Protein Description

Gene Symbol IL1B
Entrez ID 3553
Uniprot ID P01584
Description interleukin 1 beta
Chromosomal Location chr2: 112,829,751-112,836,903
Ontology GO ID GO Term Definition Evidence

BP

GO:0000165

MAPK cascade

An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.

IMP

BP

GO:0000187

activation of MAPK activity

The initiation of the activity of the inactive enzyme MAP kinase (MAPK).

IDA

BP

GO:0001660

fever generation

The heat generation process that results in a rise in body temperature above the normal, often as a response to infection.

IEA

BP

GO:0001934

positive regulation of protein phosphorylation

Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.

IDA|NAS

BP

GO:0002711

positive regulation of T cell mediated immunity

Any process that activates or increases the frequency, rate, or extent of T cell mediated immunity.

IC

BP

GO:0006915

apoptotic process

A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.

TAS

BP

GO:0006954

inflammatory response

The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.

IDA|NAS

BP

GO:0006955

immune response

Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.

IEA

BP

GO:0007165

signal transduction

The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

TAS

BP

GO:0007267

cell-cell signaling

Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.

TAS

BP

GO:0007566

embryo implantation

Attachment of the blastocyst to the uterine lining.

TAS

BP

GO:0008285

negative regulation of cell proliferation

Any process that stops, prevents or reduces the rate or extent of cell proliferation.

IDA

BP

GO:0009743

response to carbohydrate

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus.

IEA

BP

GO:0010575

positive regulation of vascular endothelial growth factor production

Any process that increases or activates the frequency, rate, or extent of production of vascular endothelial growth factor.

IDA|ISS

BP

GO:0010628

positive regulation of gene expression

Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.

IDA

BP

GO:0010829

negative regulation of glucose transport

Any process that decreases the frequency, rate or extent of glucose transport. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

ISS

BP

GO:0014805

smooth muscle adaptation

Any process in which smooth muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities.

NAS

BP

GO:0019221

cytokine-mediated signaling pathway

A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.

IDA

BP

GO:0030213

hyaluronan biosynthetic process

The chemical reactions and pathways resulting in the formation of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine.

IDA

BP

GO:0030593

neutrophil chemotaxis

The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.

IEA

BP

GO:0030730

sequestering of triglyceride

The process of binding or confining any triester of glycerol such that it is separated from other components of a biological system.

IDA

BP

GO:0030949

positive regulation of vascular endothelial growth factor receptor signaling pathway

Any process that activates or increases the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity.

IC

BP

GO:0031622

positive regulation of fever generation

Any process that activates or increases the frequency, rate, or extent of fever generation.

ISS

BP

GO:0031663

lipopolysaccharide-mediated signaling pathway

A series of molecular signals initiated by the binding of a lipopolysaccharide (LPS) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Lipopolysaccharides are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system.

IDA

BP

GO:0032308

positive regulation of prostaglandin secretion

Any process that activates or increases the frequency, rate or extent of the regulated release of a prostaglandin from a cell.

ISS

BP

GO:0032611

interleukin-1 beta production

The appearance of interleukin-1 beta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

IEA

BP

GO:0032725

positive regulation of granulocyte macrophage colony-stimulating factor production

Any process that activates or increases the frequency, rate, or extent of granulocyte macrophage colony-stimulating factor production.

IDA

BP

GO:0032729

positive regulation of interferon-gamma production

Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.

IDA

BP

GO:0032755

positive regulation of interleukin-6 production

Any process that activates or increases the frequency, rate, or extent of interleukin-6 production.

TAS

BP

GO:0032757

positive regulation of interleukin-8 production

Any process that activates or increases the frequency, rate, or extent of interleukin-8 production.

IDA

BP

GO:0033129

positive regulation of histone phosphorylation

Any process that activates or increases the frequency, rate or extent of the addition of one or more phosphate groups to a histone protein.

NAS

BP

GO:0033198

response to ATP

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus.

IEA

BP

GO:0034116

positive regulation of heterotypic cell-cell adhesion

Any process that activates or increases the frequency, rate, or extent of heterotypic cell-cell adhesion.

IDA|NAS

BP

GO:0035066

positive regulation of histone acetylation

Any process that activates or increases the frequency, rate or extent of the addition of an acetyl group to a histone protein.

NAS

BP

GO:0035234

ectopic germ cell programmed cell death

Programmed cell death of an errant germ line cell that is outside the normal migratory path or ectopic to the gonad. This is an important mechanism of regulating germ cell survival within the embryo.

IEA

BP

GO:0035505

positive regulation of myosin light chain kinase activity

Any process that activates or increases the frequency, rate or extent of myosin light chain kinase activity.

IDA

BP

GO:0035690

cellular response to drug

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.

