| Gene Symbol | HSPE1 |
| Entrez ID | 3336 |
| Uniprot ID | P61604 |
| Description | heat shock protein family E (Hsp10) member 1 |
| Chromosomal Location | chr2: 197,499,994-197,503,457 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0001649 |
osteoblast differentiation |
The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone. |
IDA |
|
BP |
GO:0006457 |
protein folding |
The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. |
TAS |
|
BP |
GO:0006919 |
activation of cysteine-type endopeptidase activity involved in apoptotic process |
Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process. |
NAS |
|
BP |
GO:0006986 |
response to unfolded protein |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus. |
TAS |
|
BP |
GO:0051085 |
chaperone mediated protein folding requiring cofactor |
The process of assisting in the correct posttranslational noncovalent assembly of proteins, which is dependent on additional protein cofactors. This process occurs over one or several cycles of nucleotide hydrolysis-dependent binding and release. |
IBA |
|
CC |
GO:0005739 |
mitochondrion |
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
IDA|ISS |
|
CC |
GO:0005759 |
mitochondrial matrix |
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. |
IBA |
|
CC |
GO:0016020 |
membrane |
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
IDA |
|
CC |
GO:0070062 |
extracellular exosome |
A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. |
IDA |
|
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
|
MF |
GO:0005524 |
ATP binding |
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
IEA |
|
MF |
GO:0044822 |
poly(A) RNA binding |
Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases. |
IDA |
|
MF |
GO:0046872 |
metal ion binding |
Interacting selectively and non-covalently with any metal ion. |
IBA |
|
MF |
GO:0051082 |
unfolded protein binding |
Interacting selectively and non-covalently with an unfolded protein. |
IBA|NAS |
|
MF |
GO:0051087 |
chaperone binding |
Interacting selectively and non-covalently with a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport. |
IPI|ISS |
| Domain ID | Description |
|---|---|
|
IPR011032 |
GroES-like |
|
IPR018369 |
Chaperonin GroES, conserved site |
|
IPR020818 |
GroES chaperonin family |
| UMLS CUI | UMLS Term |
|---|---|
|
C0878544 |
Cardiomyopathies |
| Tissue | Cell Type |
|---|---|
|
adrenal gland |
glandular cells |
|
appendix |
glandular cells |
|
appendix |
lymphoid tissue |
|
bone marrow |
hematopoietic cells |
|
breast |
glandular cells |
|
breast |
myoepithelial cells |
|
bronchus |
respiratory epithelial cells |
|
caudate |
glial cells |
|
caudate |
neuronal cells |
|
cerebellum |
cells in granular layer |
|
cerebellum |
Purkinje cells |
|
cerebral cortex |
glial cells |
|
cerebral cortex |
neuronal cells |
|
cervix, uterine |
squamous epithelial cells |
|
colon |
glandular cells |
|
duodenum |
glandular cells |
|
endometrium |
cells in endometrial stroma |
|
endometrium |
glandular cells |
|
esophagus |
