BP

GO:0000122

negative regulation of transcription from RNA polymerase II promoter

Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter.

IEA

BP

GO:0001656

metanephros development

The process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. In mammals, the metanephros is the excretory organ of the fetus, which develops into the mature kidney and is formed from the rear portion of the nephrogenic cord. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine.

IEA

BP

GO:0001779

natural killer cell differentiation

The process in which a relatively unspecialized cell acquires the specialized features of a natural killer cell.

IEA

BP

GO:0001966

thigmotaxis

The directed movement of a motile cell or organism in response to touch.

IEA

BP

GO:0003149

membranous septum morphogenesis

The process in which the membranous septum is generated and organized. The membranous septum is the upper part of ventricular septum.

IEA

BP

GO:0003166

bundle of His development

The process whose specific outcome is the progression of the bundle of His over time, from its formation to the mature structure. The bundle of His is part of the His-Purkinje system that transmits signals from the AV node to the cardiac Purkinje fibers.

IEA

BP

GO:0006351

transcription, DNA-templated

The cellular synthesis of RNA on a template of DNA.

IEA

BP

GO:0007275

multicellular organism development

The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

TAS

BP

GO:0008344

adult locomotory behavior

Locomotory behavior in a fully developed and mature organism.

IEA

BP

GO:0010628

positive regulation of gene expression

Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.

ISS

BP

GO:0010629

negative regulation of gene expression

Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.

ISS

BP

GO:0014003

oligodendrocyte development

The process aimed at the progression of an oligodendrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An oligodendrocyte is a type of glial cell involved in myelinating the axons in the central nervous system.

IEA

BP

GO:0019216

regulation of lipid metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids.

ISS

BP

GO:0021772

olfactory bulb development

The progression of the olfactory bulb over time from its initial formation until its mature state. The olfactory bulb coordinates neuronal signaling involved in the perception of smell. It receives input from the sensory neurons and outputs to the olfactory cortex.

IEA

BP

GO:0032922

circadian regulation of gene expression

Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.

ISS

BP

GO:0033598

mammary gland epithelial cell proliferation

The multiplication or reproduction of mammary gland epithelial cells, resulting in the expansion of a cell population. Mammary gland epithelial cells make up the covering of surfaces of the mammary gland. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk.

ISS

BP

GO:0042752

regulation of circadian rhythm

Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.

ISS

BP

GO:0043153

entrainment of circadian clock by photoperiod

The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night).

ISS

BP

GO:0043353

enucleate erythrocyte differentiation

The process in which a myeloid precursor cell acquires specialized features of an erythrocyte without a nucleus. An example of this process is found in Mus musculus.

IEA

BP

GO:0043392

negative regulation of DNA binding

Any process that stops or reduces the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid).

IEA

BP

GO:0043433

negative regulation of sequence-specific DNA binding transcription factor activity

Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.

IDA

BP

GO:0045475

locomotor rhythm

The rhythm of the locomotor activity of an organism during its 24 hour activity cycle.

ISS

BP

GO:0045578

negative regulation of B cell differentiation

Any process that stops, prevents, or reduces the frequency, rate or extent of B cell differentiation.

IEA

BP

GO:0045600

positive regulation of fat cell differentiation

Any process that activates or increases the frequency, rate or extent of adipocyte differentiation.

IEA

BP

GO:0045648

positive regulation of erythrocyte differentiation

Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation.

IEA

BP

GO:0045651

positive regulation of macrophage differentiation

Any process that activates or increases the frequency, rate or extent of macrophage differentiation.

IEA

BP

GO:0045665

negative regulation of neuron differentiation

Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation.

ISS

BP

GO:0045668

negative regulation of osteoblast differentiation

Any process that stops, prevents, or reduces the frequency, rate or extent of osteoblast differentiation.

IEA

BP

GO:0045777

positive regulation of blood pressure

Any process in which the force of blood traveling through the circulatory system is increased.

