Protein Description

Gene Symbol ICA1
Entrez ID 3382
Uniprot ID Q05084
Description islet cell autoantigen 1
Chromosomal Location chr7: 8,113,184-8,262,687
Ontology GO ID GO Term Definition Evidence

BP

GO:0006836

neurotransmitter transport

The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell.

IEA

BP

GO:0050796

regulation of insulin secretion

Any process that modulates the frequency, rate or extent of the regulated release of insulin.

IEA

CC

GO:0000139

Golgi membrane

The lipid bilayer surrounding any of the compartments of the Golgi apparatus.

IDA

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

IDA

CC

GO:0005794

Golgi apparatus

A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.

IDA

CC

GO:0005829

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

ISS

CC

GO:0030054

cell junction

A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.

IEA

CC

GO:0030667

secretory granule membrane

The lipid bilayer surrounding a secretory granule.

IDA

CC

GO:0030672

synaptic vesicle membrane

The lipid bilayer surrounding a synaptic vesicle.

ISS

MF

GO:0003674

molecular_function

Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.

ND

MF

GO:0019904

protein domain specific binding

Interacting selectively and non-covalently with a specific domain of a protein.

IEA

Domain ID Description

IPR006723

Islet cell autoantigen Ica1, C-terminal

IPR010504

Arfaptin homology (AH) domain

IPR024114

Islet cell autoantigen 1/Ica1-like

IPR027267

Arfaptin homology (AH) domain/BAR domain

IPR030796

Islet cell autoantigen 1

Pathway ID Pathway Term Pathway Source

hsa04940

Type I diabetes mellitus

KEGG

UMLS CUI UMLS Term

C0028754

Obesity

Tissue Cell Type

heart muscle

myocytes

placenta

decidual cells

skeletal muscle

myocytes

smooth muscle

smooth muscle cells

No databases found.

Pubmed ID Author Year Title

26459919

Lan et al.

2015

Functional microarray analysis of differentially expressed genes in granulosa cells from women with polycystic ovary syndrome related to MAPK/ERK signaling

Gene Symbol Entrez ID Uniprot ID Score

MYC

4609

P01106

0.49

MORF4L1

10933

Q9UBU8

0.49

RAB2A

5862

P61019

0.63

CCDC28A

25901

Q8IWP9

0.63

MBD3

53615

O95983

0.63

ING5

84289

Q8WYH8

0.63

RAB2B

84932

Q8WUD1

0.63

MKKS

N/A

Q9HB66

0.63

MKKS

8195

Q9NPJ1

0.72

CNTF

1270

P26441

0.76

KRT33B

3884

Q14525

0.76

STK16

8576

O75716

0.76

EXOC5

10640

O00471

0.63

PICK1

9463

Q9NRD5

0.70