Gene Symbol | IL1B |
Entrez ID | 3553 |
Uniprot ID | P01584 |
Description | interleukin 1 beta |
Chromosomal Location | chr2: 112,829,751-112,836,903 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0000165 |
MAPK cascade |
An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell. |
IMP |
BP |
GO:0000187 |
activation of MAPK activity |
The initiation of the activity of the inactive enzyme MAP kinase (MAPK). |
IDA |
BP |
GO:0001660 |
fever generation |
The heat generation process that results in a rise in body temperature above the normal, often as a response to infection. |
IEA |
BP |
GO:0001934 |
positive regulation of protein phosphorylation |
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein. |
IDA|NAS |
BP |
GO:0002711 |
positive regulation of T cell mediated immunity |
Any process that activates or increases the frequency, rate, or extent of T cell mediated immunity. |
IC |
BP |
GO:0006915 |
apoptotic process |
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. |
TAS |
BP |
GO:0006954 |
inflammatory response |
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. |
IDA|NAS |
BP |
GO:0006955 |
immune response |
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. |
IEA |
BP |
GO:0007165 |
signal transduction |
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
TAS |
BP |
GO:0007267 |
cell-cell signaling |
Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions. |
TAS |
BP |
GO:0007566 |
embryo implantation |
Attachment of the blastocyst to the uterine lining. |
TAS |
BP |
GO:0008285 |
negative regulation of cell proliferation |
Any process that stops, prevents or reduces the rate or extent of cell proliferation. |
IDA |
BP |
GO:0009743 |
response to carbohydrate |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus. |
IEA |
BP |
GO:0010575 |
positive regulation of vascular endothelial growth factor production |
Any process that increases or activates the frequency, rate, or extent of production of vascular endothelial growth factor. |
IDA|ISS |
BP |
GO:0010628 |
positive regulation of gene expression |
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form. |
IDA |
BP |
GO:0010829 |
negative regulation of glucose transport |
Any process that decreases the frequency, rate or extent of glucose transport. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
ISS |
BP |
GO:0014805 |
smooth muscle adaptation |
Any process in which smooth muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. |
NAS |
BP |
GO:0019221 |
cytokine-mediated signaling pathway |
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. |
IDA |
BP |
GO:0030213 |
hyaluronan biosynthetic process |
The chemical reactions and pathways resulting in the formation of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine. |
IDA |
BP |
GO:0030593 |
neutrophil chemotaxis |
The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding. |
IEA |
BP |
GO:0030730 |
sequestering of triglyceride |
The process of binding or confining any triester of glycerol such that it is separated from other components of a biological system. |
IDA |
BP |
GO:0030949 |
positive regulation of vascular endothelial growth factor receptor signaling pathway |
Any process that activates or increases the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity. |
IC |
BP |
GO:0031622 |
positive regulation of fever generation |
Any process that activates or increases the frequency, rate, or extent of fever generation. |
ISS |
BP |
GO:0031663 |
lipopolysaccharide-mediated signaling pathway |
A series of molecular signals initiated by the binding of a lipopolysaccharide (LPS) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Lipopolysaccharides are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system. |
IDA |
BP |
GO:0032308 |
positive regulation of prostaglandin secretion |
Any process that activates or increases the frequency, rate or extent of the regulated release of a prostaglandin from a cell. |
ISS |
BP |
GO:0032611 |
interleukin-1 beta production |
The appearance of interleukin-1 beta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. |