squamous epithelial cells |
|
fallopian tube |
glandular cells |
|
gallbladder |
glandular cells |
|
heart muscle |
myocytes |
|
hippocampus |
glial cells |
|
kidney |
cells in tubules |
|
liver |
bile duct cells |
|
liver |
hepatocytes |
|
lung |
macrophages |
|
lung |
pneumocytes |
|
lymph node |
germinal center cells |
|
lymph node |
non-germinal center cells |
|
nasopharynx |
respiratory epithelial cells |
|
oral mucosa |
squamous epithelial cells |
|
pancreas |
exocrine glandular cells |
|
pancreas |
islets of Langerhans |
|
parathyroid gland |
glandular cells |
|
placenta |
trophoblastic cells |
|
prostate |
glandular cells |
|
rectum |
glandular cells |
|
salivary gland |
glandular cells |
|
seminal vesicle |
glandular cells |
|
skeletal muscle |
myocytes |
|
skin |
fibroblasts |
|
skin |
epidermal cells |
|
small intestine |
glandular cells |
|
soft tissue |
adipocytes |
|
soft tissue |
chondrocytes |
|
spleen |
cells in red pulp |
|
spleen |
cells in white pulp |
|
stomach |
glandular cells |
|
testis |
cells in seminiferous ducts |
|
testis |
Leydig cells |
|
thyroid gland |
glandular cells |
|
tonsil |
germinal center cells |
|
tonsil |
non-germinal center cells |
|
urinary bladder |
urothelial cells |
|
vagina |
squamous epithelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
17557764 |
Ma et al. |
2007 |
Proteomic analysis of human ovaries from normal and polycystic ovarian syndrome |
|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
|
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
AKR1B1 |
231 |
P15121 |
0.49 |
|
CAT |
847 |
P04040 |
0.49 |
|
ESD |
2098 |
P10768 |
0.49 |
|
HSPA4 |
3308 |
P34932 |
0.49 |
|
HSPA9 |
3313 |
P38646 |
0.49 |
|
IMPA2 |
3613 |
O14732 |
0.49 |
|
PGK2 |
5232 |
P07205 |
0.49 |
|
PIN1 |
5300 |
Q13526 |
0.49 |
|
PPIA |
5478 |
P62937 |
0.49 |
|
CCT3 |
7203 |
P49368 |
0.49 |
|
RGN |
9104 |
Q15493 |
0.49 |
|
GRHPR |
9380 |
Q9UBQ7 |
0.49 |
|
PPIF |
10105 |
P30405 |
0.49 |
|
HSPH1 |
10808 |
Q92598 |
0.49 |
|
HSPA4L |
22824 |
O95757 |
0.49 |
|
CCT5 |
22948 |
P48643 |
0.49 |
|
UFM1 |
51569 |
P61960 |
0.49 |
|
PGM2L1 |
283209 |
Q6PCE3 |
0.49 |
|
MPI |
4351 |
P34949 |
0.59 |
|
ALDH2 |
217 |
P05091 |
0.63 |
|
CRMP1 |
1400 |
Q14194 |
0.63 |
|
RBBP7 |
5931 |
Q16576 |
0.63 |
|
TLE1 |
7088 |
Q04724 |
0.63 |
|
UNC119 |
9094 |
Q13432 |
0.63 |
|
C14orf1 |
11161 |
Q9UKR5 |
0.63 |
|
RIF1 |
55183 |
Q5UIP0 |
0.63 |
|
LRIF1 |
55791 |
Q5T3J3 |
0.63 |
|
GBP7 |
388646 |
Q8N8V2 |
0.63 |
|
ZHX1 |
11244 |
Q9UKY1 |
0.73 |
|
HSPD1 |
3329 |
P10809 |
0.99 |
|
ABAT |
18 |
P80404 |
0.49 |
|
ACAT2 |
39 |
Q9BWD1 |
0.49 |
|
ALDOA |
226 |
P04075 |
0.49 |
|
CBS |
875 |
P35520 |
0.49 |
|
CFL1 |
1072 |
P23528 |
0.49 |
|
CKB |
1152 |
P12277 |
0.49 |
|
CKMT2 |
1160 |
P17540 |
0.49 |
|
CLTB |
1212 |
P09497 |
0.49 |
|
CTH |
1491 |
P32929 |
0.49 |
|
DBI |
1622 |
P07108 |
0.49 |
|
ENO2 |
2026 |
P09104 |
0.49 |
|
ENO3 |
2027 |
P13929 |
0.49 |
|
EWSR1 |
2130 |
Q01844 |
0.49 |
|
FABP5 |
2171 |
Q01469 |
0.49 |
|
FKBP1A |
2280 |
P62942 |
0.49 |
|
GLO1 |
2739 |
Q04760 |
0.49 |
|
GOT1 |
2805 |
P17174 |