ISS

BP

GO:0045892

negative regulation of transcription, DNA-templated

Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.

IDA

BP

GO:0045893

positive regulation of transcription, DNA-templated

Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.

ISS

BP

GO:0048469

cell maturation

A developmental process, independent of morphogenetic (shape) change, that is required for a cell to attain its fully functional state.

IEA

BP

GO:0048541

Peyer's patch development

The process whose specific outcome is the progression of Peyer's patches over time, from their formation to the mature structure. Peyer's patches are typically found as nodules associated with gut epithelium with distinct internal structures including B- and T-zones for the activation of lymphocytes.

IEA

BP

GO:0048557

embryonic digestive tract morphogenesis

The process in which the anatomical structures of the digestive tract are generated and organized during embryonic development. The digestive tract is the anatomical structure through which food passes and is processed.

ISS

BP

GO:0048661

positive regulation of smooth muscle cell proliferation

Any process that activates or increases the rate or extent of smooth muscle cell proliferation.

ISS

BP

GO:0048663

neuron fate commitment

The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron.

ISS

BP

GO:0048667

cell morphogenesis involved in neuron differentiation

The process in which the structures of a neuron are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a neuron.

IEA

BP

GO:0048711

positive regulation of astrocyte differentiation

Any process that activates or increases the frequency, rate or extent of astrocyte differentiation.

IEA

BP

GO:0048715

negative regulation of oligodendrocyte differentiation

Any process that stops, prevents, or reduces the frequency, rate or extent of oligodendrocyte differentiation.

IEA

BP

GO:0060612

adipose tissue development

The process whose specific outcome is the progression of adipose tissue over time, from its formation to the mature structure. Adipose tissue is specialized tissue that is used to store fat.

IEA

BP

GO:0060749

mammary gland alveolus development

The progression of the mammary gland alveolus over time, from its formation to its mature state. The mammary gland alveolus is a sac-like structure that is found in the mature gland.

ISS

BP

GO:0061030

epithelial cell differentiation involved in mammary gland alveolus development

The process in which a relatively unspecialized epithelial cell becomes a more specialized epithelial cell of the mammary gland alveolus.

ISS

BP

GO:0061031

endodermal digestive tract morphogenesis

The process in which the anatomical structures of the endodermal digestive tract are generated and organized. The endodermal digestive tract includes those portions of the digestive tract that are derived from endoderm.

ISS

BP

GO:0071158

positive regulation of cell cycle arrest

Any process that increases the rate, frequency, or extent of cell cycle arrest, the process in which the cell cycle is halted during one of the normal phases.

ISS

BP

GO:0071285

cellular response to lithium ion

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lithium (Li+) ion stimulus.

IEA

BP

GO:0071931

positive regulation of transcription involved in G1/S transition of mitotic cell cycle

Any process that activates or increases transcription as part of the G1/S transition of the mitotic cell cycle.

IC

BP

GO:0090398

cellular senescence

A cell aging process stimulated in response to cellular stress, whereby normal cells lose the ability to divide through irreversible cell cycle arrest.

ISS

BP

GO:2000045

regulation of G1/S transition of mitotic cell cycle

Any cell cycle regulatory process that controls the commitment of a cell from G1 to S phase of the mitotic cell cycle.

IMP

BP

GO:2000178

negative regulation of neural precursor cell proliferation

Any process that stops, prevents, or reduces the frequency, rate or extent of neural precursor cell proliferation.

ISS

CC

GO:0005634

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

IDA

CC

GO:0005654

nucleoplasm

That part of the nuclear content other than the chromosomes or the nucleolus.

IDA

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

IDA

CC

GO:0005813

centrosome

A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.

IDA

CC

GO:0005829

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

IDA

CC

GO:0043234

protein complex

A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical.

ISS

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0044325

ion channel binding

Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.

IPI

MF

GO:0046983

protein dimerization activity

The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.

IEA