IEA |
BP |
GO:0032725 |
positive regulation of granulocyte macrophage colony-stimulating factor production |
Any process that activates or increases the frequency, rate, or extent of granulocyte macrophage colony-stimulating factor production. |
IDA |
BP |
GO:0032729 |
positive regulation of interferon-gamma production |
Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon. |
IDA |
BP |
GO:0032755 |
positive regulation of interleukin-6 production |
Any process that activates or increases the frequency, rate, or extent of interleukin-6 production. |
TAS |
BP |
GO:0032757 |
positive regulation of interleukin-8 production |
Any process that activates or increases the frequency, rate, or extent of interleukin-8 production. |
IDA |
BP |
GO:0033129 |
positive regulation of histone phosphorylation |
Any process that activates or increases the frequency, rate or extent of the addition of one or more phosphate groups to a histone protein. |
NAS |
BP |
GO:0033198 |
response to ATP |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus. |
IEA |
BP |
GO:0034116 |
positive regulation of heterotypic cell-cell adhesion |
Any process that activates or increases the frequency, rate, or extent of heterotypic cell-cell adhesion. |
IDA|NAS |
BP |
GO:0035066 |
positive regulation of histone acetylation |
Any process that activates or increases the frequency, rate or extent of the addition of an acetyl group to a histone protein. |
NAS |
BP |
GO:0035234 |
ectopic germ cell programmed cell death |
Programmed cell death of an errant germ line cell that is outside the normal migratory path or ectopic to the gonad. This is an important mechanism of regulating germ cell survival within the embryo. |
IEA |
BP |
GO:0035505 |
positive regulation of myosin light chain kinase activity |
Any process that activates or increases the frequency, rate or extent of myosin light chain kinase activity. |
IDA |
BP |
GO:0035690 |
cellular response to drug |
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease. |
IDA |
BP |
GO:0042102 |
positive regulation of T cell proliferation |
Any process that activates or increases the rate or extent of T cell proliferation. |
IDA |
BP |
GO:0042346 |
positive regulation of NF-kappaB import into nucleus |
Any process that activates or increases the frequency, rate or extent of transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane. |
IDA |
BP |
GO:0043122 |
regulation of I-kappaB kinase/NF-kappaB signaling |
Any process that modulates I-kappaB kinase/NF-kappaB signaling. |
IDA |
BP |
GO:0043407 |
negative regulation of MAP kinase activity |
Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity. |
ISS |
BP |
GO:0043491 |
protein kinase B signaling |
A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase B (also called AKT), which occurs as a result of a single trigger reaction or compound. |
IMP |
BP |
GO:0045080 |
positive regulation of chemokine biosynthetic process |
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chemokines. |
IEA |
BP |
GO:0045086 |
positive regulation of interleukin-2 biosynthetic process |
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-2. |
IMP |
BP |
GO:0045410 |
positive regulation of interleukin-6 biosynthetic process |
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6. |
IEA |
BP |
GO:0045429 |
positive regulation of nitric oxide biosynthetic process |
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide. |
IDA |
BP |
GO:0045766 |
positive regulation of angiogenesis |
Any process that activates or increases angiogenesis. |
ISS |
BP |
GO:0045833 |
negative regulation of lipid metabolic process |
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipids. |
ISS |
BP |
GO:0045840 |
positive regulation of mitotic nuclear division |
Any process that activates or increases the frequency, rate or extent of mitosis. |
IMP |
BP |
GO:0045893 |
positive regulation of transcription, DNA-templated |
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. |
IDA |
BP |
GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
IEA |
BP |
GO:0046330 |