IDA

BP

GO:0042102

positive regulation of T cell proliferation

Any process that activates or increases the rate or extent of T cell proliferation.

IDA

BP

GO:0042346

positive regulation of NF-kappaB import into nucleus

Any process that activates or increases the frequency, rate or extent of transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane.

IDA

BP

GO:0043122

regulation of I-kappaB kinase/NF-kappaB signaling

Any process that modulates I-kappaB kinase/NF-kappaB signaling.

IDA

BP

GO:0043407

negative regulation of MAP kinase activity

Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity.

ISS

BP

GO:0043491

protein kinase B signaling

A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase B (also called AKT), which occurs as a result of a single trigger reaction or compound.

IMP

BP

GO:0045080

positive regulation of chemokine biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chemokines.

IEA

BP

GO:0045086

positive regulation of interleukin-2 biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-2.

IMP

BP

GO:0045410

positive regulation of interleukin-6 biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6.

IEA

BP

GO:0045429

positive regulation of nitric oxide biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.

IDA

BP

GO:0045766

positive regulation of angiogenesis

Any process that activates or increases angiogenesis.

ISS

BP

GO:0045833

negative regulation of lipid metabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipids.

ISS

BP

GO:0045840

positive regulation of mitotic nuclear division

Any process that activates or increases the frequency, rate or extent of mitosis.

IMP

BP

GO:0045893

positive regulation of transcription, DNA-templated

Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.

IDA

BP

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.

IEA

BP

GO:0046330

positive regulation of JNK cascade

Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade.

IBA

BP

GO:0046627

negative regulation of insulin receptor signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling.

ISS

BP

GO:0046827

positive regulation of protein export from nucleus

Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the nucleus into the cytoplasm.

NAS

BP

GO:0050766

positive regulation of phagocytosis

Any process that activates or increases the frequency, rate or extent of phagocytosis.

IMP

BP

GO:0050796

regulation of insulin secretion

Any process that modulates the frequency, rate or extent of the regulated release of insulin.

IDA

BP

GO:0050995

negative regulation of lipid catabolic process

Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids.

IDA

BP

GO:0050996

positive regulation of lipid catabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids.

ISS

BP

GO:0050999

regulation of nitric-oxide synthase activity

Any process that modulates the activity of the enzyme nitric-oxide synthase.

IDA

BP

GO:0051044

positive regulation of membrane protein ectodomain proteolysis

Any process that activates or increases the frequency, rate or extent of membrane protein ectodomain peptidolysis.

IDA

BP

GO:0051091

positive regulation of sequence-specific DNA binding transcription factor activity

Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.

IDA

BP

GO:0051092

positive regulation of NF-kappaB transcription factor activity

Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.

IDA

BP

GO:0051781

positive regulation of cell division

Any process that activates or increases the frequency, rate or extent of cell division.

IEA

BP

GO:0060355

positive regulation of cell adhesion molecule production

Any process that increases the rate, frequency or extent of cell adhesion molecule production. Cell adhesion molecule production is the appearance of a cell adhesion molecule as a result of its biosynthesis or a decrease in its catabolism.

NAS

BP

GO:0060559

positive regulation of calcidiol 1-monooxygenase activity

Any process that increases the rate, frequency or extent of calcidiol 1-monooxygenase activity. Calcidiol 1-monooxygenase activity is the catalysis of the reaction: calcidiol + NADPH + H+ + O2 = calcitriol + NADP+ + H2O.

IDA

BP

GO:0070164

negative regulation of adiponectin secretion

Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of adiponectin from a cell.

ISS

BP

GO:0070487

monocyte aggregation

The adhesion of one monocyte to one or more other monocytes via adhesion molecules.

IDA

BP

GO:0071260

cellular response to mechanical stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.

IEP

BP

GO:0071310

cellular response to organic substance

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus.

IDA

BP

GO:0071407

cellular response to organic cyclic compound

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.

IDA

BP

GO:0071639

positive regulation of monocyte chemotactic protein-1 production

Any process that activates or increases the frequency, rate, or extent of production of monocyte chemotactic protein-1.

IDA

BP

GO:0097192

extrinsic apoptotic signaling pathway in absence of ligand

A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered.

IEA

BP

GO:1903140

regulation of establishment of endothelial barrier

Any process that modulates the frequency, rate or extent of establishment of endothelial barrier.

IDA

BP

GO:2000778

positive regulation of interleukin-6 secretion

Any process that activates or increases the frequency, rate or extent of interleukin-6 secretion.

IEA

BP

GO:2001240

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand.

IDA

CC

GO:0005576

extracellular region

The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

IDA|NAS|TAS

CC

GO:0005615

extracellular space

That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

IDA|IMP

CC

GO:0005764

lysosome

A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.

