T cell differentiation

Any process that activates or increases the frequency, rate or extent of memory T cell differentiation.

ISS

BP

GO:0071346

cellular response to interferon-gamma

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon gamma is the only member of the type II interferon found so far.

IDA

BP

GO:2000318

positive regulation of T-helper 17 type immune response

Any process that activates or increases the frequency, rate or extent of T-helper 17 type immune response.

ISS

BP

GO:2000330

positive regulation of T-helper 17 cell lineage commitment

Any process that activates or increases the frequency, rate or extent of T-helper 17 cell lineage commitment.

ISS

CC

GO:0005886

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

TAS

CC

GO:0009897

external side of plasma membrane

The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.

IEA

CC

GO:0042022

interleukin-12 receptor complex

A protein complex that binds interleukin-12 and that consists of, at a minimum, a dimeric interleukin and its two receptor subunits as well as optional additional kinase subunits.

IDA

CC

GO:0072536

interleukin-23 receptor complex

A protein complex that binds interleukin-23 and that consists of, at a minimum, a dimeric interleukin and its two receptor subunits as well as optional additional kinase subunits.

IDA

MF

GO:0004896

cytokine receptor activity

Combining with a cytokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

TAS

MF

GO:0005143

interleukin-12 receptor binding

Interacting selectively and non-covalently with the interleukin-12 receptor.

IPI

MF

GO:0016517

interleukin-12 receptor activity

Combining with interleukin-12 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

IDA

MF

GO:0042019

interleukin-23 binding

Interacting selectively and non-covalently with interleukin-23.

IPI

MF

GO:0042020

interleukin-23 receptor activity

Combining with interleukin-23 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

IDA