positive regulation of JNK cascade |
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade. |
IBA |
BP |
GO:0046627 |
negative regulation of insulin receptor signaling pathway |
Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling. |
ISS |
BP |
GO:0046827 |
positive regulation of protein export from nucleus |
Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the nucleus into the cytoplasm. |
NAS |
BP |
GO:0050766 |
positive regulation of phagocytosis |
Any process that activates or increases the frequency, rate or extent of phagocytosis. |
IMP |
BP |
GO:0050796 |
regulation of insulin secretion |
Any process that modulates the frequency, rate or extent of the regulated release of insulin. |
IDA |
BP |
GO:0050995 |
negative regulation of lipid catabolic process |
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids. |
IDA |
BP |
GO:0050996 |
positive regulation of lipid catabolic process |
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids. |
ISS |
BP |
GO:0050999 |
regulation of nitric-oxide synthase activity |
Any process that modulates the activity of the enzyme nitric-oxide synthase. |
IDA |
BP |
GO:0051044 |
positive regulation of membrane protein ectodomain proteolysis |
Any process that activates or increases the frequency, rate or extent of membrane protein ectodomain peptidolysis. |
IDA |
BP |
GO:0051091 |
positive regulation of sequence-specific DNA binding transcription factor activity |
Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription. |
IDA |
BP |
GO:0051092 |
positive regulation of NF-kappaB transcription factor activity |
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB. |
IDA |
BP |
GO:0051781 |
positive regulation of cell division |
Any process that activates or increases the frequency, rate or extent of cell division. |
IEA |
BP |
GO:0060355 |
positive regulation of cell adhesion molecule production |
Any process that increases the rate, frequency or extent of cell adhesion molecule production. Cell adhesion molecule production is the appearance of a cell adhesion molecule as a result of its biosynthesis or a decrease in its catabolism. |
NAS |
BP |
GO:0060559 |
positive regulation of calcidiol 1-monooxygenase activity |
Any process that increases the rate, frequency or extent of calcidiol 1-monooxygenase activity. Calcidiol 1-monooxygenase activity is the catalysis of the reaction: calcidiol + NADPH + H+ + O2 = calcitriol + NADP+ + H2O. |
IDA |
BP |
GO:0070164 |
negative regulation of adiponectin secretion |
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of adiponectin from a cell. |
ISS |
BP |
GO:0070487 |
monocyte aggregation |
The adhesion of one monocyte to one or more other monocytes via adhesion molecules. |
IDA |
BP |
GO:0071260 |
cellular response to mechanical stimulus |
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus. |
IEP |
BP |
GO:0071310 |
cellular response to organic substance |
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus. |
IDA |
BP |
GO:0071407 |
cellular response to organic cyclic compound |
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus. |
IDA |
BP |
GO:0071639 |
positive regulation of monocyte chemotactic protein-1 production |
Any process that activates or increases the frequency, rate, or extent of production of monocyte chemotactic protein-1. |
IDA |
BP |
GO:0097192 |
extrinsic apoptotic signaling pathway in absence of ligand |
A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered. |
IEA |
BP |
GO:1903140 |
regulation of establishment of endothelial barrier |
Any process that modulates the frequency, rate or extent of establishment of endothelial barrier. |
IDA |
BP |
GO:2000778 |
positive regulation of interleukin-6 secretion |
Any process that activates or increases the frequency, rate or extent of interleukin-6 secretion. |
IEA |
BP |
GO:2001240 |
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand |
Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand. |
IDA |
CC |
GO:0005576 |
extracellular region |
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
IDA|NAS|TAS |