IEA

CC

GO:0005776

autophagosome

A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the vacuole/lysosome for degradation as part of macroautophagy.

IEA

CC

GO:0005829

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

TAS

CC

GO:0030141

secretory granule

A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules.

IEA

CC

GO:0070062

extracellular exosome

A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.

IEA

MF

GO:0005125

cytokine activity

Functions to control the survival, growth, differentiation and effector function of tissues and cells.

IDA|IMP

MF

GO:0005149

interleukin-1 receptor binding

Interacting selectively and non-covalently with the interleukin-1 receptor.

IBA|NAS

MF

GO:0019904

protein domain specific binding

Interacting selectively and non-covalently with a specific domain of a protein.

IPI

Domain ID Description

IPR000975

Interleukin-1 family

IPR003296

Interleukin-1 beta

IPR003502

Interleukin-1 propeptide

IPR008996

Cytokine IL1/FGF

IPR020877

Interleukin-1 conserved site

Pathway ID Pathway Term Pathway Source

hsa01523

Antifolate resistance

KEGG

hsa04010

MAPK signaling pathway

KEGG

hsa04060

Cytokine-cytokine receptor interaction

KEGG

hsa04064

NF-kappa B signaling pathway

KEGG

hsa04380

Osteoclast differentiation

KEGG

hsa04620

Toll-like receptor signaling pathway

KEGG

hsa04621

NOD-like receptor signaling pathway

KEGG

hsa04623

Cytosolic DNA-sensing pathway

KEGG

hsa04640

Hematopoietic cell lineage

KEGG

hsa04657

IL-17 signaling pathway

KEGG

hsa04659

Th17 cell differentiation

KEGG

hsa04668

TNF signaling pathway

KEGG

hsa04750

Inflammatory mediator regulation of TRP channels

KEGG

hsa04932

Non-alcoholic fatty liver disease (NAFLD)

KEGG

hsa04933

AGE-RAGE signaling pathway in diabetic complications

KEGG

hsa04940

Type I diabetes mellitus

KEGG

hsa05010

Alzheimer's disease

KEGG

hsa05020

Prion diseases

KEGG

hsa05132

Salmonella infection

KEGG

hsa05133

Pertussis

KEGG

hsa05134

Legionellosis

KEGG

hsa05140

Leishmaniasis

KEGG

hsa05142

Chagas disease (American trypanosomiasis)

KEGG

hsa05143

African trypanosomiasis

KEGG

hsa05144

Malaria

KEGG

hsa05146

Amoebiasis

KEGG

hsa05152

Tuberculosis

KEGG

hsa05162

Measles

KEGG

hsa05164

Influenza A

KEGG

hsa05168

Herpes simplex infection

KEGG

hsa05321

Inflammatory bowel disease (IBD)

KEGG

hsa05323

Rheumatoid arthritis

KEGG

hsa05332

Graft-versus-host disease

KEGG

hsa05418

Fluid shear stress and atherosclerosis

KEGG

WP1533

Vitamin B12 Metabolism

WikiPathways

WP2431

Spinal Cord Injury

WikiPathways

WP195

IL-1 signaling pathway

WikiPathways

WP619

Type II interferon signaling (IFNG)