0.49 |
|
GPX4 |
2879 |
P36969 |
0.49 |
|
HAGH |
3029 |
Q16775 |
0.49 |
|
HINT1 |
3094 |
P49773 |
0.49 |
|
HSP90AA1 |
3320 |
P07900 |
0.49 |
|
LASP1 |
3927 |
Q14847 |
0.49 |
|
ALDH6A1 |
4329 |
Q02252 |
0.49 |
|
MSN |
4478 |
P26038 |
0.49 |
|
MSRA |
4482 |
Q9UJ68 |
0.49 |
|
PEBP1 |
5037 |
P30086 |
0.49 |
|
PCK2 |
5106 |
Q16822 |
0.49 |
|
PEPD |
5184 |
P12955 |
0.49 |
|
PGM5 |
5239 |
Q15124 |
0.49 |
|
PLS3 |
5358 |
P13797 |
0.49 |
|
PPIB |
5479 |
P23284 |
0.49 |
|
MAP2K7 |
5609 |
O14733 |
0.49 |
|
QDPR |
5860 |
P09417 |
0.49 |
|
RCN1 |
5954 |
Q15293 |
0.49 |
|
RDX |
5962 |
P35241 |
0.49 |
|
SHMT1 |
6470 |
P34896 |
0.49 |
|
SHMT2 |
6472 |
P34897 |
0.49 |
|
SOD1 |
6647 |
P00441 |
0.49 |
|
SOD2 |
6648 |
P04179 |
0.49 |
|
SPR |
6697 |
P35270 |
0.49 |
|
TAGLN |
6876 |
Q01995 |
0.49 |
|
TKT |
7086 |
P29401 |
0.49 |
|
TXN |
7295 |
P10599 |
0.49 |
|
UBE2L3 |
7332 |
P68036 |
0.49 |
|
UGP2 |
7360 |
Q16851 |
0.49 |
|
EZR |
7430 |
P15311 |
0.49 |
|
TAGLN2 |
8407 |
P37802 |
0.49 |
|
PIR |
8544 |
O00625 |
0.49 |
|
GSTO1 |
9446 |
P78417 |
0.49 |
|
CCT4 |
10575 |
P50991 |
0.49 |
|
CCT2 |
10576 |
P78371 |
0.49 |
|
AHSA1 |
10598 |
O95433 |
0.49 |
|
PAICS |
10606 |
P22234 |
0.49 |
|
CLPX |
10845 |
O76031 |
0.49 |
|
STIP1 |
10963 |
P31948 |
0.49 |
|
DSTN |
11034 |
P60981 |
0.49 |
|
PHGDH |
26227 |
O43175 |
0.49 |
|
TAGLN3 |
29114 |
Q9UI15 |
0.49 |
|
PNPO |
55163 |
Q9NVS9 |
0.49 |
|
GCNT6 |
644378 |
Q5T4J0 |
0.49 |
|
CKMT1A; CKMT1B |
1159 |
P12532 |
0.49 |
|
HSP90AB1 |
3326 |
P08238 |
0.56 |
|
ADSS |
159 |
P30520 |
0.63 |
|
APLP1 |
333 |
P51693 |
0.63 |
|
CDK2 |
1017 |
P24941 |
0.63 |
|
DCK |
1633 |
P27707 |
0.63 |
|
EEF1A1 |
1915 |
P68104 |
0.63 |
|
EPB41 |
2035 |
P11171 |
0.63 |
|
ESR1 |
2099 |
P03372 |
0.63 |
|
FN1 |
2335 |
P02751 |
0.63 |
|
GBP2 |
2634 |
P32456 |
0.63 |
|
HLA-B |
3106 |
P30480 |
0.63 |
|
IDH1 |
3417 |
O75874 |
0.63 |
|
ILK |
3611 |
Q13418 |
0.63 |
|
ITGA4 |
3676 |
P13612 |
0.63 |
|
MDM2 |
4193 |
Q00987 |
0.63 |
|
MPG |
4350 |
P29372 |
0.63 |
|
PTMS |
5763 |
P20962 |
0.63 |
|
ABCE1 |
6059 |
P61221 |
0.63 |
|
SAT1 |
6303 |
P21673 |
0.63 |
|
STK3 |
6788 |
Q13188 |
0.63 |
|
TALDO1 |
6888 |
P37837 |
0.63 |
|
THOP1 |
7064 |
P52888 |
0.63 |
|
TRAF6 |
7189 |
Q9Y4K3 |
0.63 |
|
VCP |
7415 |
P55072 |
0.63 |
|
VHL |
7428 |
P40337 |
0.63 |
|
TNFRSF14 |
8764 |
Q92956 |
0.63 |
|
TNFRSF10D |
8793 |
Q9UBN6 |
0.63 |
|
ATG5 |
9474 |
Q9H1Y0 |
0.63 |
|
IKBKE |
9641 |
Q14164 |
0.63 |
|
KIAA0101 |
9768 |
Q15004 |
0.63 |
|
CBX3 |
11335 |
Q13185 |
0.63 |
|
GABARAP |
11337 |
O95166 |
0.63 |
|
GABARAPL2 |
11345 |
P60520 |
0.63 |
|
GABARAPL1 |
23710 |
Q9H0R8 |
0.63 |
|
FTSJ1 |
24140 |
Q9UET6 |
0.63 |
|
CHMP4A |
29082 |
Q9BY43 |
0.63 |
|
OTUB1 |
55611 |
Q96FW1 |
0.63 |
|
FBXO11 |
80204 |
Q86XK2 |
0.63 |
|
UNK |
85451 |
Q9C0B0 |
0.63 |
|
ABL1 |
25 |
P00519 |
0.72 |
|
ATF2 |
1386 |
P15336 |
0.72 |
|
STRN3 |
29966 |
Q13033 |
0.72 |
|
UBA5 |
79876 |
Q9GZZ9 |
0.72 |
|
CASP3 |
836 |
P42574 |
0.73 |
|
WDR1 |
9948 |
O75083 |
0.73 |
|
FHIT |
2272 |
P49789 |
0.75 |
|
DSTYK |
25778 |
Q6XUX3 |
0.76 |
|
VCAM1 |
7412 |
P19320 |
0.82 |