CC |
GO:0005615 |
extracellular space |
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. |
IDA|IMP |
CC |
GO:0005764 |
lysosome |
A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. |
IEA |
CC |
GO:0005776 |
autophagosome |
A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the vacuole/lysosome for degradation as part of macroautophagy. |
IEA |
CC |
GO:0005829 |
cytosol |
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
TAS |
CC |
GO:0030141 |
secretory granule |
A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules. |
IEA |
CC |
GO:0070062 |
extracellular exosome |
A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. |
IEA |
MF |
GO:0005125 |
cytokine activity |
Functions to control the survival, growth, differentiation and effector function of tissues and cells. |
IDA|IMP |
MF |
GO:0005149 |
interleukin-1 receptor binding |
Interacting selectively and non-covalently with the interleukin-1 receptor. |
IBA|NAS |
MF |
GO:0019904 |
protein domain specific binding |
Interacting selectively and non-covalently with a specific domain of a protein. |
IPI |
Domain ID | Description |
---|---|
IPR000975 |
Interleukin-1 family |
IPR003296 |
Interleukin-1 beta |
IPR003502 |
Interleukin-1 propeptide |
IPR008996 |
Cytokine IL1/FGF |
IPR020877 |
Interleukin-1 conserved site |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
hsa01523 |
Antifolate resistance |
KEGG |
hsa04010 |
MAPK signaling pathway |
KEGG |
hsa04060 |
Cytokine-cytokine receptor interaction |
KEGG |
hsa04064 |
NF-kappa B signaling pathway |
KEGG |
hsa04380 |
Osteoclast differentiation |
KEGG |
hsa04620 |
Toll-like receptor signaling pathway |
KEGG |
hsa04621 |
NOD-like receptor signaling pathway |
KEGG |
hsa04623 |
Cytosolic DNA-sensing pathway |
KEGG |
hsa04640 |
Hematopoietic cell lineage |
KEGG |
hsa04657 |
IL-17 signaling pathway |
KEGG |
hsa04659 |
Th17 cell differentiation |
KEGG |
hsa04668 |
TNF signaling pathway |
KEGG |
hsa04750 |
Inflammatory mediator regulation of TRP channels |
KEGG |
hsa04932 |
Non-alcoholic fatty liver disease (NAFLD) |
KEGG |
hsa04933 |
AGE-RAGE signaling pathway in diabetic complications |
KEGG |
hsa04940 |
Type I diabetes mellitus |
KEGG |
hsa05010 |
Alzheimer's disease |
KEGG |
hsa05020 |
Prion diseases |
KEGG |
hsa05132 |
Salmonella infection |
KEGG |
hsa05133 |
Pertussis |
KEGG |
hsa05134 |
Legionellosis |
KEGG |
hsa05140 |
Leishmaniasis |
KEGG |
hsa05142 |
Chagas disease (American trypanosomiasis) |
KEGG |
hsa05143 |
African trypanosomiasis |
KEGG |
hsa05144 |
Malaria |
KEGG |
hsa05146 |
Amoebiasis |
KEGG |
hsa05152 |
Tuberculosis |
KEGG |
hsa05162 |
Measles |
KEGG |
hsa05164 |
Influenza A |
KEGG |
hsa05168 |
Herpes simplex infection |
KEGG |
hsa05321 |
Inflammatory bowel disease (IBD) |
KEGG |
hsa05323 |
Rheumatoid arthritis |
KEGG |
hsa05332 |
Graft-versus-host disease |
KEGG |
hsa05418 |
Fluid shear stress and atherosclerosis |
KEGG |
WP1533 |
Vitamin B12 Metabolism |
WikiPathways |
WP2431 |
Spinal Cord Injury |
WikiPathways |
WP195 |
IL-1 signaling pathway |
WikiPathways |
WP619 |
Type II interferon signaling (IFNG) |
WikiPathways |
WP3893 |
Development and heterogeneity of the ILC family |
WikiPathways |
WP2849 |
Hematopoietic Stem Cell Differentiation |
WikiPathways |
WP706 |
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways |
WikiPathways |
WP2059 |
Alzheimers Disease |
WikiPathways |
WP15 |
Selenium Micronutrient Network |
WikiPathways |
WP2328 |
Allograft Rejection |
WikiPathways |
WP2865 |
IL1 and megakaryocytes in obesity |
WikiPathways |
WP75 |
Toll-like Receptor Signaling Pathway |
WikiPathways |
WP1455 |
Serotonin Transporter Activity |
WikiPathways |
WP289 |
Myometrial Relaxation and Contraction Pathways |
WikiPathways |
WP3624 |
Lung fibrosis |
WikiPathways |
WP2034 |
Leptin signaling pathway |
WikiPathways |
WP3617 |
Photodynamic therapy-induced NF-kB survival signaling |
WikiPathways |
WP1449 |
Regulation of toll-like receptor signaling pathway |
WikiPathways |
WP382 |
MAPK Signaling Pathway |
WikiPathways |
WP2873 |
Aryl Hydrocarbon Receptor Pathway |
