Gene Symbol | ICA1 |
Entrez ID | 3382 |
Uniprot ID | Q05084 |
Description | islet cell autoantigen 1 |
Chromosomal Location | chr7: 8,113,184-8,262,687 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0006836 |
neurotransmitter transport |
The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. |
IEA |
BP |
GO:0050796 |
regulation of insulin secretion |
Any process that modulates the frequency, rate or extent of the regulated release of insulin. |
IEA |
CC |
GO:0000139 |
Golgi membrane |
The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
IDA |
CC |
GO:0005737 |
cytoplasm |
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
IDA |
CC |
GO:0005794 |
Golgi apparatus |
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. |
IDA |
CC |
GO:0005829 |
cytosol |
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
ISS |
CC |
GO:0030054 |
cell junction |
A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix. |
IEA |
CC |
GO:0030667 |
secretory granule membrane |
The lipid bilayer surrounding a secretory granule. |
IDA |
CC |
GO:0030672 |
synaptic vesicle membrane |
The lipid bilayer surrounding a synaptic vesicle. |
ISS |
MF |
GO:0003674 |
molecular_function |
Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions. |
ND |
MF |
GO:0019904 |
protein domain specific binding |
Interacting selectively and non-covalently with a specific domain of a protein. |
IEA |
Domain ID | Description |
---|---|
IPR006723 |
Islet cell autoantigen Ica1, C-terminal |
IPR010504 |
Arfaptin homology (AH) domain |
IPR024114 |
Islet cell autoantigen 1/Ica1-like |
IPR027267 |
Arfaptin homology (AH) domain/BAR domain |
IPR030796 |
Islet cell autoantigen 1 |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
hsa04940 |
Type I diabetes mellitus |
KEGG |
UMLS CUI | UMLS Term |
---|---|
C0028754 |
Obesity |
Tissue | Cell Type |
---|---|
heart muscle |
myocytes |
placenta |
decidual cells |
skeletal muscle |
myocytes |
smooth muscle |
smooth muscle cells |
Pubmed ID | Author | Year | Title |
---|---|---|---|
26459919 |
Lan et al. |
2015 |
Functional microarray analysis of differentially expressed genes in granulosa cells from women with polycystic ovary syndrome related to MAPK/ERK signaling |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
MYC |
4609 |
P01106 |
0.49 |
MORF4L1 |
10933 |
Q9UBU8 |
0.49 |
RAB2A |
5862 |
P61019 |
0.63 |
CCDC28A |
25901 |
Q8IWP9 |
0.63 |
MBD3 |
53615 |
O95983 |
0.63 |
ING5 |
84289 |
Q8WYH8 |
0.63 |
RAB2B |
84932 |
Q8WUD1 |
0.63 |
MKKS |
N/A |
Q9HB66 |
0.63 |
MKKS |
8195 |
Q9NPJ1 |
0.72 |
CNTF |
1270 |
P26441 |
0.76 |
KRT33B |
3884 |
Q14525 |
0.76 |
STK16 |
8576 |
O75716 |
0.76 |
EXOC5 |
10640 |
O00471 |
0.63 |
PICK1 |
9463 |
Q9NRD5 |
0.70 |