BP

GO:0006629

lipid metabolic process

The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.

IEA

BP

GO:0006955

immune response

Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.

NAS

BP

GO:0030073

insulin secretion

The regulated release of proinsulin from secretory granules (B granules) in the B cells of the pancreas; accompanied by cleavage of proinsulin to form mature insulin.

IEA

BP

GO:0034115

negative regulation of heterotypic cell-cell adhesion

Any process that stops, prevents, or reduces the frequency, rate, or extent of heterotypic cell-cell adhesion.

IDA

BP

GO:0051384

response to glucocorticoid

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.

IDA

BP

GO:2000660

negative regulation of interleukin-1-mediated signaling pathway

Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-1-mediated signaling pathway.

IDA

CC

GO:0005615

extracellular space

That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

IDA

CC

GO:0005622

intracellular

The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

NAS

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

IEA

CC

GO:0005886

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

TAS

CC

GO:0070062

extracellular exosome

A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.

IDA

MF

GO:0005125

cytokine activity

Functions to control the survival, growth, differentiation and effector function of tissues and cells.

IBA

MF

GO:0005150

interleukin-1, Type I receptor binding

Interacting selectively and non-covalently with a Type I interleukin-1 receptor.

IPI

MF

GO:0005151

interleukin-1, Type II receptor binding

Interacting selectively and non-covalently with a Type II interleukin-1 receptor.

IPI

MF

GO:0005152

interleukin-1 receptor antagonist activity

Blocks the binding of interleukin-1 to the interleukin-1 receptor complex.

IDA|TAS

MF

GO:0045352

interleukin-1 Type I receptor antagonist activity

Blocks the binding of interleukin-1 to interleukin-1 Type I receptors.

IDA

MF

GO:0045353

interleukin-1 Type II receptor antagonist activity

Blocks the binding of interleukin-1 to interleukin-1 Type II receptors.

IDA