WikiPathways |
WP176 |
Folate Metabolism |
WikiPathways |
WP615 |
Senescence and Autophagy in Cancer |
WikiPathways |
WP1433 |
Nucleotide-binding Oligomerization Domain (NOD) pathway |
WikiPathways |
WP530 |
Cytokines and Inflammatory Response |
WikiPathways |
WP727 |
Monoamine Transport |
WikiPathways |
WP69 |
T-Cell antigen Receptor (TCR) Signaling Pathway |
WikiPathways |
h_il5Pathway |
IL 5 Signaling Pathway |
BioCarta |
h_mspPathway |
Msp/Ron Receptor Signaling Pathway |
BioCarta |
h_nthiPathway |
NFkB activation by Nontypeable Hemophilus influenzae |
BioCarta |
h_il1rPathway |
Signal transduction through IL1R |
BioCarta |
UMLS CUI | UMLS Term |
---|---|
C0000786 |
Spontaneous Abortion |
C0001418 |
Adenocarcinoma |
C0002395 |
Alzheimer'S Disease |
C0003123 |
Anorexia |
C0003165 |
Anthracosis |
C0003873 |
Rheumatoid Arthritis |
C0004096 |
Asthma |
C0006287 |
Bronchopulmonary Dysplasia |
C0006663 |
Calcinosis |
C0007786 |
Brain Ischemia |
C0009319 |
Colitis |
C0009324 |
Ulcerative Colitis |
C0009375 |
Colonic Neoplasms |
C0011615 |
Dermatitis, Atopic |
C0011633 |
Dermatomyositis |
C0011853 |
Diabetes Mellitus, Experimental |
C0014324 |
Entamoebiasis |
C0015967 |
Fever |
C0016059 |
Fibrosis |
C0017154 |
Gastritis, Atrophic |
C0017636 |
Glioblastoma |
C0017658 |
Glomerulonephritis |
C0018099 |
Gout |
C0018800 |
Cardiomegaly |
C0018801 |
Heart Failure |
C0018824 |
Heart Valve Disease |
C0018843 |
Heat Stroke |
C0019061 |
Hemolytic-Uremic Syndrome |
C0020429 |
Hyperalgesia |
C0020452 |
Hyperemia |
C0020517 |
Hypersensitivity |
C0020615 |
Hypoglycemia |
C0020649 |
Hypotension |
C0021368 |
Inflammation |
C0022541 |
Kearns-Sayre Syndrome |
C0023186 |
Learning Disorders |
C0023283 |
Leishmaniasis, Cutaneous |
C0023290 |
Leishmaniasis, Visceral |
C0023380 |
Lethargy |
C0023518 |
Leukocytosis |
C0023893 |
Liver Cirrhosis, Experimental |
C0024121 |
Lung Neoplasms |
C0024312 |
Lymphopenia |
C0025261 |
Memory Disorders |
C0026769 |
Multiple Sclerosis |
C0026848 |
Myopathy |
C0027051 |
Myocardial Infarction |
C0027540 |
Necrosis |
C0027947 |
Neutropenia |
C0029408 |
Degenerative Polyarthritis |
C0029458 |
Osteoporosis, Postmenopausal |
C0030920 |
Peptic Ulcer |
C0032231 |
Pleurisy |
C0032285 |
Pneumonia |
C0033860 |
Psoriasis |
C0034069 |
Pulmonary Fibrosis |
C0035126 |
Reperfusion Injury |
C0036341 |
Schizophrenia |
C0036572 |
Seizures |
C0037116 |
Silicosis |
C0037274 |
Dermatologic Disorders |
C0038356 |
Stomach Neoplasms |
C0038358 |
Gastric Ulcer |
C0038454 |
Cerebrovascular Accident |
C0040136 |
Thyroid Neoplasm |
C0042109 |
Urticaria |
C0085655 |
Polymyositis |
C0151744 |
Myocardial Ischemia |
C0162670 |
Mitochondrial Myopathies |
C0162671 |
Melas Syndrome |
C0162672 |
Merrf Syndrome |
C0162674 |
Chronic Progressive External Ophthalmoplegia |
C0311375 |
Arsenic Poisoning |
C0333355 |
Inflammatory Disease Of Mucous Membrane |
C0343755 |
HIV Wasting Syndrome |
C0677050 |
Manganese Poisoning |
C0860207 |
Drug-Induced Liver Injury |
C0878544 |
Cardiomyopathies |
C0917796 |
Optic Atrophy, Hereditary, Leber |
C0993582 |
Arthritis, Experimental |
C1458155 |
Mammary Neoplasms |
C4042891 |
Sleep Wake Disorders |
Database Name |
---|
DisGeNET |
DGA |
Pubmed ID | Author | Year | Title |
---|---|---|---|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
IRF5 |
3663 |
Q13568 |
0.00 |
MYD88 |
4615 |
Q99836 |
0.00 |
TLR2 |
7097 |
O60603 |
0.00 |
TLR3 |
7098 |
O15455 |
0.00 |
IL1B |
3553 |
P01584 |
0.55 |
APP |
351 |
P05067 |
0.56 |
EGR1 |
1958 |
P18146 |
0.63 |
SP1 |
6667 |
P08047 |
0.63 |
IKBKG |
8517 |
Q9Y6K9 |
0.63 |
PKM |
5315 |
P14618 |
0.68 |
A2M |
2 |
P01023 |
0.69 |
ADRB2 |
154 |
P07550 |
0.52 |
CMA1 |
1215 |
P23946 |
0.52 |
MMP2 |
4313 |
P08253 |
0.52 |
PRTN3 |
5657 |
P24158 |
0.52 |
IL1R2 |
7850 |
P27930 |
0.52 |
FYN |
2534 |
P06241 |
0.56 |
LYN |
4067 |
P07948 |
0.56 |
CASP4 |
837 |
P49662 |
0.62 |
ELAVL1 |
1994 |
Q15717 |
0.63 |
MYC |
4609 |
P01106 |
0.63 |
PTPN1 |
5770 |
P18031 |
0.63 |
ZC3H12A |
80149 |
Q5D1E8 |
0.63 |
CASP1 |
834 |
P29466 |
0.69 |
IL1R1 |
3554 |
P14778 |
0.88 |
IL1RAP |
3556 |
Q9NPH3 |
0.88 |