WikiPathways

WP3893

Development and heterogeneity of the ILC family

WikiPathways

WP2849

Hematopoietic Stem Cell Differentiation

WikiPathways

WP706

Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways

WikiPathways

WP2059

Alzheimers Disease

WikiPathways

WP15

Selenium Micronutrient Network

WikiPathways

WP2328

Allograft Rejection

WikiPathways

WP2865

IL1 and megakaryocytes in obesity

WikiPathways

WP75

Toll-like Receptor Signaling Pathway

WikiPathways

WP1455

Serotonin Transporter Activity

WikiPathways

WP289

Myometrial Relaxation and Contraction Pathways

WikiPathways

WP3624

Lung fibrosis

WikiPathways

WP2034

Leptin signaling pathway

WikiPathways

WP3617

Photodynamic therapy-induced NF-kB survival signaling

WikiPathways

WP1449

Regulation of toll-like receptor signaling pathway

WikiPathways

WP382

MAPK Signaling Pathway

WikiPathways

WP2873

Aryl Hydrocarbon Receptor Pathway

WikiPathways

WP176

Folate Metabolism

WikiPathways

WP615

Senescence and Autophagy in Cancer

WikiPathways

WP1433

Nucleotide-binding Oligomerization Domain (NOD) pathway

WikiPathways

WP530

Cytokines and Inflammatory Response

WikiPathways

WP727

Monoamine Transport

WikiPathways

WP69

T-Cell antigen Receptor (TCR) Signaling Pathway

WikiPathways

h_il5Pathway

IL 5 Signaling Pathway

BioCarta

h_mspPathway

Msp/Ron Receptor Signaling Pathway

BioCarta

h_nthiPathway

NFkB activation by Nontypeable Hemophilus influenzae

BioCarta

h_il1rPathway

Signal transduction through IL1R

BioCarta

UMLS CUI UMLS Term

C0000786

Spontaneous Abortion

C0001418

Adenocarcinoma

C0002395

Alzheimer'S Disease

C0003123

Anorexia

C0003165

Anthracosis

C0003873

Rheumatoid Arthritis

C0004096

Asthma

C0006287

Bronchopulmonary Dysplasia

C0006663

Calcinosis

C0007786

Brain Ischemia

C0009319

Colitis

C0009324

Ulcerative Colitis

C0009375

Colonic Neoplasms

C0011615

Dermatitis, Atopic

C0011633

Dermatomyositis

C0011853

Diabetes Mellitus, Experimental

C0014324

Entamoebiasis

C0015967

Fever

C0016059

Fibrosis

C0017154

Gastritis, Atrophic

C0017636

Glioblastoma

C0017658

Glomerulonephritis

C0018099

Gout

C0018800

Cardiomegaly

C0018801

Heart Failure

C0018824

Heart Valve Disease

C0018843

Heat Stroke

C0019061

Hemolytic-Uremic Syndrome

C0020429

Hyperalgesia

C0020452

Hyperemia

C0020517

Hypersensitivity

C0020615

Hypoglycemia

C0020649

Hypotension

C0021368

Inflammation

C0022541

Kearns-Sayre Syndrome

C0023186

Learning Disorders

C0023283

Leishmaniasis, Cutaneous

C0023290

Leishmaniasis, Visceral

C0023380

Lethargy

C0023518

Leukocytosis

C0023893

Liver Cirrhosis, Experimental

C0024121

Lung Neoplasms

C0024312

Lymphopenia

C0025261

Memory Disorders

C0026769

Multiple Sclerosis

C0026848

Myopathy

C0027051

Myocardial Infarction

C0027540

Necrosis

C0027947

Neutropenia

C0029408

Degenerative Polyarthritis

C0029458

Osteoporosis, Postmenopausal

C0030920

Peptic Ulcer

C0032231

Pleurisy

C0032285

Pneumonia

C0033860

Psoriasis

C0034069

Pulmonary Fibrosis

C0035126

Reperfusion Injury

C0036341

Schizophrenia

C0036572

Seizures

C0037116

Silicosis

C0037274

Dermatologic Disorders

C0038356

Stomach Neoplasms

C0038358

Gastric Ulcer

C0038454

Cerebrovascular Accident

C0040136

Thyroid Neoplasm

C0042109

Urticaria

C0085655

Polymyositis

C0151744

Myocardial Ischemia

C0162670

Mitochondrial Myopathies

C0162671

Melas Syndrome

C0162672

Merrf Syndrome

C0162674

Chronic Progressive External Ophthalmoplegia

C0311375

Arsenic Poisoning

C0333355

Inflammatory Disease Of Mucous Membrane

C0343755

HIV Wasting Syndrome

C0677050

Manganese Poisoning

C0860207

Drug-Induced Liver Injury

C0878544

Cardiomyopathies

C0917796

Optic Atrophy, Hereditary, Leber

C0993582

Arthritis, Experimental

C1458155

Mammary Neoplasms

C4042891

Sleep Wake Disorders

No tissues found.

Database Name

DisGeNET

DGA

Pubmed ID Author Year Title

22617121

Ouandaogo et al.

2012

Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

22951915

Haozi et al.

2012

Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

Gene Symbol Entrez ID Uniprot ID Score

IRF5

3663

Q13568

0.00

MYD88

4615

Q99836

0.00

TLR2

7097

O60603

0.00

TLR3

7098

O15455

0.00

IL1B

3553

P01584

0.55

APP

351

P05067

0.56

EGR1

1958

P18146

0.63

SP1

6667

P08047

0.63

IKBKG

8517

Q9Y6K9

0.63

PKM

5315

P14618

0.68

A2M

2

P01023

0.69

ADRB2

154

P07550

0.52

CMA1

1215

P23946

0.52

MMP2

4313

P08253

0.52

PRTN3

5657

P24158

0.52

IL1R2

7850

P27930

0.52

FYN

2534

P06241

0.56

LYN

4067

P07948

0.56

CASP4

837

P49662

0.62

ELAVL1

1994

Q15717

0.63

MYC

4609

P01106

0.63

PTPN1

5770

P18031

0.63

ZC3H12A

80149

Q5D1E8

0.63

CASP1

834

P29466

0.69

IL1R1

3554

P14778

0.88

IL1RAP

3556

Q9NPH3

0.88