BP

GO:0002532

production of molecular mediator involved in inflammatory response

The synthesis or release of any molecular mediator of the inflammatory response following an inflammatory stimulus, resulting in an increase in its intracellular or extracellular levels.

IEA

BP

GO:0002639

positive regulation of immunoglobulin production

Any process that activates or increases the frequency, rate, or extent of immunoglobulin production.

IEA

BP

GO:0006955

immune response

Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.

TAS

BP

GO:0007165

signal transduction

The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

TAS

BP

GO:0016064

immunoglobulin mediated immune response

An immune response mediated by immunoglobulins, whether cell-bound or in solution.

IEA

BP

GO:0030728

ovulation

The release of a mature ovum/oocyte from an ovary.

IEA

BP

GO:0035771

interleukin-4-mediated signaling pathway

A series of molecular signals initiated by the binding of interleukin-4 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.

IEA

BP

GO:0042127

regulation of cell proliferation

Any process that modulates the frequency, rate or extent of cell proliferation.

IEA

BP

GO:0042832

defense response to protozoan

Reactions triggered in response to the presence of a protozoan that act to protect the cell or organism.

IEA

BP

GO:0043032

positive regulation of macrophage activation

Any process that stimulates, induces or increases the rate of macrophage activation.

IEA

BP

GO:0043306

positive regulation of mast cell degranulation

Any process that activates or increases the frequency, rate or extent of mast cell degranulation.

IEA

BP

GO:0043627

response to estrogen

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics.

IEA

BP

GO:0045626

negative regulation of T-helper 1 cell differentiation

Any process that stops, prevents, or reduces the frequency, rate or extent of T-helper 1 cell differentiation.

IEA

BP

GO:0045630

positive regulation of T-helper 2 cell differentiation

Any process that activates or increases the frequency, rate or extent of T-helper 2 cell differentiation.

IEA

BP

GO:0090197

positive regulation of chemokine secretion

Any process that increases the rate, frequency or extent of chemokine secretion, the regulated release of chemokines from a cell.

IEA

BP

GO:1901741

positive regulation of myoblast fusion

Any process that activates or increases the frequency, rate or extent of myoblast fusion.

IEA

CC

GO:0005615

extracellular space

That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

IEA

CC

GO:0005887

integral component of plasma membrane

The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

TAS

CC

GO:0043235

receptor complex

Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

IDA

MF

GO:0004913

interleukin-4 receptor activity

Combining with interleukin-4 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

TAS

MF

GO:0005057

receptor signaling protein activity

Conveys a signal from an upstream receptor or intracellular signal transducer, converting the signal into a form where it can ultimately trigger a change in the state or activity of a cell.

TAS

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI